ES2118151T3 - Derivados de pirazolo(3,4-a)acridina como analgesicos. - Google Patents

Derivados de pirazolo(3,4-a)acridina como analgesicos.

Info

Publication number
ES2118151T3
ES2118151T3 ES93103604T ES93103604T ES2118151T3 ES 2118151 T3 ES2118151 T3 ES 2118151T3 ES 93103604 T ES93103604 T ES 93103604T ES 93103604 T ES93103604 T ES 93103604T ES 2118151 T3 ES2118151 T3 ES 2118151T3
Authority
ES
Spain
Prior art keywords
hydrogen
loweralkyl
aryl
arylloweralkyl
integer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93103604T
Other languages
English (en)
Inventor
Gregory Shutske
John Dick Tomer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Application granted granted Critical
Publication of ES2118151T3 publication Critical patent/ES2118151T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS QUE TIENEN LA FORMULA I DONDE, X ES HIDROGENO, ALQUILO INFERIOR, ALCOXI INFERIOR, HALOGENO O TRIFLUOROMETILO; R1 ES HIDROGENO O -NR4R5, DONDE CADA R4 Y R5 SON, INDEPENDIENTEMENTE, HIDROGENO, ALQUILO INFERIOR O ARILALQUILO INFERIOR; R2, QUE ES UN SUSTITUYENTE EN UNO DE LOS DOS ATOMOS DE NITROGENO DEL ANILLO DE PIRAZOL, ES HIDROGENO, ALQUILO INFERIOR, ALQUENILO INFERIOR, ARILO, ARILALQUILO INFERIOR, CIANOALQUILO INFERIOR, CMH2MCOOR6, -NR7R8, -CNH2NNR7R8 O -N=CH-ARILO, R6 ES HIDROGENO O ALQUILO INFERIOR, M ES UN ENTERO DE 1 A 3, CADA R7 Y R8 ES, INDEPENDIENTEMENTE, HIDROGENO O ALQUILO INFERIOR Y N ES UN ENTERO DE 2 A 4; Y R3 ES HIDROGENO O -CHOH-ARILO; O A LAS SALES DE ADICION ACIDAS FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS Y A UN PROCESO PARA SU PREPARACION. LOS COMPUESTOS MUESTRAN ACTIVIDAD ANALGESICA Y, POR TANTO, SE PUEDEN UTILIZAR COMO MEDICAMENTOS.
ES93103604T 1992-03-09 1993-03-05 Derivados de pirazolo(3,4-a)acridina como analgesicos. Expired - Lifetime ES2118151T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/848,558 US5179100A (en) 1992-03-09 1992-03-09 4,5-dihydropyrazolo[3,4-a]acridines

Publications (1)

Publication Number Publication Date
ES2118151T3 true ES2118151T3 (es) 1998-09-16

Family

ID=25303626

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93103604T Expired - Lifetime ES2118151T3 (es) 1992-03-09 1993-03-05 Derivados de pirazolo(3,4-a)acridina como analgesicos.

Country Status (7)

Country Link
US (1) US5179100A (es)
EP (1) EP0560231B1 (es)
JP (1) JP2656201B2 (es)
AT (1) ATE166874T1 (es)
DE (1) DE69318869T2 (es)
DK (1) DK0560231T3 (es)
ES (1) ES2118151T3 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5179100A (en) * 1992-03-09 1993-01-12 Hoechst-Roussel Pharmaceuticals Inc. 4,5-dihydropyrazolo[3,4-a]acridines
US5428040A (en) * 1993-08-31 1995-06-27 The Du Pont Merck Pharmaceutical Company Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4999430A (en) * 1989-07-31 1991-03-12 Warner-Lambert Company Derivatives of 1,2,3,4-tetrahydro-9-acrisinamine
US5179100A (en) * 1992-03-09 1993-01-12 Hoechst-Roussel Pharmaceuticals Inc. 4,5-dihydropyrazolo[3,4-a]acridines

Also Published As

Publication number Publication date
ATE166874T1 (de) 1998-06-15
DE69318869T2 (de) 1998-11-12
JP2656201B2 (ja) 1997-09-24
DK0560231T3 (da) 1999-03-22
DE69318869D1 (de) 1998-07-09
EP0560231B1 (en) 1998-06-03
JPH0649067A (ja) 1994-02-22
EP0560231A1 (en) 1993-09-15
US5179100A (en) 1993-01-12

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