ES2115760T3 - Derivados de 4''-desoxieritromicina. - Google Patents
Derivados de 4''-desoxieritromicina.Info
- Publication number
- ES2115760T3 ES2115760T3 ES93904533T ES93904533T ES2115760T3 ES 2115760 T3 ES2115760 T3 ES 2115760T3 ES 93904533 T ES93904533 T ES 93904533T ES 93904533 T ES93904533 T ES 93904533T ES 2115760 T3 ES2115760 T3 ES 2115760T3
- Authority
- ES
- Spain
- Prior art keywords
- derivatives
- desoxieritromicina
- erythromycin
- enhancers
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
DERIVADOS 4 -DEOXI DE ERITROMICIN QUE TIENE LA FORMULA (I) Y LAS SALES DE ELLO ACEPTABLES FARMACEUTICAMENTE, QUE SON INCREMENTADORES DE LA MOTILIDAD GASTRICA PERO TIENEN ACTIVIDAD ANTIBACTERIAL MINIMA, COMO TAMBIEN LAS COMPOSICIONES FARMACEUTICAS QUE CONTIENEN EL MISMO Y LOS METODOS PARA SU USO Y PREPARACION.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82349092A | 1992-01-21 | 1992-01-21 | |
US94415092A | 1992-09-11 | 1992-09-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2115760T3 true ES2115760T3 (es) | 1998-07-01 |
Family
ID=27124738
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93904533T Expired - Lifetime ES2115760T3 (es) | 1992-01-21 | 1993-01-19 | Derivados de 4''-desoxieritromicina. |
Country Status (16)
Country | Link |
---|---|
US (3) | US5578579A (es) |
EP (1) | EP0623021B1 (es) |
JP (1) | JP2662094B2 (es) |
KR (1) | KR0179379B1 (es) |
AT (1) | ATE164848T1 (es) |
AU (1) | AU656462B2 (es) |
CA (1) | CA2125478A1 (es) |
DE (1) | DE69317877T2 (es) |
DK (1) | DK0623021T3 (es) |
ES (1) | ES2115760T3 (es) |
HK (1) | HK1010054A1 (es) |
HU (1) | HU211337A9 (es) |
IL (1) | IL104437A (es) |
MX (1) | MX9300278A (es) |
PH (1) | PH31561A (es) |
WO (1) | WO1993013780A1 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY113693A (en) * | 1992-05-26 | 2002-05-31 | Chugai Pharmaceutical Co Ltd | Erythromycin derivatives having an enterokinesis stimulating action |
US5922849A (en) * | 1996-11-22 | 1999-07-13 | Abbott Laboratories | Process for preparation of N-demethyl-4"-deoxy-erthromycins A and B |
US5760198A (en) * | 1997-01-17 | 1998-06-02 | Abbott Laboratories | Process for preparation of 4"-deoxyerythromycins A and B |
US7910548B2 (en) * | 1997-06-06 | 2011-03-22 | Amylin Pharmaceuticals, Inc. | Methods for treating obesity |
US5780605A (en) * | 1997-09-08 | 1998-07-14 | Abbott Laboratories | 6,9-bridged erythromycin derivatives |
US5883236A (en) * | 1997-11-19 | 1999-03-16 | Abbott Laboratories | Process for N-desmethylating erythromycins and derivatives thereof |
US5932710A (en) * | 1997-12-01 | 1999-08-03 | Abbott Laboratories | Process for preparing 6-O-alkyl-9-oxime erythromycin B |
US6040440A (en) * | 1998-03-06 | 2000-03-21 | Abbott Laboratories | Hypophosphite deoxygenation reactions in the synthesis of erythromycin derivatives |
US6084079A (en) * | 1998-05-15 | 2000-07-04 | Keyes; Robert F. | Process for preparing N-demethyl-N-alkyl erythromycin derivatives |
CA2399198A1 (en) | 2000-02-18 | 2001-08-23 | Christopher Carreras | Motilide compounds |
CA2437576A1 (en) | 2001-02-15 | 2002-08-22 | Kosan Biosciences, Inc. | Method for evaluating therapeutic efficacy |
CN100363359C (zh) * | 2002-08-29 | 2008-01-23 | 菲塞股份有限公司 | 运动内酯化合物 |
CN1708309A (zh) * | 2002-10-25 | 2005-12-14 | 中外制药株式会社 | 排便功能障碍的治疗和/或预防剂 |
US20050113319A1 (en) * | 2003-08-26 | 2005-05-26 | Christopher Carreras | 11-Deoxy-6,9-ether erythromycin compounds |
US7407941B2 (en) * | 2003-08-26 | 2008-08-05 | Pfizer, Inc. | N-desmethyl-N-substituted-11-deoxyerythromycin compounds |
US7211568B2 (en) * | 2003-12-18 | 2007-05-01 | Kosan Biosciences Incorporated | 9-Desoxoerythromycin compounds as prokinetic agents |
US7582611B2 (en) * | 2005-05-24 | 2009-09-01 | Pfizer Inc. | Motilide compounds |
CA2632779A1 (en) * | 2005-12-08 | 2007-06-14 | Pfizer Inc. | Method for demethylating the 3'-dimethylamino group of erythromycin compounds |
EP2054429B1 (en) | 2006-09-11 | 2013-11-06 | Tranzyme Pharma, Inc. | Macrocyclic antagonists of the motilin receptor for treatment of gastrointestinal dysmotility disorders |
CN101547931B (zh) | 2006-12-05 | 2012-11-14 | 辉瑞有限公司 | 促动内酯多晶型 |
US20080287371A1 (en) * | 2007-05-17 | 2008-11-20 | Tranzyme Pharma Inc. | Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5849396A (ja) * | 1981-09-07 | 1983-03-23 | Toyo Jozo Co Ltd | 4″−デオキシ−14員環マクロライド抗生物質 |
JPS6187625A (ja) * | 1984-10-05 | 1986-05-06 | Satoshi Omura | 消化管収縮運動促進剤 |
US5175150A (en) * | 1985-08-31 | 1992-12-29 | Kitasato, Kenkyusho | Erythromycin derivative |
US5008249A (en) * | 1985-08-31 | 1991-04-16 | Kitasato Kenkyusho | Therapeutic method of stimulating digestive tract contractile motion in mammals |
DE3689758T2 (de) * | 1985-08-31 | 1994-08-18 | Kitasato Inst | Erythromycinderivat und Verfahren zu dessen Herstellung. |
US4681872A (en) * | 1985-11-12 | 1987-07-21 | Abbott Laboratories | Erythromycin A 11,12-carbonate and method of use |
US4640910A (en) * | 1985-11-12 | 1987-02-03 | Abbott Laboratories | Erythromycin A silylated compounds and method of use |
US4833236A (en) * | 1986-05-02 | 1989-05-23 | Taisho Pharmaceutical Co., Ltd. | Erythromycin derivatives |
MY103197A (en) * | 1987-02-20 | 1993-05-29 | Kitasato Inst | A growth promoting composition and production thereof |
US4920102A (en) * | 1988-04-18 | 1990-04-24 | Eli Lilly And Company | Method for treating gastrointestinal disorders |
-
1993
- 1993-01-19 EP EP93904533A patent/EP0623021B1/en not_active Expired - Lifetime
- 1993-01-19 IL IL104437A patent/IL104437A/xx not_active IP Right Cessation
- 1993-01-19 KR KR1019940702489A patent/KR0179379B1/ko not_active IP Right Cessation
- 1993-01-19 CA CA002125478A patent/CA2125478A1/en not_active Abandoned
- 1993-01-19 ES ES93904533T patent/ES2115760T3/es not_active Expired - Lifetime
- 1993-01-19 DK DK93904533T patent/DK0623021T3/da active
- 1993-01-19 DE DE69317877T patent/DE69317877T2/de not_active Expired - Fee Related
- 1993-01-19 MX MX9300278A patent/MX9300278A/es not_active IP Right Cessation
- 1993-01-19 AU AU35861/93A patent/AU656462B2/en not_active Ceased
- 1993-01-19 JP JP5512713A patent/JP2662094B2/ja not_active Expired - Lifetime
- 1993-01-19 AT AT93904533T patent/ATE164848T1/de not_active IP Right Cessation
- 1993-01-19 WO PCT/US1993/000468 patent/WO1993013780A1/en active IP Right Grant
- 1993-01-21 PH PH45597A patent/PH31561A/en unknown
-
1994
- 1994-08-02 US US08/284,730 patent/US5578579A/en not_active Expired - Fee Related
-
1995
- 1995-05-04 US US08/435,903 patent/US5834438A/en not_active Expired - Fee Related
- 1995-05-04 US US08/435,900 patent/US5654411A/en not_active Expired - Fee Related
- 1995-06-30 HU HU95P/P00662P patent/HU211337A9/hu unknown
-
1998
- 1998-09-23 HK HK98110890A patent/HK1010054A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU3586193A (en) | 1993-08-03 |
EP0623021A4 (en) | 1994-12-14 |
MX9300278A (es) | 1993-12-31 |
US5654411A (en) | 1997-08-05 |
US5834438A (en) | 1998-11-10 |
EP0623021B1 (en) | 1998-04-08 |
IL104437A (en) | 1997-03-18 |
PH31561A (en) | 1998-11-03 |
HK1010054A1 (en) | 1999-06-11 |
DE69317877D1 (en) | 1998-05-14 |
IL104437A0 (en) | 1993-05-13 |
DE69317877T2 (de) | 1998-10-29 |
AU656462B2 (en) | 1995-02-02 |
DK0623021T3 (da) | 1999-02-08 |
JP2662094B2 (ja) | 1997-10-08 |
HU211337A9 (en) | 1995-11-28 |
CA2125478A1 (en) | 1993-07-22 |
EP0623021A1 (en) | 1994-11-09 |
KR0179379B1 (ko) | 1999-04-01 |
US5578579A (en) | 1996-11-26 |
ATE164848T1 (de) | 1998-04-15 |
JPH06511257A (ja) | 1994-12-15 |
WO1993013780A1 (en) | 1993-07-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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