ES2115760T3 - Derivados de 4''-desoxieritromicina. - Google Patents

Derivados de 4''-desoxieritromicina.

Info

Publication number
ES2115760T3
ES2115760T3 ES93904533T ES93904533T ES2115760T3 ES 2115760 T3 ES2115760 T3 ES 2115760T3 ES 93904533 T ES93904533 T ES 93904533T ES 93904533 T ES93904533 T ES 93904533T ES 2115760 T3 ES2115760 T3 ES 2115760T3
Authority
ES
Spain
Prior art keywords
derivatives
desoxieritromicina
erythromycin
enhancers
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93904533T
Other languages
English (en)
Inventor
Paul A Lartey
Hugh N Nellans
Larry L Klein
Ramin Faghih
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2115760T3 publication Critical patent/ES2115760T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

DERIVADOS 4 -DEOXI DE ERITROMICIN QUE TIENE LA FORMULA (I) Y LAS SALES DE ELLO ACEPTABLES FARMACEUTICAMENTE, QUE SON INCREMENTADORES DE LA MOTILIDAD GASTRICA PERO TIENEN ACTIVIDAD ANTIBACTERIAL MINIMA, COMO TAMBIEN LAS COMPOSICIONES FARMACEUTICAS QUE CONTIENEN EL MISMO Y LOS METODOS PARA SU USO Y PREPARACION.
ES93904533T 1992-01-21 1993-01-19 Derivados de 4''-desoxieritromicina. Expired - Lifetime ES2115760T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82349092A 1992-01-21 1992-01-21
US94415092A 1992-09-11 1992-09-11

Publications (1)

Publication Number Publication Date
ES2115760T3 true ES2115760T3 (es) 1998-07-01

Family

ID=27124738

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93904533T Expired - Lifetime ES2115760T3 (es) 1992-01-21 1993-01-19 Derivados de 4''-desoxieritromicina.

Country Status (16)

Country Link
US (3) US5578579A (es)
EP (1) EP0623021B1 (es)
JP (1) JP2662094B2 (es)
KR (1) KR0179379B1 (es)
AT (1) ATE164848T1 (es)
AU (1) AU656462B2 (es)
CA (1) CA2125478A1 (es)
DE (1) DE69317877T2 (es)
DK (1) DK0623021T3 (es)
ES (1) ES2115760T3 (es)
HK (1) HK1010054A1 (es)
HU (1) HU211337A9 (es)
IL (1) IL104437A (es)
MX (1) MX9300278A (es)
PH (1) PH31561A (es)
WO (1) WO1993013780A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY113693A (en) * 1992-05-26 2002-05-31 Chugai Pharmaceutical Co Ltd Erythromycin derivatives having an enterokinesis stimulating action
US5922849A (en) * 1996-11-22 1999-07-13 Abbott Laboratories Process for preparation of N-demethyl-4"-deoxy-erthromycins A and B
US5760198A (en) * 1997-01-17 1998-06-02 Abbott Laboratories Process for preparation of 4"-deoxyerythromycins A and B
US7910548B2 (en) * 1997-06-06 2011-03-22 Amylin Pharmaceuticals, Inc. Methods for treating obesity
US5780605A (en) * 1997-09-08 1998-07-14 Abbott Laboratories 6,9-bridged erythromycin derivatives
US5883236A (en) * 1997-11-19 1999-03-16 Abbott Laboratories Process for N-desmethylating erythromycins and derivatives thereof
US5932710A (en) * 1997-12-01 1999-08-03 Abbott Laboratories Process for preparing 6-O-alkyl-9-oxime erythromycin B
US6040440A (en) * 1998-03-06 2000-03-21 Abbott Laboratories Hypophosphite deoxygenation reactions in the synthesis of erythromycin derivatives
US6084079A (en) * 1998-05-15 2000-07-04 Keyes; Robert F. Process for preparing N-demethyl-N-alkyl erythromycin derivatives
CA2399198A1 (en) 2000-02-18 2001-08-23 Christopher Carreras Motilide compounds
CA2437576A1 (en) 2001-02-15 2002-08-22 Kosan Biosciences, Inc. Method for evaluating therapeutic efficacy
CN100363359C (zh) * 2002-08-29 2008-01-23 菲塞股份有限公司 运动内酯化合物
CN1708309A (zh) * 2002-10-25 2005-12-14 中外制药株式会社 排便功能障碍的治疗和/或预防剂
US20050113319A1 (en) * 2003-08-26 2005-05-26 Christopher Carreras 11-Deoxy-6,9-ether erythromycin compounds
US7407941B2 (en) * 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
US7211568B2 (en) * 2003-12-18 2007-05-01 Kosan Biosciences Incorporated 9-Desoxoerythromycin compounds as prokinetic agents
US7582611B2 (en) * 2005-05-24 2009-09-01 Pfizer Inc. Motilide compounds
CA2632779A1 (en) * 2005-12-08 2007-06-14 Pfizer Inc. Method for demethylating the 3'-dimethylamino group of erythromycin compounds
EP2054429B1 (en) 2006-09-11 2013-11-06 Tranzyme Pharma, Inc. Macrocyclic antagonists of the motilin receptor for treatment of gastrointestinal dysmotility disorders
CN101547931B (zh) 2006-12-05 2012-11-14 辉瑞有限公司 促动内酯多晶型
US20080287371A1 (en) * 2007-05-17 2008-11-20 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5849396A (ja) * 1981-09-07 1983-03-23 Toyo Jozo Co Ltd ４″−デオキシ−１４員環マクロライド抗生物質
JPS6187625A (ja) * 1984-10-05 1986-05-06 Satoshi Omura 消化管収縮運動促進剤
US5175150A (en) * 1985-08-31 1992-12-29 Kitasato, Kenkyusho Erythromycin derivative
US5008249A (en) * 1985-08-31 1991-04-16 Kitasato Kenkyusho Therapeutic method of stimulating digestive tract contractile motion in mammals
DE3689758T2 (de) * 1985-08-31 1994-08-18 Kitasato Inst Erythromycinderivat und Verfahren zu dessen Herstellung.
US4681872A (en) * 1985-11-12 1987-07-21 Abbott Laboratories Erythromycin A 11,12-carbonate and method of use
US4640910A (en) * 1985-11-12 1987-02-03 Abbott Laboratories Erythromycin A silylated compounds and method of use
US4833236A (en) * 1986-05-02 1989-05-23 Taisho Pharmaceutical Co., Ltd. Erythromycin derivatives
MY103197A (en) * 1987-02-20 1993-05-29 Kitasato Inst A growth promoting composition and production thereof
US4920102A (en) * 1988-04-18 1990-04-24 Eli Lilly And Company Method for treating gastrointestinal disorders

Also Published As

Publication number Publication date
AU3586193A (en) 1993-08-03
EP0623021A4 (en) 1994-12-14
MX9300278A (es) 1993-12-31
US5654411A (en) 1997-08-05
US5834438A (en) 1998-11-10
EP0623021B1 (en) 1998-04-08
IL104437A (en) 1997-03-18
PH31561A (en) 1998-11-03
HK1010054A1 (en) 1999-06-11
DE69317877D1 (en) 1998-05-14
IL104437A0 (en) 1993-05-13
DE69317877T2 (de) 1998-10-29
AU656462B2 (en) 1995-02-02
DK0623021T3 (da) 1999-02-08
JP2662094B2 (ja) 1997-10-08
HU211337A9 (en) 1995-11-28
CA2125478A1 (en) 1993-07-22
EP0623021A1 (en) 1994-11-09
KR0179379B1 (ko) 1999-04-01
US5578579A (en) 1996-11-26
ATE164848T1 (de) 1998-04-15
JPH06511257A (ja) 1994-12-15
WO1993013780A1 (en) 1993-07-22

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