ES2114948T3 - Compuestos disminuidores del colesterol y procedimiento para prepararlos. - Google Patents

Compuestos disminuidores del colesterol y procedimiento para prepararlos.

Info

Publication number
ES2114948T3
ES2114948T3 ES92921189T ES92921189T ES2114948T3 ES 2114948 T3 ES2114948 T3 ES 2114948T3 ES 92921189 T ES92921189 T ES 92921189T ES 92921189 T ES92921189 T ES 92921189T ES 2114948 T3 ES2114948 T3 ES 2114948T3
Authority
ES
Spain
Prior art keywords
preparing
hydroxymethylhexose
sterol
procedure
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92921189T
Other languages
English (en)
Inventor
Adam Wieslaw Mazur
Stanislaw Pikul
Bruce Paul Daggy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Application granted granted Critical
Publication of ES2114948T3 publication Critical patent/ES2114948T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J17/005—Glycosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring

Abstract

SE DESCRIBEN UNA NUEVAS SAPONIFICADORAS QUE CONTIENEN 5-CHIDROXIMETILHEXOSA Y UN ESTEROL O TRITERPENA. ESTOS MATERIALES, CUANDO SON CONSUMIDOS POR LOS HUMANOS Y ANIMALES, REDUCEN EL NIVEL DE COLESTEROL EN LA SANGRE. LOS COMPUESTOS SE PUEDEN ADMINISTRAR COMO PREPARACION FARMACEUTICA A LA DIETA, O INCORPORADOS EN COMPOSICIONES ALIMENTICIAS. LAS COMPOSICIONES ESTAN LISTAS AL PREPARARLAS Y LUEGO HACER REACCIONAR FLUOR O BROMO 5-C-HIDROXIMETILHEXOSA HEXAACILATADA CON EL ESTEROL. EN UN SEGUNDO METODO LA 5-C-HIDROXIMETILHEXOSA HEXAACILATADA REACCIONA CON UN ESTEROL EN PRESENCIA DE UN SULFONATO TRIFLUOROMETANO TRIMETILSILILO.
ES92921189T 1991-10-04 1992-09-29 Compuestos disminuidores del colesterol y procedimiento para prepararlos. Expired - Lifetime ES2114948T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77170991A 1991-10-04 1991-10-04
US77166891A 1991-10-04 1991-10-04

Publications (1)

Publication Number Publication Date
ES2114948T3 true ES2114948T3 (es) 1998-06-16

Family

ID=27118506

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92921189T Expired - Lifetime ES2114948T3 (es) 1991-10-04 1992-09-29 Compuestos disminuidores del colesterol y procedimiento para prepararlos.

Country Status (9)

Country Link
EP (1) EP0607245B1 (es)
JP (1) JPH06511250A (es)
AT (1) ATE165367T1 (es)
AU (1) AU2753292A (es)
DE (1) DE69225233T2 (es)
ES (1) ES2114948T3 (es)
GR (1) GR3026698T3 (es)
PT (1) PT100922B (es)
WO (1) WO1993007167A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994000480A1 (en) * 1992-06-26 1994-01-06 Pfizer Inc. Steroidal glycosides for treating hypercholesterolemia
CZ280195A3 (en) * 1993-04-28 1996-02-14 Pfizer Crystalline spirostanyl glycoside, monohydrate thereof, pharmaceutical composition based thereon and process for preparing crystalline steroidal glycoside
US5502038A (en) * 1993-06-21 1996-03-26 Medical Research Foundation Of Oregon Cholesterol sequestrant glycosides that inhibit intestinal cholesterol absorption
ES2074006B1 (es) * 1993-07-05 1996-03-16 Pfizer Glicosidos esteroidales para tratar hipercolesterolemia.
US6150336A (en) * 1995-05-29 2000-11-21 Pfizer Inc. Steroidal glycosides
US5756470A (en) * 1996-10-29 1998-05-26 Schering Corporation Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
AU1122301A (en) * 1999-11-01 2001-05-14 Forbes Medi-Tech Inc. Novel glycosides comprising pentose mono-, di-, tri-, or oligosaccharides and phytosterols and/or phytostanols
FI20010780A0 (fi) 2001-04-12 2001-04-12 Raisio Benecol Oy Parannetut koostumukset
JP5696156B2 (ja) 2009-11-02 2015-04-08 ファイザー・インク ジオキサ−ビシクロ［３．２．１］オクタン−２，３，４−トリオール誘導体
JP6193513B2 (ja) 2014-05-19 2017-09-06 ファイザー・インク Ａｓｇｐｒ標的化剤としての置換６，８−ジオキサビシクロ［３．２．１］オクタン−２，３−ジオール化合物
MX2017011879A (es) 2015-03-20 2018-04-10 Univ Aarhus Inhibidores de pcsk9 para el tratamiento de trastornos del metabolismo de lipoproteínas".
US11173177B2 (en) 2016-09-20 2021-11-16 Aarhus Universitet Compounds for treatment of lipoprotein metabolism disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4602005A (en) * 1982-05-17 1986-07-22 Medical Research Foundation Of Oregon Tigogenin cellobioside for treating hypercholesterolemia and atherosclerosis
US5041541A (en) * 1988-05-05 1991-08-20 The Procter & Gamble Company Functional sugar substituted with reduced calories

Also Published As

Publication number Publication date
PT100922A (pt) 1993-10-29
ATE165367T1 (de) 1998-05-15
GR3026698T3 (en) 1998-07-31
AU2753292A (en) 1993-05-03
DE69225233T2 (de) 1998-11-19
PT100922B (pt) 1999-08-31
EP0607245A1 (en) 1994-07-27
JPH06511250A (ja) 1994-12-15
DE69225233D1 (de) 1998-05-28
EP0607245B1 (en) 1998-04-22
WO1993007167A1 (en) 1993-04-15

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