ES2113952T3 - Complejos de manganeso con ligandos macrociclicos nitrogenados eficaces como catalizadores para dismutar superoxidos. - Google Patents

Complejos de manganeso con ligandos macrociclicos nitrogenados eficaces como catalizadores para dismutar superoxidos.

Info

Publication number
ES2113952T3
ES2113952T3 ES92915849T ES92915849T ES2113952T3 ES 2113952 T3 ES2113952 T3 ES 2113952T3 ES 92915849 T ES92915849 T ES 92915849T ES 92915849 T ES92915849 T ES 92915849T ES 2113952 T3 ES2113952 T3 ES 2113952T3
Authority
ES
Spain
Prior art keywords
dismute
nitrogenated
superoxides
catalysts
manganese complexes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92915849T
Other languages
English (en)
Inventor
Karl William Aston
Patric James Lennon
Anil Shrikrishna Modak
William Lojda Neuman
Dennis Patrick Riley
Randy Herman Weiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Application granted granted Critical
Publication of ES2113952T3 publication Critical patent/ES2113952T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

LA INVENCION SE DIRIGE A IMITADORES DE BAJO PESO MOLECULAR DE DISMUTASA SUPEROXIDA (SOD) REPRESENTADA POR LA FORMULA GENERAL (I), DONDE R, R'', R1, R''1, R2, R''2, R3, R''3, R4, R''4, R5, R''5, R6, R''6, R7, R''7, R8, R''8, R9 Y R''9 Y X, Y, Z Y N SON COMO AQUI SE DEFINEN, UTILES COMO AGENTES TERAPEUTICOS PARA ESTADOS Y DESORDENES DE ENFERMEDAD INFLAMATORIA , DERRAME CEREBRAL, ATEROSCLEROSIS, HIPERTENSION Y TODAS LAS CONDICIONES DE DAÑOS DE LOS TEJIDOS OXIDANTE-INDUCIDOS.
ES92915849T 1991-07-19 1992-07-02 Complejos de manganeso con ligandos macrociclicos nitrogenados eficaces como catalizadores para dismutar superoxidos. Expired - Lifetime ES2113952T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73285391A 1991-07-19 1991-07-19
US82986592A 1992-02-03 1992-02-03

Publications (1)

Publication Number Publication Date
ES2113952T3 true ES2113952T3 (es) 1998-05-16

Family

ID=27112468

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92915849T Expired - Lifetime ES2113952T3 (es) 1991-07-19 1992-07-02 Complejos de manganeso con ligandos macrociclicos nitrogenados eficaces como catalizadores para dismutar superoxidos.

Country Status (11)

Country Link
EP (2) EP0598753B1 (es)
JP (1) JP3155552B2 (es)
KR (1) KR0145953B1 (es)
AT (1) ATE164164T1 (es)
AU (1) AU661023B2 (es)
DE (1) DE69224839T2 (es)
ES (1) ES2113952T3 (es)
IE (1) IE922211A1 (es)
IL (1) IL102408A0 (es)
NZ (2) NZ272364A (es)
WO (1) WO1993002090A1 (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2072934C (en) * 1991-07-19 2007-08-28 Karl William Aston Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
US6204259B1 (en) * 1993-01-14 2001-03-20 Monsanto Company Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
US5747026A (en) * 1993-10-15 1998-05-05 University Of Alabama At Birmingham Research Foundation Antioxidants
US6127356A (en) * 1993-10-15 2000-10-03 Duke University Oxidant scavengers
US5994339A (en) * 1993-10-15 1999-11-30 University Of Alabama At Birmingham Research Foundation Oxidant scavengers
HUT76318A (en) * 1994-04-22 1997-08-28 Searle & Co Diagnostic image analysis with metal complexes
CA2189528A1 (en) * 1994-05-13 1995-11-23 Michael Keith Stern Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor
US6245758B1 (en) 1994-05-13 2001-06-12 Michael K. Stern Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor
WO1996009053A1 (en) * 1994-09-20 1996-03-28 Duke University Oxidoreductase activity of manganic porphyrins
US6525041B1 (en) 1995-06-06 2003-02-25 Pharmacia Corporation Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
JPH11507621A (ja) * 1995-06-07 1999-07-06 モンサント カンパニー 置換ポリアザ大環状化合物の製造法
CA2229777A1 (en) * 1995-08-17 1997-02-27 Monsanto Company Methods of diagnostic image analysis using metal complexes of nitrogen-containing macrocyclic ligands
WO1997006824A2 (en) * 1995-08-17 1997-02-27 Monsanto Company Bioconjugates of manganese complexes and their application as catalysts
CA2229781A1 (en) 1995-08-17 1997-02-27 Monsanto Company Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands
AU2065697A (en) * 1996-03-13 1997-10-01 Monsanto Company Iron complexes of nitrogen-containing macrocyclic ligands effective as cataly sts for dismutating superoxide
WO1997033877A1 (en) * 1996-03-13 1997-09-18 Monsanto Company Bioconjugates of manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
NZ506515A (en) 1996-10-15 2002-05-31 G COX-2 inhibitor (4-[5-(4-chlorophenyl)-3(difluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide) for treating neoplasia
US6214817B1 (en) 1997-06-20 2001-04-10 Monsanto Company Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity
US6180620B1 (en) * 1997-06-20 2001-01-30 G.D. Searle & Co. Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals
ATE238307T1 (de) 1997-11-03 2003-05-15 Univ Duke Substituierte porphyrinen
DE69928655T2 (de) 1998-04-24 2006-08-24 Duke University Substituierte porphyrine
CA2359116C (en) 1999-01-25 2009-03-17 National Jewish Medical And Research Center Substituted porphyrins
ATE291446T1 (de) 1999-05-27 2005-04-15 Monsanto Co Biomaterialien, modifiziert mit superoxid- dismutase imitatoren
EP1577313B1 (en) * 1999-05-27 2008-01-09 Monsanto Company Biomaterials modified with superoxide dismutase mimics
US6448239B1 (en) 1999-06-03 2002-09-10 Trustees Of Princeton University Peroxynitrite decomposition catalysts and methods of use thereof
US20030050297A1 (en) 2001-01-19 2003-03-13 Crapo James D. Cancer therapy
EP1353655A2 (en) * 2001-01-26 2003-10-22 Metaphore Pharmaceuticals Inc. Method of treatment of neurodegenerative disorders using pentaaza-macrocyclic ligand complexes
CA2449024A1 (en) 2001-06-01 2002-12-12 National Jewish Medical And Research Center Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance
CA2488500A1 (en) 2002-06-07 2003-12-18 Duke University Substituted porphyrins
WO2005095408A1 (ja) * 2004-03-30 2005-10-13 Nagoya Institute Of Technology ケージ状配位子を有する多核金属錯体
WO2008094222A2 (en) 2006-10-06 2008-08-07 Trustees Of Princeton Porphyrin catalysts and methods of use thereof
PT2056675T (pt) 2006-10-12 2019-05-09 Galera Labs Llc Métodos de tratamento da mucosite oral
WO2008054298A1 (en) * 2006-11-03 2008-05-08 Magnus Sendel Method of producing a device and a device produced according to said method
ES2600469T3 (es) 2008-05-23 2017-02-09 National Jewish Health Un compuesto para su uso en el tratamiento de lesiones asociadas con la exposición al gas fosgeno o al gas de cloro
AU2012316397B2 (en) 2011-09-26 2016-07-21 Galera Labs, Llc Methods for treatment of diseases
MX2018001605A (es) * 2015-08-11 2018-09-26 Galera Labs Llc Complejos de anillos macrocíclicos de pentaaza que poseen biodisponibilidad oral.
WO2018045348A2 (en) 2016-09-01 2018-03-08 Galera Labs, Llc Combination cancer therapy with pentaaza macrocyclic ring complex and ascorbate compound
EA201992431A1 (ru) 2017-10-13 2020-03-13 ГАЛЕРА ЛЭБЗ, ЭлЭлСи Комбинированная иммунотерапия рака с использованием пента-аза-макроциклического кольцевого комплекса

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223538A (en) * 1987-03-31 1993-06-29 Duke University Superoxide dismutase mimic
FR2614020B1 (fr) * 1987-04-14 1989-07-28 Guerbet Sa Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands.
US4952289A (en) * 1988-05-09 1990-08-28 Aquanautics Corporation Macrocyclic amine complexes for ligand extraction and generation
GB9024208D0 (en) * 1990-11-07 1990-12-19 Salutar Inc Compounds

Also Published As

Publication number Publication date
JP3155552B2 (ja) 2001-04-09
AU2338392A (en) 1993-02-23
ATE164164T1 (de) 1998-04-15
JPH06509566A (ja) 1994-10-27
WO1993002090A1 (en) 1993-02-04
DE69224839T2 (de) 1998-10-08
EP0598753A1 (en) 1994-06-01
IL102408A0 (en) 1993-01-14
NZ243530A (en) 1997-08-22
NZ272364A (en) 1996-02-27
EP0598753B1 (en) 1998-03-18
IE922211A1 (en) 1993-01-27
KR0145953B1 (ko) 1998-08-17
EP0524161A1 (en) 1993-01-20
AU661023B2 (en) 1995-07-13
DE69224839D1 (de) 1998-04-23

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