DE69224839D1 - Mangan-Komplexe mit Stickstoff enthaltenden makrozyklischen Liganden, wirksam als Superoxiddismutasekatalysatoren. - Google Patents
Mangan-Komplexe mit Stickstoff enthaltenden makrozyklischen Liganden, wirksam als Superoxiddismutasekatalysatoren.Info
- Publication number
- DE69224839D1 DE69224839D1 DE69224839T DE69224839T DE69224839D1 DE 69224839 D1 DE69224839 D1 DE 69224839D1 DE 69224839 T DE69224839 T DE 69224839T DE 69224839 T DE69224839 T DE 69224839T DE 69224839 D1 DE69224839 D1 DE 69224839D1
- Authority
- DE
- Germany
- Prior art keywords
- superoxide dismutase
- catalysts
- nitrogen
- effective
- manganese complexes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000019197 Superoxide Dismutase Human genes 0.000 title abstract 3
- 108010012715 Superoxide dismutase Proteins 0.000 title abstract 3
- 239000003054 catalyst Substances 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 150000002696 manganese Chemical class 0.000 title 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 title 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 206010063837 Reperfusion injury Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 208000037906 ischaemic injury Diseases 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 230000000451 tissue damage Effects 0.000 abstract 1
- 231100000827 tissue damage Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73285391A | 1991-07-19 | 1991-07-19 | |
US82986592A | 1992-02-03 | 1992-02-03 | |
PCT/US1992/005805 WO1993002090A1 (en) | 1991-07-19 | 1992-07-02 | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69224839D1 true DE69224839D1 (de) | 1998-04-23 |
DE69224839T2 DE69224839T2 (de) | 1998-10-08 |
Family
ID=27112468
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69224839T Expired - Fee Related DE69224839T2 (de) | 1991-07-19 | 1992-07-02 | Mangan-Komplexe mit Stickstoff enthaltenden makrozyklischen Liganden, wirksam als Superoxiddismutasekatalysatoren. |
Country Status (11)
Country | Link |
---|---|
EP (2) | EP0598753B1 (de) |
JP (1) | JP3155552B2 (de) |
KR (1) | KR0145953B1 (de) |
AT (1) | ATE164164T1 (de) |
AU (1) | AU661023B2 (de) |
DE (1) | DE69224839T2 (de) |
ES (1) | ES2113952T3 (de) |
IE (1) | IE922211A1 (de) |
IL (1) | IL102408A0 (de) |
NZ (2) | NZ272364A (de) |
WO (1) | WO1993002090A1 (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2072934C (en) * | 1991-07-19 | 2007-08-28 | Karl William Aston | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
US6204259B1 (en) * | 1993-01-14 | 2001-03-20 | Monsanto Company | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
US5747026A (en) * | 1993-10-15 | 1998-05-05 | University Of Alabama At Birmingham Research Foundation | Antioxidants |
US6127356A (en) * | 1993-10-15 | 2000-10-03 | Duke University | Oxidant scavengers |
US5994339A (en) * | 1993-10-15 | 1999-11-30 | University Of Alabama At Birmingham Research Foundation | Oxidant scavengers |
HUT76318A (en) * | 1994-04-22 | 1997-08-28 | Searle & Co | Diagnostic image analysis with metal complexes |
CA2189528A1 (en) * | 1994-05-13 | 1995-11-23 | Michael Keith Stern | Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor |
US6245758B1 (en) | 1994-05-13 | 2001-06-12 | Michael K. Stern | Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor |
WO1996009053A1 (en) * | 1994-09-20 | 1996-03-28 | Duke University | Oxidoreductase activity of manganic porphyrins |
US6525041B1 (en) | 1995-06-06 | 2003-02-25 | Pharmacia Corporation | Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
JPH11507621A (ja) * | 1995-06-07 | 1999-07-06 | モンサント カンパニー | 置換ポリアザ大環状化合物の製造法 |
CA2229777A1 (en) * | 1995-08-17 | 1997-02-27 | Monsanto Company | Methods of diagnostic image analysis using metal complexes of nitrogen-containing macrocyclic ligands |
WO1997006824A2 (en) * | 1995-08-17 | 1997-02-27 | Monsanto Company | Bioconjugates of manganese complexes and their application as catalysts |
CA2229781A1 (en) | 1995-08-17 | 1997-02-27 | Monsanto Company | Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands |
AU2065697A (en) * | 1996-03-13 | 1997-10-01 | Monsanto Company | Iron complexes of nitrogen-containing macrocyclic ligands effective as cataly sts for dismutating superoxide |
WO1997033877A1 (en) * | 1996-03-13 | 1997-09-18 | Monsanto Company | Bioconjugates of manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
NZ506515A (en) | 1996-10-15 | 2002-05-31 | G | COX-2 inhibitor (4-[5-(4-chlorophenyl)-3(difluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide) for treating neoplasia |
US6214817B1 (en) | 1997-06-20 | 2001-04-10 | Monsanto Company | Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity |
US6180620B1 (en) * | 1997-06-20 | 2001-01-30 | G.D. Searle & Co. | Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals |
ATE238307T1 (de) | 1997-11-03 | 2003-05-15 | Univ Duke | Substituierte porphyrinen |
DE69928655T2 (de) | 1998-04-24 | 2006-08-24 | Duke University | Substituierte porphyrine |
CA2359116C (en) | 1999-01-25 | 2009-03-17 | National Jewish Medical And Research Center | Substituted porphyrins |
ATE291446T1 (de) | 1999-05-27 | 2005-04-15 | Monsanto Co | Biomaterialien, modifiziert mit superoxid- dismutase imitatoren |
EP1577313B1 (de) * | 1999-05-27 | 2008-01-09 | Monsanto Company | Biomaterialien, modifiziert mit Superoxid-Dismutase Imitatoren |
US6448239B1 (en) | 1999-06-03 | 2002-09-10 | Trustees Of Princeton University | Peroxynitrite decomposition catalysts and methods of use thereof |
US20030050297A1 (en) | 2001-01-19 | 2003-03-13 | Crapo James D. | Cancer therapy |
EP1353655A2 (de) * | 2001-01-26 | 2003-10-22 | Metaphore Pharmaceuticals Inc. | Verfahren zur behandlung von neurodegenerativen erkrankungen mit pentaaza-makrozyklischen ligandkomplexen |
CA2449024A1 (en) | 2001-06-01 | 2002-12-12 | National Jewish Medical And Research Center | Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance |
CA2488500A1 (en) | 2002-06-07 | 2003-12-18 | Duke University | Substituted porphyrins |
WO2005095408A1 (ja) * | 2004-03-30 | 2005-10-13 | Nagoya Institute Of Technology | ケージ状配位子を有する多核金属錯体 |
WO2008094222A2 (en) | 2006-10-06 | 2008-08-07 | Trustees Of Princeton | Porphyrin catalysts and methods of use thereof |
PT2056675T (pt) | 2006-10-12 | 2019-05-09 | Galera Labs Llc | Métodos de tratamento da mucosite oral |
WO2008054298A1 (en) * | 2006-11-03 | 2008-05-08 | Magnus Sendel | Method of producing a device and a device produced according to said method |
ES2600469T3 (es) | 2008-05-23 | 2017-02-09 | National Jewish Health | Un compuesto para su uso en el tratamiento de lesiones asociadas con la exposición al gas fosgeno o al gas de cloro |
AU2012316397B2 (en) | 2011-09-26 | 2016-07-21 | Galera Labs, Llc | Methods for treatment of diseases |
MX2018001605A (es) * | 2015-08-11 | 2018-09-26 | Galera Labs Llc | Complejos de anillos macrocíclicos de pentaaza que poseen biodisponibilidad oral. |
WO2018045348A2 (en) | 2016-09-01 | 2018-03-08 | Galera Labs, Llc | Combination cancer therapy with pentaaza macrocyclic ring complex and ascorbate compound |
EA201992431A1 (ru) | 2017-10-13 | 2020-03-13 | ГАЛЕРА ЛЭБЗ, ЭлЭлСи | Комбинированная иммунотерапия рака с использованием пента-аза-макроциклического кольцевого комплекса |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5223538A (en) * | 1987-03-31 | 1993-06-29 | Duke University | Superoxide dismutase mimic |
FR2614020B1 (fr) * | 1987-04-14 | 1989-07-28 | Guerbet Sa | Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands. |
US4952289A (en) * | 1988-05-09 | 1990-08-28 | Aquanautics Corporation | Macrocyclic amine complexes for ligand extraction and generation |
GB9024208D0 (en) * | 1990-11-07 | 1990-12-19 | Salutar Inc | Compounds |
-
1992
- 1992-07-02 ES ES92915849T patent/ES2113952T3/es not_active Expired - Lifetime
- 1992-07-02 AU AU23383/92A patent/AU661023B2/en not_active Ceased
- 1992-07-02 AT AT92915849T patent/ATE164164T1/de not_active IP Right Cessation
- 1992-07-02 EP EP92915849A patent/EP0598753B1/de not_active Expired - Lifetime
- 1992-07-02 DE DE69224839T patent/DE69224839T2/de not_active Expired - Fee Related
- 1992-07-02 KR KR98701831A patent/KR0145953B1/ko active
- 1992-07-02 WO PCT/US1992/005805 patent/WO1993002090A1/en active IP Right Grant
- 1992-07-02 JP JP50287293A patent/JP3155552B2/ja not_active Expired - Fee Related
- 1992-07-02 EP EP92870097A patent/EP0524161A1/de active Pending
- 1992-07-03 IL IL102408A patent/IL102408A0/xx unknown
- 1992-07-07 IE IE221192A patent/IE922211A1/en not_active IP Right Cessation
- 1992-07-13 NZ NZ272364A patent/NZ272364A/en not_active IP Right Cessation
- 1992-07-13 NZ NZ243530A patent/NZ243530A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
JP3155552B2 (ja) | 2001-04-09 |
AU2338392A (en) | 1993-02-23 |
ATE164164T1 (de) | 1998-04-15 |
JPH06509566A (ja) | 1994-10-27 |
WO1993002090A1 (en) | 1993-02-04 |
DE69224839T2 (de) | 1998-10-08 |
EP0598753A1 (de) | 1994-06-01 |
IL102408A0 (en) | 1993-01-14 |
NZ243530A (en) | 1997-08-22 |
NZ272364A (en) | 1996-02-27 |
EP0598753B1 (de) | 1998-03-18 |
IE922211A1 (en) | 1993-01-27 |
ES2113952T3 (es) | 1998-05-16 |
KR0145953B1 (ko) | 1998-08-17 |
EP0524161A1 (de) | 1993-01-20 |
AU661023B2 (en) | 1995-07-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |