ES2109967T3 - Procedimiento para la preparacion por via enzimatica de 2- y 5-monoesteres de isosorbida asi como su transformacion en 2- y 5-nitratos de isosorbida. - Google Patents

Procedimiento para la preparacion por via enzimatica de 2- y 5-monoesteres de isosorbida asi como su transformacion en 2- y 5-nitratos de isosorbida.

Info

Publication number
ES2109967T3
ES2109967T3 ES92114587T ES92114587T ES2109967T3 ES 2109967 T3 ES2109967 T3 ES 2109967T3 ES 92114587 T ES92114587 T ES 92114587T ES 92114587 T ES92114587 T ES 92114587T ES 2109967 T3 ES2109967 T3 ES 2109967T3
Authority
ES
Spain
Prior art keywords
isosorbide
preparation
monosters
nitrates
transformation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92114587T
Other languages
English (en)
Inventor
Manfred Prof Dr Schneider
Robert Dr Seemayer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Application granted granted Critical
Publication of ES2109967T3 publication Critical patent/ES2109967T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCESO PARA LA FABRICACION ENCIMATICA DE COMPUESTOS PUROS EN ISOMEROS DE LAS FORMULAS GENERALES I Y II EN LAS QUE LOS SUSTITUYENTES R TIENEN EL SIGNIFICADO INDICADO EN LAS REIVINDICACIONES, ASI COMO SU EMPLEO PARA LA FABRICACION DE NITRATOS 2-ISOSORBIDO PUROS EN ISOMEROS DE LA FORMULA V E NITRATOS 5-ISOSORBIDO DE LA FORMULA VI, LOS DOS SON IMPORTANTES COMO TERAPEUTICOS PARA ENFERMEDADES CORONARIAS.
ES92114587T 1991-09-02 1992-08-27 Procedimiento para la preparacion por via enzimatica de 2- y 5-monoesteres de isosorbida asi como su transformacion en 2- y 5-nitratos de isosorbida. Expired - Lifetime ES2109967T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4129093A DE4129093A1 (de) 1991-09-02 1991-09-02 Verfahren zur enzymatischen herstellung isomerenreiner isosorbid-2- und -5-monoester sowie deren ueberfuehrung in isosorbid-2- und -5-nitrat

Publications (1)

Publication Number Publication Date
ES2109967T3 true ES2109967T3 (es) 1998-02-01

Family

ID=6439651

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92114587T Expired - Lifetime ES2109967T3 (es) 1991-09-02 1992-08-27 Procedimiento para la preparacion por via enzimatica de 2- y 5-monoesteres de isosorbida asi como su transformacion en 2- y 5-nitratos de isosorbida.

Country Status (5)

Country Link
EP (1) EP0530671B1 (es)
JP (1) JP3098332B2 (es)
AT (1) ATE159050T1 (es)
DE (2) DE4129093A1 (es)
ES (1) ES2109967T3 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019202038A2 (en) * 2018-04-19 2019-10-24 University Of Tartu Synthesis and polymerization of isosorbide-based monomethacrylates
CN110590799B (zh) * 2019-09-24 2022-04-22 山东致泰医药技术有限公司 2-o-乙酰基-5-硝酸异山梨酯和5-o-乙酰基-2-硝酸异山梨酯的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3102947A1 (de) * 1981-01-29 1982-09-02 Heinrich Mack Nachf., 7918 Illertissen Verfahren zur herstellung von isosorbid-5-nitrat
DE3124410A1 (de) * 1981-06-22 1983-01-05 Heinrich Mack Nachf., 7918 Illertissen Verfahren zur herstellung von isosorbid-2-nitrat
DE3624703A1 (de) * 1986-07-22 1988-01-28 Hoechst Ag Chirale synthesebausteine aus prochiralem glycerin
US5032523A (en) * 1987-01-14 1991-07-16 Lion Corporation Preparation of optically active esters

Also Published As

Publication number Publication date
DE59208954D1 (de) 1997-11-13
EP0530671A3 (en) 1994-06-29
JP3098332B2 (ja) 2000-10-16
ATE159050T1 (de) 1997-10-15
JPH05268978A (ja) 1993-10-19
DE4129093A1 (de) 1993-03-04
EP0530671B1 (de) 1997-10-08
EP0530671A2 (de) 1993-03-10

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