ES2107376A1 - New pyrimidone derivatives having antifungal activity - Google Patents
New pyrimidone derivatives having antifungal activityInfo
- Publication number
- ES2107376A1 ES2107376A1 ES09501564A ES9501564A ES2107376A1 ES 2107376 A1 ES2107376 A1 ES 2107376A1 ES 09501564 A ES09501564 A ES 09501564A ES 9501564 A ES9501564 A ES 9501564A ES 2107376 A1 ES2107376 A1 ES 2107376A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- optionally
- substituted
- phenyl
- antifungal activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compounds of formula I, in the form of racemates or pure biologically active enantiomers, and their salts and solvates, where Ar is a phenyl group which is optionally substituted by one or more halogen and/or trifluoromethyl groups, R1 is C1-C4 alkyl, R2 is hydrogen or C1-C4 alkyl, or R1 with R2 form a polymethylene C2-C4 chain, R3 is hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, C3-C6 cycloalkyl -C1-C4 alkyl, C1-C4 haloalkyl, phenyl-C1-C4 alkyl, OH, SH, optionally substituted phenyl, naphthyl, a heterocyclic group containing 5 to 6 atoms which may optionally be substituted, A represents a benzene ring or a heterocyclic group containing 5 to 6 atoms which may optionally be substituted. The said compounds are useful as antifungal agents. Processes for obtaining them and pharmaceutical compositions containing them are also described. <IMAGE>
Priority Applications (28)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9501564A ES2107376B1 (en) | 1995-08-02 | 1995-08-02 | NEW DERIVATIVES OF PIRIMIDONA WITH ANTIFUNGAL ACTIVITY. |
EP96929201A EP0783501B9 (en) | 1995-08-02 | 1996-08-02 | pyrimidone derivatives with antifungal activity |
KR1019970701515A KR100423590B1 (en) | 1995-08-02 | 1996-08-02 | New pyrimidone derivatives with antifungal activity |
JP50725497A JP4049207B2 (en) | 1995-08-02 | 1996-08-02 | Novel pyrimidone derivatives with antifungal activity |
EP96928404A EP0783502A1 (en) | 1995-08-02 | 1996-08-02 | New carboxamides with antifungal activity |
MX9702382A MX9702382A (en) | 1995-08-02 | 1996-08-02 | New pyrimidone derivatives with antifungal activity. |
BR9606546A BR9606546A (en) | 1995-08-02 | 1996-08-02 | New carboxamides with fungicidal activity |
PCT/EP1996/003420 WO1997005130A1 (en) | 1995-08-02 | 1996-08-02 | New pyrimidone derivatives with antifungal activity |
PT96929201T PT783501E (en) | 1995-08-02 | 1996-08-02 | PYRIMIDONE DERIVATIVES WITH ANTIFUNGAL ACTIVITY |
BR9606547A BR9606547A (en) | 1995-08-02 | 1996-08-02 | New pyrimidone derivatives with fungicidal activity |
AU68703/96A AU6870396A (en) | 1995-08-02 | 1996-08-02 | New pyrimidone derivatives with antifungal activity |
AT96929201T ATE198593T1 (en) | 1995-08-02 | 1996-08-02 | PYRIMIDONE DERIVATIVES WITH ANTI-FUNGAL EFFECT |
US08/809,967 US5807854A (en) | 1995-08-02 | 1996-08-02 | Pyrimidone derivatives with antifungal activity |
CA002201477A CA2201477C (en) | 1995-08-02 | 1996-08-02 | New pyrimidone derivatives with antifungal activity |
ES96929201T ES2153975T3 (en) | 1995-08-02 | 1996-08-02 | DERIVATIVES OF PIRIMIDONA WITH ANTIFUNGIC ACTIVITY. |
MX9702380A MX9702380A (en) | 1995-08-02 | 1996-08-02 | New carboxamides with antifungal activity. |
DE69611512T DE69611512T2 (en) | 1995-08-02 | 1996-08-02 | PYRIMIDONE DERIVATIVES WITH ANTIFUNGAL EFFECT |
JP9507253A JPH10507205A (en) | 1995-08-02 | 1996-08-02 | Novel carbonamide with antifungal activity |
KR1019970701516A KR970705560A (en) | 1995-08-02 | 1996-08-02 | NEW CARBOXAMIDES WITH ANTIFUNGAL ACTIVITY WITH ANTIFUNGAL ACTIVITY |
PCT/EP1996/003419 WO1997005131A1 (en) | 1995-08-02 | 1996-08-02 | New carboxamides with antifungal activity |
CA002201478A CA2201478A1 (en) | 1995-08-02 | 1996-08-02 | New carboxamides with antifungal activity |
US08/809,815 US5888941A (en) | 1995-08-02 | 1996-08-02 | Carbozamides with antifungal activity |
DK96929201T DK0783501T3 (en) | 1995-08-02 | 1996-08-02 | Pyrimidone derivatives with anti-fungal activity |
AU67889/96A AU6788996A (en) | 1995-08-02 | 1996-08-02 | New carboxamides with antifungal activity |
ARP960103877A AR004180A1 (en) | 1995-08-02 | 1996-08-05 | NEW PIRIMIDONE DERIVATIVES WITH ANTIFUNGAL ACTIVITY AND PROCEDURE TO PREPARE THEM. |
NO19971470A NO312898B1 (en) | 1995-08-02 | 1997-04-01 | New pyrimidone derivatives with fungicidal activity |
NO971471A NO971471L (en) | 1995-08-02 | 1997-04-01 | New carboxamides with fungicidal activity |
GR20010400466T GR3035621T3 (en) | 1995-08-02 | 2001-03-23 | New pyrimidone derivatives with antifungal activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9501564A ES2107376B1 (en) | 1995-08-02 | 1995-08-02 | NEW DERIVATIVES OF PIRIMIDONA WITH ANTIFUNGAL ACTIVITY. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2107376A1 true ES2107376A1 (en) | 1997-11-16 |
ES2107376B1 ES2107376B1 (en) | 1998-07-01 |
Family
ID=8291256
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9501564A Expired - Fee Related ES2107376B1 (en) | 1995-08-02 | 1995-08-02 | NEW DERIVATIVES OF PIRIMIDONA WITH ANTIFUNGAL ACTIVITY. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2107376B1 (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0239500A2 (en) * | 1986-03-28 | 1987-09-30 | Roussel-Uclaf | 1-Styrene-sulfonyl-2-oxo-5-hydroxy-pyrrolidine derivatives, their intermediates, process for their preparation, compositions containing them and their use as medicines |
EP0357241A1 (en) * | 1988-08-13 | 1990-03-07 | Pfizer Limited | Triazole antifungal agents |
EP0567982A1 (en) * | 1992-04-28 | 1993-11-03 | Takeda Chemical Industries, Ltd. | Azole compounds, their production and use |
-
1995
- 1995-08-02 ES ES9501564A patent/ES2107376B1/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0239500A2 (en) * | 1986-03-28 | 1987-09-30 | Roussel-Uclaf | 1-Styrene-sulfonyl-2-oxo-5-hydroxy-pyrrolidine derivatives, their intermediates, process for their preparation, compositions containing them and their use as medicines |
EP0357241A1 (en) * | 1988-08-13 | 1990-03-07 | Pfizer Limited | Triazole antifungal agents |
EP0567982A1 (en) * | 1992-04-28 | 1993-11-03 | Takeda Chemical Industries, Ltd. | Azole compounds, their production and use |
Also Published As
Publication number | Publication date |
---|---|
ES2107376B1 (en) | 1998-07-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19971116 Kind code of ref document: A1 Effective date: 19971116 |
|
PC2A | Transfer of patent | ||
FD2A | Announcement of lapse in spain |
Effective date: 20151126 |