ES2100037T3 - Proceso para preparar enantiomeros sustancialmente puros de acidos fenilpropionicos. - Google Patents

Proceso para preparar enantiomeros sustancialmente puros de acidos fenilpropionicos.

Info

Publication number
ES2100037T3
ES2100037T3 ES94901940T ES94901940T ES2100037T3 ES 2100037 T3 ES2100037 T3 ES 2100037T3 ES 94901940 T ES94901940 T ES 94901940T ES 94901940 T ES94901940 T ES 94901940T ES 2100037 T3 ES2100037 T3 ES 2100037T3
Authority
ES
Spain
Prior art keywords
pct
stage
date jun
substantially pure
pure enantiomers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94901940T
Other languages
English (en)
Inventor
Robert Hardy
Paul Frederick Coe
Adrian Hirst
Hugh Owen O'donnell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott GmbH and Co KG
Original Assignee
Knoll GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929225203A external-priority patent/GB9225203D0/en
Priority claimed from GB929225202A external-priority patent/GB9225202D0/en
Application filed by Knoll GmbH filed Critical Knoll GmbH
Application granted granted Critical
Publication of ES2100037T3 publication Critical patent/ES2100037T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE DESCRIBE UN PROCESO PARA LA PRODUCCION DE UN PRODUCTO QUE SE ENRIQUECE EN UN ENANTIOMERO DESEADO DE UN ACIDO FENILPROPIONICO SELECCIONADO DE IBUPROFENO Y FLURBIPROFENO, O SUS SALES ACEPTADAS FARMACEUTICAMENTE, QUE COMPRENDE LAS SIGUIENTES ETAPAS: (A) UNA ETAPA DE RESOLUCION, EN LA CUAL UNA SAL DE (OMEGA)METILOBENCILAMINA DEL ACIDO FENILPROPIONICO ES PREPARADA LA CUAL ES ENRIQUECIDA EN EL ENANTIOMERO DESEADO MEDIANTE CONTACTO, EN UNA MEZCLA DE TOLUENO Y METANOL COMO DISOLVENTE, UNA MEZCLA SUBSTANCIALMENTE RACEMICA DEL ACIDO FENILPROPIONICO CON UN ENANTIOMERO DE (OMEGA)-METILOBENCILAMINA, EL PORCENTAJE MOLAR RESPECTIVO DEL ACIDO FENILPROPIONICO SUBSTANCIALMENTE RACEMICO RESPECTO A LA (OMEGA)-METILOBENCILAMINA ESTANDO EN UN RANGO DE 1:0.25 A 1:1; (B) UNA ETAPA DE RECRISTALIZACION, EN LA CUAL LA SAL ENRIQUECIDA RESULTANTE SE RECRISTALIZA DESDE UNA MEZCLA DE METANOL Y TOLUENO PARA DAR UNA SAL DE (OMEGA)-METILOBENCILAMINA DEL ACIDO FENILPROPIONICO QUE ADEMAS ES ENRIQUECIDA EN EL ENANTIOMERO DESEADO; (C) UNA ETAPA DE LIBERACION OPCIONAL, EN LA CUAL EL ACIDO FENILPROPIONICO QUE ADEMAS ESTA ENRIQUECIDO EN EL ENANTIOMERO DESEADO SE LIBERA DE LA SAL RECRISTALIZADA; (D) UNA ETAPA DE PREPARACION DE LA SAL OPCIONAL EN LA CUAL UNA SAL SOLIDA DEL ACIDO FENILPROPIONICO ENRIQUECIDO ADEMAS EN EL ENANTIOMERO DESEADO ES AISLADA, LA SAL SOLIDA OPCIONALMENTE ES INCLUSO ADEMAS ENANTIOMERICAMENTE ENRIQUECIDA EN EL ENANTIOMERO DESEADO. EL ENANTIOMERO DESEADO ES PREFERIBLEMENTE EL (S)-ENANTIOMERO, LAS SALES PREFERIDAS SON LA (OMEGA)-METILOBENCILAMINA, LISINA Y SALES DE SODIO.
ES94901940T 1992-12-02 1993-11-30 Proceso para preparar enantiomeros sustancialmente puros de acidos fenilpropionicos. Expired - Lifetime ES2100037T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929225203A GB9225203D0 (en) 1992-12-02 1992-12-02 Process
GB929225202A GB9225202D0 (en) 1992-12-02 1992-12-02 Process

Publications (1)

Publication Number Publication Date
ES2100037T3 true ES2100037T3 (es) 1997-06-01

Family

ID=26302084

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94901940T Expired - Lifetime ES2100037T3 (es) 1992-12-02 1993-11-30 Proceso para preparar enantiomeros sustancialmente puros de acidos fenilpropionicos.

Country Status (12)

Country Link
US (1) US5599969A (es)
EP (1) EP0672030B1 (es)
JP (1) JPH08504193A (es)
KR (1) KR100280766B1 (es)
AT (1) ATE151740T1 (es)
AU (1) AU672269B2 (es)
CA (1) CA2150355C (es)
DE (1) DE69309958T2 (es)
ES (1) ES2100037T3 (es)
FI (1) FI110776B (es)
RU (1) RU2133733C1 (es)
WO (1) WO1994012460A1 (es)

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US5380867A (en) * 1992-12-02 1995-01-10 Hoechst Celanese Corporation Selective precipitation of α-aryl carboxylic acid salts
IN189741B (es) * 1998-11-09 2003-04-19 Council Scient Ind Res
CA2406383A1 (en) * 2000-04-13 2001-10-25 Mayo Foundation For Medical Education And Research A.beta.42 lowering agents
JP2002069030A (ja) * 2000-08-30 2002-03-08 Kyowa Hakko Kogyo Co Ltd ナトリウム２−｛４−［（２−オキソシクロペンチル）メチル］フェニル｝プロピオネート２水和物の製造法
JP2006335639A (ja) * 2003-01-23 2006-12-14 Nagase & Co Ltd 光学活性なフルルビプロフェンの製造方法
EP1603548A4 (en) * 2003-02-05 2007-10-10 Myriad Genetics Inc COMPOSITION AND METHOD FOR TREATING NEURODEGENERATIVE DISORDERS
EP1651195A4 (en) * 2003-07-11 2007-10-03 Myriad Genetics Inc PHARMACEUTICAL PROCESSES, DOSIERSCHEMATA AND DOSAGE FORMS FOR THE TREATMENT OF ALZHEIMER DISEASE
US20070293538A1 (en) * 2004-04-13 2007-12-20 Myriad Genetics, Incorporated Pharmaceutical Composition And Methods For Treating Neurodegenerative Disorders
AU2005241023A1 (en) * 2004-04-29 2005-11-17 Keystone Retaining Wall Systems, Inc. Veneers for walls, retaining walls and the like
WO2006020850A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
WO2006020852A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
CA2580363A1 (en) * 2004-10-28 2006-05-11 Idexx Laboratories, Inc. Compositions for controlled delivery of pharmaceutically active compounds
WO2007014124A2 (en) * 2005-07-22 2007-02-01 Myriad Genetics, Inc. High drug load formulations and dosage forms
US7754679B2 (en) * 2005-11-16 2010-07-13 Idexx Laboratories, Inc. Pharmaceutical compositions for the administration of aptamers
US8114440B2 (en) * 2005-11-16 2012-02-14 Idexx Laboratories Inc. Pharmaceutical compositions for the administration of aptamers
US20080033045A1 (en) * 2006-07-07 2008-02-07 Myriad Genetics, Incorporated Treatment of psychiatric disorders
CA2677125C (en) * 2007-02-01 2018-07-10 Myriad Genetics, Inc. Drug substance preparations, pharmaceutical compositions and dosage forms
US8828960B2 (en) * 2007-07-17 2014-09-09 Idexx Laboratories, Inc. Amino acid vitamin ester compositions for controlled delivery of pharmaceutically active compounds
GB0811851D0 (en) * 2008-06-30 2008-07-30 Aesica Pharmaceuticals Ltd Process
GB201216893D0 (en) * 2012-09-21 2012-11-07 Aesica Pharmaceuticals Ltd Drug substance preparations, pharmaceutical compositions and dosage forms comprising s-(+)-flurbiprofen
GB201405456D0 (en) * 2014-03-26 2014-05-07 Aesica Pharmaceuticals Ltd Process for the manufacture of S-(+)-Flurbiprofen
CN115286501A (zh) * 2022-08-10 2022-11-04 浙江新和成股份有限公司 一种布洛芬结晶母液的综合利用方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1497044A (en) * 1974-03-07 1978-01-05 Prodotti Antibiotici Spa Salts of phenyl-alkanoic acids
IT1059677B (it) * 1974-03-22 1982-06-21 Neopharmed Spa Sale di lisina ad azione terapeutica
JPS55136245A (en) * 1979-04-09 1980-10-23 Sumitomo Chem Co Ltd Optical resolution of alpha-isopropyl-p-chlorophenyl-acetic acid
DE3824353A1 (de) * 1988-07-19 1990-01-25 Paz Arzneimittelentwicklung Verfahren zur trennung von gemischen enantiomerer arylpropionsaeuren
NO902190L (no) * 1989-05-16 1990-11-19 Puetter Medice Chem Pharm Fremgangsmaate for fremstilling av optisk aktive 2-arylalkanonsyrer, saerlig 2-arylpropionsyrer.
DK0424028T3 (da) * 1989-10-17 1996-01-29 Merck & Co Inc S(+)-ibuprofen-L-aminosyre og S(+)-ibuprofen-D-aminosyre som et forbedret smertestillende middel med fremskyndet indtrædelse
US5200558A (en) * 1989-10-17 1993-04-06 Merck & Co., Inc. S(+)-ibuprofen-L-amino acid and S(+)-ibuprofen-D-amino acid as onset-hastened enhanced analgesics
US4994604A (en) * 1990-01-10 1991-02-19 Merck & Co., Inc. Formation and resolution of ibuprofen lysinate
US5015764A (en) * 1990-06-18 1991-05-14 Ethyl Corporation Preparation of optically active aliphatic carboxylic acids
DE4028906A1 (de) * 1990-09-12 1992-03-19 Paz Arzneimittelentwicklung Arzneimittel sowie deren herstellung und deren verwendung bei der bekaempfung von schmerzen und/oder entzuendungen und/oder fieber an tieren und menschen
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US5380867A (en) * 1992-12-02 1995-01-10 Hoechst Celanese Corporation Selective precipitation of α-aryl carboxylic acid salts

Also Published As

Publication number Publication date
EP0672030A1 (en) 1995-09-20
AU672269B2 (en) 1996-09-26
EP0672030B1 (en) 1997-04-16
DE69309958T2 (de) 1997-07-24
JPH08504193A (ja) 1996-05-07
RU95113445A (ru) 1997-06-10
FI952677A (fi) 1995-06-01
DE69309958D1 (de) 1997-05-22
CA2150355A1 (en) 1994-06-09
KR100280766B1 (ko) 2001-02-01
FI952677A0 (fi) 1995-06-01
KR950704226A (ko) 1995-11-17
FI110776B (fi) 2003-03-31
AU5650494A (en) 1994-06-22
ATE151740T1 (de) 1997-05-15
WO1994012460A1 (en) 1994-06-09
US5599969A (en) 1997-02-04
CA2150355C (en) 2008-03-11
RU2133733C1 (ru) 1999-07-27

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