ATE151740T1 - Verfahren zur herstellung von im wesentlichen enantiomeren der phenylpropionsäuren - Google Patents

Verfahren zur herstellung von im wesentlichen enantiomeren der phenylpropionsäuren

Info

Publication number
ATE151740T1
ATE151740T1 AT94901940T AT94901940T ATE151740T1 AT E151740 T1 ATE151740 T1 AT E151740T1 AT 94901940 T AT94901940 T AT 94901940T AT 94901940 T AT94901940 T AT 94901940T AT E151740 T1 ATE151740 T1 AT E151740T1
Authority
AT
Austria
Prior art keywords
pct
stage
enantiomers
date jun
sec
Prior art date
Application number
AT94901940T
Other languages
English (en)
Inventor
Robert Hardy
Paul Frederick Coe
Adrian Hirst
Hugh Owen O'donnell
Original Assignee
Knoll Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929225202A external-priority patent/GB9225202D0/en
Priority claimed from GB929225203A external-priority patent/GB9225203D0/en
Application filed by Knoll Ag filed Critical Knoll Ag
Application granted granted Critical
Publication of ATE151740T1 publication Critical patent/ATE151740T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT94901940T 1992-12-02 1993-11-30 Verfahren zur herstellung von im wesentlichen enantiomeren der phenylpropionsäuren ATE151740T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929225202A GB9225202D0 (en) 1992-12-02 1992-12-02 Process
GB929225203A GB9225203D0 (en) 1992-12-02 1992-12-02 Process

Publications (1)

Publication Number Publication Date
ATE151740T1 true ATE151740T1 (de) 1997-05-15

Family

ID=26302084

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94901940T ATE151740T1 (de) 1992-12-02 1993-11-30 Verfahren zur herstellung von im wesentlichen enantiomeren der phenylpropionsäuren

Country Status (12)

Country Link
US (1) US5599969A (de)
EP (1) EP0672030B1 (de)
JP (1) JPH08504193A (de)
KR (1) KR100280766B1 (de)
AT (1) ATE151740T1 (de)
AU (1) AU672269B2 (de)
CA (1) CA2150355C (de)
DE (1) DE69309958T2 (de)
ES (1) ES2100037T3 (de)
FI (1) FI110776B (de)
RU (1) RU2133733C1 (de)
WO (1) WO1994012460A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380867A (en) * 1992-12-02 1995-01-10 Hoechst Celanese Corporation Selective precipitation of α-aryl carboxylic acid salts
IN189741B (de) * 1998-11-09 2003-04-19 Council Scient Ind Res
JP2003530437A (ja) * 2000-04-13 2003-10-14 マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ Ａβ４２低下物質
JP2002069030A (ja) * 2000-08-30 2002-03-08 Kyowa Hakko Kogyo Co Ltd ナトリウム２−｛４−［（２−オキソシクロペンチル）メチル］フェニル｝プロピオネート２水和物の製造法
JP2006335639A (ja) * 2003-01-23 2006-12-14 Nagase & Co Ltd 光学活性なフルルビプロフェンの製造方法
WO2004071431A2 (en) * 2003-02-05 2004-08-26 Myriad Genetics, Inc. Method and composition for treating neurodegenerative disorders
US20050042284A1 (en) * 2003-07-11 2005-02-24 Myriad Genetics, Incorporated Pharmaceutical methods, dosing regimes and dosage forms for the treatment of Alzheimer's disease
US20070293538A1 (en) * 2004-04-13 2007-12-20 Myriad Genetics, Incorporated Pharmaceutical Composition And Methods For Treating Neurodegenerative Disorders
AU2005241023A1 (en) * 2004-04-29 2005-11-17 Keystone Retaining Wall Systems, Inc. Veneers for walls, retaining walls and the like
WO2006020850A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
WO2006020852A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
EP1804771A2 (de) * 2004-10-28 2007-07-11 Idexx Laboratories, Inc. Zusammensetzungen zur kontrollierten verabreichung pharmazeutisch aktiver zusammensetzungen
EA200800360A1 (ru) * 2005-07-22 2008-06-30 Мириад Дженетикс, Инк. Формуляции с высоким содержанием лекарства и дозированные формы
US7754679B2 (en) * 2005-11-16 2010-07-13 Idexx Laboratories, Inc. Pharmaceutical compositions for the administration of aptamers
US8114440B2 (en) * 2005-11-16 2012-02-14 Idexx Laboratories Inc. Pharmaceutical compositions for the administration of aptamers
US20080033045A1 (en) * 2006-07-07 2008-02-07 Myriad Genetics, Incorporated Treatment of psychiatric disorders
EP2117302A1 (de) * 2007-02-01 2009-11-18 Myriad Genetics, Inc. Arzneiwirkstoffpräparate, pharmazeutische zusammensetzungen und verabreichungsformen
US8828960B2 (en) * 2007-07-17 2014-09-09 Idexx Laboratories, Inc. Amino acid vitamin ester compositions for controlled delivery of pharmaceutically active compounds
GB0811851D0 (en) * 2008-06-30 2008-07-30 Aesica Pharmaceuticals Ltd Process
GB201216893D0 (en) * 2012-09-21 2012-11-07 Aesica Pharmaceuticals Ltd Drug substance preparations, pharmaceutical compositions and dosage forms comprising s-(+)-flurbiprofen
GB201405456D0 (en) 2014-03-26 2014-05-07 Aesica Pharmaceuticals Ltd Process for the manufacture of S-(+)-Flurbiprofen
CN115286501A (zh) * 2022-08-10 2022-11-04 浙江新和成股份有限公司 一种布洛芬结晶母液的综合利用方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1497044A (en) * 1974-03-07 1978-01-05 Prodotti Antibiotici Spa Salts of phenyl-alkanoic acids
IT1059677B (it) * 1974-03-22 1982-06-21 Neopharmed Spa Sale di lisina ad azione terapeutica
JPS55136245A (en) * 1979-04-09 1980-10-23 Sumitomo Chem Co Ltd Optical resolution of alpha-isopropyl-p-chlorophenyl-acetic acid
DE3824353A1 (de) * 1988-07-19 1990-01-25 Paz Arzneimittelentwicklung Verfahren zur trennung von gemischen enantiomerer arylpropionsaeuren
DE4015781A1 (de) * 1989-05-16 1990-12-13 Puetter Medice Chem Pharm Verfahren zur herstellung optisch aktiver 2-aryl-alkansaeuren, insbesondere von 2-aryl-propionsaeuren
EP0424028B1 (de) * 1989-10-17 1995-09-27 Merck & Co. Inc. S(+)-Ibuprofen-L-Aminosäure und S(+)-Ibuprofen-D-Aminosäure als Analgetika mit grösserem pharmakologischem Potential
US5200558A (en) * 1989-10-17 1993-04-06 Merck & Co., Inc. S(+)-ibuprofen-L-amino acid and S(+)-ibuprofen-D-amino acid as onset-hastened enhanced analgesics
US4994604A (en) * 1990-01-10 1991-02-19 Merck & Co., Inc. Formation and resolution of ibuprofen lysinate
US5015764A (en) * 1990-06-18 1991-05-14 Ethyl Corporation Preparation of optically active aliphatic carboxylic acids
DE4028906A1 (de) * 1990-09-12 1992-03-19 Paz Arzneimittelentwicklung Arzneimittel sowie deren herstellung und deren verwendung bei der bekaempfung von schmerzen und/oder entzuendungen und/oder fieber an tieren und menschen
HUT59692A (en) * 1990-11-15 1992-06-29 Puetter Medice Chem Pharm Process for producing complexes containing s/+/-phenyl-alkanoic acids and aminosugars
HUT59656A (en) * 1990-11-15 1992-06-29 Puetter Medice Chem Pharm Process for producing s/+/-phenyl-alkanoic acids and alpha-amino-acids containing complexes and pharmaceutical compositions containing them as active components
ES2093192T3 (es) * 1991-03-22 1996-12-16 Merck & Co Inc Formulacion farmaceutica con elevado contenido de lisinato de ibuprofeno.
US6525214B1 (en) * 1991-05-13 2003-02-25 Bernard John Armitage Therapeutic agent
FR2687673B1 (fr) * 1992-01-13 1995-07-07 Jung Jean Sels amines d'acides arylcarboxyliques, sterilisables, solubles dans l'eau, utilises en ophtalmologie et/ou dans la sphere otorhinolaryngologique.
US5302751A (en) * 1992-01-21 1994-04-12 Ethyl Corporation Profen resolution
US5288507A (en) * 1992-07-29 1994-02-22 Merck & Co., Inc. Ibuprofen antacid combinations
AU4682193A (en) * 1992-07-29 1994-03-03 Merck & Co., Inc. Dexibuprofen/antacid/simethicone combinations
CA2144152A1 (en) * 1992-09-29 1994-04-14 Robert T. Sims Ibuprofen-caffine combinations
US5278337A (en) * 1992-10-14 1994-01-11 Ethyl Corporation Enantiomeric resolution of aryl-substituted aliphatic carboxylic acids
US5248813A (en) * 1992-10-14 1993-09-28 Ethyl Corporation Enantiomeric resolution
US5260482A (en) * 1992-10-14 1993-11-09 Ethyl Corporation Enantiomeric resolution
US5380867A (en) * 1992-12-02 1995-01-10 Hoechst Celanese Corporation Selective precipitation of α-aryl carboxylic acid salts

Also Published As

Publication number Publication date
US5599969A (en) 1997-02-04
WO1994012460A1 (en) 1994-06-09
FI952677A (fi) 1995-06-01
FI952677A0 (fi) 1995-06-01
AU672269B2 (en) 1996-09-26
DE69309958T2 (de) 1997-07-24
FI110776B (fi) 2003-03-31
CA2150355C (en) 2008-03-11
KR950704226A (ko) 1995-11-17
EP0672030B1 (de) 1997-04-16
AU5650494A (en) 1994-06-22
RU2133733C1 (ru) 1999-07-27
ES2100037T3 (es) 1997-06-01
EP0672030A1 (de) 1995-09-20
DE69309958D1 (de) 1997-05-22
RU95113445A (ru) 1997-06-10
CA2150355A1 (en) 1994-06-09
KR100280766B1 (ko) 2001-02-01
JPH08504193A (ja) 1996-05-07

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