ES2099699T3 - Fijacion covalente de los miembros de union especificos a las fases solidas. - Google Patents
Fijacion covalente de los miembros de union especificos a las fases solidas.Info
- Publication number
- ES2099699T3 ES2099699T3 ES90108317T ES90108317T ES2099699T3 ES 2099699 T3 ES2099699 T3 ES 2099699T3 ES 90108317 T ES90108317 T ES 90108317T ES 90108317 T ES90108317 T ES 90108317T ES 2099699 T3 ES2099699 T3 ES 2099699T3
- Authority
- ES
- Spain
- Prior art keywords
- specific
- ligature
- members
- solid phases
- solid phase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
- G01N33/56988—HIV or HTLV
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/974—Aids related test
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/815—Carrier is a synthetic polymer
- Y10S530/816—Attached to the carrier via a bridging agent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
LA PRESENTE INVENCION PROVEE METODOS NOVEDOSOS PARA LA UNION COVALENTE DE UN MIEMBRO ESPECIFICO DE LIGADURA A UNA FASE SOLIDA A TRAVES DE LA REACCION DE UNA FASE SOLIDA TIOLADA Y UN MIEMBRO DE LIGADURA ESPECIFICA QUE SE COMPLEJA A UN AGENTE DE ACOPLAMIENTO HETEROBIFUNCIONAL. PUEDE UTILIZARSE EL MIEMBRO DE LIGADURA ESPECIFICA INMOBILIZADO RESULTANTE PARA DIAGNOSTICAR ENSAYOS DE LIGADURA. EL INVENTO PERMITE LA PRODUCCION DE MIEMBROS DE LIGADURA ESPECIFICA INMOVILIZADOS DE MAYOR SENSIBILIDAD, ESPECIFICIDAD Y ESTBILIDAD, A LA VEZ QUE REQUIEREN UNA MENOR UTILIZACION DE MIEMBROS DE LIGADURA ESPECIFICOS. ACTIVACION DE UN MIEMBRO DE LIGADURA ESPECIFICO UTILIZANDO UN REACTIVO HETEROBIFUNCIONAL DE ESTER ACTIVO DE MALEIMIDA-NH5.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34610889A | 1989-05-02 | 1989-05-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2099699T3 true ES2099699T3 (es) | 1997-06-01 |
Family
ID=23357993
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90108317T Expired - Lifetime ES2099699T3 (es) | 1989-05-02 | 1990-05-02 | Fijacion covalente de los miembros de union especificos a las fases solidas. |
Country Status (6)
Country | Link |
---|---|
US (1) | US5399501A (es) |
EP (1) | EP0396116B1 (es) |
JP (1) | JP3124018B2 (es) |
CA (1) | CA2015938C (es) |
DE (1) | DE69029873T2 (es) |
ES (1) | ES2099699T3 (es) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8927365D0 (en) * | 1989-12-04 | 1990-01-31 | Ici Plc | Reagent |
DE4033714C3 (de) * | 1990-10-24 | 1995-09-07 | Brahms Diagnostica Gmbh | Neues Hapten-Analytikum basierend auf dem Prinzip einer Antigen-Antikörper-Reaktion |
DE59106527D1 (de) * | 1990-11-14 | 1995-10-26 | Hoffmann La Roche | Immunsensorischer Wandler und Verfahren zu seiner Herstellung. |
GB9105031D0 (en) * | 1991-03-09 | 1991-04-24 | Fisons Plc | Processing analytical reagents |
ATE175275T1 (de) * | 1992-02-05 | 1999-01-15 | Yamasa Corp | Festphasenreagenz und selbiges verwendendes antikörpertestverfahren |
US5294536A (en) * | 1992-04-23 | 1994-03-15 | Pb Diagnostic Systems, Inc. | Conjugates |
US6194144B1 (en) | 1993-01-07 | 2001-02-27 | Sequenom, Inc. | DNA sequencing by mass spectrometry |
US5605798A (en) | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
US5527711A (en) * | 1993-12-13 | 1996-06-18 | Hewlett Packard Company | Method and reagents for binding chemical analytes to a substrate surface, and related analytical devices and diagnostic techniques |
US6428955B1 (en) | 1995-03-17 | 2002-08-06 | Sequenom, Inc. | DNA diagnostics based on mass spectrometry |
US7803529B1 (en) | 1995-04-11 | 2010-09-28 | Sequenom, Inc. | Solid phase sequencing of biopolymers |
US6184344B1 (en) * | 1995-05-04 | 2001-02-06 | The Scripps Research Institute | Synthesis of proteins by native chemical ligation |
DE69521815T2 (de) * | 1995-05-04 | 2002-04-04 | The Scripps Research Institute, La Jolla | Proteinsynthese mittels nativer chemischer ligation (07.01.97) |
DE19534988A1 (de) * | 1995-09-21 | 1997-03-27 | Forssmann Wolf Georg | Verfahren zur Herstellung und Anwendung synthetischer, biotinylierter Peptide |
DE19621177A1 (de) * | 1996-05-24 | 1997-11-27 | Basf Ag | Kohlenhydratderivate und ihre Synthese an fester Phase |
US5681754A (en) * | 1996-06-07 | 1997-10-28 | Abbott Laboratories | Method for improving the performance of an immunoreagent in an immunoassay |
FR2751989B1 (fr) * | 1996-08-01 | 1998-10-30 | Soc D Rech Et De Dev En Activa | Methode d'identification de cellules eucaryotes par fixation desdites cellules sur un support et support pour mettre en oeuvre ladite methode |
ATE375403T1 (de) * | 1996-11-06 | 2007-10-15 | Sequenom Inc | Dna-diagnostik mittels massenspektrometrie |
US6140053A (en) | 1996-11-06 | 2000-10-31 | Sequenom, Inc. | DNA sequencing by mass spectrometry via exonuclease degradation |
US5900481A (en) * | 1996-11-06 | 1999-05-04 | Sequenom, Inc. | Bead linkers for immobilizing nucleic acids to solid supports |
US6024925A (en) | 1997-01-23 | 2000-02-15 | Sequenom, Inc. | Systems and methods for preparing low volume analyte array elements |
ES2215241T3 (es) | 1996-11-06 | 2004-10-01 | Sequenom, Inc. | Procedimiento de espectrometria de masa. |
US6133436A (en) * | 1996-11-06 | 2000-10-17 | Sequenom, Inc. | Beads bound to a solid support and to nucleic acids |
US7285422B1 (en) | 1997-01-23 | 2007-10-23 | Sequenom, Inc. | Systems and methods for preparing and analyzing low volume analyte array elements |
CA2267070A1 (en) * | 1996-11-06 | 1998-05-14 | Sequenom, Inc. | Compositions and methods for immobilizing nucleic acids to solid supports |
US6268131B1 (en) | 1997-12-15 | 2001-07-31 | Sequenom, Inc. | Mass spectrometric methods for sequencing nucleic acids |
US6723564B2 (en) | 1998-05-07 | 2004-04-20 | Sequenom, Inc. | IR MALDI mass spectrometry of nucleic acids using liquid matrices |
US6306665B1 (en) * | 1999-10-13 | 2001-10-23 | A-Fem Medical Corporation | Covalent bonding of molecules to an activated solid phase material |
KR100649342B1 (ko) | 2000-10-30 | 2006-11-27 | 시쿼넘, 인코포레이티드 | 기판 상으로 서브마이크로리터 볼륨들을 전달하기 위한 방법 및 장치 |
IL145210A (en) | 2000-12-06 | 2011-12-29 | Aposense Ltd | Materials that bind shaken membranes |
WO2002090961A2 (en) * | 2001-05-03 | 2002-11-14 | Immunetics, Inc. | Systems and methods for detection of analytes in biological fluids |
US7297553B2 (en) | 2002-05-28 | 2007-11-20 | Nanosphere, Inc. | Method for attachment of silylated molecules to glass surfaces |
CA2563510A1 (en) * | 2001-07-13 | 2005-11-17 | Nanosphere, Inc. | Method for preparing substrates having immobilized molecules and substrates |
WO2003006676A2 (en) * | 2001-07-13 | 2003-01-23 | Nanosphere, Inc. | Method for immobilizing molecules onto surfaces |
US8481334B1 (en) * | 2001-11-06 | 2013-07-09 | Charm Sciences, Inc. | Method of attaching a ligand to a solid support |
IL148598A (en) * | 2002-03-10 | 2008-04-13 | Ely Morag | Multifunctional complex for targeting specific phagocytosis of a target agent and a composition comprising it |
AU2003278987A1 (en) * | 2002-09-26 | 2004-04-19 | The Children's Hospital Of Philadelphia | Method of determining surface binding capacity |
WO2004075855A2 (en) | 2003-02-26 | 2004-09-10 | Biomed Solutions, Llc | Process for in vivo treatment of specific biological targets in bodily fluid |
IL158140A0 (en) * | 2003-09-25 | 2004-03-28 | Hadasit Med Res Service | Multiepitope polypeptides for cancer immunotherapy |
US20050112786A1 (en) * | 2003-11-25 | 2005-05-26 | Qing Wang | Method of immobilizing a substance of interest to a solid phase |
US7846201B2 (en) * | 2004-02-20 | 2010-12-07 | The Children's Hospital Of Philadelphia | Magnetically-driven biodegradable gene delivery nanoparticles formulated with surface-attached polycationic complex |
US8562505B2 (en) * | 2004-02-20 | 2013-10-22 | The Children's Hospital Of Philadelphia | Uniform field magnetization and targeting of therapeutic formulations |
US9028829B2 (en) * | 2004-02-20 | 2015-05-12 | The Children's Hospital Of Philadelphia | Uniform field magnetization and targeting of therapeutic formulations |
WO2009039122A2 (en) | 2007-09-17 | 2009-03-26 | Sequenom, Inc. | Integrated robotic sample transfer device |
CA2793959C (en) | 2010-03-25 | 2019-06-04 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
PT2691530T (pt) | 2011-06-10 | 2018-05-10 | Univ Oregon Health & Science | Glicoproteínas e vectores recombinantes cmv |
CA2789539A1 (en) | 2011-09-12 | 2013-03-12 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
EP2586461A1 (en) | 2011-10-27 | 2013-05-01 | Christopher L. Parks | Viral particles derived from an enveloped virus |
ES2631608T3 (es) | 2012-06-27 | 2017-09-01 | International Aids Vaccine Initiative | Variante de la glicoproteína Env del VIH-1 |
EP2848937A1 (en) | 2013-09-05 | 2015-03-18 | International Aids Vaccine Initiative | Methods of identifying novel HIV-1 immunogens |
US10058604B2 (en) | 2013-10-07 | 2018-08-28 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
US10174292B2 (en) | 2015-03-20 | 2019-01-08 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
EP3072901A1 (en) | 2015-03-23 | 2016-09-28 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1412647A (en) * | 1972-10-17 | 1975-11-05 | Nat Res Dev | Separation of enzymes |
US4176006A (en) * | 1978-01-13 | 1979-11-27 | Redpath Sugars Limited | Enzyme immobilization with a disulphide bridge |
SE448631B (sv) * | 1978-04-28 | 1987-03-09 | Toyo Jozo Kk | Disulfidforening av en berare med s-s-utbytesreaktivitet |
JPS55136261A (en) * | 1979-04-12 | 1980-10-23 | Toyo Jozo Co Ltd | Novel compound and kit comprising it |
DE3224788A1 (de) * | 1981-07-17 | 1983-02-03 | South African Inventions Development Corp., Scientia, Pretoria,Transvaal | Traegergebundenes immunogenes material |
US4529712A (en) * | 1981-09-18 | 1985-07-16 | Research Corporation | Coated cells and their use |
US4886755A (en) * | 1984-12-07 | 1989-12-12 | Bioprobe International, Inc. | Preparation of polymeric thiol gels for covalent bonding of biologically active ligands |
US4889916A (en) * | 1985-11-19 | 1989-12-26 | The Johns Hopkins University | Protein label and drug delivery system |
JPS62132172A (ja) * | 1985-12-04 | 1987-06-15 | Shionogi & Co Ltd | 固相化抗体およびその製造方法 |
JPS62228025A (ja) * | 1985-12-27 | 1987-10-06 | Teijin Ltd | 抗体複合体の製造方法 |
US4981979A (en) * | 1987-09-10 | 1991-01-01 | Neorx Corporation | Immunoconjugates joined by thioether bonds having reduced toxicity and improved selectivity |
CA1340387C (en) * | 1987-10-30 | 1999-02-09 | Carol A. Schlesinger | Heterobifunctional coupling agents |
US5002883A (en) * | 1987-10-30 | 1991-03-26 | Abbott Laboratories | Covalent attachment of antibodies and antigens to solid phases using extended length heterobifunctional coupling agents |
-
1990
- 1990-05-02 DE DE69029873T patent/DE69029873T2/de not_active Expired - Fee Related
- 1990-05-02 JP JP02116692A patent/JP3124018B2/ja not_active Expired - Fee Related
- 1990-05-02 ES ES90108317T patent/ES2099699T3/es not_active Expired - Lifetime
- 1990-05-02 EP EP90108317A patent/EP0396116B1/en not_active Expired - Lifetime
- 1990-05-02 CA CA002015938A patent/CA2015938C/en not_active Expired - Fee Related
-
1992
- 1992-03-16 US US07/852,837 patent/US5399501A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0396116A3 (en) | 1992-01-22 |
CA2015938C (en) | 1999-09-07 |
CA2015938A1 (en) | 1990-11-02 |
JP3124018B2 (ja) | 2001-01-15 |
EP0396116A2 (en) | 1990-11-07 |
US5399501A (en) | 1995-03-21 |
DE69029873D1 (de) | 1997-03-20 |
EP0396116B1 (en) | 1997-02-05 |
DE69029873T2 (de) | 1997-08-07 |
JPH02304364A (ja) | 1990-12-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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