ES2095909T3 - Metodo para producir acido eicosapentaenoico o un ester derivado del mismo. - Google Patents
Metodo para producir acido eicosapentaenoico o un ester derivado del mismo.Info
- Publication number
- ES2095909T3 ES2095909T3 ES91305044T ES91305044T ES2095909T3 ES 2095909 T3 ES2095909 T3 ES 2095909T3 ES 91305044 T ES91305044 T ES 91305044T ES 91305044 T ES91305044 T ES 91305044T ES 2095909 T3 ES2095909 T3 ES 2095909T3
- Authority
- ES
- Spain
- Prior art keywords
- eicosapentaenoic acid
- ester derived
- producing eicosapentaenoic
- present
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
- C07C51/44—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation by distillation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
- C07C67/54—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation by distillation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fats And Perfumes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LA INVENCION ACTUAL PROPORCIONA UN METODO PARA PRODUCIR ACIDO EICOSAPENTANOICO Y EL ESTER DERIVADO DEL MISMO, CON UNA CONCENTRACION TAN ELEVADA DEL 80% O MAS, UTILIZANDO UN PROCESO UNICO DE DESTILACION CONTINUA BAJO UNA PRESION REDUCIDA. LA INVENCION ACTUAL PROPORCIONA TAMBIEN UN METODO QUE UTILIZA UN PROCESO DE DESTILACION CONTINUA Y DE ADUCCION DE UREA MEDIANTE LA CONSTRUCCION DE UN APARATO ESPECIFICO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2145618A JP3005638B2 (ja) | 1990-06-04 | 1990-06-04 | 高濃度エイコサペンタエン酸またはそのエステルの製造方法 |
JP2145617A JP3040136B2 (ja) | 1990-06-04 | 1990-06-04 | エイコサペンタエン酸またはそのエステルの製造方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2095909T3 true ES2095909T3 (es) | 1997-03-01 |
Family
ID=26476703
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91305044T Expired - Lifetime ES2095909T3 (es) | 1990-06-04 | 1991-06-04 | Metodo para producir acido eicosapentaenoico o un ester derivado del mismo. |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0460917B1 (es) |
JP (1) | JPH11236591A (es) |
KR (1) | KR100208701B1 (es) |
AT (1) | ATE147062T1 (es) |
AU (1) | AU641016B2 (es) |
CA (1) | CA2043615C (es) |
DE (1) | DE69123880T2 (es) |
DK (1) | DK0460917T3 (es) |
ES (1) | ES2095909T3 (es) |
GR (1) | GR3022660T3 (es) |
NO (1) | NO177699C (es) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3400466B2 (ja) * | 1991-10-28 | 2003-04-28 | 日本水産株式会社 | 高純度エイコサペンタエン酸またはそのエステルの製造方法 |
EP0933107B1 (en) * | 1998-01-30 | 2005-10-26 | Ube Industries, Ltd. | Process for refining heat-deteriorative compound, contained in multi-component liquid mixture, by distillation |
NZ332331A (en) * | 1998-10-15 | 2000-03-27 | Craig Nazzer | Continuous process for removing solids from miscible liquid mixture; lower boiling point liquid(s) removed by flashing or boiling |
GB9901809D0 (en) | 1999-01-27 | 1999-03-17 | Scarista Limited | Highly purified ethgyl epa and other epa derivatives for psychiatric and neurological disorderes |
JP4558870B2 (ja) | 1999-11-08 | 2010-10-06 | 株式会社日本触媒 | 塔式処理方法および装置 |
FR2833006A1 (fr) * | 2001-11-30 | 2003-06-06 | Cognis France Sa | Procede de preparation d'ester methylique d'acide oleique industriel |
JP5924834B2 (ja) | 2008-09-02 | 2016-05-25 | アマリン ファーマシューティカルズ アイルランド リミテッド | エイコサペンタエン酸およびニコチン酸を含む製薬組成物ならびにこの製薬組成物を用いる方法 |
PT2596786T (pt) | 2009-02-10 | 2020-03-04 | Amarin Pharmaceuticals Ie Ltd | Utilização de éster etílico de ácido eicosapentaenoico para tratamento de hipertrigliceridemia |
CN106822080A (zh) | 2009-04-29 | 2017-06-13 | 阿马里纳药物爱尔兰有限公司 | 含有epa和心血管剂的药物组合物以及使用其的方法 |
AU2010241571B2 (en) | 2009-04-29 | 2014-06-26 | Amarin Pharmaceuticals Ireland Limited | Stable pharmaceutical composition and methods of using same |
CA3129996A1 (en) | 2009-06-15 | 2010-12-23 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy |
NZ599061A (en) | 2009-09-23 | 2014-05-30 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same |
US11712429B2 (en) | 2010-11-29 | 2023-08-01 | Amarin Pharmaceuticals Ireland Limited | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
EP2646013A4 (en) | 2010-11-29 | 2014-03-26 | Amarin Pharma Inc | COMPOSITION WITH LOW IMPACT EFFECT AND METHOD FOR THE TREATMENT AND / OR PREVENTION OF CARDIOVASCULAR DISEASES IN A PATIENT WITH FISH ALLERGY / SENSITIVITY |
CN102417447B (zh) * | 2011-10-31 | 2014-04-30 | 广西亿康药业股份有限公司 | 十一烯酸的生产方法 |
US11291643B2 (en) | 2011-11-07 | 2022-04-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
US20130131170A1 (en) | 2011-11-07 | 2013-05-23 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
WO2013103958A1 (en) | 2012-01-06 | 2013-07-11 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering levels of high-sensitivity (hs-crp) in a subject |
ES2900618T3 (es) | 2012-05-14 | 2022-03-17 | Nippon Suisan Kaisha Ltd | Acido graso altamente insaturado o etil éster de ácido graso altamente insaturado con contaminantes ambientales reducidos y método para la producción de los mismos |
CN102776067A (zh) * | 2012-05-31 | 2012-11-14 | 源华能源科技(福建)有限公司 | 一种分子蒸馏提纯粗脂肪酸甲酯工艺 |
SG10201913645RA (en) | 2012-06-29 | 2020-03-30 | Amarin Pharmaceuticals Ie Ltd | Methods of reducing the risk of a cardiovascular event in a subject on statin therapy |
US20150265566A1 (en) | 2012-11-06 | 2015-09-24 | Amarin Pharmaceuticals Ireland Limited | Compositions and Methods for Lowering Triglycerides without Raising LDL-C Levels in a Subject on Concomitant Statin Therapy |
US20140187633A1 (en) | 2012-12-31 | 2014-07-03 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis |
US9814733B2 (en) | 2012-12-31 | 2017-11-14 | A,arin Pharmaceuticals Ireland Limited | Compositions comprising EPA and obeticholic acid and methods of use thereof |
US9452151B2 (en) | 2013-02-06 | 2016-09-27 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing apolipoprotein C-III |
US9624492B2 (en) | 2013-02-13 | 2017-04-18 | Amarin Pharmaceuticals Ireland Limited | Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof |
US9662307B2 (en) | 2013-02-19 | 2017-05-30 | The Regents Of The University Of Colorado | Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof |
US9283201B2 (en) | 2013-03-14 | 2016-03-15 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for treating or preventing obesity in a subject in need thereof |
US20140271841A1 (en) | 2013-03-15 | 2014-09-18 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin |
US10966968B2 (en) | 2013-06-06 | 2021-04-06 | Amarin Pharmaceuticals Ireland Limited | Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof |
US20150065572A1 (en) | 2013-09-04 | 2015-03-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing prostate cancer |
US9585859B2 (en) | 2013-10-10 | 2017-03-07 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy |
CN103570590B (zh) * | 2013-10-30 | 2016-04-06 | 临沂远博化工有限公司 | 一种生产硫酸二甲酯的设备 |
LT3077489T (lt) | 2013-12-04 | 2021-07-26 | Nippon Suisan Kaisha, Ltd. | Mikrobinis aliejus, kurio sudėtyje yra dihomo-gama-linoleno rūgštis, ir mikrobinė biomasė, kurios sudėtyje yra dihomo-gama-linoleno rūgštis |
US10561631B2 (en) | 2014-06-11 | 2020-02-18 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing RLP-C |
US10172818B2 (en) | 2014-06-16 | 2019-01-08 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids |
WO2016043251A1 (ja) | 2014-09-17 | 2016-03-24 | 日本水産株式会社 | エイコサペンタエン酸アルキルエステルを含有する組成物及びその製造方法 |
US10406130B2 (en) | 2016-03-15 | 2019-09-10 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids |
TW201900160A (zh) | 2017-05-19 | 2019-01-01 | 愛爾蘭商艾瑪琳製藥愛爾蘭有限公司 | 用於降低腎功能下降之個體中的三酸甘油酯之組合物及方法 |
US11058661B2 (en) | 2018-03-02 | 2021-07-13 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L |
MA51765A (fr) | 2018-09-24 | 2020-12-16 | Amarin Pharmaceuticals Ie Ltd | Procédés de réduction du risque d'événements cardiovasculaires chez un sujet |
KR20240012390A (ko) | 2021-04-21 | 2024-01-29 | 애머린 파마슈티칼스 아일랜드 리미티드 | 심부전의 위험을 감소시키는 방법 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2055892C3 (de) * | 1970-11-13 | 1979-08-16 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Reinigung von Butandiol |
DE2220922C2 (de) * | 1972-04-28 | 1985-06-20 | Feld & Hahn Gmbh, 5413 Bendorf | Verfahren und Vorrichtung zur Abtrennung von Fettsäuren durch Destillation |
JPS57149400A (en) * | 1981-03-12 | 1982-09-14 | Kureha Chemical Ind Co Ltd | Manufacture of high purity long chain highly unsaturated fatty acid ester |
JPS588037A (ja) * | 1981-07-03 | 1983-01-18 | Nippon Suisan Kaisha Ltd | エイコサペンタエン酸またはそのエステルの製法 |
US4377526A (en) * | 1981-05-15 | 1983-03-22 | Nippon Suisan Kaisha, Ltd. | Method of purifying eicosapentaenoic acid and its esters |
DE3226116A1 (de) * | 1981-07-16 | 1983-02-03 | VEB Chemieanlagenbaukombinat Leipzig-Grimma, DDR 7240 Grimma | Verfahren und vorrichtung zur kontinuierlichen rektifikation von mehr- und vielstoffgemischen |
GB2218984B (en) * | 1988-05-27 | 1992-09-23 | Renafield Limited | Process for preparing high-concentration mixtures of polyunsaturated fatty acids & their esters and their prophylactic or therapeutic uses |
JPH02268133A (ja) * | 1989-04-10 | 1990-11-01 | Nippon Suisan Kaisha Ltd | エイコサペンタエン酸またはそのエステルの製造法 |
-
1991
- 1991-06-03 CA CA002043615A patent/CA2043615C/en not_active Expired - Fee Related
- 1991-06-04 EP EP91305044A patent/EP0460917B1/en not_active Expired - Lifetime
- 1991-06-04 NO NO912144A patent/NO177699C/no unknown
- 1991-06-04 ES ES91305044T patent/ES2095909T3/es not_active Expired - Lifetime
- 1991-06-04 DE DE69123880T patent/DE69123880T2/de not_active Expired - Fee Related
- 1991-06-04 DK DK91305044.9T patent/DK0460917T3/da active
- 1991-06-04 AT AT91305044T patent/ATE147062T1/de not_active IP Right Cessation
- 1991-06-04 KR KR1019910009345A patent/KR100208701B1/ko not_active IP Right Cessation
- 1991-06-04 AU AU78186/91A patent/AU641016B2/en not_active Ceased
-
1997
- 1997-02-26 GR GR970400347T patent/GR3022660T3/el unknown
-
1998
- 1998-12-14 JP JP10354409A patent/JPH11236591A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ATE147062T1 (de) | 1997-01-15 |
KR100208701B1 (ko) | 1999-07-15 |
GR3022660T3 (en) | 1997-05-31 |
CA2043615A1 (en) | 1991-12-05 |
DE69123880D1 (de) | 1997-02-13 |
AU7818691A (en) | 1991-12-05 |
NO912144D0 (no) | 1991-06-04 |
AU641016B2 (en) | 1993-09-09 |
EP0460917A2 (en) | 1991-12-11 |
EP0460917A3 (en) | 1993-07-07 |
JPH11236591A (ja) | 1999-08-31 |
DK0460917T3 (da) | 1997-01-20 |
KR920000690A (ko) | 1992-01-29 |
CA2043615C (en) | 2001-08-14 |
EP0460917B1 (en) | 1997-01-02 |
NO177699C (no) | 1995-11-08 |
NO912144L (no) | 1991-12-05 |
DE69123880T2 (de) | 1997-07-03 |
NO177699B (no) | 1995-07-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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