ES2093395T3 - Esteres de acil carnitinas con alcoholes alifaticos de cadena larga y composiciones farmaceuticas que los contienen con actividad antibacteriana. - Google Patents
Esteres de acil carnitinas con alcoholes alifaticos de cadena larga y composiciones farmaceuticas que los contienen con actividad antibacteriana.Info
- Publication number
- ES2093395T3 ES2093395T3 ES93830009T ES93830009T ES2093395T3 ES 2093395 T3 ES2093395 T3 ES 2093395T3 ES 93830009 T ES93830009 T ES 93830009T ES 93830009 T ES93830009 T ES 93830009T ES 2093395 T3 ES2093395 T3 ES 2093395T3
- Authority
- ES
- Spain
- Prior art keywords
- acil
- pharmaceutical compositions
- antibacterial activity
- contain
- long chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical class C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 title 1
- 150000001298 alcohols Chemical class 0.000 title 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- -1 ISOVALERYL Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
ESTA INVENCION SE REFIERE A LOS ESTERES DE LAS L-CARNITINAS DE ACILO DE FORMULA GENERAL (I): EN DONDE R ES UN GRUPO ACILO RECTO O RAMIFICADO QUE TIENE 2 A 16 ATOMOS DE CARBONO, EN PARTICULAR ISOBUTIRILO Y ISOVALERILO; N ES UN ENTERO COMPRENDIDO ENTRE 7 Y 15, PARTICULARMENTE 10; Y X ES EL ANION DE UN ACIDO FARMACOLOGICAMENTE ACEPTABLE ESTAN DOTADOS DE UNA POTENTE ACTIVIDAD ANTIBACTERIANA. COMPOSICIONES FARMACEUTICAS QUE CONTIENEN UN ESTER DE FORMULA (I) SE PUEDE UTILIZAR EN LA TERAPIA HUMANA Y EN EL AMBITO VETERINARIO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITRM920027A IT1254135B (it) | 1992-01-16 | 1992-01-16 | Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antibatterica. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2093395T3 true ES2093395T3 (es) | 1996-12-16 |
Family
ID=11400572
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93830009T Expired - Lifetime ES2093395T3 (es) | 1992-01-16 | 1993-01-15 | Esteres de acil carnitinas con alcoholes alifaticos de cadena larga y composiciones farmaceuticas que los contienen con actividad antibacteriana. |
Country Status (13)
Country | Link |
---|---|
US (2) | US5498632A (es) |
EP (1) | EP0552137B1 (es) |
JP (1) | JP3294653B2 (es) |
KR (1) | KR100251888B1 (es) |
AT (1) | ATE144492T1 (es) |
CA (1) | CA2087085C (es) |
DE (1) | DE69305540T2 (es) |
DK (1) | DK0552137T3 (es) |
ES (1) | ES2093395T3 (es) |
GR (1) | GR3021479T3 (es) |
HK (1) | HK1005724A1 (es) |
IT (1) | IT1254135B (es) |
ZA (1) | ZA93162B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1261828B (it) | 1993-07-14 | 1996-06-03 | Sigma Tau Ind Farmaceuti | Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico. |
US5741816A (en) * | 1994-06-20 | 1998-04-21 | Tanabe Seiyaku Co., Ltd. | Hair-growth agent |
IT1274157B (it) * | 1994-09-08 | 1997-07-15 | Avantgarde Spa | "sale della l-carnitina e composizioni farmaceutiche che lo contengonoper il trattamento di affezioni cutanee" |
IT1274156B (it) * | 1994-09-08 | 1997-07-15 | Avantgarde Spa | "sale della l-carnitina e composizioni farmaceutiche che lo contengonoper il trattamento di affezioni cutanee" |
JPH08133971A (ja) * | 1994-09-16 | 1996-05-28 | Toyama Chem Co Ltd | 抗ヘリコバクター剤 |
IT1283955B1 (it) * | 1996-03-20 | 1998-05-07 | Sigma Tau Ind Farmaceuti | Bis alcanoil esteri della carnitina ad attivita' antibatterica, antimicotica ed antiprotozoaria. |
KR100513996B1 (ko) * | 1996-11-21 | 2005-12-07 | 아지노모토 가부시키가이샤 | 연속발효에의한l-글루탐산의제조방법 |
US6403124B1 (en) * | 1997-04-16 | 2002-06-11 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Storage and maintenance of blood products including red blood cells and platelets |
US20080063699A1 (en) | 2003-10-15 | 2008-03-13 | Michael Teifel | Method of Administering Cationic Liposomes Comprising an Active Drug |
US8128977B2 (en) * | 2003-10-16 | 2012-03-06 | Techcom Group, Llc | Reduced digestible carbohydrate food having reduced blood glucose response |
US20050232911A1 (en) * | 2004-04-19 | 2005-10-20 | Schreiber Brian D | Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid |
US9233094B2 (en) | 2005-05-04 | 2016-01-12 | Medigene Ag | Method of administering a cationic liposomal preparation |
CA2646156C (en) | 2006-03-22 | 2016-05-24 | Medigene Ag | Treatment of triple receptor negative breast cancer |
EP2394640A1 (en) | 2010-05-21 | 2011-12-14 | MediGene AG | Improved liposomal formulations of lipophilic compounds |
WO2011147926A2 (en) | 2010-05-26 | 2011-12-01 | Erik Reimhult | Magnetically responsive membrane structures |
ES2700742T3 (es) | 2012-03-16 | 2019-02-19 | Merck Patent Gmbh | Lípidos aminoácidos |
AU2013231638B2 (en) | 2012-03-16 | 2017-10-12 | Merck Patent Gmbh | Targeting aminoacid lipids |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH596147A5 (es) * | 1974-09-25 | 1978-02-28 | Lonza Ag | |
CH588443A5 (es) * | 1974-09-25 | 1977-06-15 | Lonza Ag | |
IT1116037B (it) * | 1979-04-23 | 1986-02-10 | Sigma Tau Ind Farmaceuti | Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico |
IT1147079B (it) * | 1980-05-30 | 1986-11-19 | Sigma Tau Ind Farmacuetiche Ri | Esteri di alcossi-acil derivati della carnitina procedimento per la loro preparatione e composizioni farmaceutiche che li contengono |
IT1170861B (it) * | 1981-03-31 | 1987-06-03 | Sigma Tau Ind Farmaceuti | Ester di mercaptoacil-carnitine procedimento per la loro preparazione e loro uso terapeutico |
IT1191945B (it) * | 1986-06-04 | 1988-03-31 | Avantgarde Spa | N-alchilammidi della d(+)-carnitina dotate di attivita' antibatterica,procedimento per la loro preparazione e composizioni farmaceutiche e cosmetiche che le contengono |
IT1235494B (it) * | 1987-12-02 | 1992-09-04 | Avantgarde Spa | N-alchilammidi della dl e l(-)carnitina dotate di attivita' antibatterica, procedimento per la loro preparazione e composizioni farmaceutiche e cosmetiche che le contengono |
IT1231751B (it) * | 1989-04-12 | 1991-12-21 | Sigma Tau Ind Farmaceuti | Procedimento per la produzione di r(+) amminocarnitina e s(-) amminocarnitina |
IT1231944B (it) * | 1989-05-05 | 1992-01-16 | Sigma Tau Ind Farmaceuti | Composizione farmaceutica per il trattamento di protozoosi, particolarmente della tripasonomiasi comprendente d-carnitina o un alcanoilderivato della d-carnitina |
IT1240775B (it) * | 1990-02-23 | 1993-12-17 | Sigma Tau Ind Farmaceuti | Esteri della l-carnitina e di acil-l-carnitine con l'acido beta-idrossibutirrico e composizioni farmaceutiche che li contengono per la inibizione della degenerazione neuronale, della proteolisi epatica e nel trattamento del coma. |
-
1992
- 1992-01-16 IT ITRM920027A patent/IT1254135B/it active
-
1993
- 1993-01-11 CA CA002087085A patent/CA2087085C/en not_active Expired - Lifetime
- 1993-01-11 ZA ZA93162A patent/ZA93162B/xx unknown
- 1993-01-14 JP JP00476493A patent/JP3294653B2/ja not_active Expired - Lifetime
- 1993-01-15 DK DK93830009.2T patent/DK0552137T3/da active
- 1993-01-15 ES ES93830009T patent/ES2093395T3/es not_active Expired - Lifetime
- 1993-01-15 AT AT93830009T patent/ATE144492T1/de active
- 1993-01-15 EP EP93830009A patent/EP0552137B1/en not_active Expired - Lifetime
- 1993-01-15 DE DE69305540T patent/DE69305540T2/de not_active Expired - Lifetime
- 1993-01-16 KR KR1019930000522A patent/KR100251888B1/ko not_active IP Right Cessation
-
1994
- 1994-05-26 US US08/250,107 patent/US5498632A/en not_active Expired - Lifetime
-
1995
- 1995-03-22 US US08/408,394 patent/US5498633A/en not_active Expired - Lifetime
-
1996
- 1996-10-24 GR GR960402838T patent/GR3021479T3/el unknown
-
1998
- 1998-06-05 HK HK98104924A patent/HK1005724A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ZA93162B (en) | 1993-09-30 |
EP0552137B1 (en) | 1996-10-23 |
US5498633A (en) | 1996-03-12 |
DE69305540D1 (de) | 1996-11-28 |
GR3021479T3 (en) | 1997-01-31 |
JP3294653B2 (ja) | 2002-06-24 |
ATE144492T1 (de) | 1996-11-15 |
ITRM920027A0 (it) | 1992-01-16 |
EP0552137A2 (en) | 1993-07-21 |
EP0552137A3 (en) | 1993-10-20 |
ITRM920027A1 (it) | 1993-07-16 |
JPH05339218A (ja) | 1993-12-21 |
IT1254135B (it) | 1995-09-08 |
CA2087085A1 (en) | 1993-07-17 |
KR100251888B1 (ko) | 2000-05-01 |
DK0552137T3 (da) | 1996-11-18 |
CA2087085C (en) | 2003-12-16 |
US5498632A (en) | 1996-03-12 |
KR930016391A (ko) | 1993-08-26 |
HK1005724A1 (en) | 1999-01-22 |
DE69305540T2 (de) | 1997-03-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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