ES2085004T3 - Metodos para detectar antagonistas de glucagon. - Google Patents

Metodos para detectar antagonistas de glucagon.

Info

Publication number
ES2085004T3
ES2085004T3 ES92904367T ES92904367T ES2085004T3 ES 2085004 T3 ES2085004 T3 ES 2085004T3 ES 92904367 T ES92904367 T ES 92904367T ES 92904367 T ES92904367 T ES 92904367T ES 2085004 T3 ES2085004 T3 ES 2085004T3
Authority
ES
Spain
Prior art keywords
glucagon
methods
response pathway
glucagon antagonists
stimulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92904367T
Other languages
English (en)
Inventor
Robert A Smith
James R Piggott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zymogenetics Inc
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/741,931 external-priority patent/US5408037A/en
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Application granted granted Critical
Publication of ES2085004T3 publication Critical patent/ES2085004T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

SE PREVEN METODOS PARA DETECTAR ANTAGONISTAS DE GLUCAGON POR MEDIO DEL EMPLEO DE TECNICAS DE DNA RECOMBINANTE. EN FORMA BREVE, POSTERIORMENTE A LA APARICION DEL EQUIVALENTE DE GLUCAGON DENTRO DE CELULAS HUESPED DESEABLES, LOS EQUIVALENTES SE EXPONEN A UN RECEPTOR DE GLUCAGON EN UNA VIA DE RESPUESTA, EN PRESENCIA DE GLUCAGON NATIVO. RESULTA UNA REDUCCION RELATIVA EN LA ESTIMULACION DE LA VIA DE RESPUESTA DE LA UNION DEL EQUIVALENTE DE GLUCAGON AL RECEPTOR DE GLUCAGON EN RELACION CON LA VIA DE RESPUESTA POR GLUCAGON NATIVO SOLO, INDICANDO ESTO LA PRESENCIA DE ANTAGONISTAS DE GLUCAGON. TAMBIEN SE PREVEN METODOS PARA LA IDENTIFICACION Y AISLAMIENTO DE LOS ANTAGONISTAS DE GLUCAGON.
ES92904367T 1991-01-17 1992-01-14 Metodos para detectar antagonistas de glucagon. Expired - Lifetime ES2085004T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64134391A 1991-01-17 1991-01-17
US07/741,931 US5408037A (en) 1991-01-17 1991-08-08 Methods for detecting glucagon antagonists

Publications (1)

Publication Number Publication Date
ES2085004T3 true ES2085004T3 (es) 1996-05-16

Family

ID=24571964

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92904367T Expired - Lifetime ES2085004T3 (es) 1991-01-17 1992-01-14 Metodos para detectar antagonistas de glucagon.

Country Status (10)

Country Link
EP (1) EP0567562B1 (es)
JP (1) JPH06504913A (es)
AT (1) ATE135372T1 (es)
AU (2) AU663861B2 (es)
CA (1) CA2100874A1 (es)
DE (1) DE69209052T2 (es)
DK (1) DK0567562T3 (es)
ES (1) ES2085004T3 (es)
GR (1) GR3019673T3 (es)
WO (1) WO1992012998A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0546013B1 (en) * 1990-08-31 1997-12-17 The Rockefeller University Glucagon analogs with asp-9 replacements or deletions
US5408037A (en) * 1991-01-17 1995-04-18 Zymogenetics, Inc. Methods for detecting glucagon antagonists
US5510459A (en) * 1991-01-17 1996-04-23 Zymogenetics, Inc. Glucagon antagonists
US5776725A (en) * 1992-08-28 1998-07-07 Zymogenetics, Inc. Recombinant production of glucagon receptors
CA2142819C (en) * 1992-08-28 2003-08-19 Wayne R. Kindsvogel Glucagon receptors
US5480867A (en) * 1993-12-29 1996-01-02 The Rockefeller University Glucagon analogs with serine replacements
AR036711A1 (es) * 2001-10-05 2004-09-29 Bayer Corp Peptidos que actuan como agonistas del receptor del glp-1 y como antagonistas del receptor del glucagon y sus metodos de uso farmacologico
EP2952202B1 (en) * 2008-06-17 2017-10-18 Indiana University Research and Technology Corporation Gip-based mixed agonists for treatment of metabolic disorders and obesity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879273A (en) * 1987-05-22 1989-11-07 The Rockefeller University Glucagon homologs and therapeutic use thereof
CA2345497A1 (en) * 1988-10-28 1990-04-28 Genentech, Inc. Growth hormone variants and method for forming growth hormone variants

Also Published As

Publication number Publication date
WO1992012998A1 (en) 1992-08-06
EP0567562A1 (en) 1993-11-03
DE69209052D1 (de) 1996-04-18
GR3019673T3 (en) 1996-07-31
EP0567562B1 (en) 1996-03-13
CA2100874A1 (en) 1992-07-18
AU1200392A (en) 1992-08-27
JPH06504913A (ja) 1994-06-09
DK0567562T3 (da) 1996-07-29
AU673648B2 (en) 1996-11-14
ATE135372T1 (de) 1996-03-15
AU663861B2 (en) 1995-10-26
DE69209052T2 (de) 1996-11-14
AU3047595A (en) 1995-12-07

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