ES2081299T3 - Sistema para el suministro en ciclo cerrado de un agente simulador de ejercicio. - Google Patents
Sistema para el suministro en ciclo cerrado de un agente simulador de ejercicio.Info
- Publication number
- ES2081299T3 ES2081299T3 ES89301553T ES89301553T ES2081299T3 ES 2081299 T3 ES2081299 T3 ES 2081299T3 ES 89301553 T ES89301553 T ES 89301553T ES 89301553 T ES89301553 T ES 89301553T ES 2081299 T3 ES2081299 T3 ES 2081299T3
- Authority
- ES
- Spain
- Prior art keywords
- responses
- exercise
- adaptive
- cad
- acute
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/044—Shape of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/56—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
- C07C215/58—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
- C07C215/60—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain the chain having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
- C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0448—Drug reservoir
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S128/00—Surgery
- Y10S128/13—Infusion monitoring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Radiology & Medical Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Electrotherapy Devices (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicinal Preparation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Abstract
METODOS Y DISPOSITIVOS ALGUNOS DE ELLOS NUEVOS, PARA LA DIAGNOSIS, EVALUACION Y TRATAMIENTO DE CORONARIO PATIAS, MEDIANTE UN SISTEMA DE LIBERACION DE FARMACO EN CISCUITO CERRADO QUE LIBERA UN AGENTE SIMULADOR DE EJERCICIO CATECOLAMINICO QUE DA LUGAR A RESPUESTAS CARDIOVASCULARES SIMILARES A LAS PRODUCIDAS POR LA ACTIVIDAD ACRILICA, LA RESPUESTA AGUDA AL AGENTE SIMULADOR DE EJERCICIO SE USO PARA LA DIAGNOSIS Y EVALUZACION DE CARDIOPATIAS EN LUGAR DE LA RESPUESTA AGUDA AL EJERCICIO AEROBICO. DEBIDO A SUS RESPUESTAS ADAPTABLES, ESTOS COMPUESTOS SE PUEDEN EMPLEAR EN LUGAR DEL EJERCICIO AEROBICO PARA EL TRATAMIENTO DE CARDIOPATIAS Y OTRAS CONDICIONES QUE PUEDEN SER TRATADAS CON EJERCICIO AEROBICO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15787588A | 1988-02-19 | 1988-02-19 | |
US07/308,683 US5108363A (en) | 1988-02-19 | 1989-02-09 | Diagnosis, evaluation and treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2081299T3 true ES2081299T3 (es) | 1996-03-01 |
Family
ID=26854551
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89301553T Expired - Lifetime ES2081299T3 (es) | 1988-02-19 | 1989-02-17 | Sistema para el suministro en ciclo cerrado de un agente simulador de ejercicio. |
ES95101920T Expired - Lifetime ES2111973T3 (es) | 1988-02-19 | 1989-02-17 | La diagnosis, la evaluacion, y el tratamiento de la enfermedad de la arteria coronaria mediante simulacion del ejercicio por la utilizacion de la administracion en ciclo cerrado de farmacos de un agente beta agonista que simula el ejercicio. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95101920T Expired - Lifetime ES2111973T3 (es) | 1988-02-19 | 1989-02-17 | La diagnosis, la evaluacion, y el tratamiento de la enfermedad de la arteria coronaria mediante simulacion del ejercicio por la utilizacion de la administracion en ciclo cerrado de farmacos de un agente beta agonista que simula el ejercicio. |
Country Status (13)
Country | Link |
---|---|
US (4) | US5108363A (es) |
EP (2) | EP0329464B1 (es) |
JP (2) | JP2806543B2 (es) |
AT (2) | ATE129644T1 (es) |
AU (1) | AU634152B2 (es) |
DE (2) | DE68924661T2 (es) |
DK (1) | DK73589A (es) |
ES (2) | ES2081299T3 (es) |
FI (1) | FI890776A (es) |
GR (2) | GR3018764T3 (es) |
IE (2) | IE80716B1 (es) |
NO (1) | NO890704L (es) |
NZ (1) | NZ239270A (es) |
Families Citing this family (126)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS6144385A (ja) * | 1984-08-07 | 1986-03-04 | Tokyu Constr Co Ltd | 構造物内の放射線吸収体の探査方法 |
IL82997A0 (en) * | 1986-07-11 | 1987-12-20 | Tanabe Seiyaku Co | Method for epimerizing an optically active benzyl alcohol derivative |
US5108363A (en) * | 1988-02-19 | 1992-04-28 | Gensia Pharmaceuticals, Inc. | Diagnosis, evaluation and treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist |
NZ235605A (en) * | 1989-10-10 | 1992-12-23 | Glaxo Group Ltd | (r)-(-)-4-hydroxy-alpha 1 -(((6-(4-phenylbutoxy)hexyl)amino)methyl)-1,3-benzenedimethanol and pharmaceutical compositions |
US5023085A (en) * | 1989-11-29 | 1991-06-11 | Pfizer Inc. | Transdermal flux enhancers in combination with iontophoresis in topical administration of pharmaceuticals |
US5556415A (en) * | 1990-01-29 | 1996-09-17 | Mcewen; James A. | Physiologic tourniquet for intravenous regional anesthesia |
US5607447A (en) * | 1993-09-28 | 1997-03-04 | Mcewen; James A. | Physiologic tourniquet |
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DE69614146T2 (de) * | 1995-12-22 | 2002-04-11 | Abbott Laboratories, Abbott Park | Verfahren zur herstellung von alkyl oder aryl aldehydzwischenprodukten |
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- 1989-02-09 US US07/308,683 patent/US5108363A/en not_active Expired - Fee Related
- 1989-02-15 NZ NZ239270A patent/NZ239270A/xx unknown
- 1989-02-17 IE IE960742A patent/IE80716B1/en not_active IP Right Cessation
- 1989-02-17 EP EP89301553A patent/EP0329464B1/en not_active Expired - Lifetime
- 1989-02-17 DE DE68924661T patent/DE68924661T2/de not_active Expired - Fee Related
- 1989-02-17 ES ES89301553T patent/ES2081299T3/es not_active Expired - Lifetime
- 1989-02-17 AT AT89301553T patent/ATE129644T1/de not_active IP Right Cessation
- 1989-02-17 AT AT95101920T patent/ATE159710T1/de not_active IP Right Cessation
- 1989-02-17 DE DE68928422T patent/DE68928422T2/de not_active Expired - Fee Related
- 1989-02-17 FI FI890776A patent/FI890776A/fi not_active Application Discontinuation
- 1989-02-17 IE IE52689A patent/IE71651B1/en not_active IP Right Cessation
- 1989-02-17 DK DK073589A patent/DK73589A/da not_active Application Discontinuation
- 1989-02-17 AU AU30088/89A patent/AU634152B2/en not_active Ceased
- 1989-02-17 ES ES95101920T patent/ES2111973T3/es not_active Expired - Lifetime
- 1989-02-17 EP EP95101920A patent/EP0658538B1/en not_active Expired - Lifetime
- 1989-02-20 NO NO89890704A patent/NO890704L/no unknown
- 1989-02-20 JP JP1042887A patent/JP2806543B2/ja not_active Expired - Lifetime
-
1990
- 1990-12-11 US US07/625,362 patent/US5286252A/en not_active Expired - Fee Related
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1993
- 1993-12-07 US US08/163,839 patent/US5460605A/en not_active Expired - Fee Related
- 1993-12-15 US US08/169,536 patent/US5395970A/en not_active Expired - Fee Related
-
1996
- 1996-01-24 GR GR960400162T patent/GR3018764T3/el unknown
-
1998
- 1998-01-14 GR GR980400065T patent/GR3025892T3/el unknown
- 1998-02-19 JP JP10037422A patent/JPH10276991A/ja active Pending
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DE68924661D1 (de) | 1995-12-07 |
US5286252A (en) | 1994-02-15 |
IE80716B1 (en) | 1998-12-30 |
EP0658538B1 (en) | 1997-10-29 |
US5460605A (en) | 1995-10-24 |
ATE129644T1 (de) | 1995-11-15 |
DK73589A (da) | 1989-08-20 |
AU3008889A (en) | 1989-08-24 |
IE890526L (en) | 1989-08-19 |
GR3018764T3 (en) | 1996-04-30 |
AU634152B2 (en) | 1993-02-18 |
ES2111973T3 (es) | 1998-03-16 |
EP0329464B1 (en) | 1995-11-02 |
EP0658538A1 (en) | 1995-06-21 |
IE71651B1 (en) | 1997-02-26 |
DK73589D0 (da) | 1989-02-17 |
NZ239270A (en) | 1993-10-26 |
NO890704D0 (no) | 1989-02-20 |
FI890776A (fi) | 1989-08-20 |
US5108363A (en) | 1992-04-28 |
DE68928422T2 (de) | 1998-02-26 |
NO890704L (no) | 1989-08-21 |
JP2806543B2 (ja) | 1998-09-30 |
IE960742L (en) | 1989-08-19 |
DE68924661T2 (de) | 1996-03-21 |
EP0329464A3 (en) | 1991-07-17 |
GR3025892T3 (en) | 1998-04-30 |
DE68928422D1 (de) | 1997-12-04 |
JPH10276991A (ja) | 1998-10-20 |
ATE159710T1 (de) | 1997-11-15 |
US5395970A (en) | 1995-03-07 |
EP0329464A2 (en) | 1989-08-23 |
FI890776A0 (fi) | 1989-02-17 |
JPH0217048A (ja) | 1990-01-22 |
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