ES2077419T3 - Emplasto con nitroglicerol y procedimiento para su produccion. - Google Patents

Emplasto con nitroglicerol y procedimiento para su produccion.

Info

Publication number
ES2077419T3
ES2077419T3 ES92911100T ES92911100T ES2077419T3 ES 2077419 T3 ES2077419 T3 ES 2077419T3 ES 92911100 T ES92911100 T ES 92911100T ES 92911100 T ES92911100 T ES 92911100T ES 2077419 T3 ES2077419 T3 ES 2077419T3
Authority
ES
Spain
Prior art keywords
plaster
nitroglycerin
weight
acrylate
costs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92911100T
Other languages
English (en)
Inventor
Dieter Beutner
V Henning Knobelsdorff
Hans-Michael Wolff
Rainer Hoffmann
Reinhold Meconi
Robert Peter Klein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanol Schwarz GmbH
UCB Pharma GmbH
LTS Lohmann Therapie Systeme AG
Original Assignee
Sanol Schwarz GmbH
LTS Lohmann Therapie Systeme AG
Schwarz Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanol Schwarz GmbH, LTS Lohmann Therapie Systeme AG, Schwarz Pharma AG filed Critical Sanol Schwarz GmbH
Application granted granted Critical
Publication of ES2077419T3 publication Critical patent/ES2077419T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA INVENCION SE REFIERE A UN EMPLASTE PRINCIPAL PARA LA ADMINISTRACION TRANSDERMAL DE NITROGLICERINA, CONSISTIENDO JUNTO A UNA LAMINA SOPORTE Y UNA LAMINA DE PROTECCION RETIRABLE DE UNA MASA DE ADHESIVOS PARTICULARMENTE CONTENIENDO NITROGLICERINA A BASE DE UN COPOLIMERIZADO DE ACETATO DE VINILO-ACRILATO RETICULADO, CUYA MEZCLA DE MONOMEROS EMPLEADOS PARA LA POLIMERIZACION CONTIENE 21 A 40% EN PESO DE ACETATO DE VINILO, 55 A 70% EN PESO DE UN ESTER DE ACIDO ACRILICO C2-8-ALQUILO Y 3 A 10% EN PESO DE UN ESTER DE ACIDO ACRILICO SE RETICULA DESPUES DE LA MEZCLA DE UN RETICULADOR USUAL Y NITROGLICERINA ADICIONALMENTE A TRAVES DE CALENTAMIENTO Y ELIMINACION DE DISOLVENTES EXISTENTES. LA MASA DE ADHESIVO ESPECIAL CON ARREGLO A LA INVENCION NO TIENE SOLAMENTE UNA ELEVADA CAPACIDAD DE ABSORCION, SINO TAMBIEN UNA CAPACIDAD DE EMISION ELEVADA Y CONTROLABLE PARA NITROGLICERINA YA QUE LA CANTIDAD DE COLOCACION LIBRE POR DIA MANTIENE PEQUEÑA LA SUPERFICIE DE COLOCACION LIBRE DEL EMPLASTE Y LOS COSTES DELEMPLASTE SON PEQUEÑOS. SIMULTANEAMENTE SE SIMPLIFICA EL PROCESO DE PRODUCCION A TRAVES DE LA MASA DE ADHESIVO SENCILLA SE ECONOMIZA LA ADICION DE OTRA MATERIA PARA ELEVAR EL TRANSPORTE DE MATERIA TRANSEPIDERMAL Y MANTENER BAJOS LOS COSTES DEL EMPLASTE Y SE EVITAN LOS RIESGOS DE IRRITACIONES PRINCIPALES.
ES92911100T 1991-06-10 1992-05-25 Emplasto con nitroglicerol y procedimiento para su produccion. Expired - Lifetime ES2077419T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4118891 1991-06-10

Publications (1)

Publication Number Publication Date
ES2077419T3 true ES2077419T3 (es) 1995-11-16

Family

ID=6433497

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92911100T Expired - Lifetime ES2077419T3 (es) 1991-06-10 1992-05-25 Emplasto con nitroglicerol y procedimiento para su produccion.

Country Status (18)

Country Link
US (1) US5498418A (es)
EP (2) EP0588839B1 (es)
JP (1) JP2579729B2 (es)
KR (1) KR0165875B1 (es)
CN (1) CN1053591C (es)
AT (1) ATE126434T1 (es)
CA (1) CA2109956C (es)
DE (1) DE59203307D1 (es)
DK (1) DK0588839T3 (es)
ES (1) ES2077419T3 (es)
FI (1) FI101854B1 (es)
GE (1) GEP19991583B (es)
GR (1) GR3017689T3 (es)
HU (1) HU210334B (es)
IE (1) IE67792B1 (es)
NO (2) NO305384B1 (es)
UA (1) UA29400C2 (es)
WO (1) WO1992022292A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5762952A (en) * 1993-04-27 1998-06-09 Hercon Laboratories Corporation Transdermal delivery of active drugs
DE4406332C1 (de) * 1994-02-28 1995-06-22 Sanol Arznei Schwarz Gmbh Pharmazeutische Verwendung von Nitroglycerin zur Verhinderung unerwünschter Wehentätigkeit bei Säugern in einer transdermalen Applikationsform
US20020048596A1 (en) * 1994-12-30 2002-04-25 Gregor Cevc Preparation for the transport of an active substance across barriers
WO1998025591A1 (en) * 1996-12-10 1998-06-18 Rotta Research B.V. Transdermal drug delivery system for the treatment of heart diseases
DE856311T1 (de) * 1996-12-10 1999-02-25 Rotta Research B.V., Amsterdam Transdermales Arzneistoff-Verabreichungssystem zur Behandlung von Herzerkrankungen
CN1070367C (zh) * 1997-08-07 2001-09-05 德阳华康药业有限公司 注射贴及其制备方法
DE19818955C2 (de) * 1998-04-28 2000-06-29 Lohmann Therapie Syst Lts Zusammensetzung, enthaltend Polyacrylat, Polyterpen, Nitroglycerin und wahlweise Polyvinylacetat
DE19830648A1 (de) * 1998-07-09 2000-01-13 Lohmann Therapie Syst Lts Glyceroltrinitrathaltige Zusammensetzung, Verfahren zu ihrer Herstellung und ihre Verwendung
DE19831418C2 (de) * 1998-07-14 2000-07-06 Lohmann Therapie Syst Lts Verfahren und Vorrichtung zum Herstellen flächenhafter Produkte aus Laminat, deren Übertragung auf eine Abdeckfolie und Endkonfektionierung
RU2207844C2 (ru) 1998-12-23 2003-07-10 Идеа Аг. УСОВЕРШЕНСТВОВАННЫЙ ПРЕПАРАТ ДЛЯ МЕСТНОГО НЕИНВАЗИВНОГО ПРИМЕНЕНИЯ in vivo
ES2173679T3 (es) 1999-01-27 2002-10-16 Idea Ag Inmunizacion/transporte transnasal con vehiculos altamente adaptables.
SI1031346T1 (en) 1999-01-27 2002-08-31 Idea Ag Noninvasive vaccination through the skin
AU5409699A (en) * 1999-07-05 2001-01-22 Idea Ag A method for the improvement of transport across adaptable semi-permeable barriers
JP5021124B2 (ja) * 2001-08-29 2012-09-05 日東電工株式会社 医療用粘着組成物、それを用いた医療用粘着テープおよび経皮吸収用テープ製剤
ES2237515T3 (es) * 2001-09-14 2005-08-01 Schwarz Pharma Ag Dispositivo de administracion transdermica para el tratamiento de trastornos del tracto urinario.
CA2487123C (en) * 2002-05-28 2011-10-18 Labtec Gesellschaft Fuer Technologische Forschung Und Entwicklung Mbh Patch containing fentanyl
US20040105881A1 (en) * 2002-10-11 2004-06-03 Gregor Cevc Aggregates with increased deformability, comprising at least three amphipats, for improved transport through semi-permeable barriers and for the non-invasive drug application in vivo, especially through the skin
KR100563194B1 (ko) * 2003-11-14 2006-03-21 (주) 에프디엘 펜타닐을 유효성분으로 함유하는 경피투여제제
US20080095722A1 (en) * 2004-11-12 2008-04-24 Idea Ag Extended Surface Aggregates in the Treatment of Skin Conditions
US8153742B2 (en) * 2005-09-23 2012-04-10 Henkel Ag & Co. Kgaa Acrylic polymer-based adhesives
US20070072986A1 (en) * 2005-09-23 2007-03-29 Allison Luciano Acrylic polymer-based adhesives
JP6843741B2 (ja) * 2014-08-25 2021-03-17 ヘンケル アイピー アンド ホールディング ゲゼルシャフト ミット ベシュレンクテル ハフツング アクリル系ポリマーおよび経皮吸収型ドラッグデリバリーにおけるその使用
CN105362254B (zh) * 2015-12-09 2017-03-15 北京邦尼康达医药科技有限公司 一种***贴膜及其制备方法
DE202016007127U1 (de) 2016-11-22 2016-12-19 Ludwig Volker Falzhilfe
CN113125596B (zh) * 2021-04-07 2023-01-13 马应龙药业集团股份有限公司 一种高效液相色谱法测定***软膏中有关物质的方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3854480A (en) 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
JPS5777617A (en) * 1980-10-20 1982-05-15 Nichiban Co Ltd Plaster for cardiac disease
JPS5843368B2 (ja) * 1980-10-30 1983-09-27 日東電工株式会社 消炎鎮痛貼付剤
JPS57116011A (en) 1981-01-08 1982-07-19 Nitto Electric Ind Co Ltd Pharmaceutical preparation
JPS6059207B2 (ja) 1981-03-13 1985-12-24 日東電工株式会社 複合製剤の製法
GB2105990B (en) 1981-08-27 1985-06-19 Nitto Electric Ind Co Adhesive skin patches
US4608249A (en) 1982-11-02 1986-08-26 Nitto Electric Industrial Co., Ltd. Hydrophilic therapeutic material
DE3315272C2 (de) 1983-04-27 1986-03-27 Lohmann Gmbh & Co Kg, 5450 Neuwied Pharmazeutisches Produkt und Verfahren zu seiner Herstellung
AU576889B2 (en) 1984-07-24 1988-09-08 Key Pharmaceuticals, Inc. Adhesive transdermal dosage layer
US4751087A (en) * 1985-04-19 1988-06-14 Riker Laboratories, Inc. Transdermal nitroglycerin delivery system
JPS62292877A (ja) * 1986-06-13 1987-12-19 Nippon Shokubai Kagaku Kogyo Co Ltd 接着剤用組成物
DE3643987A1 (de) 1986-12-22 1988-06-23 Lohmann Therapie Syst Lts Basische, wirkstoffdurchlaessige haftklebende polymermasse, insbesondere zum einsatz mit basischen wirkstoffen, verfahren zu ihrer herstellung und ihre verwendung
JPH0696529B2 (ja) 1987-03-31 1994-11-30 積水化学工業株式会社 ニトログリセリン貼付剤およびその製造方法
US4814168A (en) * 1988-03-04 1989-03-21 Noven Pharmaceuticals, Inc. Transdermal multipolymer drug delivery system
US4994267A (en) * 1988-03-04 1991-02-19 Noven Pharmaceuticals, Inc. Transdermal acrylic multipolymer drug delivery system
JP2524190B2 (ja) * 1988-05-11 1996-08-14 日東電工株式会社 クロニジンを含有する粘着テ―プ製剤
EP0435199B2 (en) * 1989-12-28 2000-01-19 Nitto Denko Corporation Acrylic gel material and acrylic gel preparation
JP2700835B2 (ja) * 1989-12-28 1998-01-21 日東電工株式会社 アクリル系ゲル材およびアクリル系ゲル製剤
JP2882843B2 (ja) * 1990-03-28 1999-04-12 日本化薬株式会社 門脈圧亢進症改善剤
JPH07116032B2 (ja) * 1990-04-06 1995-12-13 積水化学工業株式会社 ニトログリセリン貼付剤

Also Published As

Publication number Publication date
NO305384B1 (no) 1999-05-25
NO934518D0 (no) 1993-12-09
FI101854B (fi) 1998-09-15
FI935522A (fi) 1993-12-09
HUT65979A (en) 1994-08-29
JPH06506944A (ja) 1994-08-04
IE67792B1 (en) 1996-04-17
GR3017689T3 (en) 1996-01-31
EP0518113A1 (de) 1992-12-16
JP2579729B2 (ja) 1997-02-12
GEP19991583B (en) 1999-04-29
NO934518L (no) 1993-12-09
FI935522A0 (fi) 1993-12-09
CA2109956C (en) 1998-05-05
DK0588839T3 (da) 1995-12-27
US5498418A (en) 1996-03-12
WO1992022292A1 (de) 1992-12-23
EP0588839A1 (de) 1994-03-30
HU9303532D0 (en) 1994-04-28
DE59203307D1 (de) 1995-09-21
KR0165875B1 (ko) 1999-01-15
EP0588839B1 (de) 1995-08-16
CN1053591C (zh) 2000-06-21
IE921863A1 (en) 1992-12-16
ATE126434T1 (de) 1995-09-15
CN1072093A (zh) 1993-05-19
UA29400C2 (uk) 2000-11-15
HU210334B (en) 1995-03-28
FI101854B1 (fi) 1998-09-15
CA2109956A1 (en) 1992-12-23

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