ES2073908T3 - Metodo para determinar la concentracion de anticoagulante. - Google Patents
Metodo para determinar la concentracion de anticoagulante.Info
- Publication number
- ES2073908T3 ES2073908T3 ES92900357T ES92900357T ES2073908T3 ES 2073908 T3 ES2073908 T3 ES 2073908T3 ES 92900357 T ES92900357 T ES 92900357T ES 92900357 T ES92900357 T ES 92900357T ES 2073908 T3 ES2073908 T3 ES 2073908T3
- Authority
- ES
- Spain
- Prior art keywords
- anticoagulatory
- concentration
- thrombin
- inhibition
- active components
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/974—Thrombin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
- G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, e.g. Konjac gum, Locust bean gum, Guar gum
- G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- External Artificial Organs (AREA)
Abstract
LA INVENCION SE REFIERE A UN METODO PARA DETERMINAR LA CONCENTRACION DE ANTICOAGULANTES COMO FUNCION DE LA INHIBICION DE LA FORMACION DE TROMBINA EN UNA MEZCLA DE ENSAYO. LA MEZCLA DE ENSAYO SE COMPONE DE DOS REAGENTES Y LA MUESTRA DE PLASMA DILUIDA. LA MUESTRA DE PLASMA DILUIDA QUE CONTIENE UNA SUBSTANCIA ANTICOAGULATORIA SE MEZCLA CON UN REAGENTE DE FACTOR DE COAGULACION, QUE ES UNA COMBINACION DE UNA CANTIDAD DE FACTORES DE COAGULACION PURIFICADOS DEL SISTEMA ENDOGENO, FOSFOLIPIDOS Y UN INHIBIDOR DE TROMBINA DEBIL, QUE PUEDE SER POTENCIADO MEDIANTE UNA SUBSTANCIA ANTICOAGULATORIA. ENTONCES SE AÑADE UN ACTIVADOR EN CASCADA DE LA COAGULACION Y CLORURO DE CALCIO, A LA MEZCLA Y LA TROMBINA FORMADA SE MIDE DESPUES DE UN TIEMPO DE INCUBACION ESCOGIDO. UNA PROPORCIONALIDAD ENTRE LA INHIBICION DE LA FORMACION DE LA TROMBINA Y DE LOS COMPONENTES ACTIVOS ANTICOAGULATORIOS PERMITE UNA DETERMINACION DE LA CONCENTRACION DE LOS COMPONENTES ACTIVOS ANTICOAGULATORIOS EN LA MUESTRA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60934090A | 1990-11-05 | 1990-11-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2073908T3 true ES2073908T3 (es) | 1995-08-16 |
Family
ID=24440379
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92900357T Expired - Lifetime ES2073908T3 (es) | 1990-11-05 | 1991-10-30 | Metodo para determinar la concentracion de anticoagulante. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5702912A (es) |
EP (1) | EP0509086B1 (es) |
JP (1) | JP3094165B2 (es) |
AT (1) | ATE121139T1 (es) |
AU (1) | AU650941B2 (es) |
CA (1) | CA2070813C (es) |
DE (1) | DE69108896T2 (es) |
DK (1) | DK0509086T3 (es) |
ES (1) | ES2073908T3 (es) |
WO (1) | WO1992007954A1 (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4203980A1 (de) * | 1992-02-11 | 1993-08-12 | Max Planck Gesellschaft | Verfahren zur bestimmung von hirudin und synthetischen thrombininhibitoren |
AT397391B (de) * | 1992-05-15 | 1994-03-25 | Immuno Ag | Verwendung von prothrombinfragmenten |
US5308755A (en) * | 1992-06-08 | 1994-05-03 | Research Corporation Technologies, Inc. | Method for measuring heparin |
WO1995009188A1 (fr) * | 1993-09-30 | 1995-04-06 | Seikagaku Kogyo Kabushiki Kaisha | Antithrombotique |
EP0871755A1 (en) * | 1995-03-23 | 1998-10-21 | Cantab Pharmaceuticals Research Limited | Vectors for gene delivery |
US6010911A (en) * | 1997-04-30 | 2000-01-04 | Medtronic, Inc. | Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique |
US5985582A (en) * | 1997-12-09 | 1999-11-16 | Sigma-Aldrich Co. | Thrombin-based assay for antithrombin III |
WO1999038997A1 (fr) * | 1998-01-30 | 1999-08-05 | Yoshitomi Pharmaceutical Industries, Ltd. | Procede de mesure de l'activite du cofacteur ii de l'heparine et boite de reactifs y relative |
US6194394B1 (en) * | 1998-07-01 | 2001-02-27 | Sigma-Aldrich Co. | Coagulation controls for prothrombin time (PT) and activated partial thromboplastin time (APTT) assays |
DE19904674A1 (de) * | 1999-02-04 | 2000-08-31 | Haemosys Gmbh | Verfahren zur Bestimmung der Konzentration von Thrombininhibitoren |
AUPP971299A0 (en) | 1999-04-12 | 1999-05-06 | South Eastern Sydney Area Health Service | Procoagulant assay |
EP1045250A1 (en) * | 1999-04-12 | 2000-10-18 | INSTRUMENTATION LABORATORY S.p.A. | A global test for evaluating the functionality of the thrombin/antithrombin system |
WO2001063299A1 (en) * | 2000-02-23 | 2001-08-30 | Besst-Test Aps | METHOD FOR CORRELATING BLOOD COAGULATION ACTIVITY WITH MARKERS IN BODY FLUIDS, e.g. URINE |
US6680177B2 (en) * | 2001-12-07 | 2004-01-20 | Cardiovascular Diagnostics, Inc. | Low molecular weight heparin assay, system and reagent therefor |
DE10330900B4 (de) * | 2003-07-01 | 2006-09-14 | Leibniz-Institut Für Polymerforschung Dresden E.V. | Biomaterial mit einem modularen Beschichtungssystem zur Anwendung in Medizinprodukten mit direktem Blutkontakt |
CA2566411A1 (en) * | 2004-05-11 | 2005-11-24 | Heptest Laboratories, Inc. | Compositions, kit and one-step method for monitoring compounds having anti-factor xa and/or anti factor iia activities |
EP1747451B1 (en) | 2004-05-17 | 2011-11-02 | Medtronic, Inc. | Point of care heparin determination system |
BRPI0511603A (pt) * | 2004-05-27 | 2008-01-02 | Avigen Inc | método para o tratamento de distúrbios do sangramento com a utilização de polissacarìdeos sulfatados |
DE102005038418A1 (de) * | 2005-08-12 | 2007-02-15 | Dade Behring Marburg Gmbh | Faktor Xa-basierter Heparinassay unter Verwendung einer Heparin-modifizierenden Komponente |
DE102006035580A1 (de) * | 2006-07-27 | 2008-02-14 | Csl Behring Gmbh | Bestimmung der biologischen Aktivität von Heparin in AT III-haltigen Präparationen |
EP1918718A1 (de) | 2006-10-31 | 2008-05-07 | Roche Diagnostics GmbH | Verfahren und Vorrichtungen zur elektrochemischen Bestimmung von Faktor Xa-Inhibitoren in Blutproben |
WO2009023538A1 (en) * | 2007-08-10 | 2009-02-19 | Mayo Foundation For Medical Education And Research | Methods and devices for detecting thrombin generation |
EP2471945A1 (de) * | 2010-12-30 | 2012-07-04 | Siemens Healthcare Diagnostics Products GmbH | Verfahren zur Bestimmung von Inhibitoren der Gerinnung |
JP6087775B2 (ja) * | 2013-09-13 | 2017-03-01 | 薫 梅野 | ハンドバイブレーターおよびハンドバイブレーター用連結具 |
CN110192105B (zh) * | 2017-01-06 | 2022-04-12 | 索尼公司 | 凝血***分析和失血量预测装置、***、方法和程序 |
CN110514851A (zh) * | 2019-08-28 | 2019-11-29 | 深圳麦科田生物医疗技术有限公司 | 血小板抑制率的检测方法和检测试剂盒 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2812943C3 (de) * | 1978-03-23 | 1981-05-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und Reagens zur Bestimmung der biologischen Aktivität von Heparin im Plasma |
DE3005540A1 (de) * | 1980-02-14 | 1981-08-20 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und reagens zur bestimmung der biologischen aktivitaet von heparin im plasma |
US4496653A (en) * | 1980-10-09 | 1985-01-29 | Boehringer Mannheim Gmbh | Process for the determination of antithrombin-BM |
US4473639A (en) * | 1982-09-15 | 1984-09-25 | Miles Laboratories, Inc. | Reagent strip test for antithrombin-III |
US4851336A (en) * | 1985-09-05 | 1989-07-25 | Yin E Thye | Composition, kit, and method for assaying heparinano a method for making the composition |
DE3536903A1 (de) * | 1985-10-16 | 1987-04-16 | Boehringer Mannheim Gmbh | Verfahren zur photometrischen bestimmung von protein c |
IT1230744B (it) * | 1989-07-07 | 1991-10-29 | Instrumentation Lab Spa | Metodo per la determinazione della attivita' funzionale della proteina s nel plasma umano. |
NL8902406A (nl) * | 1989-09-27 | 1991-04-16 | Hendrik Coenraad Hemker Prof D | Werkwijze voor het bepalen van de endogene trombinepotentiaal van plasma, en bloed alsmede een bij deze werkwijze te gebruiken kit. |
-
1991
- 1991-10-30 EP EP92900357A patent/EP0509086B1/en not_active Expired - Lifetime
- 1991-10-30 DK DK92900357.2T patent/DK0509086T3/da active
- 1991-10-30 ES ES92900357T patent/ES2073908T3/es not_active Expired - Lifetime
- 1991-10-30 AT AT92900357T patent/ATE121139T1/de not_active IP Right Cessation
- 1991-10-30 WO PCT/US1991/008117 patent/WO1992007954A1/en active IP Right Grant
- 1991-10-30 CA CA002070813A patent/CA2070813C/en not_active Expired - Fee Related
- 1991-10-30 DE DE69108896T patent/DE69108896T2/de not_active Expired - Lifetime
- 1991-10-30 JP JP04501268A patent/JP3094165B2/ja not_active Expired - Lifetime
-
1992
- 1992-01-09 AU AU10154/92A patent/AU650941B2/en not_active Ceased
-
1995
- 1995-11-30 US US08/564,986 patent/US5702912A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0509086B1 (en) | 1995-04-12 |
ATE121139T1 (de) | 1995-04-15 |
CA2070813C (en) | 1996-10-29 |
JPH05503223A (ja) | 1993-06-03 |
DE69108896T2 (de) | 1995-08-24 |
DE69108896D1 (de) | 1995-05-18 |
US5702912A (en) | 1997-12-30 |
WO1992007954A1 (en) | 1992-05-14 |
AU650941B2 (en) | 1994-07-07 |
DK0509086T3 (da) | 1995-07-03 |
JP3094165B2 (ja) | 2000-10-03 |
CA2070813A1 (en) | 1992-05-06 |
EP0509086A1 (en) | 1992-10-21 |
AU1015492A (en) | 1992-06-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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