ES2072251T3 - Composiciones y metodos para la sintesis y ensayo de enquefalinasa. - Google Patents

Composiciones y metodos para la sintesis y ensayo de enquefalinasa.

Info

Publication number
ES2072251T3
ES2072251T3 ES87311365T ES87311365T ES2072251T3 ES 2072251 T3 ES2072251 T3 ES 2072251T3 ES 87311365 T ES87311365 T ES 87311365T ES 87311365 T ES87311365 T ES 87311365T ES 2072251 T3 ES2072251 T3 ES 2072251T3
Authority
ES
Spain
Prior art keywords
enquefalinasa
synthesis
compositions
test
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87311365T
Other languages
English (en)
Inventor
Bernard Malfroy-Camine
Peter R Schofield
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ES2072251T3 publication Critical patent/ES2072251T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6494—Neprilysin (3.4.24.11), i.e. enkephalinase or neutral-endopeptidase 24.11
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24011—Neprilysin (3.4.24.11), i.e. enkephalinase or neutral endopeptidase 24.11
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486—Metalloendopeptidases (3.4.24)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE PROPORCIONAN AISLADOS DE DNA, QUE CODIFICAN PARA ENQUEFALINASA, Y METODOS PARA OBTENER TAL DNA, JUNTO CON LOS SISTEMAS DE EXPRESION PARA LA PRODUCCION RECOMBINANTE DE ENQUEFALINASA PARA UTILIZAR EN COMPOSICIONES TERAPEUTICAS O DE DIAGNOSIS. LOS ENSAYOS DE ENQUEFALINASA SE FACILITAN POR SUBSTRATOS DE ENQUEFALINASA NUEVOS.
ES87311365T 1986-12-24 1987-12-23 Composiciones y metodos para la sintesis y ensayo de enquefalinasa. Expired - Lifetime ES2072251T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94656686A 1986-12-24 1986-12-24
US07/002,478 US4960700A (en) 1986-12-24 1987-01-12 Compositions and methods for the synthesis and assay of a mammalian enkephalinase

Publications (1)

Publication Number Publication Date
ES2072251T3 true ES2072251T3 (es) 1995-07-16

Family

ID=26670440

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87311365T Expired - Lifetime ES2072251T3 (es) 1986-12-24 1987-12-23 Composiciones y metodos para la sintesis y ensayo de enquefalinasa.

Country Status (11)

Country Link
US (2) US4960700A (es)
EP (2) EP0272928B1 (es)
JP (1) JP2685468B2 (es)
AT (1) ATE119936T1 (es)
AU (1) AU623845B2 (es)
DE (1) DE3751169T2 (es)
DK (1) DK684087A (es)
ES (1) ES2072251T3 (es)
IE (1) IE66333B1 (es)
IL (1) IL84928A (es)
NZ (1) NZ223028A (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0272929B1 (en) * 1986-12-24 1996-03-20 Genentech, Inc. Enkephalinase for therapeutic use
IL88535A0 (en) * 1987-12-04 1989-06-30 Dana Farber Cancer Inst Inc Common acute lymphoblastic leukemia antigen
US6043211A (en) * 1988-02-02 2000-03-28 The Regents Of The University Of California Method for inhibiting the activity of a platelet-derived growth factor receptor binding protein
US5486599A (en) * 1989-03-29 1996-01-23 The Board Of Trustees Of The Leland Stanford Junior University Construction and use of synthetic constructs encoding syndecan
US5541083A (en) * 1989-10-24 1996-07-30 The Regents Of The University Of California Method for producing secretable glycosyltransferases and other golgi processing enzymes
FR2664287A1 (fr) * 1990-07-03 1992-01-10 Inst Nat Sante Rech Med Nouveau polypeptide presentant une activite enzymatique, et gene codant pour ce polypeptide.
FI102072B (fi) * 1990-09-14 1998-10-15 Aventis Pharma Gmbh 2-dansyylietoksiklooriformiaattihydrokloridin käyttö hydroksiryhmän su ojaamiseen oligonukleotidisynteesissä, näin suojattuja välituotteita, menetelmiä niiden valmistamiseksi ja menetelmä oligonukleotidien synte tisoimiseksi
JP3581148B2 (ja) * 1991-03-15 2004-10-27 アプライド・リサーチ・システムズ・アルス・ホールディング・エヌ・ブイ ヒト濾胞刺激ホルモンの受容体
US6048975A (en) * 1991-09-12 2000-04-11 Hoechst Aktiengesellschaft Process for the chemical synthesis of oligonucleotides
WO1994010322A1 (en) * 1992-10-29 1994-05-11 Board Of Regents, The University Of Texas System Adenovirus-mediated ldl receptor gene transfer and targeting
WO1994012209A1 (en) * 1992-12-02 1994-06-09 Dana-Farber Cancer Institute, Inc. Malignant cell growth regulation by common acute lymphoblastic leukemia antigen
US5807711A (en) * 1993-03-23 1998-09-15 Taisho Pharmaceutical Co., Ltd. Parenchymal hepatocyte growth factors
JP4043535B2 (ja) * 1994-06-21 2008-02-06 サントリー株式会社 ペプチド基質並びにこれを用いるプロテイナーゼａ活性およびビールの泡安定性の測定方法
GB9525403D0 (en) * 1995-12-13 1996-02-14 Univ Sunderland Method for monitoring enzymes
GB9815163D0 (en) * 1998-07-13 1998-09-09 Brax Genomics Ltd Compounds
FR2777291B1 (fr) * 1998-04-08 2000-07-07 Inst Nat Sante Rech Med Nouvelle metalloprotease membranaire nep ii et son utilisation pour le criblage d'inhibiteurs utiles en therapie
EP1069188A1 (en) * 1999-07-15 2001-01-17 Sanofi-Synthelabo Three neprilysin-like membrane metallopeptidases
DK1234025T3 (da) * 1999-11-19 2008-11-17 Solvay Pharm Bv Humane enzymer fra metalloproteasefamilien
US20020120409A1 (en) * 2000-05-19 2002-08-29 Affymetrix, Inc. Methods for gene expression analysis
CA2450316A1 (en) * 2001-06-11 2002-12-19 Medarex, Inc. Cd10-activated prodrug compounds
US20060029590A1 (en) * 2004-06-10 2006-02-09 Christopher Thanos Administration of neutral endopeptidase to treat inflammatory bowel disease

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4760025A (en) * 1984-05-29 1988-07-26 Genencor, Inc. Modified enzymes and methods for making same
US5262178A (en) * 1987-01-12 1993-11-16 Genentech, Inc. Therapeutic use of enkephalinase

Also Published As

Publication number Publication date
AU8305887A (en) 1988-06-30
JP2685468B2 (ja) 1997-12-03
EP0272928B1 (en) 1995-03-15
EP0596355A1 (en) 1994-05-11
DE3751169T2 (de) 1995-10-26
ATE119936T1 (de) 1995-04-15
DE3751169D1 (de) 1995-04-20
NZ223028A (en) 1990-09-26
JPH01104178A (ja) 1989-04-21
EP0272928A3 (en) 1990-04-04
EP0272928A2 (en) 1988-06-29
IE66333B1 (en) 1995-12-27
US5780025A (en) 1998-07-14
IL84928A (en) 1994-02-27
DK684087D0 (da) 1987-12-23
IL84928A0 (en) 1988-06-30
AU623845B2 (en) 1992-05-28
IE873535L (en) 1988-06-24
DK684087A (da) 1988-10-03
US4960700A (en) 1990-10-02

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