FR2777291B1 - Nouvelle metalloprotease membranaire nep ii et son utilisation pour le criblage d'inhibiteurs utiles en therapie - Google Patents
Nouvelle metalloprotease membranaire nep ii et son utilisation pour le criblage d'inhibiteurs utiles en therapieInfo
- Publication number
- FR2777291B1 FR2777291B1 FR9804389A FR9804389A FR2777291B1 FR 2777291 B1 FR2777291 B1 FR 2777291B1 FR 9804389 A FR9804389 A FR 9804389A FR 9804389 A FR9804389 A FR 9804389A FR 2777291 B1 FR2777291 B1 FR 2777291B1
- Authority
- FR
- France
- Prior art keywords
- nep
- therapy
- screening
- inhibitors useful
- novel membrane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9804389A FR2777291B1 (fr) | 1998-04-08 | 1998-04-08 | Nouvelle metalloprotease membranaire nep ii et son utilisation pour le criblage d'inhibiteurs utiles en therapie |
PCT/FR1999/000807 WO1999053077A1 (fr) | 1998-04-08 | 1999-04-07 | Nouvelle metalloprotease membranaire nep ii et son utilisation pour le criblage d'inhibiteurs utiles en therapie |
EP99911898A EP1068336A2 (fr) | 1998-04-08 | 1999-04-07 | Nouvelle metalloprotease membranaire nep ii et son utilisation pour le criblage d'inhibiteurs utiles en therapie |
CA002325599A CA2325599A1 (fr) | 1998-04-08 | 1999-04-07 | Nouvelle metalloprotease membranaire nep ii et son utilisation pour le criblage d'inhibiteurs utiles en therapie |
JP2000543624A JP2002511271A (ja) | 1998-04-08 | 1999-04-07 | 新規膜メタロプロテアーゼnepii及び治療において有用な阻害因子のスクリーニングのためのその使用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9804389A FR2777291B1 (fr) | 1998-04-08 | 1998-04-08 | Nouvelle metalloprotease membranaire nep ii et son utilisation pour le criblage d'inhibiteurs utiles en therapie |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2777291A1 FR2777291A1 (fr) | 1999-10-15 |
FR2777291B1 true FR2777291B1 (fr) | 2000-07-07 |
Family
ID=9525008
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR9804389A Expired - Fee Related FR2777291B1 (fr) | 1998-04-08 | 1998-04-08 | Nouvelle metalloprotease membranaire nep ii et son utilisation pour le criblage d'inhibiteurs utiles en therapie |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1068336A2 (fr) |
JP (1) | JP2002511271A (fr) |
CA (1) | CA2325599A1 (fr) |
FR (1) | FR2777291B1 (fr) |
WO (1) | WO1999053077A1 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020086405A1 (en) * | 2000-09-25 | 2002-07-04 | Inmaculada Silos-Santiago | 56638, a novel human neprilysin protease and uses thereof |
CA2260376A1 (fr) | 1999-02-11 | 2000-08-11 | Universite De Montreal | Nouvelles metalloproteases de la famille de la neprilysine |
EP1069188A1 (fr) * | 1999-07-15 | 2001-01-17 | Sanofi-Synthelabo | Métallopeptidases membranaires de type neprolysin |
ES2310527T3 (es) * | 1999-11-19 | 2009-01-16 | Solvay Pharmaceuticals B.V. | Enzimas humanas de la familia de las metaloproteasas. |
JP2001275687A (ja) * | 2000-04-04 | 2001-10-09 | Masafumi Matsuo | 膜結合型メタロプロテアーゼ及びその可溶性分泌型 |
GB0017387D0 (en) * | 2000-07-14 | 2000-08-30 | Pfizer Ltd | Novel enzyme |
US6991916B2 (en) | 2000-07-14 | 2006-01-31 | Pfizer Inc. | Compounds for the treatment of sexual dysfunction |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4960700A (en) * | 1986-12-24 | 1990-10-02 | Genentech, Inc. | Compositions and methods for the synthesis and assay of a mammalian enkephalinase |
-
1998
- 1998-04-08 FR FR9804389A patent/FR2777291B1/fr not_active Expired - Fee Related
-
1999
- 1999-04-07 CA CA002325599A patent/CA2325599A1/fr not_active Abandoned
- 1999-04-07 JP JP2000543624A patent/JP2002511271A/ja not_active Withdrawn
- 1999-04-07 EP EP99911898A patent/EP1068336A2/fr not_active Withdrawn
- 1999-04-07 WO PCT/FR1999/000807 patent/WO1999053077A1/fr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1068336A2 (fr) | 2001-01-17 |
JP2002511271A (ja) | 2002-04-16 |
FR2777291A1 (fr) | 1999-10-15 |
WO1999053077A1 (fr) | 1999-10-21 |
CA2325599A1 (fr) | 1999-10-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |
Effective date: 20051230 |