ES2070535T3 - Acetilsaliciloil-carnitina y procedimiento para su preparacion. - Google Patents

Acetilsaliciloil-carnitina y procedimiento para su preparacion.

Info

Publication number
ES2070535T3
ES2070535T3 ES92101617T ES92101617T ES2070535T3 ES 2070535 T3 ES2070535 T3 ES 2070535T3 ES 92101617 T ES92101617 T ES 92101617T ES 92101617 T ES92101617 T ES 92101617T ES 2070535 T3 ES2070535 T3 ES 2070535T3
Authority
ES
Spain
Prior art keywords
carnitine
acid
acetilsaliciloil
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92101617T
Other languages
English (en)
Inventor
Thomas Dr Meul
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Application granted granted Critical
Publication of ES2070535T3 publication Critical patent/ES2070535T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE DESCRIBEN ESTERES DE ACIDO ACETILSALICILICO DE LA CARNITINA. LOS COMPUESTOS SE CARACTERIZAN EN CONTRA DEL ACIDO ACETILSALICILICO A TRAVES DE UNA ALTA SOLUBILIDAD EN AGUA, TOXICIDAD DISMINUIDA Y BUENA TOLERANCIA EN EL ESTOMAGO Y SON FABRICABLES A TRAVES DE LA ACETILINIZACION DE LOS CORRESPONDIENTES ESTERES DE ACIDO SALICILICO DE LA CARNITINA.
ES92101617T 1990-07-04 1992-01-31 Acetilsaliciloil-carnitina y procedimiento para su preparacion. Expired - Lifetime ES2070535T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH2222/90A CH679856A5 (es) 1990-07-04 1990-07-04
CH2999/90A CH679395A5 (es) 1990-07-04 1990-09-17

Publications (1)

Publication Number Publication Date
ES2070535T3 true ES2070535T3 (es) 1995-06-01

Family

ID=40316909

Family Applications (2)

Application Number Title Priority Date Filing Date
ES92101618T Expired - Lifetime ES2070536T3 (es) 1990-07-04 1992-01-31 Saliciloil-carnitina y procedimiento para su preparacion.
ES92101617T Expired - Lifetime ES2070535T3 (es) 1990-07-04 1992-01-31 Acetilsaliciloil-carnitina y procedimiento para su preparacion.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES92101618T Expired - Lifetime ES2070536T3 (es) 1990-07-04 1992-01-31 Saliciloil-carnitina y procedimiento para su preparacion.

Country Status (4)

Country Link
US (2) US5227513A (es)
EP (2) EP0553384B1 (es)
CH (2) CH679856A5 (es)
ES (2) ES2070536T3 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH679856A5 (es) * 1990-07-04 1992-04-30 Lonza Ag
IL105244A (en) * 1993-03-31 2003-07-31 Dpharm Ltd Prodrugs with enhanced penetration into cells
US6413949B1 (en) 1995-06-07 2002-07-02 D-Pharm, Ltd. Prodrugs with enhanced penetration into cells
IT1261696B (it) * 1993-06-02 1996-05-29 Avantgarde Spa Uso di esteri sull'ossidrile della l-carnitina con acidi aromatici perprodurre composizioni farmaceutiche per il trattamento di affezioni cutanee.
US6313106B1 (en) 1995-06-07 2001-11-06 D-Pharm Ltd. Phospholipid derivatives of valproic acid and mixtures thereof
IT1306184B1 (it) 1999-08-05 2001-05-30 Sigma Tau Ind Farmaceuti Nitrilossi derivati della (r) e (s)-carnitina.
NZ597510A (en) * 2009-06-25 2012-12-21 Tetra Sia NOVEL ACETYLSALICYLIC ACID SALTS, the salts are 4-trimethylammoniobutanoate, L-carnitine and meldonium
US10723691B2 (en) * 2016-08-30 2020-07-28 Drug'on Pharma Switzerland Ag Process for preparing salicyloyl-L-carnitine hydrochloride
EP3326999B1 (de) 2016-11-24 2019-08-07 Drug'On Pharma Switzerland AG Salicyloylcarnitin sulfonate

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH389641A (de) * 1961-01-20 1965-03-31 Mundipharma Ag Verfahren zur Herstellung von Betainsalicylat
US4336400A (en) * 1969-04-01 1982-06-22 Sterling Drug Inc. 3-(Hydroxy or hydroxymethyl)-4-hydroxy-alpha(aminomethyl)benzyl alcohols and methods of use
DE2914721A1 (de) * 1978-04-17 1979-10-18 Kyowa Hakko Kogyo Kk Verfahren zur bestimmung der cholinesterase-aktivitaet sowie fuer dieses verfahren verwendbare cholin-derivate
IT1156840B (it) * 1978-06-27 1987-02-04 Sigma Tau Ind Farmaceuti Acil derivati della carnitina
US4402974A (en) * 1981-06-23 1983-09-06 American Hospital Supply Corporation Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents
EP0150688B1 (en) * 1983-12-28 1987-04-22 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same
CH679856A5 (es) * 1990-07-04 1992-04-30 Lonza Ag
JPH0721352A (ja) * 1993-07-05 1995-01-24 Hitachi Ltd 分散オーサリング・システム

Also Published As

Publication number Publication date
US5227513A (en) 1993-07-13
EP0553384B1 (de) 1995-03-29
CH679856A5 (es) 1992-04-30
EP0553384A1 (de) 1993-08-04
EP0553385A1 (de) 1993-08-04
ES2070536T3 (es) 1995-06-01
CH679395A5 (es) 1992-02-14
US5227514A (en) 1993-07-13
EP0553385B1 (de) 1995-03-29

Similar Documents

Publication Publication Date Title
ES498766A0 (es) Procedimiento para la preparacion de acidos carboxilicos
ES2159851T3 (es) Amidas de acidos aminotiofenocarboxilicos y su empleo como inhibidores de la fosfodiestearasa.
ES2070535T3 (es) Acetilsaliciloil-carnitina y procedimiento para su preparacion.
ATE22533T1 (de) Pharmazeutische zusammensetzung.
NO301542B1 (no) Nye pyrazin-derivater
ES557515A0 (es) Procedimiento para la obtencion de derivados del acido piridin-3-carboxilico
JPS567716A (en) Preventive and remedy for cerebral angiospasm
FI833200A0 (fi) Isokinolinderivat, foerfaranden foer deras framstaellning, pao dessa foereningar baserade farmaceutpreparat och deras anvaendning
SE7811455L (sv) 2-imino-imidazolidin-derivat
AR007052A1 (es) Un derivado de carbohidrato, su uso y una composicion farmaceutica que lo comprende
ES2083983T3 (es) Sales del acido n5-n10-metilen-5,6,7,8-tetrahidrofolico.
MX9203234A (es) Derivados de 5-halovinil-2-desoxiuridina y composiciones farmaceuticas que los contienen.
SE8004383L (sv) Farmaceutisk beredning for oral administrering och forfarande for dess framstellning
AU553874B2 (en) Thiazaspirane derivatives
ES2156877T3 (es) Anilidas de acidos cicloalquilcarboxilicos.
SE8800846D0 (sv) Optiskt aktiva oxo-isoindolinderivat
ES2171056T3 (es) Procedimiento para la fabricacion de cefuroxima axetil cristalina soluble.
ES2071843T3 (es) Derivado de acido d-2-(6-metoxi-2-naftil)-propionico opticamente activo y composiciones farmaceuticas que lo contienen.
JPS5731617A (en) Carcinostatic agent
SU1406849A1 (ru) Способ приготовления раствора пентагастрина для инъекций
DE69632078D1 (de) 3-aminopropoxyphenyl-derivate
ES2079185T3 (es) Isoindoles con actividad cardiovascular.
JPS53137982A (en) Antibiotics tylosin derivatives
ES455692A1 (es) Procedimiento para la produccion de derivados de alquilen- dioxipiperacina.
ES444829A1 (es) Procedimiento para la preparacion de dibenzofuranos.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 553384

Country of ref document: ES