ES2063965T3 - Vacunas para haemophilus influenzae no tipificable. - Google Patents
Vacunas para haemophilus influenzae no tipificable.Info
- Publication number
- ES2063965T3 ES2063965T3 ES90905112T ES90905112T ES2063965T3 ES 2063965 T3 ES2063965 T3 ES 2063965T3 ES 90905112 T ES90905112 T ES 90905112T ES 90905112 T ES90905112 T ES 90905112T ES 2063965 T3 ES2063965 T3 ES 2063965T3
- Authority
- ES
- Spain
- Prior art keywords
- influenzae
- typable
- protein
- haemophilus influenzae
- influenzae vaccines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000606768 Haemophilus influenzae Species 0.000 title abstract 6
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 229940047650 haemophilus influenzae Drugs 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 5
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 102000004895 Lipoproteins Human genes 0.000 abstract 1
- 108090001030 Lipoproteins Proteins 0.000 abstract 1
- 206010033078 Otitis media Diseases 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002458 infectious effect Effects 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 229940031348 multivalent vaccine Drugs 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1242—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
LA PROTEINA "E" DE H. INFLUENZAE, UNA LIPOPROTEINA DE APROXIMADAMENTE 2.800 DALTONS, SE HA PURIFICADO Y SECUENCIADO. LA PROTEINA "E" Y LOS PEPTIDOS O PROTEINAS QUE TIENEN UN EPITOPE COMPARTIDO, PUEDEN UTILIZARSE PARA VACUNAR CONTRA H. INFLUENZAE NO TIPIFICABLE (Y TIPIFICABLE) Y PARA PREVENIR LA OTITIS MEDIA CANSADA POR H. INFLUENZAE. CON ESTE PROPOSITO, LA PROTEINA "E" O SUS DERIVADOS PUEDEN PRODUCIRSE DE FORMA NATURAL, SINTETICA O RECOMBINANTE Y PUEDEN ADMINISTRARSE SOLAS O JUNTO CON OTROS ANTIGENOS DE H. INFLUENZAE. LA PROTEINA "E" PUEDE UTILIZARSE TAMBIEN EN VACUNAS MULTIVALENTES DISEÑADAS PARA H. INFLUENZAE Y UNO O MAS MICROORGANISMOS INFECCIOSOS DIFERENTES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32097189A | 1989-03-09 | 1989-03-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2063965T3 true ES2063965T3 (es) | 1995-01-16 |
Family
ID=23248627
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90905112T Expired - Lifetime ES2063965T3 (es) | 1989-03-09 | 1990-03-09 | Vacunas para haemophilus influenzae no tipificable. |
ES94100492T Expired - Lifetime ES2150450T3 (es) | 1989-03-09 | 1990-03-09 | Procedimiento para el aislamiento de la proteina e de haemophilus influenzae. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94100492T Expired - Lifetime ES2150450T3 (es) | 1989-03-09 | 1990-03-09 | Procedimiento para el aislamiento de la proteina e de haemophilus influenzae. |
Country Status (13)
Country | Link |
---|---|
US (4) | US5601831A (es) |
EP (2) | EP0462210B1 (es) |
JP (1) | JP2955014B2 (es) |
KR (1) | KR100188323B1 (es) |
AT (2) | ATE195076T1 (es) |
AU (1) | AU648251B2 (es) |
CA (1) | CA2047681C (es) |
DE (2) | DE69012318T2 (es) |
DK (2) | DK0462210T3 (es) |
ES (2) | ES2063965T3 (es) |
FI (1) | FI914241A0 (es) |
NO (1) | NO913518L (es) |
WO (1) | WO1990010458A1 (es) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1340888C (en) * | 1988-09-01 | 2000-02-01 | Algis Anilionis | Vaccines and diagnostic assays for haemophilus influenzae |
US6797272B1 (en) | 1991-10-16 | 2004-09-28 | University Of Saskatchewan | Enhanced immunogenicity using leukotoxin chimeras |
US5422110A (en) * | 1991-10-16 | 1995-06-06 | University Of Saskatchewan | Enhanced immunogenicity using leukotoxin chimeras |
AU2699192A (en) * | 1991-10-16 | 1993-05-21 | University Of Saskatchewan | Enhanced immunogenicity using leukotoxin chimeras |
DK0624376T3 (da) * | 1993-05-13 | 2000-07-24 | American Cyanamid Co | Fremstilling og anvendelse af LOS-udtømte ydre membranproteiner af gram-negative cocci |
US5681570A (en) * | 1995-01-12 | 1997-10-28 | Connaught Laboratories Limited | Immunogenic conjugate molecules |
US20020032316A1 (en) * | 1995-03-31 | 2002-03-14 | Cantab Pharmaceuticals Research Limited | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same |
EP0824360A1 (en) * | 1995-04-17 | 1998-02-25 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Induction and enhancement of the immune response to polysaccharides with bacterial lipoproteins |
AR003125A1 (es) * | 1995-06-01 | 1998-07-08 | Astra Ab | Antigenos bacterianos para el diagnostico de infecciones con helicobacter pylori, una molecula de adn que lo codifica, un vector, una celula huesped,procedimiento para producir el polipeptido, composiciones para vacunas adecuadas para uso terapeutico y profilactico, el uso del polipeptido en la |
GB9513074D0 (en) * | 1995-06-27 | 1995-08-30 | Cortecs Ltd | Novel anigen |
US20040126381A1 (en) * | 1996-04-23 | 2004-07-01 | Xin-Xing Gu | Intranasal immunization with detoxified lipooligosaccharide from nontypeable haemophilus influenzae or moraxella |
US6207157B1 (en) * | 1996-04-23 | 2001-03-27 | The United States Of America As Represented By The Department Of Health And Human Services | Conjugate vaccine for nontypeable Haemophilus influenzae |
CN1511519A (zh) * | 1997-11-12 | 2004-07-14 | - | 2型t辅助细胞介导的免疫病的治疗 |
US6255050B1 (en) * | 1998-05-22 | 2001-07-03 | Lorne Park Research, Inc. | Dynamic hybridization system |
ES2315234T3 (es) | 1999-06-25 | 2009-04-01 | Wyeth Holdings Corporation | Extraccion de proteinas de la membrana intrega. |
US7101989B1 (en) | 1999-07-09 | 2006-09-05 | University Of North Carolina At Chapel Hill | DsrA protein and polynucleotides encoding the same |
US6391313B1 (en) * | 1999-07-15 | 2002-05-21 | Aventis Pasteur Limited | Multi-component vaccine to protect against disease caused by Haemophilus influenzae and Moraxella catarrhalis |
JP2003507433A (ja) * | 1999-08-20 | 2003-02-25 | ザ ゼネラル ホスピタル コーポレーション | 敗血症治療において治療に用いる対象としての外膜タンパク質a、ペプチドグリカン関連リポタンパク質およびムレインリポタンパク質 |
US7384640B1 (en) * | 1999-09-30 | 2008-06-10 | Wyeth Holdings Corporation | Mutant cholera holotoxin as an adjuvant |
US20030232055A1 (en) * | 2000-07-31 | 2003-12-18 | Ruslan Medzhitov | Innate immune system-directed vaccines |
WO2002009748A1 (en) * | 2000-07-31 | 2002-02-07 | Yale University | Innate immune system-directed vaccines |
GB0025486D0 (en) * | 2000-10-17 | 2000-11-29 | Smithkline Beecham Biolog | Novel compounds |
US20030175287A1 (en) * | 2001-01-03 | 2003-09-18 | Yale University | Innate immune system-directed vaccines |
AT410798B (de) * | 2001-01-26 | 2003-07-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
US6834384B2 (en) * | 2001-03-14 | 2004-12-21 | General Instrument Corporation | Methods and apparatus for upgrading firmware in an embedded system |
CA2446355A1 (en) * | 2001-05-03 | 2002-11-14 | The Government Of The United States Of America | Intranasal immunization with detoxified lipooligosaccharide from nontypeable haemophilus influenzae or moraxella catarrhalis |
EP1404368B1 (en) | 2001-06-07 | 2009-12-09 | Wyeth Holdings Corporation | Mutant forms of cholera holotoxin as an adjuvant |
CN1541111A (zh) * | 2001-06-07 | 2004-10-27 | ���Ͽع�����˾ | 作为佐剂的霍乱全毒素的突变形式 |
WO2002100891A2 (en) * | 2001-06-12 | 2002-12-19 | Glaxosmithkline Biologicals S.A. | Proteins derived from non-typable haemophilus influenzae (nthi) strain |
GB0117762D0 (en) * | 2001-07-20 | 2001-09-12 | Glaxosmithkline Biolog Sa | Novel compounds |
MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
KR100981471B1 (ko) | 2002-03-15 | 2010-09-10 | 더 큐레이터스 오브 더 유니버시티 오브 미주리 | 효소 활성이 감소된 형별불능 헤모필러스 인플루엔자의p4 변형 단백질 |
US7709001B2 (en) | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
CN102716480B (zh) | 2005-04-08 | 2023-03-21 | 惠氏有限责任公司 | 多价肺炎球菌多糖-蛋白质缀合物组合物 |
KR20070047455A (ko) * | 2005-11-02 | 2007-05-07 | 삼성에스디아이 주식회사 | 전자 방출 표시 디바이스 |
CA2638760A1 (en) * | 2006-03-07 | 2007-09-13 | Vaxinnate Corporation | Compositions that include hemagglutinin, methods of making and methods of use thereof |
PL1915913T3 (pl) * | 2006-10-23 | 2016-06-30 | Nestec Sa | Modulowanie smaku oraz aromatu w mlecznych produktach poprzez biotransformację |
AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
CN102216781B (zh) * | 2009-01-07 | 2014-05-21 | 大塚制药株式会社 | 全部流感嗜血杆菌的测定方法 |
HRP20210242T4 (hr) | 2010-08-23 | 2024-05-10 | Wyeth Llc | Stabilne formulacije antigena iz bakterije neisseria meningitidis rlp2086 |
CN103096920B (zh) | 2010-09-10 | 2016-03-23 | 惠氏有限责任公司 | 脑膜炎奈瑟球菌orf2086抗原的非脂质化变体 |
TW201302779A (zh) * | 2011-04-13 | 2013-01-16 | Glaxosmithkline Biolog Sa | 融合蛋白質及組合疫苗 |
SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
BR122016004924A2 (pt) | 2012-03-09 | 2019-07-30 | Pfizer Inc. | Polipeptídeo isolado e composições imunogênicas compreendendo os mesmos |
JP6446377B2 (ja) | 2013-03-08 | 2018-12-26 | ファイザー・インク | 免疫原性融合ポリペプチド |
CA2923129C (en) | 2013-09-08 | 2020-06-09 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
AU2016221318B2 (en) | 2015-02-19 | 2020-06-25 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
AU2018215585B2 (en) | 2017-01-31 | 2022-03-17 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4220717A (en) * | 1977-12-22 | 1980-09-02 | American Cyanamid Company | Isolation and purification of polyribosyl ribitol phosphate from Haemophilus influenzae type b. |
US4220722A (en) * | 1978-02-10 | 1980-09-02 | Syva Company | Method for conjugating to polyamino compounds employing haloacyl groups and compositions prepared thereby |
US4356170A (en) * | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
US4496538A (en) * | 1982-07-06 | 1985-01-29 | Connaught Laboratories, Inc. | Haemophilus influenzae b polysaccharide-diphtheria toxoid conjugate vaccine |
US4661347A (en) | 1982-11-12 | 1987-04-28 | Scripps Clinic | Cytotoxic compositions |
US4762713A (en) * | 1983-07-05 | 1988-08-09 | The University Of Rochester | Boosting of immunogenic conjugate vaccinations by unconjugated bacterial capsular polymers |
NZ214503A (en) * | 1984-12-20 | 1990-02-26 | Merck & Co Inc | Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins, and methods of preparing such polysaccharides and conjugates |
US4873090A (en) * | 1985-03-27 | 1989-10-10 | Broncostat Pty. Limited | Non-adjuvenated vaccine |
US4707543A (en) * | 1985-09-17 | 1987-11-17 | The United States Of America As Represented By The Secretary Of The Army | Process for the preparation of detoxified polysaccharide-outer membrane protein complexes, and their use as antibacterial vaccines |
JP2534529B2 (ja) * | 1986-07-24 | 1996-09-18 | ブリティシュ・テレコミュニケ−ションズ・パブリック・リミテッド・カンパニ | 放射発生器 |
US5173294A (en) * | 1986-11-18 | 1992-12-22 | Research Foundation Of State University Of New York | Dna probe for the identification of haemophilus influenzae |
AU623353B2 (en) * | 1987-12-10 | 1992-05-14 | Board Of Regents, The University Of Texas System | Methods and compositions for the production of haemophilus influenzae type b major outer membrane protein antigens |
-
1990
- 1990-03-09 ES ES90905112T patent/ES2063965T3/es not_active Expired - Lifetime
- 1990-03-09 JP JP2505084A patent/JP2955014B2/ja not_active Expired - Lifetime
- 1990-03-09 DK DK90905112.0T patent/DK0462210T3/da active
- 1990-03-09 DK DK94100492T patent/DK0606921T3/da active
- 1990-03-09 AU AU53326/90A patent/AU648251B2/en not_active Expired
- 1990-03-09 DE DE69012318T patent/DE69012318T2/de not_active Expired - Lifetime
- 1990-03-09 AT AT94100492T patent/ATE195076T1/de not_active IP Right Cessation
- 1990-03-09 ES ES94100492T patent/ES2150450T3/es not_active Expired - Lifetime
- 1990-03-09 KR KR1019910701102A patent/KR100188323B1/ko not_active IP Right Cessation
- 1990-03-09 AT AT90905112T patent/ATE110965T1/de not_active IP Right Cessation
- 1990-03-09 EP EP90905112A patent/EP0462210B1/en not_active Expired - Lifetime
- 1990-03-09 DE DE69033600T patent/DE69033600T2/de not_active Expired - Lifetime
- 1990-03-09 WO PCT/US1990/001317 patent/WO1990010458A1/en active IP Right Grant
- 1990-03-09 CA CA002047681A patent/CA2047681C/en not_active Expired - Lifetime
- 1990-03-09 EP EP94100492A patent/EP0606921B1/en not_active Expired - Lifetime
- 1990-03-09 US US07/491,466 patent/US5601831A/en not_active Expired - Lifetime
-
1991
- 1991-09-06 NO NO91913518A patent/NO913518L/no unknown
- 1991-09-09 FI FI914241A patent/FI914241A0/fi not_active Application Discontinuation
-
1995
- 1995-05-23 US US08/447,653 patent/US5780601A/en not_active Expired - Lifetime
- 1995-05-23 US US08/448,097 patent/US6420134B1/en not_active Expired - Fee Related
- 1995-05-23 US US08/449,406 patent/US5955580A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0462210B1 (en) | 1994-09-07 |
DE69012318T2 (de) | 1995-03-09 |
AU5332690A (en) | 1990-10-09 |
NO913518D0 (no) | 1991-09-06 |
DK0606921T3 (da) | 2000-09-04 |
EP0606921A1 (en) | 1994-07-20 |
DE69033600T2 (de) | 2001-04-05 |
ATE110965T1 (de) | 1994-09-15 |
DE69012318D1 (de) | 1994-10-13 |
CA2047681A1 (en) | 1990-09-10 |
DE69033600D1 (de) | 2000-09-07 |
ATE195076T1 (de) | 2000-08-15 |
JPH07508972A (ja) | 1995-10-05 |
ES2150450T3 (es) | 2000-12-01 |
US5780601A (en) | 1998-07-14 |
KR100188323B1 (ko) | 1999-06-01 |
CA2047681C (en) | 2000-02-01 |
FI914241A0 (fi) | 1991-09-09 |
DK0462210T3 (da) | 1994-10-10 |
EP0606921B1 (en) | 2000-08-02 |
NO913518L (no) | 1991-10-29 |
US6420134B1 (en) | 2002-07-16 |
AU648251B2 (en) | 1994-04-21 |
JP2955014B2 (ja) | 1999-10-04 |
US5601831A (en) | 1997-02-11 |
EP0462210A1 (en) | 1991-12-27 |
US5955580A (en) | 1999-09-21 |
WO1990010458A1 (en) | 1990-09-20 |
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