ES2062292T3 - Un proceso para la preparacion del compuesto que tiene la estructura (7alfa,17alfa)-17-hidroxi-7-metil-19-nor-17-pregn-5(10)-in-3-ona. - Google Patents

Un proceso para la preparacion del compuesto que tiene la estructura (7alfa,17alfa)-17-hidroxi-7-metil-19-nor-17-pregn-5(10)-in-3-ona.

Info

Publication number
ES2062292T3
ES2062292T3 ES90200574T ES90200574T ES2062292T3 ES 2062292 T3 ES2062292 T3 ES 2062292T3 ES 90200574 T ES90200574 T ES 90200574T ES 90200574 T ES90200574 T ES 90200574T ES 2062292 T3 ES2062292 T3 ES 2062292T3
Authority
ES
Spain
Prior art keywords
compound
pregn
methyl
7alfa
17alfa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90200574T
Other languages
English (en)
Inventor
G A J M T Sas
Doornum E M Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=19854317&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2062292(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Akzo NV filed Critical Akzo NV
Application granted granted Critical
Publication of ES2062292T3 publication Critical patent/ES2062292T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

COMPOSICION FARMACEUTICA QUE CONTIENE UN SOPORTE FARMACEUTICAMENTE ADECUADO Y COMPUESTO CON LA ESTRUCTURA (7(ALFA)-17(ALFA))-17-HIDROXI-7-METIL-19NOR-17-PREGN-5(10)-EN-20-IN-3-ONA, CON LAS CARACTERISTICAS DE QUE DICHO COMPUESTO ES CRISTALINO, PURO Y LIBRE EN SU TOTALIDAD O PRACTICAMENTE EN SU TOTALIDAD DE LA OTRA FORMA CRISTALINA.
ES90200574T 1989-03-18 1990-03-12 Un proceso para la preparacion del compuesto que tiene la estructura (7alfa,17alfa)-17-hidroxi-7-metil-19-nor-17-pregn-5(10)-in-3-ona. Expired - Lifetime ES2062292T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8900673 1989-03-18

Publications (1)

Publication Number Publication Date
ES2062292T3 true ES2062292T3 (es) 1994-12-16

Family

ID=19854317

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90200574T Expired - Lifetime ES2062292T3 (es) 1989-03-18 1990-03-12 Un proceso para la preparacion del compuesto que tiene la estructura (7alfa,17alfa)-17-hidroxi-7-metil-19-nor-17-pregn-5(10)-in-3-ona.

Country Status (17)

Country Link
US (1) US5037817A (es)
EP (1) EP0389035B1 (es)
JP (2) JP3139709B2 (es)
KR (1) KR0183401B1 (es)
AT (1) ATE98490T1 (es)
AU (1) AU625083B2 (es)
CA (1) CA2011452C (es)
DE (1) DE69005165T2 (es)
DK (1) DK0389035T3 (es)
ES (1) ES2062292T3 (es)
FI (1) FI94865C (es)
HK (1) HK1002019A1 (es)
IE (1) IE63051B1 (es)
MX (1) MX9203787A (es)
NZ (1) NZ232946A (es)
PT (1) PT93488B (es)
ZA (1) ZA901674B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0613687B1 (en) * 1993-03-05 1999-06-02 Akzo Nobel N.V. Use of a pregnane derivatives for the treatment of tumours
US6242434B1 (en) * 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
IL123984A (en) 1997-04-22 2004-09-27 Akzo Nobel Nv Pharmacological dosage units containing tibolone and carrier pharmacy are acceptable
HUP0104206A3 (en) * 1998-10-16 2002-06-28 Akzo Nobel Nv High purity composition comprising (7alpha,17alpha)- 17-hydroxy- 7-methyl- 19nor-17-pregn-5(10)-en-20-yn-3-one and process for its preparation
BR0005392A (pt) * 1999-03-18 2001-01-30 Genelabs Tech Inc Composição de dhea e processo
US7045513B1 (en) 1999-03-18 2006-05-16 Genelabs Technologies, Inc. DHEA composition and method
TWI265167B (en) * 1999-11-29 2006-11-01 Akzo Nobel Nv 3-methylene steroid derivatives
US20040229854A1 (en) * 2000-11-28 2004-11-18 Pieter Haan De Immediate release dosage form for HRT
PT1444247E (pt) * 2001-10-18 2007-07-09 Norton Healthcare Ltd Formulações de tibolona.
GB0125061D0 (en) * 2001-10-18 2001-12-12 Norton Healthcare Ltd Pharmaceutical composition
KR20040073572A (ko) * 2002-01-22 2004-08-19 악조 노벨 엔.브이. 내인성 에스트로겐의 합성을 예방하는 약물의 투여와관련된 호소 증상의 치료에서의 티볼론
GB0304927D0 (en) 2003-03-04 2003-04-09 Resolution Chemicals Ltd Process for the production of tibolone
CN1324041C (zh) * 2003-04-01 2007-07-04 上海迪赛诺医药科技开发有限公司 替勃龙晶型i的制备方法
KR20060028822A (ko) * 2003-05-23 2006-04-03 엔.브이. 오가논 다형성 티볼론을 포함하는 즉시-방출형 약학 제형
EP1883648A1 (en) * 2005-05-23 2008-02-06 Newchem S.p.A. Process for the preparation of pure crystalline tibolone
EP1821571A1 (en) * 2006-02-15 2007-08-22 Oticon A/S Loop antenna for in the ear audio device
ITMI20130120A1 (it) * 2013-01-25 2014-07-26 Ind Chimica Srl Processo per la preparazione in forma cristallina di tibolone, (7alfa,17alfa)-17-idrossi-7-metil-19-norpregn-5(10)-en-20-in-3-one
MX2018013274A (es) 2016-05-04 2019-03-06 Mithra Pharmaceuticals S A Uso de alcoholes de azucar en composiciones de tibolona.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE665514A (es) * 1964-06-16
US4933168A (en) * 1975-05-27 1990-06-12 Syntex Pharmaceuticals International Limited Stable, crystalline flunisolide
US4273710A (en) * 1979-05-21 1981-06-16 Syntex Corporation Process for preparing flunisolide
US4447426A (en) * 1982-01-18 1984-05-08 E. R. Squibb & Sons, Inc. Steroid monohydrates, formulations containing same and method
US4391755A (en) * 1982-01-18 1983-07-05 E. R. Squibb & Sons, Inc. Steroid monohydrates, formulations containing same and method
US4701450A (en) * 1984-03-21 1987-10-20 Akzo N.V. Steroids for use as immunomodulators

Also Published As

Publication number Publication date
JPH0347195A (ja) 1991-02-28
DE69005165D1 (de) 1994-01-27
FI901328A0 (fi) 1990-03-16
CA2011452A1 (en) 1990-09-18
MX9203787A (es) 1992-07-01
IE900709L (en) 1990-09-18
ATE98490T1 (de) 1994-01-15
FI94865C (fi) 1995-11-10
FI94865B (fi) 1995-07-31
EP0389035A1 (en) 1990-09-26
ZA901674B (en) 1990-12-28
KR0183401B1 (ko) 1999-05-01
IE63051B1 (en) 1995-03-22
CA2011452C (en) 1999-05-25
HK1002019A1 (en) 1998-07-24
KR900013950A (ko) 1990-10-22
DE69005165T2 (de) 1994-05-05
JP3139709B2 (ja) 2001-03-05
AU625083B2 (en) 1992-07-02
EP0389035B1 (en) 1993-12-15
NZ232946A (en) 1991-08-27
DK0389035T3 (da) 1994-02-14
PT93488A (pt) 1990-11-07
PT93488B (pt) 1996-02-29
JP2001139473A (ja) 2001-05-22
AU5139490A (en) 1990-09-20
US5037817A (en) 1991-08-06

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