ES2060541B1 - NEW PROCEDURE FOR THE SYNTHESIS OF A DERIVATIVE OF 2- (2-PIRIDILMETILSUFINIL) BENCIMIDAZOLE, AND NEW INTERMEDIATE PRODUCTS OBTAINED WITH THE SAME. - Google Patents

NEW PROCEDURE FOR THE SYNTHESIS OF A DERIVATIVE OF 2- (2-PIRIDILMETILSUFINIL) BENCIMIDAZOLE, AND NEW INTERMEDIATE PRODUCTS OBTAINED WITH THE SAME.

Info

Publication number
ES2060541B1
ES2060541B1 ES9300384A ES9300384A ES2060541B1 ES 2060541 B1 ES2060541 B1 ES 2060541B1 ES 9300384 A ES9300384 A ES 9300384A ES 9300384 A ES9300384 A ES 9300384A ES 2060541 B1 ES2060541 B1 ES 2060541B1
Authority
ES
Spain
Prior art keywords
methyl
new
piridilmetilsufinil
bencimidazole
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9300384A
Other languages
Spanish (es)
Other versions
ES2060541A1 (en
Inventor
Vinas Antonio Buxade
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Vinas SA
Original Assignee
Laboratorios Vinas SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Vinas SA filed Critical Laboratorios Vinas SA
Priority to ES9300384A priority Critical patent/ES2060541B1/en
Publication of ES2060541A1 publication Critical patent/ES2060541A1/en
Application granted granted Critical
Publication of ES2060541B1 publication Critical patent/ES2060541B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Abstract

EL METODO, DE ACUERDO CON LA INVENCI6N, ES UN PROCESO MULTI-PASO (ESQUEMA I) PARA PREPARAR 2-(((3-METIL-4-(2,2,2- TRIFLUOROETOXI)-2-PIRIDIL)METIL)SULFINIL)-1H-BENZIMIDAZOL QUE COMPRENDE LOS PASOS SIGUIENTES: PASO A): SUSTITUCION NUCLEOFILA DEL GRUPO Z DEL 2- (((3-METIL-4-Z-2-PIRIDIL)METIL)SULFINIL)-1H-BENCIMIDAZOL POR 2,2,2-TRIFLUOROETANOL; PASO B): OBTENCI6N DEL 2-(((3-METIL-4-Z-2-PIRIDIL)ME- TIL)SULFINIL)-LH-BENCIMIDAZOL POR OXIDACI6N DEL 2-(((3- METIL-4-Z-2-PIRIDIL)METIL)TIO)-LH-BENCIMIDAZOL; PASO C): PREPARACI6N DEL 2-(((3-METIL-4-Z-2-PIRI- DIL)METIL)TIO)-1H-BENCIMIDAZOL A PARTIR DE N-6XIDO DE 2,3- DIMETIL-4-NITROPIRIDINA.THE METHOD, ACCORDING TO THE INVENTION, IS A MULTI-STEP PROCESS (SCHEME I) TO PREPARE 2 - ((((3-METHYL-4- (2,2,2- TRIFLUOROETOXI) -2-PIRIDYL) METHYL) SULFINYL) -1H-BENZIMIDAZOLE UNDERSTANDING THE FOLLOWING STEPS: STEP A): NUCLEOPHYL SUBSTITUTION OF GROUP Z 2- (((3-METHYL-4-Z-2-PIRIDYL) METHYL) SULFINYL BY -1, 2-TRIFLUOROETHANOL; STEP B): OBTAINING 2 - ((((3-METHYL-4-Z-2-PIRIDIL) METHYL) SULFINYL) -LH-BENZMIDAZOLE BY OXIDATION OF 2 - (((3- METHYL-4-Z-2 -PIRIDIL) METHYL) THIO) -LH-BENZMIDAZOLE; STEP C): PREPARATION OF 2 - ((((3-METHYL-4-Z-2-PIRI- DIL) METHYL) THIO) -1H-BENZMIDAZOLE FROM 2,3-DIMETHYL-4-NITROPYRIDINE.

ES9300384A 1993-02-26 1993-02-26 NEW PROCEDURE FOR THE SYNTHESIS OF A DERIVATIVE OF 2- (2-PIRIDILMETILSUFINIL) BENCIMIDAZOLE, AND NEW INTERMEDIATE PRODUCTS OBTAINED WITH THE SAME. Expired - Fee Related ES2060541B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9300384A ES2060541B1 (en) 1993-02-26 1993-02-26 NEW PROCEDURE FOR THE SYNTHESIS OF A DERIVATIVE OF 2- (2-PIRIDILMETILSUFINIL) BENCIMIDAZOLE, AND NEW INTERMEDIATE PRODUCTS OBTAINED WITH THE SAME.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9300384A ES2060541B1 (en) 1993-02-26 1993-02-26 NEW PROCEDURE FOR THE SYNTHESIS OF A DERIVATIVE OF 2- (2-PIRIDILMETILSUFINIL) BENCIMIDAZOLE, AND NEW INTERMEDIATE PRODUCTS OBTAINED WITH THE SAME.

Publications (2)

Publication Number Publication Date
ES2060541A1 ES2060541A1 (en) 1994-11-16
ES2060541B1 true ES2060541B1 (en) 1995-11-16

Family

ID=8280919

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9300384A Expired - Fee Related ES2060541B1 (en) 1993-02-26 1993-02-26 NEW PROCEDURE FOR THE SYNTHESIS OF A DERIVATIVE OF 2- (2-PIRIDILMETILSUFINIL) BENCIMIDAZOLE, AND NEW INTERMEDIATE PRODUCTS OBTAINED WITH THE SAME.

Country Status (1)

Country Link
ES (1) ES2060541B1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2343935A1 (en) * 2008-12-29 2010-08-12 Laboratorios Viñas S.A. Useful intermediates for the obtaining of 2- (2-pyridinylmetilsulfinil) -1H-benzimidazoles and corresponding procedures (Machine-translation by Google Translate, not legally binding)
ES2363075A1 (en) * 2009-12-23 2011-07-20 Laboratorios Viñas S.A. Procedure for the preparation of 4-chloro-2-chloromethyl-3-methylpyr. (Machine-translation by Google Translate, not legally binding)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2166269B1 (en) * 1999-07-14 2003-04-01 Sint Quimica Sa NEW PROCEDURE FOR OBTAINING DERIVATIVES OF 2- (2-PIRIDINILMETILSULFINIL) -1H-BENZIMIDAZOL.
ES2163372B1 (en) * 2000-03-13 2003-05-01 Esteve Quimica Sa OXIDATION PROCEDURE OF A SULFOXIDE TIOETER GROUP.
ES2187248B1 (en) * 2000-08-25 2004-01-16 Sint Quimica Sa NEW PROCEDURE FOR OBTAINING DERIVATIVES OF 2- (2-PIRIDINILMETILSULFINIL) -1H-BENZIMIDAZOL.
ES2185459B1 (en) * 2000-10-02 2003-12-16 Dinamite Dipharma Spa PROCEDURE FOR OBTAINING PANTOPRAZOL AND INTERMEDIATE COMPOUNDS FOR THE SAME.
TWI270542B (en) 2002-02-07 2007-01-11 Sumitomo Chemical Co Method for preparing sulfone or sulfoxide compound
AU2003288703A1 (en) * 2003-12-05 2005-06-24 Hetero Drugs Limited A process for the preparation of substitited pyridinylmethylsulfinyl- benzimidazole enantiomers
ES2264362B1 (en) * 2004-12-22 2007-11-01 Laboratorios Viñas S.A. "PROCEDURE FOR OBTAINING DERIVATIVES OF 2- (2-PIRIDINILMETILSUFINIL-1H-BENZIMIDAZOLES").
WO2009010937A1 (en) 2007-07-17 2009-01-22 Ranbaxy Laboratories Limited Process for the preparation op pantoprazole sodium and pantoprazole sodium sesquihydrate
IT1391776B1 (en) 2008-11-18 2012-01-27 Dipharma Francis Srl PROCEDURE FOR THE PREPARATION OF DEXLANSOPRAZOL
IT1395118B1 (en) 2009-07-29 2012-09-05 Dipharma Francis Srl PROCEDURE FOR THE PREPARATION OF CRYSTALLINE DEXLANSOPRAZOLE
JP6377334B2 (en) * 2013-10-25 2018-08-22 東洋鋼鈑株式会社 Nonlinear optical dye, photorefractive material composition, photorefractive substrate, and hologram recording medium

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8204879D0 (en) * 1982-08-26 1982-08-26 Haessle Ab NOVEL CHEMICAL INTERMEDIATES
JPS6150978A (en) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd Pyridine derivative and preparation thereof
DK171989B1 (en) * 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Process for the preparation of 2- (2-pyridylmethylsulfinyl) benzimidazoles
ES2023609A6 (en) * 1990-11-29 1992-01-16 Inke Sa Process for obtaining 2-[[[3-methyl-4-(2,2,2- trifluoroethoxy)-2-pyridinyl]methyl]sulphinyl]-1H- benzimidazole
ES2036948B1 (en) * 1991-11-21 1994-09-01 Genesis Para La Investigacion PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2343935A1 (en) * 2008-12-29 2010-08-12 Laboratorios Viñas S.A. Useful intermediates for the obtaining of 2- (2-pyridinylmetilsulfinil) -1H-benzimidazoles and corresponding procedures (Machine-translation by Google Translate, not legally binding)
ES2363075A1 (en) * 2009-12-23 2011-07-20 Laboratorios Viñas S.A. Procedure for the preparation of 4-chloro-2-chloromethyl-3-methylpyr. (Machine-translation by Google Translate, not legally binding)

Also Published As

Publication number Publication date
ES2060541A1 (en) 1994-11-16

Similar Documents

Publication Publication Date Title
ES2060541B1 (en) NEW PROCEDURE FOR THE SYNTHESIS OF A DERIVATIVE OF 2- (2-PIRIDILMETILSUFINIL) BENCIMIDAZOLE, AND NEW INTERMEDIATE PRODUCTS OBTAINED WITH THE SAME.
ES2160237T3 (en) O-CARBAMOIL-PHENYLALANINOL THAT HAS A SUBSTITUTE IN BENZENE RING, ITS PHARMACEUTICALLY USEFUL SALTS, AND METHOD FOR THE PREPARATION OF THE SAME.
ES2051719T3 (en) A PROCEDURE FOR PRODUCING A BENZOILUREA COMPOUND.
DE3667660D1 (en) CHINOLYLGLYCINAMIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THERAPEUTIC USE AS A PSYCHOTROPE.
BR0114437A (en) Propionic Acid Derivatives
ES2091324T3 (en) PROCESS FOR THE PREPARATION OF ASPARTAMA FROM A DICETOPIPERAZINE AND NEW INTERMEDIATE COMPOUNDS AND DERIVATIVES FOR SUCH PROCESS.
ATE18054T1 (en) DERIVATIVES AND REDUCTION PRODUCTS OF DGLUCOPYRANOSYL-ALPHA(1-5)-D-ARABONIC ACID, THEIR PRODUCTION AND USE.
DK357482A (en) PROCEDURE FOR PREPARING 4-METHYL-6-PHENYL-PYRIDAZINE DERIVATIVES
DE59007076D1 (en) METHOD FOR THE STEREOSELECTIVE PRODUCTION OF 8-g (a), 12-OXIDO-13,14,15,16-TETRANORLABDANE.
AR246521A1 (en) 2,2-dimethyl chromene derivatives, preparation process and pharmaceutical compositions containing them
FI875596A0 (en) FOERFARANDE FOER FRAMSTAELLNING AV TIENYLETYLAMINER OCH AEVEN DITIENYLETYLAMINER.
AR245935A1 (en) Process for the preparation of 1-alkyl-5-nitro-imidazoles
GR3021686T3 (en) METHOD OF PREPARING -g(b)-CARBOLINES.
AR005878A1 (en) PROCEDURE FOR THE ELABORATION OF THE METHYL ESTER OF THE 2- (2- METHYLPHENYL) -3-METOXYACRYLIC ACID
ES2089449T3 (en) NEW PROCEDURE FOR THE PREPARATION OF HYDROCORTISONE AND NEW INTERMEDIATE PRODUCTS.
YU47914B (en) 9-ALFA-HYDROXY-3-OXO-4,24 (25) -STIGMASTADIEN-26-ACID DERIVATIVES AND PROCEDURE FOR OBTAINING THE SAME
ATE311496T1 (en) METHOD FOR MAKING PAPER
DK23887D0 (en) benzimidazole
EA199801084A1 (en) HOW TO OBTAIN PHENYL-HETEROCYCLIC COMPOUNDS USED AS CYCLOOXYGENASE-2 INHIBITORS
ES2051955T3 (en) CYCLICAL AZAALIFATIC COMPOUNDS WITH NITROXI FUNCTION, PROCEDURE FOR THEIR PRODUCTION AND MEDICINES CONTAINING THESE COMPOUNDS.
ES2078370T3 (en) PROCEDURE FOR PREPARING 2-HALOGEN-3-HYDROXY-3-PHENYLPROPIONIC ACID ESTER COMPOUNDS.
NO940090L (en) Mixture for macro-defect-free cement, as well as process for making it
AR017097A1 (en) COMPOUNDS OF 2- (3H) -OXAZOLONA, USEFUL AS SELECTIVE COX-2 INHIBITORS; PROCEDURE TO PREPARE SUCH COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FORMED WITH SUCH COMPOUNDS
IT1258788B (en) SULPHURATED DERIVATIVES OF BILIARY ACIDS
ES2052613T3 (en) A PROCEDURE FOR PREPARING A NEW 2-ANYLINOPHENYLACETIC ACID DERIVATIVE.

Legal Events

Date Code Title Description
FD2A Announcement of lapse in spain

Effective date: 20141120