ES2059558T3 - Ciclosporins y su uso como productos farmaceuticos. - Google Patents
Ciclosporins y su uso como productos farmaceuticos.Info
- Publication number
- ES2059558T3 ES2059558T3 ES88810403T ES88810403T ES2059558T3 ES 2059558 T3 ES2059558 T3 ES 2059558T3 ES 88810403 T ES88810403 T ES 88810403T ES 88810403 T ES88810403 T ES 88810403T ES 2059558 T3 ES2059558 T3 ES 2059558T3
- Authority
- ES
- Spain
- Prior art keywords
- residue
- cyclosporins
- mebmt
- dihydro
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
LA INVENCION SE REFIERE A CICLOSPORINAS EN LAS QUE EL RESIDUO DE LA POSICION -1 (TIPICAMENTE -MEBNT- O -DIHIDRO-MEBMT-) ESTA 3''-O-ACETILADO O 3''-OXO O-ALCOXI (1 A 4 C) SUSTITUIDO, O EN LA QUE EL RESIDUO DE LAPOSICION 2 ESTA BETA-O-ACIL O BETA-OXO SUSTITUIDO, O EN LA QUE EL RESIDUO DE LA POSICION 11 ES -MEALA-, -MEILE- O -MEALLOILE ASI COMO VARIOS DIHIDRO-DERIVADOS DE CAFALOSPORINAS NATURALMENTE OCURRENTES,QUE SON UTILES PARA INVERTIS LA RESISTENCIA A LA QUIMIOTERAPIA,PARTICULARMENTE A LA TERAPIA CITOSTATICA O ANTINEOPLASICA. VARIAS DE ESTAS CEFALOSPORINAS Y PRODUCTOS INTERMEDIOS PARA SU PRODUCCION SON NUEVOS. LOS PRODUCTOS INTREMEDIOS ENLOS QUE EL RESIDUO DE LA POSICION -1 ES 8''-ALCOXI O 7''-DESMETIL-7''-HIDROCARBIL SUSTITUIDO SON NUEVOS Y UTILES COMO AGENTES INMUNOSUPRESORES ANTIINFLAMATORIOS Y ANTIPARASITARIOS.
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB878714093A GB8714093D0 (en) | 1987-06-17 | 1987-06-17 | Organic compounds |
GB878714125A GB8714125D0 (en) | 1987-06-17 | 1987-06-17 | Organic compounds |
GB878714100A GB8714100D0 (en) | 1987-06-17 | 1987-06-17 | Organic compounds |
GB878714118A GB8714118D0 (en) | 1987-06-17 | 1987-06-17 | Organic compounds |
GB878714090A GB8714090D0 (en) | 1987-06-17 | 1987-06-17 | Organic compounds |
GB878714115A GB8714115D0 (en) | 1987-06-17 | 1987-06-17 | Organic compounds |
GB878714119A GB8714119D0 (en) | 1987-06-17 | 1987-06-17 | Organic compounds |
GB878714098A GB8714098D0 (en) | 1987-06-17 | 1987-06-17 | Organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2059558T3 true ES2059558T3 (es) | 1994-11-16 |
Family
ID=27571252
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88810403T Expired - Lifetime ES2059558T3 (es) | 1987-06-17 | 1988-06-14 | Ciclosporins y su uso como productos farmaceuticos. |
Country Status (21)
Country | Link |
---|---|
US (1) | US5525590A (es) |
EP (1) | EP0296122B1 (es) |
JP (2) | JPH0832724B2 (es) |
KR (1) | KR970010927B1 (es) |
AT (1) | ATE95193T1 (es) |
AU (1) | AU614086B2 (es) |
CA (1) | CA1338728C (es) |
CY (1) | CY1939A (es) |
CZ (1) | CZ411791A3 (es) |
DE (1) | DE3884470T2 (es) |
DK (1) | DK173873B1 (es) |
ES (1) | ES2059558T3 (es) |
HK (1) | HK152796A (es) |
HU (1) | HU211678A9 (es) |
IE (1) | IE62482B1 (es) |
IL (1) | IL86751A (es) |
MY (1) | MY103582A (es) |
NZ (1) | NZ225041A (es) |
PT (1) | PT87745B (es) |
SA (1) | SA97170746A (es) |
SK (1) | SK411791A3 (es) |
Families Citing this family (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0283801A3 (en) * | 1987-03-27 | 1990-05-30 | Abbott Laboratories | Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies |
US5236899A (en) * | 1987-11-16 | 1993-08-17 | Merck & Co., Inc. | 6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance |
GB2222770B (en) * | 1988-09-16 | 1992-07-29 | Sandoz Ltd | Pharmaceutical compositions containing cyclosporins |
US6007840A (en) * | 1988-09-16 | 1999-12-28 | Novartis Ag | Pharmaceutical compositions comprising cyclosporins |
BE1003009A5 (fr) * | 1989-02-09 | 1991-10-22 | Sandoz Sa | Nouvelles compositions pharmaceutiques a base de cyclosporines. |
US5540931A (en) * | 1989-03-03 | 1996-07-30 | Charles W. Hewitt | Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants |
GB8916901D0 (en) * | 1989-07-24 | 1989-09-06 | Sandoz Ltd | Improvements in or relating to organic compounds |
US5122511A (en) * | 1990-02-27 | 1992-06-16 | Merck & Co., Inc. | Immunosuppressive cyclosporin analogs with modified amino acids at position-8 |
US6262022B1 (en) | 1992-06-25 | 2001-07-17 | Novartis Ag | Pharmaceutical compositions containing cyclosporin as the active agent |
GB9204466D0 (en) * | 1992-03-02 | 1992-04-15 | Sandoz Ltd | Improvements in or relating to organic compounds |
GB9208712D0 (en) * | 1992-04-22 | 1992-06-10 | Sandoz Ltd | Pharmaceutical compositions containing cyclosporin derivates |
SG45449A1 (en) | 1992-05-13 | 1998-01-16 | Sandoz Ltd | Ophthalmic compositions |
CZ278863B6 (en) * | 1992-09-07 | 1994-07-13 | Galena | Medicinal preparations with n-methylated cyclic undecapeptides |
DK0589843T3 (da) | 1992-09-25 | 2002-04-02 | Novartis Ag | Cyclosporinholdige farmaceutiske præparater |
US20020099067A1 (en) * | 1993-07-08 | 2002-07-25 | Ulrich Posanski | Pharmaceutical compositions for sparingly soluble therapeutic agents |
GB9318612D0 (en) * | 1993-09-08 | 1993-10-27 | Sandoz Ltd | An assay |
US6187547B1 (en) | 1993-09-08 | 2001-02-13 | Novartis Ag | Assay kit |
US6334997B1 (en) | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
WO1995026325A2 (en) * | 1994-03-25 | 1995-10-05 | Isotechnika Inc. | Enhancement of the efficacy of drugs by deuteration |
DE59510233D1 (de) | 1994-11-03 | 2002-07-11 | Novartis Ag | Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung |
GR1002687B (el) * | 1995-04-17 | 1997-05-06 | Novartis Ag (Novartis Sa) (Novartis Inc.) | Διαδικασια παραγωγης. |
US6245805B1 (en) | 1995-10-26 | 2001-06-12 | Baker Norton Pharmaceuticals, Inc. | Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
US6395770B1 (en) * | 1995-10-26 | 2002-05-28 | Baker Norton Pharmaceuticals, Inc. | Method and compositions for administering taxanes orally to human patients |
DE19549852B4 (de) | 1995-11-29 | 2009-06-04 | Novartis Ag | Cyclosporin enthaltende Präparate |
GB9601120D0 (en) | 1996-01-19 | 1996-03-20 | Sandoz Ltd | Organic compounds |
EP0988046B1 (en) | 1997-01-30 | 2004-09-15 | Novartis AG | Oil-free pharmaceutical compositions containing cyclosporin a |
DE69832984T2 (de) * | 1997-10-08 | 2006-09-21 | Isotechnika, Inc., Edmonton | DEUTERIERtE und undeuterierte CYCLOSPORIN-ANALOGA UND IHRE VERWENDUNG ALS IMMUNMODULIERENDE AGENtIEN |
US20030220234A1 (en) * | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
US6657104B1 (en) | 1997-10-16 | 2003-12-02 | Texas Systems, University Of The Board Of The Regents | Transgenic mouse model for cardiac hypertrophy and methods of use thereof |
JP4350898B2 (ja) | 1998-07-01 | 2009-10-21 | デビオファーム・ソシエテ・アノニム | 活性の特徴が改善された新規のシクロスポリン |
JP2002534370A (ja) | 1998-12-30 | 2002-10-15 | デクセル リミテッド | サイクロスポリンを送達するための分散可能な濃縮物 |
US6255280B1 (en) * | 1999-04-08 | 2001-07-03 | University Of Kentucky Research Foundation | Protection against traumatic brain injury |
US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
US6784156B2 (en) | 2001-03-05 | 2004-08-31 | Enanta Pharmaceuticals, Inc. | Cyclosporins for the treatment of respiratory diseases |
GB0113663D0 (en) * | 2001-06-05 | 2001-07-25 | Novartis Ag | Use of organic compounds |
US6809077B2 (en) * | 2001-10-12 | 2004-10-26 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogs for the treatment of autoimmune diseases |
US20030087813A1 (en) | 2001-10-12 | 2003-05-08 | Or Yat Sun | Cyclosporin analogs for the treatment of lung diseases |
NZ531946A (en) | 2001-10-19 | 2005-09-30 | Isotechnika Inc | Preconcentrate formulations comprising cyclosporin analogue microemulsions that reduce adverse effects while maintaining high bioavailability |
AU2007221839B2 (en) * | 2001-10-19 | 2011-05-12 | Aurinia Pharmaceuticals Inc. | Synthesis of cyclosporin analogs |
MXPA04003624A (es) * | 2001-10-19 | 2004-12-06 | Isotechnika Inc | Mezclas analogas de ciclosporina y su uso como agentes inmunolomoduladores. |
PL210795B1 (pl) * | 2001-10-19 | 2012-03-30 | Isotechnika Inc | Sposób wytwarzania mieszaniny ISATX247 wzbogaconej w izomer (E), sposób wytwarzania mieszaniny ISATX247 wzbogaconej w izomer (Z), sposób stereoselektywnej syntezy izomeru (E) ISATX247, sposób stereoselektywnej syntezy izomeru (Z) ISATX247 i sposób wytwarzania mieszaniny izomerów ISATX247 |
US7012065B2 (en) | 2003-02-07 | 2006-03-14 | Enanta Pharmaceuticals, Inc. | Cyclosporins for the treatment of immune disorders |
AU2004222306A1 (en) * | 2003-03-17 | 2004-09-30 | Albany Molecular Research, Inc. | Novel cyclosporins |
TW200505946A (en) * | 2003-04-08 | 2005-02-16 | Hoffmann La Roche | Process for preparation of cyclosporin a analog |
CN1960726A (zh) * | 2004-04-08 | 2007-05-09 | 应用研究***Ars股份公司 | 包含jnk抑制剂和环孢菌素的组合物 |
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JP2008514702A (ja) * | 2004-09-29 | 2008-05-08 | エーエムアール テクノロジー インコーポレイテッド | 新規シクロスポリン類似体およびそれらの薬学的使用 |
JP2008514701A (ja) * | 2004-09-29 | 2008-05-08 | エーエムアール テクノロジー インコーポレイテッド | シクロスポリンアルキン類似体およびそれらの薬学的使用 |
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BRPI0517207A (pt) * | 2004-12-17 | 2008-09-30 | Isotechnika Inc | composto isolado, metabólito isolado de ciclo {{(e)- e (z)- (2s,3r,4r)-3-hidróxi-4-metil-2-(metilamino)-6,8-nonadien oil}-l-2-aminobutiril-n-metil-glicil-n-metil-l-leucil-l-v alil-n-metil-l-leucil-l-alanil-d-alanil-n-metil-l-leucil- n-metil-l-leucil-n-metil-l-valil} (isa247) e os sais e solvatos farmaceuticamente aceitáveis dos mesmos, método de preparação de metabólitos de isa247 in vitro, método de produção de um metabólito hidroxilado de isa247, metabólito hidroxilado isolado de isa247, metabólito hidroxilado isolado, método de produção de um metabólito de epóxido de isa247 in vitro, metabólito isolado de epóxido de isa247, metabólito isolado de epóxido, método de produção de um metabólito de diol de isa247 in vitro, metabólito de diol isolado de isa247, metabólito de diol isolado, método de produção de um metabólito de diol de isa247, método de produção de um metabólito de diol de isa247 e composição farmacêutica |
US7696165B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
US7696166B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
US20080206287A1 (en) * | 2006-09-18 | 2008-08-28 | Reed John C | Use of cyclosporin A to sensitize resistant cancer cells to death receptor ligands |
MX2009007045A (es) * | 2007-01-04 | 2009-10-07 | Debiopharm Sa | Ciclosporina no inmunosupresora para el tratamiento de distrofia muscular congenita de ullrich. |
TW200932240A (en) | 2007-10-25 | 2009-08-01 | Astellas Pharma Inc | Pharmaceutical composition containing lipophilic substance which inhibits IL-2 production |
CN102164948A (zh) * | 2008-07-30 | 2011-08-24 | 伊索技术制药公司 | 非免疫抑制的环孢菌素类似分子 |
US8642536B2 (en) | 2008-10-17 | 2014-02-04 | Wisconsin Alumni Research Foundation | Method of making biologically active alpha-beta peptides |
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WO2012145427A1 (en) | 2011-04-18 | 2012-10-26 | The Trustees Of Columbia University In The City Of New York | Methods to treat cancer using cyclosporine and cyclosporine derivatives |
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Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH614931A5 (es) * | 1975-11-04 | 1979-12-28 | Sandoz Ag | |
US4210581A (en) * | 1975-11-04 | 1980-07-01 | Sandoz Ltd. | Organic compounds |
EP0034567B1 (en) * | 1980-02-14 | 1984-11-07 | Sandoz Ag | A method for the total synthesis of cyclosporins and novel cyclosporins |
GB8407618D0 (en) * | 1984-03-23 | 1984-05-02 | Sandoz Ltd | Organic compounds |
CH667274A5 (de) * | 1984-03-23 | 1988-09-30 | Sandoz Ag | Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen. |
EP0194972B1 (en) * | 1985-03-11 | 1992-07-29 | Sandoz Ag | Novel cyclosporins |
US4798823A (en) * | 1987-06-03 | 1989-01-17 | Merck & Co., Inc. | New cyclosporin analogs with modified "C-9 amino acids" |
-
1988
- 1988-06-14 EP EP88810403A patent/EP0296122B1/en not_active Expired - Lifetime
- 1988-06-14 ES ES88810403T patent/ES2059558T3/es not_active Expired - Lifetime
- 1988-06-14 DE DE88810403T patent/DE3884470T2/de not_active Expired - Lifetime
- 1988-06-14 AT AT88810403T patent/ATE95193T1/de not_active IP Right Cessation
- 1988-06-15 MY MYPI88000662A patent/MY103582A/en unknown
- 1988-06-15 NZ NZ225041A patent/NZ225041A/en unknown
- 1988-06-15 DK DK198803265A patent/DK173873B1/da not_active IP Right Cessation
- 1988-06-15 CA CA000569523A patent/CA1338728C/en not_active Expired - Fee Related
- 1988-06-15 IE IE180788A patent/IE62482B1/en not_active IP Right Cessation
- 1988-06-15 IL IL8675188A patent/IL86751A/en not_active IP Right Cessation
- 1988-06-15 AU AU17679/88A patent/AU614086B2/en not_active Expired
- 1988-06-16 PT PT87745A patent/PT87745B/pt not_active IP Right Cessation
- 1988-06-16 JP JP63149227A patent/JPH0832724B2/ja not_active Expired - Lifetime
- 1988-06-16 KR KR1019880007330A patent/KR970010927B1/ko not_active IP Right Cessation
-
1991
- 1991-12-27 SK SK4117-91A patent/SK411791A3/sk unknown
- 1991-12-27 CZ CS914117A patent/CZ411791A3/cs unknown
-
1994
- 1994-11-10 US US08/337,346 patent/US5525590A/en not_active Expired - Lifetime
-
1995
- 1995-06-22 HU HU95P/P00332P patent/HU211678A9/hu unknown
- 1995-08-16 JP JP7208783A patent/JP2772372B2/ja not_active Expired - Lifetime
-
1996
- 1996-08-08 HK HK152796A patent/HK152796A/xx not_active IP Right Cessation
-
1997
- 1997-03-25 SA SA97170746A patent/SA97170746A/ar unknown
- 1997-05-16 CY CY193997A patent/CY1939A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA1338728C (en) | 1996-11-19 |
US5525590A (en) | 1996-06-11 |
JPS6445396A (en) | 1989-02-17 |
EP0296122A2 (en) | 1988-12-21 |
JPH0832724B2 (ja) | 1996-03-29 |
AU1767988A (en) | 1988-12-22 |
ATE95193T1 (de) | 1993-10-15 |
SA97170746A (ar) | 2005-12-03 |
HK152796A (en) | 1996-08-16 |
SK411791A3 (en) | 1995-07-11 |
PT87745B (pt) | 1992-10-30 |
DE3884470T2 (de) | 1994-03-10 |
IL86751A (en) | 1994-02-27 |
AU614086B2 (en) | 1991-08-22 |
DK326588D0 (da) | 1988-06-15 |
KR970010927B1 (ko) | 1997-07-02 |
KR890000519A (ko) | 1989-03-15 |
NZ225041A (en) | 1991-03-26 |
MY103582A (en) | 1993-08-28 |
JPH0848696A (ja) | 1996-02-20 |
DK173873B1 (da) | 2002-01-21 |
PT87745A (pt) | 1988-07-01 |
CZ411791A3 (en) | 1993-02-17 |
IL86751A0 (en) | 1988-11-30 |
DK326588A (da) | 1988-12-18 |
IE62482B1 (en) | 1995-02-08 |
DE3884470D1 (de) | 1993-11-04 |
CY1939A (en) | 1997-05-16 |
HU211678A9 (en) | 1995-12-28 |
IE881807L (en) | 1988-12-17 |
EP0296122A3 (en) | 1990-06-20 |
JP2772372B2 (ja) | 1998-07-02 |
EP0296122B1 (en) | 1993-09-29 |
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