ES2153842T3 - Derivados de 3-oxo-pirido(1,2-a-)bencimidazol-4-carboxilo y de 4-oxo-azepino(1,2-a)bencimidazol-5-carboxilo utiles en el tratamiento de enfermedades del sistema nervioso central. - Google Patents

Derivados de 3-oxo-pirido(1,2-a-)bencimidazol-4-carboxilo y de 4-oxo-azepino(1,2-a)bencimidazol-5-carboxilo utiles en el tratamiento de enfermedades del sistema nervioso central.

Info

Publication number
ES2153842T3
ES2153842T3 ES93920193T ES93920193T ES2153842T3 ES 2153842 T3 ES2153842 T3 ES 2153842T3 ES 93920193 T ES93920193 T ES 93920193T ES 93920193 T ES93920193 T ES 93920193T ES 2153842 T3 ES2153842 T3 ES 2153842T3
Authority
ES
Spain
Prior art keywords
bencimidazol
oxo
carboxyl
treatment
nervous system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93920193T
Other languages
English (en)
Inventor
Bruce E Maryanoff
David F Mccomsey
Ho Winston
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
McNeilab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by McNeilab Inc filed Critical McNeilab Inc
Application granted granted Critical
Publication of ES2153842T3 publication Critical patent/ES2153842T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE PRESENTA UN COMPUESTO DE FORMULA GENERAL (I) UTIL EN EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL. TAMBIEN SE PRESENTAN COMPOSICIONES FARMACEUTICAS Y METODOS DE TRATAMIENTO.
ES93920193T 1992-08-19 1993-08-18 Derivados de 3-oxo-pirido(1,2-a-)bencimidazol-4-carboxilo y de 4-oxo-azepino(1,2-a)bencimidazol-5-carboxilo utiles en el tratamiento de enfermedades del sistema nervioso central. Expired - Lifetime ES2153842T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93217692A 1992-08-19 1992-08-19

Publications (1)

Publication Number Publication Date
ES2153842T3 true ES2153842T3 (es) 2001-03-16

Family

ID=25461897

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93920193T Expired - Lifetime ES2153842T3 (es) 1992-08-19 1993-08-18 Derivados de 3-oxo-pirido(1,2-a-)bencimidazol-4-carboxilo y de 4-oxo-azepino(1,2-a)bencimidazol-5-carboxilo utiles en el tratamiento de enfermedades del sistema nervioso central.

Country Status (16)

Country Link
US (2) US5639760A (es)
EP (1) EP0656002B1 (es)
JP (1) JP3463935B2 (es)
KR (1) KR100262762B1 (es)
AT (1) ATE197455T1 (es)
AU (1) AU679938B2 (es)
BR (1) BR9306929A (es)
CA (1) CA2142700C (es)
DE (1) DE69329654T2 (es)
DK (1) DK0656002T3 (es)
ES (1) ES2153842T3 (es)
GR (1) GR3035292T3 (es)
HU (1) HU221369B1 (es)
NZ (1) NZ255821A (es)
PT (1) PT656002E (es)
WO (1) WO1994004532A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2267943A1 (en) * 1996-10-07 1998-04-16 Ortho-Mcneil Pharmaceutical, Inc. 5-heteroatom-containing alkyl substituted-3-oxo-pyrido(1,2-a) benzimidazole-4-carboxamide derivatives useful in treating central nervous system disorders
EP1420018A1 (en) * 1996-10-07 2004-05-19 Ortho-McNeil Pharmaceutical, Inc. Pyrido[1,2-a]benzimidazole derivatives useful in treating central nervous system disorders
US5922731A (en) * 1997-06-30 1999-07-13 Ortho Pharmaceutical Corporation 5- (heteroaryl)alkyl!-3-oxo-pyrido 1,2-a!benzimidazole-4-carboxamide derivatives useful in treating central nervous system disorders
ATE229953T1 (de) * 1997-10-07 2003-01-15 Ortho Mcneil Pharm Inc Naphtho-imidazo(1,2-a)pyridin derivate, deren herstellung und deren verwendung in der behandlung von störungen des zentralnervensystems
EP1023291B1 (en) * 1997-10-07 2004-05-26 Ortho-McNeil Pharmaceutical, Inc. Dipyridoimidazolderivatives useful in treating central nervous system disorders
AU2003204221B2 (en) * 1997-10-07 2006-07-27 Ortho-Mcneil Pharmaceutical, Inc. Dipyridoimidazolderivatives useful in treating central nervous system disorders
AU2653499A (en) * 1998-02-04 1999-08-23 Neurogen Corporation Oxo-dipyridoimidazole-carboxamides: gaba brain receptor ligands
US6177569B1 (en) 1998-08-25 2001-01-23 Neurogen Corporation Oxo-pyridoimidazole-carboxamides: GABA brain receptor ligands
DE69926378T2 (de) * 1998-08-25 2005-12-29 Neurogen Corp., Branford Oxo-pyridoimidazol-carboxamide: gaba-rezeptor-liganden im gehirn
BR0010308A (pt) * 1999-05-06 2002-01-08 Neurogen Corp Composto, composição farmacêutica, uso de um composto, e, métodos para o tratamento de uma doença ou distúrbio associados com o agonismo patogênico, agonismo inverso ou antagonismo do receptor de gabaa, para localizar receptores de gabaa em uma amostra de tecido, para inibir a ligação de um composto de benzodiazepina a um receptor de gabaa e para alterar a atividade da transdução de sinal dos receptores de gabaa, e, composição farmacêutica embalada
AU779686B2 (en) * 1999-08-02 2005-02-03 Ortho-Mcneil Pharmaceutical, Inc. C-6 ring-substituted pyrido(1,2-a)benzimidazole derivatives useful in treating central nervous system disorders
GB0203058D0 (en) 2002-02-09 2002-03-27 Bp Chem Int Ltd Production of olefins

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2663934B1 (fr) * 1990-06-27 1994-06-03 Adir Nouveaux derives de l'acide 4 - amino butyrique, leur procede de preparation et les preparations pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
US5639760A (en) 1997-06-17
WO1994004532A1 (en) 1994-03-03
HUT72654A (en) 1996-05-28
JPH08500594A (ja) 1996-01-23
KR100262762B1 (ko) 2000-08-01
GR3035292T3 (en) 2001-04-30
PT656002E (pt) 2001-02-28
BR9306929A (pt) 1999-01-12
HU221369B1 (en) 2002-09-28
NZ255821A (en) 1996-10-28
DE69329654T2 (de) 2001-03-15
DE69329654D1 (de) 2000-12-14
AU5080893A (en) 1994-03-15
HU9500476D0 (en) 1995-04-28
DK0656002T3 (da) 2000-11-27
US6218384B1 (en) 2001-04-17
CA2142700C (en) 2007-01-09
AU679938B2 (en) 1997-07-17
CA2142700A1 (en) 1994-03-03
JP3463935B2 (ja) 2003-11-05
EP0656002B1 (en) 2000-11-08
ATE197455T1 (de) 2000-11-11
EP0656002A1 (en) 1995-06-07

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