ES2057334T3 - Procedimiento para la preparacion de acido 1-(aminometil) ciclohexanoacetico. - Google Patents
Procedimiento para la preparacion de acido 1-(aminometil) ciclohexanoacetico.Info
- Publication number
- ES2057334T3 ES2057334T3 ES90121827T ES90121827T ES2057334T3 ES 2057334 T3 ES2057334 T3 ES 2057334T3 ES 90121827 T ES90121827 T ES 90121827T ES 90121827 T ES90121827 T ES 90121827T ES 2057334 T3 ES2057334 T3 ES 2057334T3
- Authority
- ES
- Spain
- Prior art keywords
- cyanocyclohexyl
- acid
- ciclohexanoacetico
- aminometil
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
SE DESCRIBE UN PROCEDIMIENTO PARA LA FABRICACION DE ACIDO 1-(AMINOMETIL) CICLOHEXANACETICO, UN FARMACO EMPLEADO COMO ANTICONVULSIVO. PARA ELLO SE DECARBALCOXILA UN ESTER DIALQUILICO DEL ACIDO (1CIANOCICLOHEXIL) MALONICO PARA FORMAR EL ESTER ALQUILICO DEL ACIDO (1-CIANOCICLOHEXIL) ACETICO CORRESPONDIENTE, LUEGO SE REESTERIFICA CON UN ALCOHOL BENCILICO Y POR ULTIMO SE HIDROGENA PARA FORMAR EL PRODUCTO FINAL . SE PUEDEN OBTENER ESTERES BENCILICOS DEL ACIDO (1-CIANOCICLOHEXIL) ACETICO TAMBIEN MEDIANTE TRANSFORMACION DE (1-CIANOCICLOHEXIL) ACETONITRILO CON UN ALCHOHOL BENCILICO EN PRESENCIA DE UN ACIDO MINERAL Y MEDIANTE HIDROLISIS SIGUIENTE CON AGUA. SE PUEDEN OBTENER ESTERES BENCILICOS DEL ACIDO (1-CIANOCICLOHEXIL) ACETICO TAMBIEN MEDIANTE TRANSFORMACION DE (1-CIANOCICLOHEXIL) ACETONITRILO CON UN ALCOHOL ALIFATICO BAJO EN PRESENCIA DE UN ACIDO MINERAL E HIDROLISIS SIGUIENTE CON AGUA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH412889 | 1989-11-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2057334T3 true ES2057334T3 (es) | 1994-10-16 |
Family
ID=4270351
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90121827T Expired - Lifetime ES2057334T3 (es) | 1989-11-16 | 1990-11-14 | Procedimiento para la preparacion de acido 1-(aminometil) ciclohexanoacetico. |
Country Status (14)
Country | Link |
---|---|
US (2) | US5095148A (es) |
EP (1) | EP0432504B1 (es) |
JP (1) | JPH03176459A (es) |
AT (1) | ATE106861T1 (es) |
CA (1) | CA2030107A1 (es) |
DE (1) | DE59006037D1 (es) |
DK (1) | DK0432504T3 (es) |
ES (1) | ES2057334T3 (es) |
FI (1) | FI905584A (es) |
IL (1) | IL96360A0 (es) |
NO (1) | NO177531C (es) |
PT (1) | PT95894B (es) |
RU (1) | RU2029761C1 (es) |
YU (1) | YU215290A (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2167717T3 (es) * | 1996-03-14 | 2002-05-16 | Warner Lambert Co | Nuevos aminoacidos ciclicos sustituidos como agentes farmaceuticos. |
US6372792B1 (en) | 1996-04-26 | 2002-04-16 | Guy Chouinard | Method for treating anxiety, anxiety disorders and insomnia |
US6255526B1 (en) | 1996-12-24 | 2001-07-03 | Teva Pharmaceutical Industries Ltd. | Preparation of gabapentin |
AU9318398A (en) | 1997-10-07 | 1999-04-27 | Warner-Lambert Company | Process for preparing a cyclic amino acid anticonvulsant compound |
HU225502B1 (en) * | 1998-12-29 | 2007-01-29 | Richter Gedeon Vegyeszet | Process for producing 1-(amino-metyl)-cyclohexene-acetic-acid and intermediates |
SK302003A3 (en) * | 2000-06-16 | 2003-07-01 | Teva Pharma | Stable gabapentin having pH within a controlled range |
US20040034248A1 (en) * | 2002-04-16 | 2004-02-19 | Taro Pharmaceutical Industries, Ltd. | Process for preparing gabapentin |
ATE418535T1 (de) * | 2002-11-18 | 2009-01-15 | Nicholas Piramal India Ltd | Verbessertes verfahren zur herstellung von gabapentin |
EP1622603A4 (en) * | 2003-03-25 | 2010-03-24 | Kiel Lab Inc | GABAPENTINIC PHENOLIC ACID SALTS IN SOLID DOSAGE FORMS AND METHODS OF USE |
WO2004093867A2 (en) * | 2003-03-25 | 2004-11-04 | Kiel Laboratories, Inc. | Phenolic acid salts of gabapentin in liquid and/or semi-solid dosage forms and methods of use |
WO2004093866A1 (en) * | 2003-03-25 | 2004-11-04 | Kiel Laboratories, Inc. | Process for preparing phenolic acid salts of gabapentin |
US7439387B2 (en) * | 2003-04-21 | 2008-10-21 | Matrix Laboratories Ltd. | Process for the preparation of Gabapentin form-II |
US20050187295A1 (en) * | 2004-02-19 | 2005-08-25 | Surendra Kalyan | Processes for the preparation of gabapentin |
GB0416228D0 (en) | 2004-07-20 | 2004-08-25 | Sandoz Ind Products S A | Process for the preparation of gabapentin |
CN101484413B (zh) * | 2006-06-30 | 2014-05-14 | Zach***股份公司 | 制备加巴喷丁的方法 |
CN101585778B (zh) * | 2008-05-19 | 2014-08-13 | 上海臣邦医药科技有限公司 | 一种普瑞巴林制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2264354A (en) * | 1937-12-22 | 1941-12-02 | Ig Farbenindustrie Ag | Addition products of dienes and unsaturated esters, ketones, or nitriles |
US2467927A (en) * | 1947-05-29 | 1949-04-19 | Goodrich Co B F | Preparation of monomeric alkyl alpha-cyano-acrylates |
DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
DE2611690A1 (de) * | 1976-03-19 | 1977-09-22 | Goedecke Ag | Cyclische sulfonyloxyimide |
YU162789A (en) * | 1988-09-01 | 1990-12-31 | Lonza Ag | 2-aza-4-(alcoxycarbonyl) spiro/4,5/decan-3-ones |
AU633612B2 (en) * | 1989-08-25 | 1993-02-04 | Warner-Lambert Company | Improved process for cyclic amino acid anticonvulsant compounds |
-
1990
- 1990-11-12 FI FI905584A patent/FI905584A/fi not_active IP Right Cessation
- 1990-11-13 YU YU215290A patent/YU215290A/sh unknown
- 1990-11-14 JP JP2306361A patent/JPH03176459A/ja active Pending
- 1990-11-14 DK DK90121827.1T patent/DK0432504T3/da active
- 1990-11-14 DE DE59006037T patent/DE59006037D1/de not_active Expired - Fee Related
- 1990-11-14 EP EP90121827A patent/EP0432504B1/de not_active Expired - Lifetime
- 1990-11-14 ES ES90121827T patent/ES2057334T3/es not_active Expired - Lifetime
- 1990-11-14 AT AT90121827T patent/ATE106861T1/de not_active IP Right Cessation
- 1990-11-15 US US07/612,985 patent/US5095148A/en not_active Expired - Fee Related
- 1990-11-15 PT PT95894A patent/PT95894B/pt not_active IP Right Cessation
- 1990-11-15 RU SU904831479A patent/RU2029761C1/ru active
- 1990-11-15 CA CA002030107A patent/CA2030107A1/en not_active Abandoned
- 1990-11-15 IL IL96360A patent/IL96360A0/xx unknown
- 1990-11-15 NO NO904953A patent/NO177531C/no unknown
-
1991
- 1991-07-10 US US07/727,939 patent/US5130455A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NO177531B (no) | 1995-06-26 |
JPH03176459A (ja) | 1991-07-31 |
DE59006037D1 (de) | 1994-07-14 |
NO177531C (no) | 1995-10-04 |
IL96360A0 (en) | 1991-08-16 |
YU215290A (sh) | 1993-05-28 |
EP0432504A1 (de) | 1991-06-19 |
FI905584A (fi) | 1991-05-17 |
PT95894B (pt) | 1998-01-30 |
US5130455A (en) | 1992-07-14 |
CA2030107A1 (en) | 1991-05-17 |
DK0432504T3 (da) | 1994-07-04 |
EP0432504B1 (de) | 1994-06-08 |
NO904953L (no) | 1991-05-21 |
PT95894A (pt) | 1991-09-13 |
US5095148A (en) | 1992-03-10 |
RU2029761C1 (ru) | 1995-02-27 |
NO904953D0 (no) | 1990-11-15 |
ATE106861T1 (de) | 1994-06-15 |
FI905584A0 (fi) | 1990-11-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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