ES2053577T3 - Desdoblamiento de racematos de 7-alfa-acil-oxi-6-beta-hidroxi-metil-2-oxa-biciclo(3.3.0)octan-3-onas por hidrolisis enzimatica estereoespecifica de acilatos. - Google Patents
Desdoblamiento de racematos de 7-alfa-acil-oxi-6-beta-hidroxi-metil-2-oxa-biciclo(3.3.0)octan-3-onas por hidrolisis enzimatica estereoespecifica de acilatos.Info
- Publication number
- ES2053577T3 ES2053577T3 ES87730148T ES87730148T ES2053577T3 ES 2053577 T3 ES2053577 T3 ES 2053577T3 ES 87730148 T ES87730148 T ES 87730148T ES 87730148 T ES87730148 T ES 87730148T ES 2053577 T3 ES2053577 T3 ES 2053577T3
- Authority
- ES
- Spain
- Prior art keywords
- stereo
- onas
- acil
- rending
- oxi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Steroid Compounds (AREA)
Abstract
LA INVENCION SE REFIERE AL PROCEDIMIENTO PARA LA OBTENCION DE (-)-OXABICICLO [3.3.0] OCTANOLONAS OPTICAMENTE ACTIVAS DE FORMULA (-=-(I) DONDE R ES HIDROGENO O UN RESTO DE FORMULA (IA) EN LA QUE R1 ES HIDROGENO, UN ALQUILO CON 1 A 7 ATOMOS DE CARBONO O FENILO. ESTE PROCEDIMIENTO SE CARACTERIZA PORQUE UN OXABICICLO [3.3.0]OCTANOLON-ACILATO DE FORMULA (+-)-(II) EN LA QUE R1 TIENE EL SIGNIFICADO INDICADO ENTERIORMENTE, SE SOMETE A UNA HIDROLISIS DE ACILATO ENZIMATICA ESTEREOESPECIFICA Y EL COMPUESTO (-)-(I) (R=IA) SE SEPARA DEL COMPUESTO (+)-(I) (R=H) SAPONIFICADO O BIEN EL COMPUESTO (-)-(I) (R=H) SE SEPARA DEL (+)-(II) NO SAPONIFICADO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19863638762 DE3638762A1 (de) | 1986-11-13 | 1986-11-13 | Racematspaltung von 7(alpha)-acyloxy-6ss-hydroxy-methyl-2-oxabicyclo (3.3.0)octan-3-onen durch stereospezifische enzymatische acylat-hydrolyse |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2053577T3 true ES2053577T3 (es) | 1994-08-01 |
Family
ID=6313862
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES87730148T Expired - Lifetime ES2053577T3 (es) | 1986-11-13 | 1987-11-12 | Desdoblamiento de racematos de 7-alfa-acil-oxi-6-beta-hidroxi-metil-2-oxa-biciclo(3.3.0)octan-3-onas por hidrolisis enzimatica estereoespecifica de acilatos. |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0271433B1 (es) |
JP (1) | JPH01501360A (es) |
AT (1) | ATE85084T1 (es) |
BG (1) | BG48098A3 (es) |
CS (1) | CS268841B2 (es) |
DD (1) | DD279689A5 (es) |
DE (2) | DE3638762A1 (es) |
ES (1) | ES2053577T3 (es) |
GR (1) | GR3007127T3 (es) |
HU (1) | HU202289B (es) |
WO (1) | WO1988003570A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9108376D0 (en) * | 1991-04-19 | 1991-06-05 | Enzymatix Ltd | Cyclopentenes |
AU3961493A (en) * | 1992-04-21 | 1993-11-18 | Chiroscience Limited | Chiral cyclopentene derivatives and their preparation |
US5840923A (en) * | 1992-04-21 | 1998-11-24 | Chiroscience Limited | Chiral cyclopentene derivatives and their preparation |
US5215918A (en) * | 1992-06-19 | 1993-06-01 | Bend Research, Inc. | Enantiomeric enrichment of (R,S)-3-quinuclidinol |
DE4435242A1 (de) * | 1994-10-04 | 1996-04-11 | Hoechst Ag | Verfahren zur enzymatischen Enantiomeren-Trennung von rac-2-Oxotricyclo 2,2,1,0·3·,·5·-heptan-7-carbonsäure bzw. der -carbonsäureester |
ATE346159T1 (de) * | 2000-05-08 | 2006-12-15 | Pfizer Prod Inc | Enzymatische spaltung von selektiven modulatoren des östrogenrezeptors |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE431750B (sv) * | 1977-05-26 | 1984-02-27 | Chinoin Gyogyszer Es Vegyeszet | Forfarande for framstellning av bicykliska laktondiolderivat |
DE3021895A1 (de) * | 1980-06-06 | 1981-12-24 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | Neues verfahren zur herstellung von carbacyclin-zwischenprodukten |
DE3465185D1 (en) * | 1983-05-25 | 1987-09-10 | Sumitomo Chemical Co | Process for producing optically active cyclopentenolones |
JPS61280294A (ja) * | 1985-06-04 | 1986-12-10 | Nisshin Flour Milling Co Ltd | 光学活性カルバサイクリン中間体の製造方法 |
-
1986
- 1986-11-13 DE DE19863638762 patent/DE3638762A1/de not_active Withdrawn
-
1987
- 1987-11-11 DD DD87308937A patent/DD279689A5/de not_active IP Right Cessation
- 1987-11-12 EP EP87730148A patent/EP0271433B1/de not_active Expired - Lifetime
- 1987-11-12 JP JP62506741A patent/JPH01501360A/ja active Pending
- 1987-11-12 HU HU875796A patent/HU202289B/hu not_active IP Right Cessation
- 1987-11-12 WO PCT/DE1987/000520 patent/WO1988003570A1/de unknown
- 1987-11-12 AT AT87730148T patent/ATE85084T1/de not_active IP Right Cessation
- 1987-11-12 DE DE8787730148T patent/DE3783885D1/de not_active Expired - Lifetime
- 1987-11-12 ES ES87730148T patent/ES2053577T3/es not_active Expired - Lifetime
- 1987-11-13 CS CS878150A patent/CS268841B2/cs unknown
-
1988
- 1988-07-12 BG BG84850A patent/BG48098A3/xx unknown
-
1993
- 1993-02-23 GR GR930400363T patent/GR3007127T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE3783885D1 (de) | 1993-03-11 |
ATE85084T1 (de) | 1993-02-15 |
CS268841B2 (en) | 1990-04-11 |
WO1988003570A1 (en) | 1988-05-19 |
BG48098A3 (en) | 1990-11-15 |
DD279689A5 (de) | 1990-06-13 |
EP0271433A1 (de) | 1988-06-15 |
HU202289B (en) | 1991-02-28 |
HUT47155A (en) | 1989-01-30 |
EP0271433B1 (de) | 1993-01-27 |
JPH01501360A (ja) | 1989-05-18 |
DE3638762A1 (de) | 1988-05-26 |
GR3007127T3 (es) | 1993-07-30 |
CS815087A2 (en) | 1989-08-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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