ES2052524T3 - A PROCEDURE FOR THE PREPARATION OF A CRYSTALLINE CARBAPENEM COMPOUND. - Google Patents

A PROCEDURE FOR THE PREPARATION OF A CRYSTALLINE CARBAPENEM COMPOUND.

Info

Publication number
ES2052524T3
ES2052524T3 ES87110992T ES87110992T ES2052524T3 ES 2052524 T3 ES2052524 T3 ES 2052524T3 ES 87110992 T ES87110992 T ES 87110992T ES 87110992 T ES87110992 T ES 87110992T ES 2052524 T3 ES2052524 T3 ES 2052524T3
Authority
ES
Spain
Prior art keywords
procedure
preparation
carbapenem compound
crystalline carbapenem
crystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87110992T
Other languages
Spanish (es)
Inventor
Makoto Sunagawa
Yutaka Isobe
Yutaka Takeuchi
Haruki Matsumura
Tetsuo Noguchi
Yukio Ozaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharmaceuticals Co Ltd
Original Assignee
Sumitomo Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharmaceuticals Co Ltd filed Critical Sumitomo Pharmaceuticals Co Ltd
Application granted granted Critical
Publication of ES2052524T3 publication Critical patent/ES2052524T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

ACIDO (4R,5S,6S,8R,2''S,4''S)-3-[4-(2-DIMETILAMINOCARBONIL) PIRROLIDINILTIO]4-METIL-6-(1-HIDROXIETIL)-1AZABICICLO[3.2.0] HEPT-2-EN-7-ONA-2-CARBOXILICO DE LA FORMULA (I) EN FORMA CRISTALINA, QUE ES UTIL COMO AGENTE ANTIBIOTICO.ACID (4R, 5S, 6S, 8R, 2''S, 4''S) -3- [4- (2-DIMETHYLAMINOCARBONYL) PYRROLIDINYLTIO] 4-METHYL-6- (1-HYDROXYETHYL) -1AZABICICLO [3.2.0 ] HEPT-2-EN-7-ONA-2-CARBOXILICO OF THE FORMULA (I) IN CRYSTALLINE FORM, WHICH IS USEFUL AS ANTIBIOTIC AGENT.

ES87110992T 1986-07-30 1987-07-29 A PROCEDURE FOR THE PREPARATION OF A CRYSTALLINE CARBAPENEM COMPOUND. Expired - Lifetime ES2052524T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP17932186 1986-07-30
JP15776987 1987-06-26

Publications (1)

Publication Number Publication Date
ES2052524T3 true ES2052524T3 (en) 1994-07-16

Family

ID=26485103

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87110992T Expired - Lifetime ES2052524T3 (en) 1986-07-30 1987-07-29 A PROCEDURE FOR THE PREPARATION OF A CRYSTALLINE CARBAPENEM COMPOUND.

Country Status (20)

Country Link
US (1) US4888344A (en)
EP (1) EP0256377B1 (en)
JP (1) JP2665767B2 (en)
AR (1) AR243189A1 (en)
AU (1) AU596857B2 (en)
CA (1) CA1322371C (en)
DE (1) DE3781980T2 (en)
DK (1) DK172666B1 (en)
ES (1) ES2052524T3 (en)
FI (1) FI88037C (en)
GR (1) GR3006254T3 (en)
HK (1) HK169595A (en)
HU (1) HU199473B (en)
IE (1) IE60588B1 (en)
IL (1) IL83372A (en)
LU (1) LU88635I2 (en)
MX (1) MX173359B (en)
NO (2) NO165543C (en)
NZ (1) NZ221224A (en)
PH (1) PH24710A (en)

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GB9503717D0 (en) * 1995-02-24 1995-04-12 Smithkline Beecham Plc Novel compounds
FR2735474B1 (en) * 1995-06-13 1997-08-08 Roussel Uclaf ZILPATEROL HYDROCHLORIDE IN A PARTICULAR CRYSTALLIZED FORM, ITS PREPARATION PROCESS AND THE INTERMEDIATE PRODUCTS USED
ID22543A (en) * 1997-02-07 1999-11-04 Kyoto Pharma Ind CARBAPENEM COMPOUNDS, USES AND COMPOUNDS
HUP0101735A3 (en) 1998-05-01 2002-02-28 Kyoto Pharma Ind Carbapenem derivatives, pharmaceutical compositions thereof and intermediate compounds
AU5105100A (en) * 1999-06-03 2000-12-28 Eisai Co. Ltd. Crystals of carbapenem derivatives and pharmaceutical preparations for injection
TWI250160B (en) 1999-07-06 2006-03-01 Sankyo Co Crystalline 1-methylcarbapenem compound
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CA2408417C (en) * 2000-05-12 2009-09-15 Novalar Pharmaceuticals, Inc. Local anesthetic methods and kits
JP5079190B2 (en) * 2001-04-27 2012-11-21 大日本住友製薬株式会社 Azetidinone derivative and method for producing the same
BR0209970A (en) * 2001-05-21 2004-04-06 Kyoto Pharma Ind Carbapenem Compound
KR100451672B1 (en) * 2001-06-05 2004-10-08 한미약품 주식회사 Crystalline acid salts of cefdinir, process for their preparation and process for the preparation of cefdinir using same
EP1426376A4 (en) * 2001-08-13 2004-12-22 Eisai Co Ltd Process for preparation of carbapenem antibiotics
WO2003026572A2 (en) 2001-09-26 2003-04-03 Merck & Co., Inc. Crystalline forms of ertapenem sodium
EP1474426B8 (en) * 2001-09-26 2011-10-12 Merck Sharp & Dohme Corp. Process for making carbapenem compounds
ITMI20012364A1 (en) * 2001-11-09 2003-05-09 Antibioticos Spa SUMMARY PROCESS OF CEFIXIMA VIA ALCHIL-O ARILSOLFONATI
EP1490090A4 (en) 2002-02-22 2006-09-20 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
US20030236306A1 (en) * 2002-06-20 2003-12-25 Chen Andrew X. Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof
US7229630B2 (en) * 2002-06-20 2007-06-12 Novalar Pharmaceuticals, Inc. Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof
WO2004024185A1 (en) 2002-09-11 2004-03-25 Michio Ishibashi Drug or cosmetic
WO2005118586A1 (en) * 2004-06-02 2005-12-15 Sandoz Ag Meropenem intermediate in crystalline form
WO2006035300A2 (en) * 2004-09-30 2006-04-06 Ranbaxy Laboratories Limited A process for the preparation of meropenem
JP4547245B2 (en) * 2004-12-16 2010-09-22 株式会社パーマケム・アジア Perindopril erbumine type I crystal and method for producing the same
US7872050B2 (en) 2005-03-14 2011-01-18 Yaupon Therapeutics Inc. Stabilized compositions of volatile alkylating agents and methods of using thereof
US8501818B2 (en) * 2005-03-14 2013-08-06 Ceptaris Therapeutics, Inc. Stabilized compositions of alkylating agents and methods of using same
US20110039943A1 (en) * 2005-03-14 2011-02-17 Robert Alonso Methods for treating skin disorders with topical nitrogen mustard compositions
US20070197781A1 (en) * 2005-07-29 2007-08-23 Neera Tewari Processes for the preparation of carbapenems
PL1926732T3 (en) 2005-09-05 2014-01-31 Ranbaxy Laboratories Ltd A process for the preparation of carbapenem compounds
EP1934221A4 (en) 2005-09-15 2011-10-26 Orchid Chemicals & Pharm Ltd An improved process for the preparation of beta-lactam antibiotic
CN100497338C (en) * 2006-01-05 2009-06-10 上海医药工业研究院 4-methyl-7-oxy-1-azabicyclo [3.2.0] hepta-2-olefin-2-carboxylic acid derivative preparation method
KR100781821B1 (en) * 2006-02-16 2007-12-03 문순구 Process for preparing carbapenem compound
KR20090007375A (en) * 2006-03-28 2009-01-16 카네카 코포레이션 Improved process for producing carbapenem compound
EP2014666A4 (en) * 2006-04-28 2011-06-01 Kaneka Corp Improved method for the crystallization of intermediates of carbapenem antibiotics
US20100256107A1 (en) * 2007-12-12 2010-10-07 Dainippon Sumitomo Pharma Co., Ltd. Preparation composition
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WO2011141847A1 (en) * 2010-05-10 2011-11-17 Orchid Chemicals And Pharmaceuticals Limited An improved process for the preparation of meropenem
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CN101962383A (en) * 2010-11-12 2011-02-02 上海巴迪生物医药科技有限公司 Synthesis method of meropenem
WO2012081033A2 (en) * 2010-12-06 2012-06-21 Sequent Scientific Limited A process for preparation of imipenem
CN102532140B (en) * 2010-12-21 2015-03-11 北大方正集团有限公司 Method for preparing meropenem trihydrate
CN102250096B (en) * 2011-09-05 2016-04-06 江西华邦药业有限公司 A kind of preparation method of meropenem
CN103570719B (en) * 2012-07-31 2016-03-02 深圳市海滨制药有限公司 A kind of meropenem bulk drug, its preparation method and comprise its pharmaceutical composition
CN103570720B (en) * 2012-07-31 2016-02-10 新乡海滨药业有限公司 A kind of meropenem bulk drug, its preparation method and comprise its pharmaceutical composition
CN103570718B (en) * 2012-07-31 2016-06-29 深圳市海滨制药有限公司 A kind of meropenem crude drug, its preparation method and comprise its pharmaceutical composition
KR101331762B1 (en) 2012-12-28 2013-11-20 주식회사 대웅제약 Process for preparing meropenem.trihydrate
CN103044429B (en) * 2013-01-28 2015-04-01 苏州二叶制药有限公司 Preparation method of meropenem
ES2835398T3 (en) 2013-02-01 2021-06-22 Ocuphire Pharma Inc Methods and compositions for daily ophthalmic administration of phentolamine to improve visual performance
DK2950648T3 (en) 2013-02-01 2019-12-02 Ocuphire Pharma Inc Aqueous ophthalmic solutions of phentolamine and its medical applications
KR102144777B1 (en) 2013-06-19 2020-08-18 제이더블유중외제약 주식회사 A process for the preparation of crystalline Meropenem trihydrate
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Also Published As

Publication number Publication date
NO873205L (en) 1988-02-01
NO1997013I1 (en) 1997-10-17
NZ221224A (en) 1989-10-27
IL83372A (en) 1992-05-25
EP0256377B1 (en) 1992-09-30
MX173359B (en) 1994-02-23
FI873299A0 (en) 1987-07-29
IE60588B1 (en) 1994-07-27
LU88635I2 (en) 1995-12-01
DK172666B1 (en) 1999-05-10
EP0256377A1 (en) 1988-02-24
DK399087D0 (en) 1987-07-30
NO165543B (en) 1990-11-19
CA1322371C (en) 1993-09-21
DK399087A (en) 1988-01-31
AU7619687A (en) 1988-03-03
AR243189A1 (en) 1993-07-30
PH24710A (en) 1990-10-01
DE3781980D1 (en) 1992-11-05
FI88037B (en) 1992-12-15
AU596857B2 (en) 1990-05-17
HK169595A (en) 1995-11-10
FI88037C (en) 1993-03-25
JP2665767B2 (en) 1997-10-22
HUT44553A (en) 1988-03-28
NO873205D0 (en) 1987-07-30
DE3781980T2 (en) 1993-02-18
IL83372A0 (en) 1987-12-31
NO165543C (en) 1991-02-27
IE871959L (en) 1988-01-30
JPS6434986A (en) 1989-02-06
MX7534A (en) 1993-10-01
US4888344A (en) 1989-12-19
FI873299A (en) 1988-01-31
GR3006254T3 (en) 1993-06-21
HU199473B (en) 1990-02-28

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