ES2043106T3 - Procedimiento para preparar s-metoprolol y sus productos intermedios. - Google Patents
Procedimiento para preparar s-metoprolol y sus productos intermedios.Info
- Publication number
- ES2043106T3 ES2043106T3 ES89850122T ES89850122T ES2043106T3 ES 2043106 T3 ES2043106 T3 ES 2043106T3 ES 89850122 T ES89850122 T ES 89850122T ES 89850122 T ES89850122 T ES 89850122T ES 2043106 T3 ES2043106 T3 ES 2043106T3
- Authority
- ES
- Spain
- Prior art keywords
- formula
- chem
- metoprolol
- isopropyloxazolidin
- hydroxymethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/06—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
- C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
- C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
SE DESCRIBE UN PROCESO PARA PREPARAR SS - METOPROLOL DE LA FORMULA I; O UNA SAL SUYA CON PUREZA ENANTIOMERICA, DONDE SE PREPARA UN ESTER DE ACIDO SULFONILO (S) - 5 HIDROXIMETIL - 3 ISOPROPILOXAZOLIDIN - 2 - ONA DE LA FORMULA II; Y ADEMAS REACCIONA CON UN FENOL 4 - (2 - METOXIETILO) DE LA FORMULA III; Y EL INTERMEDIARIO INTERMEDIO DE LA FORMULA IV; SE HIDROLIZA A S METOPROLOL, Y DONDE EL ESTER DE ACIDO SULFONICO (S) - 5 HIDROXI METIL - 3 - ISOPROPILOXAZOLIDIN - 2 - ONA DE LA FORMULA II SE PREPARA POR REACCION DE (S) - 3 - ISOPROPILAMINO - 1,2 - PROPENEDIOL DE LA FORMULA V; CON UN ESTER ACIDO CLOROFORMICO DE LA FORMULA VI; DONDE R'', ES UN GRUPO ALQUILO QUE TIENE DE 1 A 3 ATOMOS DE CARBONO O UN GRUPO FENILO PARA LA FORMACION DE (S) - 5 HIDROXIMETIL - 3 ISOPROPILOXAZOLIDIN - 2 - ONA DE LA FORMULA VII; QUE REACCIONA CON UN ACIDO SULFONICO DE LA FORMULA VIII; DONDE R'''' ES UN GRUPO ARILO TAL QUE TOLILO Y X ES UN HALOGENO CL, PARA LA FORMACION DEL ESTER DE LA FORMULA II QUE SE ENRIQUECE CONEL (S) ENANTIOMERO POR CRISTALIZACION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8801518A SE8801518D0 (sv) | 1988-04-22 | 1988-04-22 | A novel process |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2043106T3 true ES2043106T3 (es) | 1993-12-16 |
Family
ID=20372103
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89850122T Expired - Lifetime ES2043106T3 (es) | 1988-04-22 | 1989-04-19 | Procedimiento para preparar s-metoprolol y sus productos intermedios. |
Country Status (12)
Country | Link |
---|---|
US (1) | US5034535A (es) |
EP (1) | EP0339006B1 (es) |
JP (1) | JP2550410B2 (es) |
AT (1) | ATE78026T1 (es) |
AU (1) | AU607323B2 (es) |
DE (1) | DE68902001T2 (es) |
ES (1) | ES2043106T3 (es) |
GR (1) | GR3005827T3 (es) |
HK (1) | HK25095A (es) |
NZ (1) | NZ228780A (es) |
SE (1) | SE8801518D0 (es) |
SG (1) | SG2195G (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0576617B1 (en) * | 1991-03-18 | 1996-08-07 | Sepracor, Inc. | Composition and method containing optically pure (s) metoprolol |
EP0647634A1 (en) * | 1993-10-08 | 1995-04-12 | Duphar International Research B.V | Method of preparing a heterocyclic intermediate for the production of optically active aryloxy-substituted vicinal aminoalcohols |
EP0647633A1 (en) * | 1993-10-08 | 1995-04-12 | Duphar International Research B.V | Method of preparing a heterocyclic intermediate for the production of optically active aryloxysubstituted vicinal aminoalcohols |
US5942633A (en) * | 1996-06-19 | 1999-08-24 | Abbott Laboratories | Process for the selective alkylation of betaxolol intermediates |
US5731463A (en) * | 1996-09-23 | 1998-03-24 | Abbott Laboratories | Selective alkylation of an alcohol substituted phenol compound |
WO2010061366A1 (en) * | 2008-11-28 | 2010-06-03 | Corden Pharma Ip Limited | Manufacture of bisoprolol and intermediates therefor |
KR101379383B1 (ko) * | 2012-03-23 | 2014-04-02 | 주식회사 알에스텍 | 고순도 ⒮―메토프롤롤의 제조방법 |
BR112019016588A2 (pt) * | 2017-02-10 | 2020-03-31 | Basf Se | Processo de remoção de gases ácidos de um fluxo de fluido e uso de absorvente |
CN111812228B (zh) * | 2020-06-19 | 2021-11-05 | 山东省药学科学院 | 一种超高效液相色谱测定酒石酸美托洛尔及其片剂杂质的方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3641152A (en) * | 1968-09-23 | 1972-02-08 | Warner Lambert Pharmaceutical | 3 4-dihydronaphthalenoneoxy-2-hydroxy-propylamines |
SE386892B (sv) * | 1972-07-06 | 1976-08-23 | Haessle Ab | Forfarande for framstellning av oxaminoforeningar |
CH635573A5 (en) * | 1977-03-24 | 1983-04-15 | Sandoz Ag | Process for preparing novel 1,2-dihydroxypropane derivatives |
US4348393A (en) * | 1978-06-09 | 1982-09-07 | Delalande S.A. | N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones |
US4296242A (en) * | 1979-06-06 | 1981-10-20 | Schering Corporation | Process for the preparation of chiral 3-amino-2-hydroxypropionic acid and N-blocked derivatives thereof |
JPS5767544A (en) * | 1980-10-13 | 1982-04-24 | Maruko Seiyaku Kk | Improved preparation of 1-2(allylphenyxy)-3-isopropylaminopropan-2-ol |
US4473501A (en) * | 1981-05-04 | 1984-09-25 | G. D. Searle & Co. | Dihydro azino isoquinolines |
JPS62108870A (ja) * | 1985-11-06 | 1987-05-20 | Kanegafuchi Chem Ind Co Ltd | 光学活性5−スルホニルオキシメチル−2−オキサゾリジノン誘導体及びその製造方法 |
WO1987003583A1 (en) * | 1985-12-04 | 1987-06-18 | E.I. Du Pont De Nemours And Company | Synthesis of aryloxypropanolamines and arylethanolamines |
US4990668A (en) * | 1985-12-04 | 1991-02-05 | E. I. Du Pont De Nemours And Company | Optically active aryloxypropanolamines and arylethanolamines |
EP0279844A4 (en) * | 1986-09-02 | 1990-06-05 | Du Pont | AFLÖSUNG VON DE dl-METHYL-3-4- (2-HYDROXY-3-ISOPROPYLAMINO) PROPOXY] PHENYLPROPIONAT (DL-ESMOLOL)]. |
-
1988
- 1988-04-22 SE SE8801518A patent/SE8801518D0/xx unknown
-
1989
- 1989-04-18 NZ NZ228780A patent/NZ228780A/xx unknown
- 1989-04-18 AU AU33115/89A patent/AU607323B2/en not_active Ceased
- 1989-04-19 DE DE8989850122T patent/DE68902001T2/de not_active Expired - Fee Related
- 1989-04-19 ES ES89850122T patent/ES2043106T3/es not_active Expired - Lifetime
- 1989-04-19 AT AT89850122T patent/ATE78026T1/de not_active IP Right Cessation
- 1989-04-19 EP EP89850122A patent/EP0339006B1/en not_active Expired - Lifetime
- 1989-04-21 JP JP1100346A patent/JP2550410B2/ja not_active Expired - Lifetime
-
1990
- 1990-05-30 US US07/529,712 patent/US5034535A/en not_active Expired - Fee Related
-
1992
- 1992-09-30 GR GR920402158T patent/GR3005827T3/el unknown
-
1995
- 1995-01-09 SG SG2195A patent/SG2195G/en unknown
- 1995-02-23 HK HK25095A patent/HK25095A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
SE8801518D0 (sv) | 1988-04-22 |
DE68902001T2 (de) | 1993-02-11 |
AU607323B2 (en) | 1991-02-28 |
AU3311589A (en) | 1989-10-26 |
EP0339006B1 (en) | 1992-07-08 |
DE68902001D1 (de) | 1992-08-13 |
SG2195G (en) | 1995-06-16 |
JP2550410B2 (ja) | 1996-11-06 |
EP0339006A1 (en) | 1989-10-25 |
HK25095A (en) | 1995-03-03 |
JPH0222253A (ja) | 1990-01-25 |
GR3005827T3 (es) | 1993-06-07 |
US5034535A (en) | 1991-07-23 |
NZ228780A (en) | 1991-10-25 |
ATE78026T1 (de) | 1992-07-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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