ES2038180T3 - Un procedimiento para preparar un compuesto que es un derivado de pirazina. - Google Patents

Un procedimiento para preparar un compuesto que es un derivado de pirazina.

Info

Publication number
ES2038180T3
ES2038180T3 ES198787305796T ES87305796T ES2038180T3 ES 2038180 T3 ES2038180 T3 ES 2038180T3 ES 198787305796 T ES198787305796 T ES 198787305796T ES 87305796 T ES87305796 T ES 87305796T ES 2038180 T3 ES2038180 T3 ES 2038180T3
Authority
ES
Spain
Prior art keywords
alkyl
aryl
alkylene
hydrogen
pirazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787305796T
Other languages
English (en)
Inventor
Masao Yaso
Yukio Suzuki
Kensuke Shibata
Daisuke Mochizuki
Eiichi Hayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Original Assignee
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Kasei Kogyo KK filed Critical Asahi Kasei Kogyo KK
Application granted granted Critical
Publication of ES2038180T3 publication Critical patent/ES2038180T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/18—Oxygen or sulfur atoms

Abstract

UN COMPUESTO QUE ES UN DERIVADO DE PIRAZINA DE FORMULA (I) DONDE Q ES -CO- O -CH2-, R ES HIDROXILO, ALCOXI C1-C4, UN HALOGENO, NH-ALQUILENO C1-C4 -OH, -NH-ALQUILENO C1-C4-ARILTIO, -NH-ALQUILENO C1-C4-HALOGENO, (II) O NH-ALQUILENO C1-C4-(III) DONDE (III) ES (II) O (IV)-ARILO Y (II) ES DIALQUILAMINO C1-C4, CICLOALQUILAMINO, MORFOLINO, (V)-ALQUILENO C1-C4 ARILO O (VI) EN DONDE R9 ES HIDROGENO, ALQUILO C1-C4 O ARILO, R10 ES HIDROGENO, ALQUILO C1-C4, HIDROXIALQUILO C1-C4, HIDROXIALCOXI C1-C4- ALQUILO C1-C4 O DI(ARILO)-ALQUILO C1-C4; M ES UN ENTERO DE 4 A 6, Y N ES 2 O 3; R1 ES ALQUILO O ARILALQUILO C1-C4; R2 Y R3 SON INDEPENDIENTEMENTE ALQUILO C1-C4 O JUNTOS FORMAN UN PUENTE TETRAMETILEMO, Y R4 ES HIDROGENO, ALQUILO C1-C4 O FENILO, ESTE ULTIMO OPCIONALMENTE SUSTITUIDO CON 1 A 3 HALOGENOS, UN GRUPO NITRO, UN ALQUILO C1-C4 O UN GRUPO ALCOXI C1-C4. ESTOS COMPUESTOS O LAS SALES FARMACOLOGICAMENTE ACEPTABLES DE LOS MISMOS SON UTILES EN EL TRATAMIENTO DE ALTERACIONES CIRCULATORIAS O METABOLICAS.
ES198787305796T 1986-06-30 1987-06-30 Un procedimiento para preparar un compuesto que es un derivado de pirazina. Expired - Lifetime ES2038180T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15374386 1986-06-30
JP15374286 1986-06-30

Publications (1)

Publication Number Publication Date
ES2038180T3 true ES2038180T3 (es) 1993-07-16

Family

ID=26482275

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787305796T Expired - Lifetime ES2038180T3 (es) 1986-06-30 1987-06-30 Un procedimiento para preparar un compuesto que es un derivado de pirazina.

Country Status (4)

Country Link
US (2) US4894453A (es)
EP (1) EP0252670B1 (es)
DE (1) DE3776011D1 (es)
ES (1) ES2038180T3 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1038586C (zh) * 1991-05-01 1998-06-03 大制药株式会社 吡嗪衍生物的制备方法
GB2266716A (en) * 1992-05-05 1993-11-10 Merck & Co Inc Inhibitors of HIV reverse transcriptase
EP0668276A1 (en) * 1992-11-09 1995-08-23 Asahi Kasei Kogyo Kabushiki Kaisha 2-alkoxy-5,6,7,8-tetrahydroquinoxaline derivative, process for producing the same, and use thereof
US5605908A (en) * 1994-10-24 1997-02-25 Eli Lilly And Company Heterocyclic compounds and their use
US5998404A (en) * 1994-10-24 1999-12-07 Eli Lilly And Company Heterocyclic compounds and their use
CN103951623A (zh) * 2014-04-15 2014-07-30 西北农林科技大学 吡嗪类化合物、其制备方法及含有它们的药物组合物
MX2018000418A (es) * 2015-07-29 2018-08-14 Esteve Labor Dr Derivados de amida que tienen actividad multimodal contra el dolor.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1473815A (fr) * 1962-11-16 1967-03-24 Nl Combinatie Chem Ind Procédé de préparation d'amines tertiaires et nouveaux composés ainsi obtenus
BE756127A (fr) * 1969-09-12 1971-03-15 Hoechst Ag Ethers heterocycliques et leur preparation
CH607585A5 (en) * 1976-10-05 1978-09-15 Ciba Geigy Ag Process for the preparation of 2-[3'-(2-(3,4-dimethoxy-phenyl)ethylamino)-2'-hydroxypropoxy]-3-cyanop yridine
DE3242195A1 (de) * 1982-11-15 1984-05-17 Basf Ag, 6700 Ludwigshafen Neue 2-aminopyrazine und verfahren zur herstellung von 2-aminopyrazinen und pyrazinen
JPS59219269A (ja) * 1983-05-30 1984-12-10 Terumo Corp ピラジン誘導体を有効成分とする血小板凝集抑制剤
JPH06299383A (ja) * 1993-04-13 1994-10-25 Suzuki Shiyoukan:Kk 真空処理装置

Also Published As

Publication number Publication date
DE3776011D1 (de) 1992-02-27
EP0252670A2 (en) 1988-01-13
EP0252670B1 (en) 1992-01-15
US4894453A (en) 1990-01-16
EP0252670A3 (en) 1989-01-11
US5001237A (en) 1991-03-19

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