ES2035317T5 - Metodo para analizar celulas hematopoyeticas en una muestra. - Google Patents
Metodo para analizar celulas hematopoyeticas en una muestra.Info
- Publication number
- ES2035317T5 ES2035317T5 ES88310507T ES88310507T ES2035317T5 ES 2035317 T5 ES2035317 T5 ES 2035317T5 ES 88310507 T ES88310507 T ES 88310507T ES 88310507 T ES88310507 T ES 88310507T ES 2035317 T5 ES2035317 T5 ES 2035317T5
- Authority
- ES
- Spain
- Prior art keywords
- sample
- analyzing
- cells
- hematopoyetic
- hematopoyetic cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 abstract 1
- 230000001785 maturational effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1402—Data analysis by thresholding or gating operations performed on the acquired signals or stored data
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1477—Multiparameters
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/80—Fluorescent dyes, e.g. rhodamine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Zoology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Dispersion Chemistry (AREA)
- Food Science & Technology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
UN METODO Y CONJUNTO PARA LA IDENTIFICACION DE ORIGENES Y ETAPAS DE CELULAS HEMATOPOYETICAS EN UNA MUESTRA, DONDE LAS CELULAS SE TRATAN CON ANTICUERPOS MONOCLONALES MARCADOS ELEGIDOS PARA DISTINGUIR ENTRE CADA ORIGEN Y ETAPAS DE MADURACION DENTRO DE CADA ORIGEN.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11849887A | 1987-11-09 | 1987-11-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2035317T3 ES2035317T3 (es) | 1993-04-16 |
ES2035317T5 true ES2035317T5 (es) | 1998-03-16 |
Family
ID=22378975
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88310507T Expired - Lifetime ES2035317T5 (es) | 1987-11-09 | 1988-11-08 | Metodo para analizar celulas hematopoyeticas en una muestra. |
Country Status (7)
Country | Link |
---|---|
US (1) | US5137809A (es) |
EP (1) | EP0317156B2 (es) |
JP (1) | JPH06105253B2 (es) |
AT (1) | ATE81724T1 (es) |
DE (1) | DE3875456T3 (es) |
ES (1) | ES2035317T5 (es) |
GR (2) | GR3006183T3 (es) |
Families Citing this family (73)
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AU7566991A (en) * | 1990-03-14 | 1991-10-10 | Biomembrane Institute, The | Monoclonal antibody and immunoconjugates for the treatment and detection of b cell disorders |
US5622853A (en) * | 1990-05-01 | 1997-04-22 | Becton Dickinson And Company | T lymphocyte precursor |
US5185438A (en) * | 1991-04-02 | 1993-02-09 | The Trustees Of Princeton University | Nucleic acids encoding hencatoporetic stem cell receptor flk-2 |
US5367057A (en) | 1991-04-02 | 1994-11-22 | The Trustees Of Princeton University | Tyrosine kinase receptor flk-2 and fragments thereof |
GR920100123A (el) * | 1991-04-12 | 1993-03-16 | Ortho Diagnostic Systems Inc | Αντιδραστήριο πολυχρωματικής κηλίδωσης και μέ?οδος ανάλυσης. |
FR2676847A1 (fr) * | 1991-05-22 | 1992-11-27 | Immunotech Sa | Procede d'enumeration des reticulocytes et les kits destines a cette enumeration. |
FR2684186B1 (fr) * | 1991-11-25 | 1994-02-25 | Pasteur Sanofi Diagnostics | Trousse pour le denombrement rapide des granulocytes, et procede utilisant ladite trousse. |
ES2051651B1 (es) * | 1992-12-10 | 1995-01-01 | Univ Salamanca | Procedimiento para la cuantificacion simultanea, en una sola medicion, de los principales tipos de linfocitos humanos y sus subpoblaciones. |
US5692220A (en) * | 1993-09-02 | 1997-11-25 | Coulter Corporation | Decision support system and method for diagnosis consultation in laboratory hematopathology |
WO1995013540A1 (en) * | 1993-11-12 | 1995-05-18 | Becton Dickinson And Company | Method for absolute counting of rare cells |
FI951778A (fi) * | 1995-04-12 | 1996-10-13 | Aboatech Ab Oy | Menetelmä allergian toteamiseksi |
US5876956A (en) * | 1995-05-15 | 1999-03-02 | Johns Hopkins University School Of Medicine | Methods for identification or purification of cells containing an enzymatic intracellular marker |
US5877299A (en) * | 1995-06-16 | 1999-03-02 | Stemcell Technologies Inc. | Methods for preparing enriched human hematopoietic cell preparations |
US6306575B1 (en) | 1995-06-16 | 2001-10-23 | Stemcell Technologies, Inc. | Methods for preparing enriched human hematopoietic cell preparations |
US6117985A (en) * | 1995-06-16 | 2000-09-12 | Stemcell Technologies Inc. | Antibody compositions for preparing enriched cell preparations |
CA2236871A1 (en) * | 1995-11-13 | 1997-05-22 | Coulter Corporation | Method and apparatus for bulk enrichment of a population or subpopulation of cells |
EP0929300B1 (en) * | 1996-09-06 | 2004-05-26 | Medarex, Inc. | Cyanidin compositions and therapeutic and diagnostic uses therefor |
JP3620946B2 (ja) | 1997-03-17 | 2005-02-16 | シスメックス株式会社 | スキャッタグラムの表示方法および粒子計測装置 |
WO2000052471A1 (en) * | 1999-03-01 | 2000-09-08 | The Board Of Trustees Of The Leland Stanford Junior University | Rapid assay for chorioamnionitis |
WO2000052472A1 (en) * | 1999-03-01 | 2000-09-08 | The Board Of Trustees Of The Leland Stanford Junior University | Rapid assay for infection in small children |
DE50015293D1 (de) * | 1999-04-13 | 2008-09-11 | Wilex Ag | Diagnostischer und therapeutischer Einsatz von Antikörpern gegen den Urokinase-Rezeptor |
US6900023B1 (en) | 1999-09-02 | 2005-05-31 | Sysmex Corporation | Method for classifying and counting leukocytes |
US7300763B2 (en) | 2000-06-08 | 2007-11-27 | Teijin Limited | Method of testing myelotoxicity with the use of flow cytometer |
US7381535B2 (en) | 2002-07-10 | 2008-06-03 | The Board Of Trustees Of The Leland Stanford Junior | Methods and compositions for detecting receptor-ligand interactions in single cells |
US7695926B2 (en) | 2001-07-10 | 2010-04-13 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for detecting receptor-ligand interactions in single cells |
US7393656B2 (en) * | 2001-07-10 | 2008-07-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for risk stratification |
DE60233574D1 (de) * | 2001-07-10 | 2009-10-15 | Univ R | Verfahren und zusammensetzungen zum nachweis des aktivierungszustands multipler proteine in einzelzellen |
DK1363126T3 (da) * | 2002-05-14 | 2006-04-18 | Univ Salamanca | Flerdimensionel differentiel analyse af leukocyter |
SI1458853T1 (sl) * | 2002-05-16 | 2010-04-30 | Absorber Ab | Postopki donorsko specifiŽŤnega navzkriĹľnega ujemanja |
USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
DK2314629T4 (da) * | 2002-07-18 | 2023-02-06 | Merus Nv | Rekombinant produktion af blandinger af antistoffer |
US7507548B2 (en) | 2003-03-04 | 2009-03-24 | University Of Salamanca | Multidimensional detection of aberrant phenotypes in neoplastic cells to be used to monitor minimal disease levels using flow cytometry measurements |
AU2004242614B2 (en) | 2003-05-30 | 2011-09-22 | Merus N.V. | Fab library for the preparation of anti vegf and anti rabies virus fabs |
US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
ES2646560T3 (es) | 2004-01-20 | 2017-12-14 | Merus N.V. | Mezclas de proteínas de unión |
JP4768706B2 (ja) * | 2004-03-03 | 2011-09-07 | ユニバーシダド デ サラマンカ | 流体血球計算測定を使用する最小疾患レベルを監視するのに使用される腫瘍性細胞中の異常表現型の多次元検出方法 |
ATE481477T1 (de) * | 2004-03-09 | 2010-10-15 | Absorber Ab | Endothelvorläuferzellen und verfahren zur verwendung davon |
US7674598B2 (en) | 2004-05-21 | 2010-03-09 | Beckman Coulter, Inc. | Method for a fully automated monoclonal antibody-based extended differential |
US7625712B2 (en) * | 2004-05-21 | 2009-12-01 | Beckman Coulter, Inc. | Method for a fully automated monoclonal antibody-based extended differential |
JP3968383B2 (ja) * | 2004-09-01 | 2007-08-29 | 株式会社日本メディカル総研 | 血液細胞の新規分類法ならびにそれを利用したテイラーメード治療および予防 |
ZA200704252B (en) | 2004-10-25 | 2009-09-30 | Cellerant Therapeutics Inc | Methods of expanding myeloid cell populations and uses thereof |
JP4864900B2 (ja) | 2004-11-18 | 2012-02-01 | イムクローン・リミテッド・ライアビリティ・カンパニー | 血管内皮成長因子受容体−iに対する抗体 |
EP1842147A2 (en) * | 2005-01-24 | 2007-10-10 | The Board of Trustees of The Leland Stanford Junior University | Method for modeling cell signaling systems by means of bayesian networks |
US7321843B2 (en) * | 2005-09-30 | 2008-01-22 | Universidad De Salamanca | Method for generating new flow cytometry data files containing an infinite number of dimensions based on data estimation |
AU2005234696B2 (en) | 2005-11-18 | 2012-02-16 | Phanos Technologies, Inc. | Fluorescent membrane intercalating probes and methods for their use |
AU2007214468B2 (en) * | 2006-02-14 | 2013-04-04 | Cellerant Therapeutics, Inc. | Methods and compositions for enhancing engraftment of hematopoietic stem cells |
US7816135B2 (en) | 2007-07-05 | 2010-10-19 | Becton, Dickinson And Company | Method of analyzing lymphocytes |
JP2011502264A (ja) | 2007-10-29 | 2011-01-20 | ベックマン コールター, インコーポレイテッド | 血小板集団の迅速な抗体ベースの分析のための方法 |
BR122021026834B1 (pt) | 2008-04-25 | 2022-11-08 | Takeda Pharmaceutical Company Limited | Anticorpos isolados que se ligam a fcrn, composição farmacêutica que compreende os mesmos e métodos para detectar e para modular fcrn |
US20090269773A1 (en) * | 2008-04-29 | 2009-10-29 | Nodality, Inc. A Delaware Corporation | Methods of determining the health status of an individual |
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US8227202B2 (en) | 2008-07-10 | 2012-07-24 | Nodality, Inc. | Methods for diagnosis, prognosis and methods of treatment |
US8399206B2 (en) | 2008-07-10 | 2013-03-19 | Nodality, Inc. | Methods for diagnosis, prognosis and methods of treatment |
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CA2807440A1 (en) | 2010-08-04 | 2012-02-09 | Cizzle Biotechnology Limited | Methods and compounds for the diagnosis and treatment of cancer |
EP2643045A4 (en) | 2010-11-23 | 2016-01-13 | Presage Biosciences Inc | THERAPEUTIC PROCESSES AND COMPOSITIONS FOR SOLID FORM DELIVERY |
AU2012262007B2 (en) | 2011-06-02 | 2017-06-22 | Takeda Pharmaceutical Company Limited | Fc receptor binding proteins |
CN114163530A (zh) | 2012-04-20 | 2022-03-11 | 美勒斯公司 | 用于产生免疫球蛋白样分子的方法和手段 |
EP3492084B1 (en) | 2012-08-01 | 2021-02-17 | United Therapeutics Corporation | Treatment of pulmonary arterial hypertension with prostacyclin-treated endothelial progenitor cells |
JP6901823B2 (ja) | 2012-08-01 | 2021-07-14 | ユナイテッド セラピューティクス コーポレイション | 間葉系幹細胞による肺動脈性高血圧症の処置 |
ES2963968T3 (es) | 2013-01-09 | 2024-04-03 | United Therapeutics Corp | Tratamiento de la vasculopatía con prostaciclina y células madre mesenquimatosas |
US9839653B2 (en) | 2013-10-24 | 2017-12-12 | Neuroplast Beheer B.V. | Method for reducing the inflammatory activity of a stem cell transplant and use thereof |
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US11207393B2 (en) | 2015-10-16 | 2021-12-28 | President And Fellows Of Harvard College | Regulatory T cell PD-1 modulation for regulating T cell effector immune responses |
CA3018332A1 (en) | 2016-03-21 | 2017-09-28 | Dana-Farber Cancer Institute, Inc. | T-cell exhaustion state-specific gene expression regulators and uses thereof |
AU2017350732B2 (en) | 2016-10-24 | 2023-07-27 | United Therapeutics Corporation | Enhancement of MSC immunomodulatory properties by treprostinil |
CN115151810A (zh) * | 2020-02-25 | 2022-10-04 | 贝克顿迪金森公司 | 实现使用单细胞样品作为单色补偿对照的双特异性探针 |
US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
EP4319800A1 (en) | 2021-04-07 | 2024-02-14 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for the treatment of cancer |
WO2023086969A2 (en) | 2021-11-12 | 2023-05-19 | Ichor Medical Systems Inc. | Treatment methods |
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---|---|---|---|---|
JPS53107413A (en) * | 1977-03-02 | 1978-09-19 | Nippon Baiotesuto Kenkiyuushiy | Detecting method and reagent kit for antibody against leucocyte |
WO1980002076A1 (en) * | 1979-03-19 | 1980-10-02 | Diagnostic Techn Int Inc | Double tagged immunoassay |
JPS5745454A (en) * | 1980-09-02 | 1982-03-15 | Fuji Photo Film Co Ltd | Immunochemical measuring method for various minor components |
JPS58171671A (ja) * | 1982-04-01 | 1983-10-08 | Fujitsu Ltd | 細胞分類方法 |
US4607007A (en) * | 1983-04-07 | 1986-08-19 | Becton, Dickinson And Company | Differentiation of natural killer cell subpopulations of cells |
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US4599307A (en) * | 1983-07-18 | 1986-07-08 | Becton, Dickinson And Company | Method for elimination of selected cell populations in analytic cytology |
US4645738A (en) * | 1983-09-30 | 1987-02-24 | Memorial Sloan-Kettering Institute Cancer Center | Method for differential diagnosis of T cell leukemias using monoclonal antibodies |
US4599304A (en) * | 1983-10-07 | 1986-07-08 | Becton, Dickinson And Company | Method for monitoring activated cell subpopulations |
US4654312A (en) * | 1984-05-14 | 1987-03-31 | Becton, Dickinson And Company | Lysing agent for analysis of peripheral blood cells |
JPH0652409B2 (ja) * | 1984-08-08 | 1994-07-06 | 富士写真フイルム株式会社 | ハロゲン化銀カラー写真感光材料 |
US4677061A (en) * | 1984-10-19 | 1987-06-30 | Genetic Systems Corporation | T-cell lymphocyte subset monitoring of immunologic disease |
US4727020A (en) * | 1985-02-25 | 1988-02-23 | Becton, Dickinson And Company | Method for analysis of subpopulations of blood cells |
CA1279008C (en) * | 1985-10-11 | 1991-01-15 | Smith Kline & French Canada Ltd. | Methods and reagents for performing subset analysis |
DE3541033A1 (de) * | 1985-11-19 | 1987-05-21 | Boehringer Mannheim Gmbh | Verfahren zur quantifizierung von zellpopulationen bzw. subpopulationen sowie hierfuer geeignetes reagenz |
-
1988
- 1988-11-08 AT AT88310507T patent/ATE81724T1/de not_active IP Right Cessation
- 1988-11-08 DE DE3875456T patent/DE3875456T3/de not_active Expired - Lifetime
- 1988-11-08 EP EP88310507A patent/EP0317156B2/en not_active Expired - Lifetime
- 1988-11-08 ES ES88310507T patent/ES2035317T5/es not_active Expired - Lifetime
- 1988-11-09 JP JP63283547A patent/JPH06105253B2/ja not_active Expired - Lifetime
-
1990
- 1990-07-19 US US07/572,303 patent/US5137809A/en not_active Expired - Lifetime
-
1992
- 1992-11-05 GR GR920402504T patent/GR3006183T3/el unknown
-
1998
- 1998-01-14 GR GR980400074T patent/GR3025901T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0317156B1 (en) | 1992-10-21 |
GR3025901T3 (en) | 1998-04-30 |
DE3875456T3 (de) | 1998-06-10 |
ATE81724T1 (de) | 1992-11-15 |
ES2035317T3 (es) | 1993-04-16 |
DE3875456T2 (de) | 1993-03-04 |
DE3875456D1 (de) | 1992-11-26 |
EP0317156B2 (en) | 1997-11-12 |
JPH01161153A (ja) | 1989-06-23 |
JPH06105253B2 (ja) | 1994-12-21 |
GR3006183T3 (en) | 1993-06-21 |
EP0317156A1 (en) | 1989-05-24 |
US5137809A (en) | 1992-08-11 |
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