ES2029269T5 - Una formulacion de liberacion lenta. - Google Patents
Una formulacion de liberacion lenta.Info
- Publication number
- ES2029269T5 ES2029269T5 ES87301231T ES87301231T ES2029269T5 ES 2029269 T5 ES2029269 T5 ES 2029269T5 ES 87301231 T ES87301231 T ES 87301231T ES 87301231 T ES87301231 T ES 87301231T ES 2029269 T5 ES2029269 T5 ES 2029269T5
- Authority
- ES
- Spain
- Prior art keywords
- slow release
- granules
- matrix
- dispersible
- water soluble
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
UNA FORMULA QUE SE LIBERA LENTAMENTE PARA SER ADMINISTRADA A HUMANOS O ANIMALES, COMPRENDIENDO GRANULOS PRIMARIOS QUE CONTIENEN UN INGREDIENTE ACTIVO Y ESTAN EN UN ELEMENTO SECUNDARIO (2) DE UN MATERIAL SOLUBLE EN EL AGUA QUE SE LIBERA LENTAMENTE, LOS GRANULOS (1) COMPRENDEN PARTICULAS (3) CONTENIENDO LOS INGREDIENTES ACTIVOS Y EN UN ELEMENTO PRIMARIO (4) DE UN MATERIAL QUE SE LIBERA LENTAMENTE SOLUBLE EN EL AGUA. OPCIONALMENTE LA FORMULA COMPRENDE UNA FASE ENLAZADORA (5) DE UN MATERIAL INSOLUBLE QUE SE LIBERA LENTAMENTE QUE TIENE EMBEBIDOS DENTRO DE EL GRANULOS SECUNDARIOS (6) COMPRENDIENDO EL ELEMENTO SECUNDARIO (2) CONTENIENDO LOS GRANULOS DEL ELEMENTO PRIMARIO (1). EL MATERIAL SOLUBLE EN EL AGUA PUEDE SER UN POLISACARIDO Y METILCELULOSA DE BAJA VISCOSIDAD ES EJEMPLIFICADA, ASI COMO ALGINATO Y GELATINA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB08603523A GB2186485B (en) | 1986-02-13 | 1986-02-13 | Slow release formulation |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2029269T3 ES2029269T3 (es) | 1992-08-01 |
ES2029269T5 true ES2029269T5 (es) | 1999-07-01 |
Family
ID=10592976
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES87301231T Expired - Lifetime ES2029269T5 (es) | 1986-02-13 | 1987-02-12 | Una formulacion de liberacion lenta. |
Country Status (14)
Country | Link |
---|---|
US (1) | US4880830A (es) |
EP (1) | EP0235986B2 (es) |
JP (1) | JPH0655669B2 (es) |
AT (1) | ATE64849T1 (es) |
DE (1) | DE3771091D1 (es) |
DK (1) | DK175055B1 (es) |
ES (1) | ES2029269T5 (es) |
FI (1) | FI91482C (es) |
GB (1) | GB2186485B (es) |
GR (2) | GR3002822T3 (es) |
IE (1) | IE59451B1 (es) |
NO (1) | NO175240C (es) |
PH (1) | PH25347A (es) |
ZA (1) | ZA871030B (es) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0418596A3 (en) * | 1989-09-21 | 1991-10-23 | American Cyanamid Company | Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form |
IL96311A (en) † | 1989-12-01 | 1995-05-26 | Abbott Lab | Medications with delayed release |
JP3011752B2 (ja) * | 1990-10-23 | 2000-02-21 | フロイント産業株式会社 | 徐放性製剤およびその製造方法 |
US5380535A (en) * | 1991-05-28 | 1995-01-10 | Geyer; Robert P. | Chewable drug-delivery compositions and methods for preparing the same |
JP2948317B2 (ja) * | 1991-05-28 | 1999-09-13 | マクニール―ピーピーシー・インコーポレーテツド | 噛める薬物投与用組成物 |
DE4119306C2 (de) * | 1991-06-12 | 1996-05-30 | Wheli Inter Ag | Organische Rohstoffe, Zwischen- und Endprodukte für die Ernährung und zur Verwendung für technische Zwecke, die Vitalstoffe enthalten |
DE4122591C1 (en) * | 1991-07-08 | 1993-02-18 | Roland 8012 Ottobrunn De Bodmeier | Producing microcapsules of water insoluble polymer and active agent - includes dissolving or dispersing active agent in aq. polymer contg. gellable assistants |
US5356629A (en) * | 1991-07-12 | 1994-10-18 | United States Surgical Corporation | Composition for effecting bone repair |
US5958459A (en) * | 1991-12-24 | 1999-09-28 | Purdue Pharma L.P. | Opioid formulations having extended controlled released |
US5968551A (en) | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
US5478577A (en) * | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
NZ260408A (en) | 1993-05-10 | 1996-05-28 | Euro Celtique Sa | Controlled release preparation comprising tramadol |
IL110014A (en) * | 1993-07-01 | 1999-11-30 | Euro Celtique Sa | Solid controlled-release oral dosage forms of opioid analgesics |
US7740881B1 (en) | 1993-07-01 | 2010-06-22 | Purdue Pharma Lp | Method of treating humans with opioid formulations having extended controlled release |
AU7966694A (en) * | 1993-07-21 | 1996-05-02 | University Of Kentucky Research Foundation, The | A multicompartment hard capsule with control release properties |
US5879705A (en) * | 1993-07-27 | 1999-03-09 | Euro-Celtique S.A. | Sustained release compositions of morphine and a method of preparing pharmaceutical compositions |
US5891471A (en) * | 1993-11-23 | 1999-04-06 | Euro-Celtique, S.A. | Pharmaceutical multiparticulates |
KR100354702B1 (ko) * | 1993-11-23 | 2002-12-28 | 유로-셀티크 소시에떼 아노뉨 | 약학조성물의제조방법및서방형조성물 |
US5458887A (en) * | 1994-03-02 | 1995-10-17 | Andrx Pharmaceuticals, Inc. | Controlled release tablet formulation |
US5843480A (en) * | 1994-03-14 | 1998-12-01 | Euro-Celtique, S.A. | Controlled release diamorphine formulation |
US5938990A (en) * | 1994-07-01 | 1999-08-17 | Roche Vitamins Inc. | Encapsulation of oleophilic substances and compositions produced thereby |
DE4426396A1 (de) * | 1994-07-26 | 1996-02-01 | Ulrich Prof Dr Zimmermann | Verfahren zur Herstellung konzentrierter Lösungen von mikroverkapselten Zellen oder von suspendierten Wirkstoffen in mikroverkapselter Form |
GB9422154D0 (en) * | 1994-11-03 | 1994-12-21 | Euro Celtique Sa | Pharmaceutical compositions and method of producing the same |
US5965161A (en) | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
US6166024A (en) * | 1995-03-30 | 2000-12-26 | Mayo Foundation For Medical Education And Research | Use of topical azathioprine and thioguanine to treat colorectal adenomas |
JP3628809B2 (ja) * | 1996-06-10 | 2005-03-16 | アルケア株式会社 | 薬剤徐放性医療用配合物及びその製造方法 |
US20030100532A1 (en) | 1997-02-14 | 2003-05-29 | Gary S. Jacob | Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections |
US6656508B2 (en) * | 1997-04-17 | 2003-12-02 | Amgen Inc. | Sustained-release alginate gels |
PT1030839E (pt) | 1997-11-10 | 2004-05-31 | Searle & Co | Utilizacao de iminoacucares para tratar a resistencia a multifarmacos |
DE69932154T2 (de) | 1998-02-12 | 2007-05-31 | G.D. Searle Llc, Chicago | Verwendung von n-substituirten-1,5-dideoxy-1,5-imino-d-glucitolen zur behandlung von hepatitis infektionen |
US6689759B1 (en) | 1998-02-12 | 2004-02-10 | G. D. Searle & Co. | Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy |
US6806294B2 (en) | 1998-10-15 | 2004-10-19 | Euro-Celtique S.A. | Opioid analgesic |
JP2002531491A (ja) | 1998-12-11 | 2002-09-24 | ノストラム・ファーマスーティカルズ・インコーポレイテッド | ヒドロコロイドおよびセルロースエーテルを含む持続放出性錠剤 |
US6419960B1 (en) | 1998-12-17 | 2002-07-16 | Euro-Celtique S.A. | Controlled release formulations having rapid onset and rapid decline of effective plasma drug concentrations |
US6673367B1 (en) * | 1998-12-17 | 2004-01-06 | Euro-Celtique, S.A. | Controlled/modified release oral methylphenidate formulations |
WO2001008672A2 (en) | 1999-02-12 | 2001-02-08 | G.D. Searle & Co. | Glucamine compounds for treating hepatitis virus infections |
EP1165080A2 (en) * | 1999-02-12 | 2002-01-02 | G.D. SEARLE & CO. | Use of substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections |
DE19918325A1 (de) | 1999-04-22 | 2000-10-26 | Euro Celtique Sa | Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion |
US6555139B2 (en) | 1999-06-28 | 2003-04-29 | Wockhardt Europe Limited | Preparation of micron-size pharmaceutical particles by microfluidization |
WO2001015665A1 (en) | 1999-09-02 | 2001-03-08 | Nostrum Pharmaceuticals, Inc. | Controlled release oral dosage suitable for oral administration |
US7235258B1 (en) | 1999-10-19 | 2007-06-26 | Nps Pharmaceuticals, Inc. | Sustained-release formulations for treating CNS-mediated disorders |
US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
NZ529928A (en) | 1999-10-29 | 2005-10-28 | Euro Celtique Sa | Controlled release hydrocodone formulations |
GB2356346A (en) * | 1999-11-19 | 2001-05-23 | Mars Uk Ltd | Food product for oral delivery of a pharmaceutical agent to a non-human animal comprising encapsulated particles of said agent distributed within the product |
AU2001236938A1 (en) * | 2000-02-14 | 2001-08-27 | Pharmacia Corporation | Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections |
JP2004512354A (ja) | 2000-10-30 | 2004-04-22 | ユーロ−セルティーク,エス.エイ. | ヒドロコドン放出制御製剤 |
US20110104214A1 (en) | 2004-04-15 | 2011-05-05 | Purdue Pharma L.P. | Once-a-day oxycodone formulations |
UA81224C2 (uk) | 2001-05-02 | 2007-12-25 | Euro Celtic S A | Дозована форма оксикодону та її застосування |
KR100540035B1 (ko) * | 2002-02-01 | 2005-12-29 | 주식회사 태평양 | 다단계 경구 약물 방출 제어 시스템 |
ATE463249T1 (de) * | 2004-08-25 | 2010-04-15 | Essentialis Inc | Pharmazeutische formulierungen von kalium-atp- kanalöffnern und deren verwendungen |
WO2006065792A2 (en) * | 2004-12-13 | 2006-06-22 | Indevus Pharmaceuticals, Inc. | Treatment of interstitial cystitis using cannabinoid analogs |
WO2006065793A2 (en) | 2004-12-13 | 2006-06-22 | Indevus Pharmaceuticals, Inc. | TREATMENT OF INTERSTITIAL CYSTITIS USING (6aR,10aR)-Δ8-TETRAHYDROCANNABINOL-11-OIC ACIDS |
US9757384B2 (en) | 2005-04-06 | 2017-09-12 | Essentialis, Inc. | Methods for treating subjects with Prader-Willi syndrome or Smith-Magenis syndrome |
DK1968601T3 (da) | 2006-01-05 | 2012-02-06 | Essentialis Inc | Salte af kalium-ATP-kanalåbnere og anvendelser heraf |
US20080069871A1 (en) * | 2006-07-21 | 2008-03-20 | Vaughn Jason M | Hydrophobic abuse deterrent delivery system |
CA2692160A1 (en) * | 2007-07-02 | 2009-01-08 | Essentialis, Inc. | Salts of potassium atp channel openers and uses thereof |
WO2012048045A1 (en) * | 2010-10-05 | 2012-04-12 | Jb Therapeutics, Inc. | Compositions, dosages, and methods of using tetrahydrocannabinol derivatives |
EP2819675A4 (en) | 2012-02-27 | 2015-07-22 | Essentialis Inc | SALTS OF KALIUM ATP CHANNEL OPENERS AND USES THEREOF |
CN105228613A (zh) | 2013-02-12 | 2016-01-06 | 柯巴斯医药有限公司 | 超纯的四氢***酚-11-羧酸 |
CA3018328A1 (en) | 2014-10-31 | 2016-04-30 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
CA2966907C (en) | 2014-11-14 | 2021-09-07 | Essentialis, Inc. | Methods for treating subjects with prader-willi syndrome or smith-magenis syndrome |
US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
NL2022614B1 (en) | 2019-02-21 | 2020-08-31 | Patrick Alexander Unger | Pharmaceutical, phyto-cannabinoid based compositions |
NL2022616B1 (en) | 2019-02-21 | 2020-09-18 | Patrick Alexander Unger | Cannabigerol and pharmaceutical compositions comprising cannabigerol for use in the treatment of insomnia |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2809917A (en) * | 1955-10-17 | 1957-10-15 | Victor M Hermelin | Sustained release pharmaceutical tablets |
US2809916A (en) * | 1955-10-17 | 1957-10-15 | Victor M Hermelin | Sustained release pharmaceutical preparations |
US3402240A (en) * | 1957-06-25 | 1968-09-17 | Pfizer & Co C | Medicinal tablet and process of making same |
US3148124A (en) * | 1962-06-12 | 1964-09-08 | William E Gaunt | Method of preparing sustained release pharmaceutical tablets |
GB1021924A (en) * | 1962-06-22 | 1966-03-09 | Smith Kline French Lab | Improvements in or relating to method of preparing sustained release tablets |
US3279998A (en) * | 1962-06-22 | 1966-10-18 | Smith Kline French Lab | Method of preparing sustained release tablets |
GB1033484A (en) * | 1963-06-28 | 1966-06-22 | Mead Johnson & Co | Process for preparing tablets containing chloral betaine |
US3400197A (en) * | 1965-01-26 | 1968-09-03 | Robins Co Inc A H | Compressible sustained release pharmaceutical tablet lipid-colloidal silica gel matrix fragment granules |
GB1137379A (en) * | 1967-10-26 | 1968-12-18 | Dow Chemical Co | Pharmaceutical preparation |
US3870790A (en) * | 1970-01-22 | 1975-03-11 | Forest Laboratories | Solid pharmaceutical formulations containing hydroxypropyl methyl cellulose |
GB1333576A (en) * | 1970-10-21 | 1973-10-10 | Alza Corp | Sustained release drug dosage device |
GB1405088A (en) * | 1971-06-03 | 1975-09-03 | Mundipharma Ag | Slow release formulation |
US3962414A (en) * | 1972-04-27 | 1976-06-08 | Alza Corporation | Structured bioerodible drug delivery device |
FR2250793B1 (es) * | 1973-11-09 | 1978-12-29 | Commissariat Energie Atomique | |
US3946110A (en) * | 1974-05-30 | 1976-03-23 | Peter, Strong Research And Development Company, Inc. | Medicinal compositions and methods of preparing the same |
EP0013131A3 (en) * | 1978-12-27 | 1981-01-07 | Mundipharma A.G. | Pharmaceutical composition in solid dosage form, and process for its production |
FI63335B (fi) * | 1979-02-02 | 1983-02-28 | Orion Yhtymae Oy | Foerfarande foer framstaellning av tabletter med foerdroejd loslighet av effektaemne |
US4369172A (en) * | 1981-12-18 | 1983-01-18 | Forest Laboratories Inc. | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose |
DE3218150C2 (de) * | 1982-05-14 | 1986-09-25 | Akzo Gmbh, 5600 Wuppertal | Wirkstoff enthaltender Körper für die Langzeitabgabe sowie Verfahren zu dessen Herstellung |
US4443428A (en) * | 1982-06-21 | 1984-04-17 | Euroceltique, S.A. | Extended action controlled release compositions |
SE457505B (sv) * | 1984-01-10 | 1989-01-09 | Lejus Medical Ab | Laminatbelagd oral farmaceutisk komposition och foerfarande foer dess framstaellning |
US4540566A (en) * | 1984-04-02 | 1985-09-10 | Forest Laboratories, Inc. | Prolonged release drug dosage forms based on modified low viscosity grade hydroxypropylmethylcellulose |
US4590062A (en) * | 1984-04-16 | 1986-05-20 | Tech Trade Corp. | Dry direct compression compositions for controlled release dosage forms |
JPS6124516A (ja) * | 1984-07-12 | 1986-02-03 | Fujisawa Pharmaceut Co Ltd | 持続性錠剤 |
-
1986
- 1986-02-13 GB GB08603523A patent/GB2186485B/en not_active Expired
-
1987
- 1987-02-09 IE IE33287A patent/IE59451B1/en not_active IP Right Cessation
- 1987-02-09 US US07/012,026 patent/US4880830A/en not_active Expired - Lifetime
- 1987-02-11 PH PH34843A patent/PH25347A/en unknown
- 1987-02-12 ES ES87301231T patent/ES2029269T5/es not_active Expired - Lifetime
- 1987-02-12 ZA ZA871030A patent/ZA871030B/xx unknown
- 1987-02-12 FI FI870588A patent/FI91482C/fi not_active IP Right Cessation
- 1987-02-12 EP EP87301231A patent/EP0235986B2/en not_active Expired - Lifetime
- 1987-02-12 AT AT87301231T patent/ATE64849T1/de not_active IP Right Cessation
- 1987-02-12 DE DE8787301231T patent/DE3771091D1/de not_active Expired - Lifetime
- 1987-02-12 NO NO870558A patent/NO175240C/no unknown
- 1987-02-13 DK DK198700741A patent/DK175055B1/da not_active IP Right Cessation
- 1987-02-13 JP JP62029969A patent/JPH0655669B2/ja not_active Expired - Lifetime
-
1991
- 1991-09-30 GR GR91401457T patent/GR3002822T3/el unknown
-
1999
- 1999-07-07 GR GR990401789T patent/GR3030706T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
IE870332L (en) | 1987-08-13 |
ZA871030B (en) | 1988-04-27 |
GB2186485A (en) | 1987-08-19 |
GB8603523D0 (en) | 1986-03-19 |
AU6877687A (en) | 1987-08-20 |
NO175240C (no) | 1998-02-10 |
FI870588A0 (fi) | 1987-02-12 |
AU589254B2 (en) | 1989-10-05 |
JPS62215519A (ja) | 1987-09-22 |
PH25347A (en) | 1991-05-13 |
GR3030706T3 (en) | 1999-11-30 |
FI91482C (fi) | 1997-05-27 |
JPH0655669B2 (ja) | 1994-07-27 |
EP0235986B2 (en) | 1999-04-21 |
DK74187A (da) | 1987-08-14 |
ATE64849T1 (de) | 1991-07-15 |
DK175055B1 (da) | 2004-05-10 |
US4880830A (en) | 1989-11-14 |
EP0235986B1 (en) | 1991-07-03 |
GR3002822T3 (en) | 1993-01-25 |
EP0235986A1 (en) | 1987-09-09 |
FI870588A (fi) | 1987-08-14 |
ES2029269T3 (es) | 1992-08-01 |
FI91482B (fi) | 1994-03-31 |
IE59451B1 (en) | 1994-02-23 |
NO175240B (no) | 1994-06-13 |
NO870558L (no) | 1987-08-14 |
DK74187D0 (da) | 1987-02-13 |
DE3771091D1 (de) | 1991-08-08 |
NO870558D0 (no) | 1987-02-12 |
GB2186485B (en) | 1988-09-07 |
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Legal Events
Date | Code | Title | Description |
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FG2A | Definitive protection |
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