ES2012283A6 - Endotoxin muteins - Google Patents
Endotoxin muteinsInfo
- Publication number
- ES2012283A6 ES2012283A6 ES8900683A ES8900683A ES2012283A6 ES 2012283 A6 ES2012283 A6 ES 2012283A6 ES 8900683 A ES8900683 A ES 8900683A ES 8900683 A ES8900683 A ES 8900683A ES 2012283 A6 ES2012283 A6 ES 2012283A6
- Authority
- ES
- Spain
- Prior art keywords
- endotoxin
- endotoxins
- muteins
- mutant
- mutation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002158 endotoxin Substances 0.000 title abstract 5
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108700003918 Bacillus Thuringiensis insecticidal crystal Proteins 0.000 abstract 1
- 241000193388 Bacillus thuringiensis Species 0.000 abstract 1
- 108020004705 Codon Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 229940097012 bacillus thuringiensis Drugs 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 230000000749 insecticidal effect Effects 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 238000010188 recombinant method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
- C07K14/325—Bacillus thuringiensis crystal peptides, i.e. delta-endotoxins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/50—Isolated enzymes; Isolated proteins
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Agronomy & Crop Science (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Mutant Bacillus thuringiensis endotoxin proteins, exhibiting the characteristic insecticidal activity shown by the wild type delta -endotoxins. At each individual point of mutation it is indicated that the codons coding for any other natural amino acid can be substituted to produce active endotoxin protein. Also described are DNA sequences encoding such endotoxins and recombinant techniques for the production of insecticidally active mutant endotoxin
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16023388A | 1988-02-25 | 1988-02-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2012283A6 true ES2012283A6 (en) | 1990-03-01 |
Family
ID=22576065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8900683A Expired - Lifetime ES2012283A6 (en) | 1988-02-25 | 1989-02-24 | Endotoxin muteins |
Country Status (23)
| Country | Link |
|---|---|
| JP (1) | JPH025872A (en) |
| CN (1) | CN1037538A (en) |
| AT (1) | AT396940B (en) |
| AU (1) | AU616945B2 (en) |
| BE (1) | BE1001877A4 (en) |
| BR (1) | BR8900881A (en) |
| DE (1) | DE3905865A1 (en) |
| DK (1) | DK84589A (en) |
| ES (1) | ES2012283A6 (en) |
| FR (1) | FR2627778B1 (en) |
| GB (1) | GB2216127B (en) |
| GR (1) | GR1000457B (en) |
| HU (1) | HU209148B (en) |
| IE (1) | IE62118B1 (en) |
| IL (1) | IL89391A (en) |
| IT (1) | IT1230483B (en) |
| MY (1) | MY104405A (en) |
| NL (1) | NL8900481A (en) |
| NZ (1) | NZ228108A (en) |
| PL (1) | PL161726B1 (en) |
| PT (1) | PT89812B (en) |
| TR (1) | TR26073A (en) |
| ZA (1) | ZA891463B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8910624D0 (en) * | 1989-05-09 | 1989-06-21 | Ici Plc | Bacterial strains |
| NZ236492A (en) * | 1989-12-18 | 1993-11-25 | Sandoz Ltd | Transformation of bacillus thuringensis cells by electroporation in a hypertonic aqueous medium; b.t. tenebrionsis or aizawai cells encoding a b.t. operable gene for a b.t. endotoxin protein |
| GB9408466D0 (en) * | 1994-04-27 | 1994-06-22 | Univ Nottingham | Cloning and functional expression of neurotoxins |
| IL124020A (en) * | 1995-10-13 | 2003-05-29 | Dow Agrosciences Llc | Plant optimized nucleotide sequence that encodes an insecticidal crystal protein |
| US6474576B1 (en) | 1999-03-10 | 2002-11-05 | Sumitomo Special Metals Co., Ltd. | Milling apparatus and milling method |
| JP4855772B2 (en) * | 2005-12-21 | 2012-01-18 | ノリタケ伊勢電子株式会社 | Fluorescent display device |
| JP4753987B2 (en) | 2008-11-10 | 2011-08-24 | 双葉電子工業株式会社 | Fluorescent display tube and driving method |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2540484B2 (en) * | 1984-12-12 | 1996-10-02 | サントリー株式会社 | Gene coding for insecticidal protein |
| EP0206613B1 (en) * | 1985-06-14 | 1992-08-19 | Repligen Corporation | Activated bacillus thuringienses delta-endotoxin produced by an engineered hybrid gene |
| CA1341092C (en) * | 1985-12-12 | 2000-09-05 | David L. Edwards | Process for altering the host range of bacillus thuringiensis toxins, and novel toxins produced thereby |
| KR960006582B1 (en) * | 1987-04-16 | 1996-05-20 | 에코겐 인코포레이티드 | Bacillus thuringiensis p-2 toxin gene and its containing microorganism |
-
1989
- 1989-01-27 BR BR898900881A patent/BR8900881A/en not_active IP Right Cessation
- 1989-02-15 HU HU89760A patent/HU209148B/en not_active IP Right Cessation
- 1989-02-22 GB GB8904016A patent/GB2216127B/en not_active Expired - Lifetime
- 1989-02-22 IT IT8947678A patent/IT1230483B/en active
- 1989-02-23 JP JP1044989A patent/JPH025872A/en active Pending
- 1989-02-23 PT PT89812A patent/PT89812B/en not_active IP Right Cessation
- 1989-02-23 GR GR890100115A patent/GR1000457B/en unknown
- 1989-02-23 AU AU30297/89A patent/AU616945B2/en not_active Ceased
- 1989-02-23 NZ NZ228108A patent/NZ228108A/en unknown
- 1989-02-23 DK DK084589A patent/DK84589A/en not_active Application Discontinuation
- 1989-02-23 IL IL8939189A patent/IL89391A/en not_active IP Right Cessation
- 1989-02-24 CN CN89101863A patent/CN1037538A/en active Pending
- 1989-02-24 BE BE8900189A patent/BE1001877A4/en not_active IP Right Cessation
- 1989-02-24 FR FR8902428A patent/FR2627778B1/en not_active Expired - Lifetime
- 1989-02-24 TR TR89/0166A patent/TR26073A/en unknown
- 1989-02-24 ES ES8900683A patent/ES2012283A6/en not_active Expired - Lifetime
- 1989-02-24 ZA ZA891463A patent/ZA891463B/en unknown
- 1989-02-24 DE DE3905865A patent/DE3905865A1/en not_active Withdrawn
- 1989-02-24 PL PL89277925A patent/PL161726B1/en unknown
- 1989-02-24 IE IE58989A patent/IE62118B1/en not_active IP Right Cessation
- 1989-02-24 MY MYPI89000227A patent/MY104405A/en unknown
- 1989-02-24 AT AT0041389A patent/AT396940B/en not_active IP Right Cessation
- 1989-02-27 NL NL8900481A patent/NL8900481A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HU209148B (en) | 1994-03-28 |
| DE3905865A1 (en) | 1989-09-07 |
| IT1230483B (en) | 1991-10-24 |
| JPH025872A (en) | 1990-01-10 |
| NL8900481A (en) | 1989-09-18 |
| ATA41389A (en) | 1993-05-15 |
| HUT50507A (en) | 1990-02-28 |
| IE890589L (en) | 1989-08-25 |
| GB2216127B (en) | 1991-11-06 |
| FR2627778B1 (en) | 1990-09-21 |
| AU616945B2 (en) | 1991-11-14 |
| CN1037538A (en) | 1989-11-29 |
| IL89391A0 (en) | 1989-09-10 |
| PL277925A1 (en) | 1990-02-05 |
| TR26073A (en) | 1993-12-16 |
| DK84589A (en) | 1989-08-26 |
| MY104405A (en) | 1994-03-31 |
| BE1001877A4 (en) | 1990-04-03 |
| IL89391A (en) | 1995-01-24 |
| ZA891463B (en) | 1990-10-31 |
| BR8900881A (en) | 1989-10-17 |
| GB8904016D0 (en) | 1989-04-05 |
| PL161726B1 (en) | 1993-07-30 |
| IE62118B1 (en) | 1994-12-14 |
| PT89812A (en) | 1989-10-04 |
| IT8947678A0 (en) | 1989-02-22 |
| NZ228108A (en) | 1992-04-28 |
| PT89812B (en) | 1994-04-29 |
| GR1000457B (en) | 1992-07-30 |
| FR2627778A1 (en) | 1989-09-01 |
| DK84589D0 (en) | 1989-02-23 |
| GB2216127A (en) | 1989-10-04 |
| AT396940B (en) | 1993-12-27 |
| AU3029789A (en) | 1989-10-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19991102 |