MD430C2 - Method for human leucocytar interferone preparation - Google Patents
Method for human leucocytar interferone preparationInfo
- Publication number
- MD430C2 MD430C2 MD95-0076A MD950076A MD430C2 MD 430 C2 MD430 C2 MD 430C2 MD 950076 A MD950076 A MD 950076A MD 430 C2 MD430 C2 MD 430C2
- Authority
- MD
- Moldova
- Prior art keywords
- pst
- pbr
- leucocytar
- interferone
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Application field: genetic engineering, leucocytar interferone preparation. The summary of the invention: the method comprises the DNA sequence detection and isolation and recombinant molecules construction, coding the polypeptide which possesses the immunologic and biologic activity of HIFN-α. there are obtained recombinant plasmide DNA, containing the Z-pBR 322 (Pst)HCIF-4c, Z-pBR 322 (Pst), HIF-2h, Z-pBR 322 (Pst) HcIF-SN-35, Z-pBR 322 (Pst) Hc1F-SN-42, Z-pKT287 (Pst) Hc1F-2h-AH6 DNA sequence as well as the sequences which are hybridizated with the mentioned insertions.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16498680A | 1980-07-01 | 1980-07-01 | |
US18490980A | 1980-09-08 | 1980-09-08 | |
US20557880A | 1980-11-10 | 1980-11-10 | |
US06/256,204 US6610830B1 (en) | 1980-07-01 | 1981-04-21 | Microbial production of mature human leukocyte interferons |
Publications (1)
Publication Number | Publication Date |
---|---|
MD430C2 true MD430C2 (en) | 1996-06-30 |
Family
ID=27389083
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MD95-0076A MD430C2 (en) | 1980-07-01 | 1994-12-30 | Method for human leucocytar interferone preparation |
Country Status (6)
Country | Link |
---|---|
US (2) | US6610830B1 (en) |
KR (1) | KR860001558B1 (en) |
CA (1) | CA1341583C (en) |
GE (1) | GEP20074163B (en) |
MD (1) | MD430C2 (en) |
ZW (1) | ZW14781A1 (en) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6835557B1 (en) * | 1980-01-08 | 2004-12-28 | Biogen, Inc. | DNA sequences, recombinant DNA molecules and processes for producing human interferon-like polypeptides |
FR2686899B1 (en) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | NOVEL BIOLOGICALLY ACTIVE POLYPEPTIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
CA2405709A1 (en) * | 2000-04-12 | 2001-10-25 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US7959910B2 (en) | 2000-07-31 | 2011-06-14 | Biolex Therapeutics, Inc. | C-terminally truncated interferon alpha variants |
EP2292652A2 (en) * | 2000-11-03 | 2011-03-09 | Pestka Biomedical Laboratories, Inc. | Interferons uses and compositions related thereto |
FR2822845B1 (en) * | 2001-03-30 | 2003-12-12 | Genodyssee | NOVEL POLYNUCLEOTIDES COMPRISING FUNCTIONAL SNP-LIKE POLYMORPHISMS IN THE NUCLEOTIDE SEQUENCE OF THE IFN-ALPHA-21 GENE AS WELL AS NEW POLYPEPTIDES ENCODED BY THESE POLYNUCLEOTIDES AND THEIR THERAPEUTIC USES |
US20050095224A1 (en) * | 2001-12-07 | 2005-05-05 | Ramachandran Radhakrishnan | Compositions and method for treating hepatitis virus infection |
CA2471363C (en) | 2001-12-21 | 2014-02-11 | Human Genome Sciences, Inc. | Albumin fusion proteins |
KR101271635B1 (en) * | 2001-12-21 | 2013-06-12 | 휴먼 게놈 사이언시즈, 인코포레이티드 | Albumin fusion proteins |
KR20040020817A (en) * | 2002-08-31 | 2004-03-09 | 씨제이 주식회사 | Glycosylated human interferon alpha isoform |
AU2003263552A1 (en) * | 2002-09-09 | 2004-03-29 | Nautilus Biotech | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules |
CA2504267A1 (en) * | 2002-11-18 | 2004-06-03 | Maxygen, Inc. | Interferon-alpha polypeptides and conjugates |
US7314613B2 (en) * | 2002-11-18 | 2008-01-01 | Maxygen, Inc. | Interferon-alpha polypeptides and conjugates |
WO2004060299A2 (en) | 2002-12-26 | 2004-07-22 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates of interferon-beta with enhanced biological potency |
RS20050501A (en) * | 2002-12-26 | 2007-08-03 | Mountain View Pharmaceuticals Inc., | Polymer conjugates of cytokines,chemokines,growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity |
AU2005211385B2 (en) | 2004-02-02 | 2008-12-11 | Ambrx, Inc. | Modified human growth hormone polypeptides and their uses |
MXPA06013412A (en) * | 2004-05-19 | 2007-01-23 | Maxygen Inc | Interferon-alpha polypeptides and conjugates. |
US20060024272A1 (en) * | 2004-07-29 | 2006-02-02 | Large Scale Biology Corporation | C-terminally truncated interferon |
WO2006111745A2 (en) * | 2005-04-20 | 2006-10-26 | Viragen Incorporated | Composition and method for treating viral infection |
JP2008545393A (en) * | 2005-05-18 | 2008-12-18 | マキシジェン, インコーポレイテッド | Advanced interferon alpha polypeptide |
US20060269516A1 (en) * | 2005-05-26 | 2006-11-30 | Schering Corporation | Interferon-IgG fusion |
CN103030690A (en) * | 2005-06-03 | 2013-04-10 | Ambrx公司 | Improved human interferon molecules and their uses |
WO2007127949A2 (en) * | 2006-04-27 | 2007-11-08 | Sko Flo Industries, Inc. | Flow control valve |
US8679472B1 (en) | 2006-10-05 | 2014-03-25 | Merck, Sharp & Dohme Corp. | Crystal of human interferon alpha 2B in complex with zinc |
WO2008127711A2 (en) * | 2007-04-11 | 2008-10-23 | Pestka Biomedical Laboratories, Inc. | Interferons of rhesus and cynomolgus origin and uses thereof |
CA2685596A1 (en) | 2007-05-02 | 2008-11-13 | Ambrx, Inc. | Modified interferon beta polypeptides and their uses |
US8137661B2 (en) * | 2007-07-25 | 2012-03-20 | Biolex Therapeutics, Inc. | Controlled release interferon drug products and treatment of HCV infections using same |
DK2196475T3 (en) * | 2007-09-04 | 2012-09-17 | Biosteed Gene Expression Tech Co Ltd | Interferon alfa 2a modified with polyethylene glycol, method of synthesis thereof and use thereof |
JP5702150B2 (en) | 2008-02-08 | 2015-04-15 | アンブルックス, インコーポレイテッドAmbrx, Inc. | Modified leptin polypeptides and their use |
EP2307367B1 (en) | 2008-07-08 | 2014-09-24 | Board of Regents, The University of Texas System | Novel inhibitors of proliferation and activation of signal transducer and activator of transcription (stats) |
BR112013032188A2 (en) | 2011-06-23 | 2016-12-20 | Digna Biotech Sl | composition, product and method for treating patients with chronic hepatitis C |
PL2822575T3 (en) | 2012-03-03 | 2020-08-10 | Immungene, Inc. | Engineered antibody-interferon mutant fusion molecules |
WO2013175487A2 (en) * | 2012-03-30 | 2013-11-28 | Krishnan Archana Rajesh | Codon optimized sequence for an antiviral protein |
CU24554B1 (en) * | 2018-05-07 | 2021-11-04 | Ct Inmunologia Molecular | FUSION PROTEINS COMPOSED OF INTERLEUKIN 2 MUTEIN AND TYPE 1 INTERFERON |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT373279B (en) | 1977-11-08 | 1984-01-10 | Genentech Inc | METHOD FOR PRODUCING A RECOMBINATION CLONING SUPPORT |
US4411994A (en) | 1978-06-08 | 1983-10-25 | The President And Fellows Of Harvard College | Protein synthesis |
IN150740B (en) * | 1978-11-24 | 1982-12-04 | Hoffmann La Roche | |
US4503035B1 (en) | 1978-11-24 | 1996-03-19 | Hoffmann La Roche | Protein purification process and product |
US4332892A (en) | 1979-01-15 | 1982-06-01 | President And Fellows Of Harvard College | Protein synthesis |
ES479300A1 (en) | 1979-04-04 | 1979-07-01 | Cusi Lab | An alpha-methyl-4(2'-thienyl-carbonyl)phenyl acetic acid derivative, process for its preparation and its pharmaceutical use. |
US4342832A (en) | 1979-07-05 | 1982-08-03 | Genentech, Inc. | Method of constructing a replicable cloning vehicle having quasi-synthetic genes |
US4530901A (en) | 1980-01-08 | 1985-07-23 | Biogen N.V. | Recombinant DNA molecules and their use in producing human interferon-like polypeptides |
US4418149A (en) | 1980-01-10 | 1983-11-29 | President And Fellows Of Harvard College | Fused hybrid gene |
US4801685A (en) | 1981-08-14 | 1989-01-31 | Hoffmann-La Roche Inc. | Microbial production of mature human leukocyte interferon K and L |
US4810645A (en) | 1981-08-14 | 1989-03-07 | Hoffmann-La Roche Inc. | Microbial production of mature human leukocyte interferon K and L |
-
1981
- 1981-04-21 US US06/256,204 patent/US6610830B1/en not_active Expired - Lifetime
- 1981-06-26 ZW ZW147/81A patent/ZW14781A1/en unknown
- 1981-06-30 CA CA000380922A patent/CA1341583C/en not_active Expired - Fee Related
- 1981-07-01 KR KR1019810002386A patent/KR860001558B1/en active
-
1988
- 1988-01-19 US US07/145,002 patent/US6482613B1/en not_active Expired - Lifetime
-
1994
- 1994-12-30 MD MD95-0076A patent/MD430C2/en unknown
-
2006
- 2006-07-28 GE GEAP20069547A patent/GEP20074163B/en unknown
Non-Patent Citations (1)
Title |
---|
Shigekazu N. et al. Synthensin E. coli of a polypeptide with human leukocyte interferon activity. Nature, v. 284, March, 1980, p. 316-320. * |
Also Published As
Publication number | Publication date |
---|---|
GEP20074163B (en) | 2007-07-10 |
CA1341583C (en) | 2008-11-18 |
US6482613B1 (en) | 2002-11-19 |
US6610830B1 (en) | 2003-08-26 |
ZW14781A1 (en) | 1982-04-21 |
KR830006422A (en) | 1983-09-24 |
KR860001558B1 (en) | 1986-10-04 |
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