ES2006076A6 - Procedimiento de preparacion de nuevos derivados peptidos de estructura policiclica nitrogenada. - Google Patents
Procedimiento de preparacion de nuevos derivados peptidos de estructura policiclica nitrogenada.Info
- Publication number
- ES2006076A6 ES2006076A6 ES8800386A ES8800386A ES2006076A6 ES 2006076 A6 ES2006076 A6 ES 2006076A6 ES 8800386 A ES8800386 A ES 8800386A ES 8800386 A ES8800386 A ES 8800386A ES 2006076 A6 ES2006076 A6 ES 2006076A6
- Authority
- ES
- Spain
- Prior art keywords
- denotes
- group
- radical
- preparation
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Financial Or Insurance-Related Operations Such As Payment And Settlement (AREA)
Abstract
PROCEDIMIENTO DE PREPARACION DE NUEVOS DERIVADOS PEPTIDOS DE ESTRUCTURA POLICICLICA NITROGENADA. LA INVENCION SE RELACIONA CON LA PREPARACION DE PEPTIDOS DE ESTRUCTURA GENERAL (I), DONDE R Y R'' REPRESENTAN DISTINTOS SUSTITUYENTES, X E Y DISTINTAS FUNCIONES HETEROATOMICAS Y EL GRUPO -N-A-CH- REPRESENTA UNA ESTRUCTURA POLICICLICA NITROGENADA, ASI COMO DE SUS DISTINTOS ENANTIOMEROS, EPIMEROS Y DIASTEROISOMEROS Y/O SUS SALES ACIDAS O BASICAS FARMACEUTICAMENTE ACEPTABLES, CARACTERIZADO POR: CONDENSACION DE UN DERIVADO 3-CARBOXILICO DE LA ESTRUCTURA POLICICLICA -N-A-CH- CONVENIENTEMENTE PROTEGIDA, CON UN NITROARGINATO DE BENCILO, PARA DAR UN COMPUESTO QUE DESPUES DE DESPROTEGIDO POR ACCION DEL ACIDO TRIFLUOROACETICO SE CONDENSA CON UN DERIVADO OXICARBONIL-LISINA, QUE UNA VEZ TRATADO NUEVAMENTE CON ACIDO TRIFLUOROACETICO, SE CONDENSA CON UN DERIVADO CARBOXILICO DE LA ESTRUCTURA HETEROCICLOCARBONILA. LOS COMPUESTOS ASI OBTENIDOS PRESENTAN IMPORTANTES PROPIEDADES INMUNOMODULADORAS, COMO POTENCIADORES DE LA RESPUESTA INMUNITARIA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8701810A FR2610934B1 (fr) | 1987-02-13 | 1987-02-13 | Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2006076A6 true ES2006076A6 (es) | 1989-04-01 |
Family
ID=9347880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8800386A Expired ES2006076A6 (es) | 1987-02-13 | 1988-02-12 | Procedimiento de preparacion de nuevos derivados peptidos de estructura policiclica nitrogenada. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4965250A (es) |
| EP (1) | EP0282374B1 (es) |
| JP (1) | JPH0649718B2 (es) |
| AT (1) | ATE63125T1 (es) |
| AU (1) | AU604090B2 (es) |
| CA (1) | CA1331672C (es) |
| DE (1) | DE3862596D1 (es) |
| DK (1) | DK74988A (es) |
| ES (1) | ES2006076A6 (es) |
| FR (1) | FR2610934B1 (es) |
| GR (1) | GR1000079B (es) |
| IE (1) | IE60073B1 (es) |
| NZ (1) | NZ223509A (es) |
| OA (1) | OA08715A (es) |
| PT (1) | PT86755B (es) |
| ZA (1) | ZA88995B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2616663B1 (fr) * | 1987-06-16 | 1989-08-18 | Adir | Nouveaux tripeptides a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CA1340588C (en) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
| GB8927913D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Amino acid derivatives |
| FR2663336B1 (fr) * | 1990-06-18 | 1992-09-04 | Adir | Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US6177405B1 (en) * | 1992-07-22 | 2001-01-23 | Kenji Nishioka | Cyclic analogs of tuftsin |
| ATE167195T1 (de) * | 1993-03-22 | 1998-06-15 | Leonida Grippa | Monoessigsäure derivate der peptide leu-phe-ala und ala-leu-phe und deren verwendung in der erkennung und vernichtung von tumorzellen und virusinfizierten zellen |
| US5569745A (en) * | 1994-02-25 | 1996-10-29 | Resolution Pharmaceuticals Inc. | Peptide-Chelator conjugates |
| US5662885A (en) * | 1994-07-22 | 1997-09-02 | Resolution Pharmaceuticals Inc. | Peptide derived radionuclide chelators |
| US6159748A (en) * | 1995-03-13 | 2000-12-12 | Affinitech, Ltd | Evaluation of autoimmune diseases using a multiple parameter latex bead suspension and flow cytometry |
| AU708620B2 (en) * | 1995-03-29 | 1999-08-05 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| AU4721897A (en) * | 1996-10-25 | 1998-05-22 | Tanabe Seiyaku Co., Ltd. | Tetrahydroisoquinoline derivatives |
| AU2009246347A1 (en) | 2008-05-16 | 2009-11-19 | Dana Farber Cancer Institute, Inc. | Immunomodulation by IAP inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2343034C2 (de) * | 1973-08-25 | 1984-08-23 | Hoechst Ag, 6230 Frankfurt | Tetrapeptide mit phagocytose-stimulierender Wirkung, Verfahren zu deren Herstellung und deren Verwendung |
| CH611878A5 (es) * | 1974-07-04 | 1979-06-29 | Takeda Chemical Industries Ltd | |
| IT8021120A0 (it) * | 1979-04-02 | 1980-04-01 | Inst Organicheskogo Sinteza Ak | Analogo ciclico del peptide naturale stimolante la fagocitosi: treonile-ciclo (n-lisile-prolile-arginile). |
| FR2575753B1 (fr) * | 1985-01-07 | 1987-02-20 | Adir | Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
1987
- 1987-02-13 FR FR8701810A patent/FR2610934B1/fr not_active Expired
-
1988
- 1988-01-25 CA CA000557303A patent/CA1331672C/fr not_active Expired - Fee Related
- 1988-01-25 US US07/148,027 patent/US4965250A/en not_active Expired - Fee Related
- 1988-02-10 OA OA59283A patent/OA08715A/xx unknown
- 1988-02-12 AU AU11669/88A patent/AU604090B2/en not_active Ceased
- 1988-02-12 ZA ZA880995A patent/ZA88995B/xx unknown
- 1988-02-12 AT AT88400315T patent/ATE63125T1/de not_active IP Right Cessation
- 1988-02-12 EP EP19880400315 patent/EP0282374B1/fr not_active Expired - Lifetime
- 1988-02-12 GR GR880100079A patent/GR1000079B/el unknown
- 1988-02-12 ES ES8800386A patent/ES2006076A6/es not_active Expired
- 1988-02-12 DE DE8888400315T patent/DE3862596D1/de not_active Expired - Lifetime
- 1988-02-12 PT PT86755A patent/PT86755B/pt not_active IP Right Cessation
- 1988-02-12 DK DK074988A patent/DK74988A/da not_active Application Discontinuation
- 1988-02-12 IE IE38288A patent/IE60073B1/en not_active IP Right Cessation
- 1988-02-12 NZ NZ223509A patent/NZ223509A/en unknown
- 1988-02-12 JP JP63030709A patent/JPH0649718B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| OA08715A (fr) | 1989-03-31 |
| DK74988A (da) | 1988-08-14 |
| US4965250A (en) | 1990-10-23 |
| GR1000079B (el) | 1990-11-29 |
| IE880382L (en) | 1988-08-13 |
| GR880100079A (en) | 1988-12-16 |
| EP0282374A1 (fr) | 1988-09-14 |
| JPH0649718B2 (ja) | 1994-06-29 |
| NZ223509A (en) | 1990-11-27 |
| AU604090B2 (en) | 1990-12-06 |
| PT86755B (pt) | 1992-05-29 |
| DE3862596D1 (de) | 1991-06-06 |
| ATE63125T1 (de) | 1991-05-15 |
| EP0282374B1 (fr) | 1991-05-02 |
| PT86755A (pt) | 1988-03-01 |
| AU1166988A (en) | 1988-08-18 |
| FR2610934A1 (fr) | 1988-08-19 |
| CA1331672C (fr) | 1994-08-23 |
| JPS63203698A (ja) | 1988-08-23 |
| DK74988D0 (da) | 1988-02-12 |
| FR2610934B1 (fr) | 1989-05-05 |
| IE60073B1 (en) | 1994-06-01 |
| ZA88995B (en) | 1988-08-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19990405 |