ES2001146A6 - Production of dilutiazem - Google Patents

Production of dilutiazem

Info

Publication number
ES2001146A6
ES2001146A6 ES8602911A ES8602911A ES2001146A6 ES 2001146 A6 ES2001146 A6 ES 2001146A6 ES 8602911 A ES8602911 A ES 8602911A ES 8602911 A ES8602911 A ES 8602911A ES 2001146 A6 ES2001146 A6 ES 2001146A6
Authority
ES
Spain
Prior art keywords
alkylation
acetylation
acetoxy
cpd
dilutiazem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8602911A
Other languages
Spanish (es)
Inventor
Tibor Gizur
Kalman Harsanyi
Zsuzsanna Aracs Trischler
Jozsef Felmeri
Katalin Berki
Aniko Demeter N Szabo
Ferenc Trischler
Zsuzsanna Vincze
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zambon Group SpA
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of ES2001146A6 publication Critical patent/ES2001146A6/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Prodn. of (25,35)-3-acetoxy-5-(N,N-dimethyl aminoethyl)-2-(4- methoxyphenyl)-2,3-dihydro -1,5-benzothiazepin-4(5H)-one (I), or its acid addn. salts, comprises (1) alkylation and acetylation, in either order, of the hydroxy cpd. (III) or (2) alkylation of the 3-acetoxy cpd. (V). The new features are that alkylation is with 2-dimethylaminoethanol mesylate hydrochloride (A) and/or acetylation is with isopropenyl acetate (B).
ES8602911A 1985-11-06 1986-11-05 Production of dilutiazem Expired ES2001146A6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU854264A HU195795B (en) 1985-11-06 1985-11-06 Process for preparing (2s,3s)-3-acetoxy-5-(n,n-dimethyl-amino-ethyl)-2-(h-methoxy-phenyl)-2,3-dihydro-1,5-benzothiazepin-h(5h)-one

Publications (1)

Publication Number Publication Date
ES2001146A6 true ES2001146A6 (en) 1988-04-16

Family

ID=10967486

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8602911A Expired ES2001146A6 (en) 1985-11-06 1986-11-05 Production of dilutiazem

Country Status (6)

Country Link
JP (1) JPS62108872A (en)
AT (1) AT393837B (en)
BE (1) BE905704A (en)
CA (1) CA1309714C (en)
ES (1) ES2001146A6 (en)
HU (1) HU195795B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6450872A (en) * 1987-08-21 1989-02-27 Tanabe Seiyaku Co Production of 1,5-benzothiazepine derivative
IT1226301B (en) * 1988-07-26 1990-12-27 Zambon Spa PROCESS FOR THE PREPARATION OF INTERMEDIATES FOR THE SYNTHESIS OF DILTIAZEM.

Also Published As

Publication number Publication date
JPS62108872A (en) 1987-05-20
AT393837B (en) 1991-12-27
HUT42767A (en) 1987-08-28
ATA294786A (en) 1991-06-15
BE905704A (en) 1987-03-02
JPH0354939B2 (en) 1991-08-21
CA1309714C (en) 1992-11-03
HU195795B (en) 1988-07-28

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2006-11-05

PC1A Transfer granted

Owner name: ZAMBON GROUP S.P.A.

FD1A Patent lapsed

Effective date: 20051107