EP3972637A4 - Compositions and methods of manufacturing trivalent filovirus vaccines - Google Patents
Compositions and methods of manufacturing trivalent filovirus vaccines Download PDFInfo
- Publication number
- EP3972637A4 EP3972637A4 EP20810813.4A EP20810813A EP3972637A4 EP 3972637 A4 EP3972637 A4 EP 3972637A4 EP 20810813 A EP20810813 A EP 20810813A EP 3972637 A4 EP3972637 A4 EP 3972637A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- trivalent
- compositions
- manufacturing
- methods
- filovirus vaccines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000711950 Filoviridae Species 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/295—Polyvalent viral antigens; Mixtures of viral and bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/14011—Filoviridae
- C12N2760/14111—Ebolavirus, e.g. Zaire ebolavirus
- C12N2760/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/14011—Filoviridae
- C12N2760/14111—Ebolavirus, e.g. Zaire ebolavirus
- C12N2760/14134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/14011—Filoviridae
- C12N2760/14211—Marburgvirus, e.g. lake Victoria marburgvirus
- C12N2760/14222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/14011—Filoviridae
- C12N2760/14211—Marburgvirus, e.g. lake Victoria marburgvirus
- C12N2760/14234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962850443P | 2019-05-20 | 2019-05-20 | |
PCT/US2020/033864 WO2020236973A1 (en) | 2019-05-20 | 2020-05-20 | Compositions and methods of manufacturing trivalent filovirus vaccines |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3972637A1 EP3972637A1 (en) | 2022-03-30 |
EP3972637A4 true EP3972637A4 (en) | 2023-06-21 |
Family
ID=73458117
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP20810813.4A Pending EP3972637A4 (en) | 2019-05-20 | 2020-05-20 | Compositions and methods of manufacturing trivalent filovirus vaccines |
Country Status (10)
Country | Link |
---|---|
US (2) | US11433129B2 (en) |
EP (1) | EP3972637A4 (en) |
CN (1) | CN114302737A (en) |
AU (1) | AU2020277403A1 (en) |
CA (1) | CA3141460A1 (en) |
GB (2) | GB2619625B (en) |
IL (1) | IL288240A (en) |
SG (1) | SG11202112887TA (en) |
WO (1) | WO2020236973A1 (en) |
ZA (1) | ZA202110437B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3141460A1 (en) * | 2019-05-20 | 2020-11-26 | Soligenix, Inc. | Compositions and methods of manufacturing trivalent filovirus vaccines |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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US20120136142A1 (en) * | 2008-09-03 | 2012-05-31 | Southern Research Institute | Vaccine Compositions For Marburg Virus |
WO2019051098A1 (en) * | 2017-09-07 | 2019-03-14 | Hawaii Biotech Inc. | Filovirus vaccine and methods of use |
Family Cites Families (19)
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DK0835663T3 (en) | 1992-05-23 | 2010-02-01 | Glaxosmithkline Biolog Sa | Combined vaccines comprising Hepatitis B surface antigen and other antigens |
ES2325301T3 (en) | 1995-06-23 | 2009-09-01 | Glaxosmithkline Biologicals S.A. | VACCINE COMPOSITION THAT INCLUDES A CONJUGATED POLISACARIDE ANTIGEN, ADSORBED ON ALUMINUM PHOSPHATE. |
SK283565B6 (en) | 1996-07-02 | 2003-09-11 | Connaught Laboratories Limited | Multivalent DTP-polio vaccines |
DK1028750T3 (en) | 1997-09-15 | 2006-05-22 | Sanofi Pasteur Msd | Process for the preparation of multivalent vaccines |
RU2130778C1 (en) | 1998-07-31 | 1999-05-27 | Акционерное общество закрытого типа НПК "Комбиотех Лтд" | Mixed vaccine for immune prophylaxis of viral hepatitis b, tetanus, diphtheria and whooping cough |
PE20020126A1 (en) | 2000-06-29 | 2002-04-27 | Smithkline Beecham Biolog | VACCINE COMPOSITION |
HUP0500539A2 (en) * | 2002-02-04 | 2006-09-28 | Corixa Corp | New immunoeffector 2-deoxi-2-amino-3-d glucopyranose derivatives |
GB0505518D0 (en) | 2005-03-17 | 2005-04-27 | Chiron Srl | Combination vaccines with whole cell pertussis antigen |
US7947286B2 (en) * | 2005-10-07 | 2011-05-24 | Panthera Biopharma Llc | Drosophila cell lines producing recombinant secretable filovirus surface glycoproteins lacking the membrane spanning domain |
GB0522765D0 (en) | 2005-11-08 | 2005-12-14 | Chiron Srl | Combination vaccine manufacture |
US8753646B2 (en) | 2006-09-29 | 2014-06-17 | Japan Poliomyelitis Research Institute | IPV-DPT vaccine |
AU2008231072B2 (en) | 2007-03-22 | 2013-08-01 | The Regents Of The University Of Colorado | Method of preparing an immunologically-active adjuvant-bound dried vaccine composition |
CA2725381A1 (en) * | 2008-05-23 | 2010-03-25 | The Regents Of The University Of Michigan | Nanoemulsion adjuvants |
CA2836273C (en) | 2011-05-17 | 2019-01-15 | Soligenix, Inc. | Thermostable vaccine compositions and methods of preparing same |
US10293041B2 (en) * | 2014-07-09 | 2019-05-21 | Soligenix, Inc. | Multivalent stable vaccine composition and methods of making same |
US10449243B2 (en) * | 2014-12-22 | 2019-10-22 | Merck Sharp & Dohme Corp. | Dengue virus vaccine compositions and methods of use thereof |
US10566193B2 (en) * | 2015-08-07 | 2020-02-18 | North Carolina State University | Synthesis and processing of Q-carbon, graphene, and diamond |
KR102632419B1 (en) * | 2016-12-23 | 2024-01-31 | 인터벳 인터내셔널 비.브이. | Combination vaccine for pigs |
CA3141460A1 (en) * | 2019-05-20 | 2020-11-26 | Soligenix, Inc. | Compositions and methods of manufacturing trivalent filovirus vaccines |
-
2020
- 2020-05-20 CA CA3141460A patent/CA3141460A1/en active Pending
- 2020-05-20 GB GB2312320.1A patent/GB2619625B/en active Active
- 2020-05-20 EP EP20810813.4A patent/EP3972637A4/en active Pending
- 2020-05-20 CN CN202080045026.1A patent/CN114302737A/en active Pending
- 2020-05-20 US US16/879,668 patent/US11433129B2/en active Active
- 2020-05-20 WO PCT/US2020/033864 patent/WO2020236973A1/en unknown
- 2020-05-20 GB GB2118425.4A patent/GB2599572B/en active Active
- 2020-05-20 SG SG11202112887TA patent/SG11202112887TA/en unknown
- 2020-05-20 AU AU2020277403A patent/AU2020277403A1/en active Pending
-
2021
- 2021-11-18 IL IL288240A patent/IL288240A/en unknown
- 2021-12-14 ZA ZA2021/10437A patent/ZA202110437B/en unknown
-
2022
- 2022-09-02 US US17/902,662 patent/US11771757B2/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120136142A1 (en) * | 2008-09-03 | 2012-05-31 | Southern Research Institute | Vaccine Compositions For Marburg Virus |
WO2019051098A1 (en) * | 2017-09-07 | 2019-03-14 | Hawaii Biotech Inc. | Filovirus vaccine and methods of use |
Non-Patent Citations (8)
Title |
---|
GROSS LISE ET AL: "Ebola vaccine development: Systematic review of pre-clinical and clinical studies, and meta-analysis of determinants of antibody response variability after vaccination", INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, INTERNATIONAL SOCIETY FOR INFECTIOUS DISEASES, HAMILTON, CA, vol. 74, 5 July 2018 (2018-07-05), pages 83 - 96, XP085462068, ISSN: 1201-9712, DOI: 10.1016/J.IJID.2018.06.022 * |
LEHRER AXEL T ET AL: "Recombinant proteins of Zaire ebola virus induce potent humoral and cellular immune responses and protect against live virus infection in mice", VACCINE, ELSEVIER, AMSTERDAM, NL, vol. 36, no. 22, 16 February 2017 (2017-02-16), pages 3090 - 3100, XP085393884, ISSN: 0264-410X, DOI: 10.1016/J.VACCINE.2017.01.068 * |
LEHRER AXEL: "DEVELOPMENT OF THERMOSTABLE FILOVIRUS VACCINES BASED ON RECOMBINANT INSECT CELL EXPRESSED SUBUNITS", 28 October 2018 (2018-10-28), XP093045383, Retrieved from the Internet <URL:https://www.astmh.org/ASTMH/media/Documents/2018-Abstract-Book-FINAL-11-13.pdf> [retrieved on 20230509] * |
ORR MARK T ET AL: "Elimination of the cold-chain dependence of a nanoemulsion adjuvanted vaccine against tuberculosis by lyophilization", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 177, 29 December 2013 (2013-12-29), pages 20 - 26, XP028621636, ISSN: 0168-3659, DOI: 10.1016/J.JCONREL.2013.12.025 * |
PRESTON KENDALL B ET AL: "Single-vial filovirus glycoprotein vaccines: Biophysical characteristics and immunogenicity after co-lyophilization with adjuvant", VACCINE, ELSEVIER, AMSTERDAM, NL, vol. 39, no. 39, 13 August 2021 (2021-08-13), pages 5650 - 5657, XP086777779, ISSN: 0264-410X, [retrieved on 20210813], DOI: 10.1016/J.VACCINE.2021.08.003 * |
PRESTON KENDALL: "Lyophilized Filovirus Glycoprotein Vaccines: Peroxides in a Vaccine Formulation with Polysorbate 80-Containing Adjuvant are Associated with Reduced Neutralizing Antibody Titers in Both Mice and Non-Human Primates", JOURNAL OF PHARMACEUTICAL SCIENCES, 21 May 2022 (2022-05-21), XP093044510 * |
REYNOLDS PIERCE ET AL: "Ebola and Marburg virus vaccines", VIRUS GENES, KLUWER ACADEMIC PUBLISHERS, BOSTON, US, vol. 53, no. 4, 26 April 2017 (2017-04-26), pages 501 - 515, XP036278063, ISSN: 0920-8569, [retrieved on 20170426], DOI: 10.1007/S11262-017-1455-X * |
VIDYASHANKARA IYER: "Feasibility of Freeze-Drying Oil-in-Water Emulsion Adjuvants and Subunit Proteins to Enable Single-Vial Vaccine Drug Products - ScienceDirect", 24 February 2017 (2017-02-24), pages 1 - 3, XP055982788, Retrieved from the Internet <URL:https://www.sciencedirect.com/science/article/abs/pii/S0022354917301338> [retrieved on 20221117] * |
Also Published As
Publication number | Publication date |
---|---|
AU2020277403A1 (en) | 2022-01-06 |
SG11202112887TA (en) | 2021-12-30 |
GB2619625B (en) | 2024-04-03 |
GB202312320D0 (en) | 2023-09-27 |
CN114302737A (en) | 2022-04-08 |
GB2599572B (en) | 2023-09-20 |
WO2020236973A1 (en) | 2020-11-26 |
US11771757B2 (en) | 2023-10-03 |
GB2599572A (en) | 2022-04-06 |
US11433129B2 (en) | 2022-09-06 |
CA3141460A1 (en) | 2020-11-26 |
US20200376109A1 (en) | 2020-12-03 |
GB2619625A (en) | 2023-12-13 |
IL288240A (en) | 2022-01-01 |
WO2020236973A8 (en) | 2021-02-04 |
ZA202110437B (en) | 2023-10-25 |
EP3972637A1 (en) | 2022-03-30 |
US20230093418A1 (en) | 2023-03-23 |
WO2020236973A9 (en) | 2020-12-30 |
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