EP3843746A4 - NEUROBLASTOMA TREATMENT WITH TAUROLIDINE HYDROLYSIS PRODUCTS - Google Patents
NEUROBLASTOMA TREATMENT WITH TAUROLIDINE HYDROLYSIS PRODUCTS Download PDFInfo
- Publication number
- EP3843746A4 EP3843746A4 EP19856239.9A EP19856239A EP3843746A4 EP 3843746 A4 EP3843746 A4 EP 3843746A4 EP 19856239 A EP19856239 A EP 19856239A EP 3843746 A4 EP3843746 A4 EP 3843746A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- taurolidine
- hydrolysis products
- neuroblastoma treatment
- neuroblastoma
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010029260 Neuroblastoma Diseases 0.000 title 1
- 230000007062 hydrolysis Effects 0.000 title 1
- 238000006460 hydrolysis reaction Methods 0.000 title 1
- AJKIRUJIDFJUKJ-UHFFFAOYSA-N taurolidine Chemical compound C1NS(=O)(=O)CCN1CN1CNS(=O)(=O)CC1 AJKIRUJIDFJUKJ-UHFFFAOYSA-N 0.000 title 1
- 229960004267 taurolidine Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862723618P | 2018-08-28 | 2018-08-28 | |
PCT/US2019/048592 WO2020047113A1 (en) | 2018-08-28 | 2019-08-28 | Neuroblastoma treatment with taurolidine hydrolysis products |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3843746A1 EP3843746A1 (en) | 2021-07-07 |
EP3843746A4 true EP3843746A4 (en) | 2022-10-19 |
Family
ID=69645349
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19856239.9A Pending EP3843746A4 (en) | 2018-08-28 | 2019-08-28 | NEUROBLASTOMA TREATMENT WITH TAUROLIDINE HYDROLYSIS PRODUCTS |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP3843746A4 (ja) |
JP (1) | JP2021535163A (ja) |
KR (1) | KR20210050544A (ja) |
CN (1) | CN113347976A (ja) |
AU (1) | AU2019330954A1 (ja) |
CA (1) | CA3111057A1 (ja) |
WO (1) | WO2020047113A1 (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116769723B (zh) * | 2023-08-09 | 2023-11-03 | 山东省成体细胞产业技术研究院有限公司 | 一种gd2嵌合抗原受体修饰的t细胞及其应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050096314A1 (en) * | 2001-04-03 | 2005-05-05 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Treatment of cancers with methylol-containing compounds and at least one electrolyte |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5602150A (en) * | 1992-10-02 | 1997-02-11 | Research Foundation For Mental Hygiene, Inc. | Treatment of central nervous system disorders associated with psychotic behavior and dementia with a combination of neuroleptic drugs and taurine, or derivatives thereof, to prevent the development of tardive dyskinesia |
US20030027818A1 (en) * | 2001-04-03 | 2003-02-06 | Redmond H. Paul | Treatment of cancers |
EP1248625A2 (en) * | 1999-12-06 | 2002-10-16 | Rhode Island Hospital | Use of methylol-containing compounds for the manufacture of a medicament for the treatment of tumors |
CA2363973C (en) * | 2000-11-28 | 2009-03-10 | Ed. Geistlich Sohne Ag Fur Chemische Industrie | Enhancement of effectiveness of 5-fluorouracil in treatment of tumor metastases and cancer |
DE60311958T2 (de) * | 2003-02-03 | 2007-11-08 | Polaschegg, Hans-Dietrich, Dr. | Zusammensetzung zur Prävention von Infektionen durch subkutane Prothesen |
US20080177217A1 (en) * | 2004-05-14 | 2008-07-24 | Hans-Dietrich Polaschegg | Taurolidine Formulations and Delivery: Therapeutic Treatments and Antimicrobial Protection Against Bacterial Biofilm Formation |
CA2636217C (en) * | 2006-01-06 | 2014-02-25 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Irradiated compositions and treatment of cancers with radiation in combination with taurolidine and/or taurultam |
CA2801309C (en) * | 2010-06-01 | 2018-07-17 | Geistlich Pharma Ag | Methods and compositions for oral pharmaceutical therapy |
AU2013239624A1 (en) * | 2012-03-30 | 2014-10-02 | Novartis Ag | Compounds for use in the treatment of neuroblastoma, Ewing's Sarcoma or rhabdomyosarcoma |
AU2017206750B2 (en) * | 2016-01-11 | 2022-10-13 | Cormedix Inc. | Therapeutic nanoparticles for the treatment of neuroblastoma and other cancers |
-
2019
- 2019-08-28 CN CN201980071416.3A patent/CN113347976A/zh active Pending
- 2019-08-28 WO PCT/US2019/048592 patent/WO2020047113A1/en unknown
- 2019-08-28 JP JP2021511544A patent/JP2021535163A/ja active Pending
- 2019-08-28 EP EP19856239.9A patent/EP3843746A4/en active Pending
- 2019-08-28 CA CA3111057A patent/CA3111057A1/en active Pending
- 2019-08-28 AU AU2019330954A patent/AU2019330954A1/en active Pending
- 2019-08-28 KR KR1020217008971A patent/KR20210050544A/ko unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050096314A1 (en) * | 2001-04-03 | 2005-05-05 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Treatment of cancers with methylol-containing compounds and at least one electrolyte |
Non-Patent Citations (7)
Title |
---|
ANONYMOUS: "Cormedix Inc. announces agreement with nanoproteagen for its proprietary nanoparticle technology, Nanopro TM, in combination with CRMD-005 for pediatric neuroblastoma", INTERNET CITATION, 11 May 2016 (2016-05-11), XP002792142, Retrieved from the Internet <URL:http://www.cormedix.com/cormedix-inc-announces-agreement-with-nanoproteagen-for-its-proprietary-nanoparticle-technology-nanopro-in-combination-with-crmd-005-for-pediatric-neuroblastoma-2/> [retrieved on 20190617] * |
BUCHHOLZ MARIE: "GMS | 130. Kongress der Deutschen Gesellschaft für Chirurgie | Effectivity and toxicity of Taurultam (TRLT) as anti-neoplastic agent in malignant tumor cells - in vitro study of pancreatic and colon cancer cell lines", 3 May 2013 (2013-05-03), pages 1 - 2, XP055959034, Retrieved from the Internet <URL:https://www.egms.de/static/de/meetings/dgch2013/13dgch861.shtml> [retrieved on 20220908] * |
ESCHENBURG GEORG ET AL: "Taurolidine cooperates with antineoplastic drugs in neuroblastoma cells", GENES & CANCER, vol. 5, no. 11-12, 9 October 2014 (2014-10-09), pages 460 - 469, XP055885452, DOI: 10.18632/genesandcancer.36 * |
GONG LI ET AL: "The Pharmacokinetics of Taurolidine Metabolites in Healthy Volunteers", THE JOURNAL OF CLINICAL PHARMACOLOGY, vol. 47, no. 6, 1 June 2007 (2007-06-01), US, pages 697 - 703, XP055958727, ISSN: 0091-2700, Retrieved from the Internet <URL:http://dx.doi.org/10.1177/0091270007299929> DOI: 10.1177/0091270007299929 * |
LUCKERT CHRISTIAN ET AL: "Taurolidine Specifically Inhibits Growth of Neuroblastoma Cell Lines In Vitro", JOURNAL OF PEDIATRIC HEMATOLOGY/ONCOLOGY, vol. 36, no. 4, 1 May 2014 (2014-05-01), US, pages e219 - e223, XP055958541, ISSN: 1077-4114, Retrieved from the Internet <URL:http://dx.doi.org/10.1097/MPH.0000000000000149> DOI: 10.1097/MPH.0000000000000149 * |
See also references of WO2020047113A1 * |
STENDEL RUEDIGER ET AL: "Pharmacokinetics of Taurolidine following Repeated Intravenous Infusions Measured by HPLC-ESI-MS/MS of the Derivatives Taurultame and Taurinamide in Glioblastoma Patients :", CLINICAL PHARMACOKINETICS., vol. 46, no. 6, 1 January 2007 (2007-01-01), NZ, pages 513 - 524, XP055945305, ISSN: 0312-5963, Retrieved from the Internet <URL:http://dx.doi.org/10.2165/00003088-200746060-00005> DOI: 10.2165/00003088-200746060-00005 * |
Also Published As
Publication number | Publication date |
---|---|
KR20210050544A (ko) | 2021-05-07 |
AU2019330954A1 (en) | 2021-04-22 |
EP3843746A1 (en) | 2021-07-07 |
CA3111057A1 (en) | 2020-02-05 |
JP2021535163A (ja) | 2021-12-16 |
WO2020047113A1 (en) | 2020-03-05 |
CN113347976A (zh) | 2021-09-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2019270211A1 (en) | Use of glycosidases in the production of oligosaccharides | |
EP3744378A4 (en) | CATHETER | |
EP3486371B8 (en) | Rail-switching unit | |
EP3804828A4 (en) | CONNECTION UNIT | |
EP3866743A4 (en) | PATIENT ELEVATION DEVICE | |
EP3781221A4 (en) | ZWITTERIONIC POLYMERS FOR BIOMEDICAL APPLICATIONS | |
EP3730109A4 (en) | DISPOSABLE DIAPER | |
EP3760175A4 (en) | DISPOSABLE CLOTHING ITEM | |
EP3863580B8 (de) | Wegwerfbare windel | |
EP3865423A4 (en) | SINGLE-DOSED FILTER COFFEE UNIT AND METHOD OF MAKING AND INFUSING THE UNIT | |
EP3831352A4 (en) | WEARABLE DISPOSABLE | |
EP3819066A4 (en) | CONNECTION | |
EP3755840A4 (en) | REFINER SEGMENT | |
EP3793501A4 (en) | FIBER PRODUCT | |
EP3666239A4 (en) | Disposable panty diaper | |
EP3843746A4 (en) | NEUROBLASTOMA TREATMENT WITH TAUROLIDINE HYDROLYSIS PRODUCTS | |
EP3828490A4 (en) | LIABILITY OFFICE | |
EP3811918A4 (en) | WHEELCHAIR | |
EP3815635A4 (en) | CATHETER | |
EP3639800A4 (en) | PULL-ON DISPOSABLE DIAPER | |
EP3744380A4 (en) | CATHETER | |
EP3570801A4 (en) | DISPOSABLE ITEM | |
EP3873528A4 (en) | TREATMENT OF RASOPATHY | |
EP3750341A4 (en) | MEDICAL ALERT APPLICATION | |
EP3842481A4 (en) | PREPREGNATED |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20210326 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20220916 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 45/06 20060101ALI20220912BHEP Ipc: A61K 31/549 20060101ALI20220912BHEP Ipc: A61K 31/541 20060101ALI20220912BHEP Ipc: A61K 31/54 20060101AFI20220912BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: EXAMINATION IS IN PROGRESS |
|
17Q | First examination report despatched |
Effective date: 20240402 |