EP3797289A1 - Analyseeinrichtung und verfahren zur analyse von substanzen durch ionenmobilitätsspektrometrie - Google Patents
Analyseeinrichtung und verfahren zur analyse von substanzen durch ionenmobilitätsspektrometrieInfo
- Publication number
- EP3797289A1 EP3797289A1 EP19726635.6A EP19726635A EP3797289A1 EP 3797289 A1 EP3797289 A1 EP 3797289A1 EP 19726635 A EP19726635 A EP 19726635A EP 3797289 A1 EP3797289 A1 EP 3797289A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- reaction chamber
- electrospray
- ion
- ion mobility
- source
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
- G01N27/622—Ion mobility spectrometry
Definitions
- the invention relates to the field of analysis of substances by ion mobility spectrometry.
- a method and a gas analysis device is known from WO 2015/091146 A1.
- ion mobility spectrometry fast and highly sensitive trace gas analysis is possible with which substances can be separated and identified by the movement of their ions through a neutral gas under the influence of an electric field.
- the ions which are also referred to below as analyte ions, to be present in the gas phase.
- the substances to be analyzed are in any case sufficiently volatile or are already present as gaseous substances anyway.
- the invention is therefore based on the object, other substances that are not already present in gaseous form to analyze by ion mobility spectrometry.
- This object is achieved by an analysis device for the analysis of substances by ion mobility spectrometry according to claim 1.
- the analysis device has the following features:
- a first field-generation device of the ion mobility spectrometer adapted to generate an electric field in the reaction chamber for generating a movement of ion ions differentiable by the ion mobility spectrometry ions towards the ion gate
- an electrospray device which has an electrospray source, wherein the electrospray device is set up to spray in an atomized form into the reaction chamber via the electrospray source a liquid supplied to the electrospray device which has a substance to be analyzed and a solvent
- an evaporation device which is set up for exclusively or predominantly carrying out the evaporation of the solvent contained in the sprayed mist within the reaction chamber, the evaporation device being formed by the first field-generating device.
- Electrospray ionization offers advantages over other methods, e.g. a thermal evaporation of the substance to be analyzed. In the case of many substances, for example, thermal evaporation would cause them to decompose before they produce sufficient vapor pressure, so that meaningful analysis by ion mobility spectrometry is no longer possible.
- the present invention optimizes electrospray ionization for the field of ion mobility spectrometry.
- the evaporation device which serves to evaporate the solvent contained in the sprayed-in mist, is formed by the first field-generating device of the ion mobility spectrometer.
- This evaporation device is used exclusively or predominantly to evaporate the solvent contained in the sprayed mist within the reaction chamber. This way you can a complete or at least sufficient vaporization of the solvent within the reaction chamber for a meaningful analysis, without any special additional effort, such as by additional introduction of a heated gas in the reaction chamber.
- the first field generation device is required anyway for the function of the ion mobility spectrometer.
- this first field-generating device is operated with a comparatively high field strength, the particles contained in the sprayed mist can already be supplied with sufficient energy, namely in the form of kinetic energy, which is sufficient for the abovementioned evaporation process of the solvent.
- the particles contained in the sprayed mist can be supplied with a higher average energy than the gas surrounding the particles by the first field-generating device.
- the analysis device according to the invention can be constructed comparatively simple.
- the analysis device can be designed without a separate heating device for heating the spray sprayed in the reaction chamber.
- a low-cost and small-sized analyzer can also be provided for the analysis of relatively large-sized substances for ion mobility spectrometry.
- the analysis device can therefore also be used for mobile use.
- Another advantage is that unwanted parasitic effects can be avoided by avoiding additional heating of the substances in the ion mobility spectrometer.
- ion mobility i. the separation size in the detector, from the temperature.
- An undesired thermal heating of the analytes can lead to a shift of the signals and thus to a reduction in the analytical performance of the analyzer.
- Such substances to be analyzed may, for example, be larger biomolecules, e.g. Proteins, fats, sugars.
- a solvent e.g. Methanol and / or water are used.
- the electrospray source may be e.g. be a needle-shaped source.
- the electrospray source is designed as a nanospray source, through which the supplied liquid in the form of nano-droplets can be sprayed into the reaction chamber in an atomized manner.
- a particularly fine distribution of the supplied liquid in the form of nanotubes is possible.
- no evaporation of the solvent within the electrospray source takes place even under vacuum conditions, but only in the desired manner within the reaction chamber.
- the nanospray source may, for example, be formed with an outlet diameter of at most 15 ⁇ m, or at most 1 ⁇ m.
- the electrospray device has a voltage source with which the electrospray source is electrically supplied, wherein the voltage source generates either a DC voltage, an AC voltage or an overlap of a DC voltage and an AC voltage.
- the electrospray device can be operated with the most suitable voltage for the respective application.
- the analysis device has a vacuum generating device, which is set up to produce a negative pressure relative to the atmospheric pressure at least in the reaction chamber.
- the negative pressure generating device can be directly or indirectly, for example via another chamber of the ion mobility spectrometer, be coupled to the reaction chamber.
- the vacuum generating device can basically be of any type, for example in the form of a pump, for example a diaphragm pump, a rotary vane pump or another pump, or in the form of a blower or a compressor.
- the negative pressure to be generated in relation to the atmospheric pressure does not have to assume an extremely large pressure difference to the atmospheric pressure, in particular not in the range of pressure values, which are usually referred to as a flocculated vacuum, as is required, for example, in a mass spectrometer.
- a negative pressure in the range of 2 mbar to 100 mbar (absolute pressure) is generated by the negative pressure generating device.
- the upper limit of the negative pressure range can also be set higher, for example at 200, 300 or 400 mbar. This has the advantage that the gas analysis device can be realized with simple low-cost components.
- the vacuum generating device can be realized with conventional, marketable products.
- the generation of the negative pressure in the reaction chamber is also conducive to the injection of the supplied liquid and the evaporation of the solvent within the reaction chamber.
- the suppression reduces the vaporization temperature on the one hand and the required electric field strength of the first field-generating device on the other hand.
- the first field-generating device can be arranged on or in the reaction chamber, or at least in the region of the reaction chamber such that the desired electric field can be generated in the reaction chamber.
- the first field-generating device can be set up, in particular, for generating an electric field with a potential gradient from an ionization-source-side region of the reaction chamber in the direction of an ion gate.
- the gas analysis device and in particular its ion mobility spectrometer can otherwise be constructed like known ion mobility spectrometers.
- the gas analysis device or its ion mobility spectrometer can have at least the following components: a) an ionization source region with an ionization source, ie in this case the electrospray source,
- the reaction chamber coupled to the ionization source region, c) a drift chamber having a drift gas supply port connected to a gas supply line for supplying drift gas into the drift chamber, d) a switchable ion gate between the reaction chamber and the Drift chamber, e) an ion detector at the end of the drift chamber facing away from the ion gate, f) a second field generating device, which is set up to generate an electric field in the drift chamber.
- the second field-generating device can be arranged on or in the drift chamber, or at least in the region of the drift chamber, in such a way that the desired electric field can be generated in the drift chamber.
- the second field-generating device can be set up in particular for generating an electric field with a potential gradient from the ion gate in the direction of the ion detector.
- the first and / or second field generating means may e.g. in the direction of the desired potential gradient of the electric field to be generated, electrodes arranged one behind the other, e.g. arranged in the reaction chamber or the drift chamber ring electrodes.
- the first and / or second field generating means may also be formed with a single electrode extending longitudinally in the direction of the desired potential gap, made of a material of relatively high resistivity, e.g. in the form of a uniform ring electrode. Due to the relatively high resistance value, the desired electric field in the longitudinal direction, i. in the desired direction of movement of the ions can be generated.
- a uniform ring electrode may e.g. be formed by a cylinder of conductive glass.
- the first and / or second field generating means may also comprise combinations of the aforementioned types of electrodes.
- the ion gate serves as a temporary barrier to the analyte ions on their way from the reaction chamber into the drift chamber.
- the ion gate is pulsed according to a certain temporal pattern, such that it is opened and closed and in the open phases, analyte ions pass from the reaction chamber into the drift chamber.
- separate measuring cycles of the gas analysis device in accordance with the switching cycle of the ion sensor, can be specified.
- the ion gate may be formed according to the ion donors in known ion mobility spectrometers, e.g. with two electrodes arranged one behind the other in the direction of movement of the analyte ions or electrodes interleaved with one another in a plane.
- the ion sensor at least three in the direction of the reaction chamber to the drift chamber arranged one behind the other electrodes.
- Such an ion gate is highly efficient in barrier action.
- the three electrodes arranged one behind the other in each case allow the mutually adjacent electrodes to be operated in pairs with an electric field with a field strength which corresponds to the field strength in the adjacent chamber, i.
- the electrodes of the ionomer can e.g. be designed as ring electrodes or as grid electrodes.
- the vacuum generating device is set up to generate a drift gas flow counter to the drift direction of the ions in the drift chamber.
- This has the advantage that the drift gas required anyway for carrying out the ion mobility spectrometry can be passed through the drift chamber without the need for additional components. Rather, the vacuum generating device can be used for this purpose.
- the drift gas flow generated constantly fresh drift gas is supplied and counteracted contamination of the drift chamber by unwanted particles, since the drift gas flow leads to a purge of the drift chamber.
- the drift gas can be cleaned by filters and dried.
- the negative pressure generating device can in principle be connected to different points of the gas analysis device or a housing body of the ion mobility spectrometer.
- the reaction chamber may be pressure-connected to the drift chamber, ie there is a pressure equalization between the reaction chamber and the drift chamber.
- the prevailing pressure in the reaction chamber and in the drift chamber is essentially the same, apart from small pressure differences occurring due to flow effects.
- the negative pressure generating device may be connected to a suction connection of the gas analysis device.
- the vacuum generating device has a suction connection, which is connected to a suction connection of the gas analysis device, which is arranged in the drift direction of the ions in front of the ion gate.
- the suction port may be e.g. open into the reaction chamber or in the lonisationsuzen area.
- the object stated in the introduction is also achieved by a method for the analysis of substances by ion mobility spectrometry, in which a liquid comprising a substance to be analyzed and a solvent is supplied in an atomized form to a reaction chamber of an ion mobility spectrometer by electrospray ionization, and the solvent is evaporated within the reaction chamber, wherein the evaporation of the solvent takes place exclusively or predominantly by an electric field generated in the reaction chamber, through which kinetic energy is supplied to the droplets of the spray sprayed and these droplets are heated so that the solvent evaporates.
- the method can be carried out, for example, with an analysis device of the type described above.
- the dispensing of the liquid in atomized form from an electrospray source takes place exclusively or predominantly through the electric field generated in the reaction chamber or in an additional region in front of the electrospray source.
- This has the advantage that no additional devices are required for the discharge of the liquid in atomized form, such as, for example, a pressure-generating device through which liquid is discharged from the electrospray source with overpressure. Therefore, the implementation cost for the analysis device can also be reduced thereby.
- the liquid is dispensed dropwise from the electrospray source. Charge carriers are already supplied to the droplets at the top of the electrospray source, so that already charged droplets which are like ions in the electric field are released into the reaction chamber.
- the above-mentioned high kinetic energy which provides for the evaporation of the solvent, can already be supplied to these ionized droplets of the sprayed-in fog.
- the method is carried out with an existing at least in the reaction chamber suppression of the atmospheric pressure. This also makes it possible to realize the advantages explained above with regard to the generation of negative pressure.
- the suppression is additionally beneficial for dispensing the liquid in atomized form from the electrospray source.
- the analyte ions to be analyzed by means of ion mobility spectrometry are freed from the solvent within the reaction chamber. As a result, a high analytical performance of the ion mobility spectrometry is achieved.
- the analysis device can be used particularly advantageously with the following operating parameters. Accordingly, the method according to the invention can also be operated.
- the field strength of the electric field generated by the first field generating device in the reactor is indicated onshunt.
- the drift chamber can be operated with comparable field strengths.
- the pressure values indicate the absolute pressure which is generated by the vacuum generating device in the reaction chamber.
- Advantageous is a field strength in the range of 4 V / cm per mbar absolute pressure to 37.5 V / cm per mbar absolute pressure, or in the range of 8 V / cm per mbar absolute pressure to 37.5 V / cm per mbar absolute pressure, or in the range from 12.5 V / cm per mbar absolute pressure to 37.5 V / cm per mbar absolute pressure.
- the absolute pressure refers to the selected negative pressure generated by the negative pressure generating device in the reaction chamber.
- FIG. 2 shows further design features of the analysis device according to FIG. 1.
- FIG. 1 shows the analysis device with regard to the structure and the electrical wiring
- FIG. 2 shows the same subject with regard to the connections of the pressure lines for the vacuum generation and the drift gas introduction.
- a combination of the electrical circuit of FIG. 1 and the further features shown in FIG. 2 is advantageous.
- the analysis device shown in FIG. 1 has an ion mobility spectrometer 2, which has an eg tubular or tubular housing body 3.
- the housing body 3 is subdivided into an ionization source region 4, a reaction chamber 5, an ion gate 6, a drift chamber 7 and an ion detector 8, which are arranged one behind the other as shown in FIG. 1 in the above-mentioned sequence.
- the ion detector 8, which may be designed, for example, as a Faraday detector, for example in the form of a cup or in the form of a metal plate, is connected to an electrical terminal 80 of the ion mobility spectrometer 2 Amplifier 9 connected.
- FIG. 1 further shows that electrodes 50, 70 of a first or second field-generating device are arranged in the reaction chamber 5 and in the drift chamber 7.
- the electrodes 50, 70 are designed as ring electrodes which form a ring in the interior of the reaction chamber 5 or the drift chamber 7.
- the illustrated ring electrodes 50 may be connected to a voltage source 51 via a voltage divider circuit constructed of resistors 52.
- the electrodes 70 can be connected to a voltage source 71 via a voltage divider circuit constructed from resistors 72.
- the first field-generation device associated with the reaction chamber 5 therefore also has the voltage source 51 and the resistors 52, apart from the electrodes 50.
- the drift chamber 7 associated second field generating device has in addition to the electrodes 70 nor the voltage source 71 and the resistors 72.
- the illustrated regions 4, 5, 6, 7, 8 of the ion mobility spectrometer 2 are connected to one another, so that the analyte ions can move freely through the housing body 3, or controlled only by the electric fields and the ion gate 6.
- the substance to be analyzed is supplied in the form of a liquid from a container 43.
- the liquid contains the substance to be analyzed and a solvent.
- This liquid is discharged via an electrospray source 40 arranged in the ionization source region 4, for example a needle-shaped electrospray source in the form of a nanospray source, into the reaction chamber 5 or initially into the ionization source region 4 in the form of a sprayed-in mist 42.
- the electro-spray source 40 is connected to a voltage source 41.
- the voltage source 41 is also connected to the nearest electrode 50 of the first field generating device.
- the mist 42 contains the finest droplets of liquid at the top the electrospray source 40 are charged and then behave like ions so that they are accelerated by the electric field.
- the solvent evaporates during this process. In this way, the desired electrospray ionization takes place.
- a relatively strong electric field is generated by the first field-generating device in the reaction chamber 5, which first accelerates the charged droplets of the mist 42 and leads to the evaporation of the solvent, and then further accelerates the remaining analyte ions, so that they then controlled by the ion gate , can be discharged into the drift chamber 7 with high kinetic energy.
- FIG. 2 shows various further components of the gas analysis device 1 connected via hollow conduits to the housing body 3 of the ion mobility spectrometer 2.
- a suction connection 44 which is arranged on the housing body 3 in the ionization source region 4, but also e.g. in the region of the reaction chamber 5 is connected to a suction port of a vacuum generating device 11, e.g. a pump.
- the housing body 3 further comprises a drift gas supply port 74, which is connected via a hollow conduit with a Driftgasvorrat.
- various gases which are chemically / physically neutral with the analyte ions and can be used as drift gas can be used, such as, for example, Nitrogen or a noble gas.
- the drift gas supply port 74 may be preceded by a mass flow controller 15, whereby the supply of the drift gas can be regulated and kept constant.
- the drift gas supply port 74 may further be preceded by a filter 14, which is particularly advantageous when using ambient air as a drift gas to clean this.
- the ionization source region 4, the reaction chamber 5, the region of the ion donor 6 and the drift chamber 7 can be pressure-connected to one another, ie there is a pressure equalization between these sections of the housing body 3.
- the desired negative pressure generated by the vacuum generating device 11 and drift gas can be sucked through the drift gas supply port 74. All aspirated gases are then sucked through the vacuum generating device 11 and discharged again.
Landscapes
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Health & Medical Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102018112349.3A DE102018112349B8 (de) | 2018-05-23 | 2018-05-23 | Analyseeinrichtung und Verfahren zur Analyse von Substanzen durch Ionenmobilitätsspektrometrie |
PCT/EP2019/063173 WO2019224227A1 (de) | 2018-05-23 | 2019-05-22 | Analyseeinrichtung und verfahren zur analyse von substanzen durch ionenmobilitätsspektrometrie |
Publications (1)
Publication Number | Publication Date |
---|---|
EP3797289A1 true EP3797289A1 (de) | 2021-03-31 |
Family
ID=66655336
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19726635.6A Withdrawn EP3797289A1 (de) | 2018-05-23 | 2019-05-22 | Analyseeinrichtung und verfahren zur analyse von substanzen durch ionenmobilitätsspektrometrie |
Country Status (5)
Country | Link |
---|---|
US (1) | US20210123887A1 (de) |
EP (1) | EP3797289A1 (de) |
CN (1) | CN112292596A (de) |
DE (1) | DE102018112349B8 (de) |
WO (1) | WO2019224227A1 (de) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102021120720A1 (de) | 2021-08-10 | 2023-02-16 | G.A.S. Gesellschaft für analytische Sensorsysteme m.b.H. | Ionenmobilitätsspektrometer |
DE102022117190A1 (de) * | 2022-07-11 | 2024-01-11 | Gottfried Wilhelm Leibniz Universität Hannover, Körperschaft des öffentlichen Rechts | Ionenmobilitätsspektrometer und Verfahren zur Analyse von Substanzen |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6690004B2 (en) * | 1999-07-21 | 2004-02-10 | The Charles Stark Draper Laboratory, Inc. | Method and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry |
US6586732B2 (en) * | 2001-02-20 | 2003-07-01 | Brigham Young University | Atmospheric pressure ionization ion mobility spectrometry |
DE102009037715B4 (de) | 2009-08-17 | 2012-04-26 | Bruker Daltonik Gmbh | Führung von Sprühtröpfchen zur Einlasskapillare eines Massenspektrometers |
DE102013114421B4 (de) | 2013-12-19 | 2016-02-18 | Gottfried Wilhelm Leibniz Universität Hannover | Gasanalyseeinrichtung und Verfahren zur Gasanalyse |
US9666423B2 (en) | 2014-05-22 | 2017-05-30 | W Henry Benner | Instruments for measuring ion size distribution and concentration |
CN107003283B (zh) | 2014-11-17 | 2020-08-07 | 株式会社岛津制作所 | 离子迁移率分析装置 |
JP6432688B2 (ja) * | 2015-08-28 | 2018-12-05 | 株式会社島津製作所 | イオン移動度分析装置 |
-
2018
- 2018-05-23 DE DE102018112349.3A patent/DE102018112349B8/de not_active Expired - Fee Related
-
2019
- 2019-05-22 US US17/057,145 patent/US20210123887A1/en not_active Abandoned
- 2019-05-22 CN CN201980033682.7A patent/CN112292596A/zh active Pending
- 2019-05-22 WO PCT/EP2019/063173 patent/WO2019224227A1/de unknown
- 2019-05-22 EP EP19726635.6A patent/EP3797289A1/de not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
CN112292596A (zh) | 2021-01-29 |
DE102018112349A1 (de) | 2019-11-28 |
DE102018112349B8 (de) | 2021-09-23 |
US20210123887A1 (en) | 2021-04-29 |
DE102018112349B4 (de) | 2021-07-29 |
WO2019224227A1 (de) | 2019-11-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE10236344B4 (de) | Ionisieren an Atmosphärendruck für massenspektrometrische Analysen | |
EP3084412B1 (de) | Gasanalyseeinrichtung und verfahren zur gasanalyse | |
DE19652021B4 (de) | Ionen-Quelle und Ionisationsverfahren | |
DE60038033T2 (de) | Atmosphärendruckphotoionisation : ein neues ionisationsverfahren für flüssigchromatographie-massenspekrometrie | |
DE69017048T2 (de) | Elektrosprühionenquelle für massenspektrometrie. | |
DE69319016T2 (de) | Isolierte Nadel zur Erzeugung eines Elektrosprays | |
DE69520331T2 (de) | Massenspektrometrie von Lösungen und Vorrichtung dafür | |
DE3913763C2 (de) | Massenspektrometer | |
DE102017000240A1 (de) | IRMS-Probenaufgabesystem und -Verfahren | |
DE112015003618B4 (de) | Verfahren zum Einführen von Ionen in einen Vakuumbereich eines Massenspektrometers | |
DE102015112869B4 (de) | Verfahren zum Betreiben eines Ionentors, Einrichtung mit einem Ionentransportbereich sowie Computerprogramm | |
DE102017108461A1 (de) | Dualmodus-ionisationsvorrichtung | |
DE112008003547T5 (de) | Probenanregungsvorrichtung und -verfahren zur spektroskopischen Analyse | |
DE112015001080T5 (de) | Probeneinbringungssystem für Spektrometer | |
DE112014002710B4 (de) | Verfahren zum Kalibrieren von Ionensignalen | |
DE102007015714A1 (de) | Vorrichtung zum Erzeugen von Ionen aus einer Elektrospray-Anordnung | |
DE4303027A1 (de) | ||
DE102011005340A1 (de) | Einlassstutzen für Massenspektrometer zur Verwendung mit Ionenquellen, die bei Atmosphärendruck arbeiten | |
WO2019224227A1 (de) | Analyseeinrichtung und verfahren zur analyse von substanzen durch ionenmobilitätsspektrometrie | |
WO2018229724A2 (de) | Vorrichtung und verfahren zur ionisation eines analyten sowie vorrichtung und verfahren zur analyse eines ionisierten analyten | |
DE112015000977B4 (de) | Umgebungsionisation mit einer Impaktorsprayquelle | |
DE112015001328T5 (de) | Matrixunterstützte Flüssigextraktions-Laserdesorptionsionisations-Ionenquelle | |
DE112015002258B4 (de) | Mehrdimensionale Ionentrennung | |
DE4408032A1 (de) | Verfahren zur Ionisierung von gelösten Atomen oder Molekülen aus Flüssigkeiten durch elektrisches Versprühen | |
DE112015000990B4 (de) | Impaktorspray-Atmosphärendruck-Ionenquelle mit einem Zielpaddel |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
17P | Request for examination filed |
Effective date: 20201106 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: KIRK, ANSGAR Inventor name: RADDATZ, CHRISTIAN-ROBERT Inventor name: THOBEN, CHRISTIAN Inventor name: ZIMMERMANN, STEFAN |
|
DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20210727 |