EP3688449A4 - Nanoelectrode devices and methods of fabrication thereof - Google Patents

Nanoelectrode devices and methods of fabrication thereof Download PDF

Info

Publication number
EP3688449A4
EP3688449A4 EP18861291.5A EP18861291A EP3688449A4 EP 3688449 A4 EP3688449 A4 EP 3688449A4 EP 18861291 A EP18861291 A EP 18861291A EP 3688449 A4 EP3688449 A4 EP 3688449A4
Authority
EP
European Patent Office
Prior art keywords
nanoelectrode
fabrication
methods
devices
nanoelectrode devices
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP18861291.5A
Other languages
German (de)
French (fr)
Other versions
EP3688449A1 (en
Inventor
Kazusuke MIHARA
Hisao Kawasaki
Valentin V. DIMITROV
Toshihiko HONKURA
Mark F. Oldham
Eric S. Nordman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quantum Biosystems Inc
Original Assignee
Quantum Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quantum Biosystems Inc filed Critical Quantum Biosystems Inc
Publication of EP3688449A1 publication Critical patent/EP3688449A1/en
Publication of EP3688449A4 publication Critical patent/EP3688449A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3276—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a hybridisation with immobilised receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6823—Release of bound markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3278—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction involving nanosized elements, e.g. nanogaps or nanoparticles
EP18861291.5A 2017-09-27 2018-09-27 Nanoelectrode devices and methods of fabrication thereof Withdrawn EP3688449A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762563859P 2017-09-27 2017-09-27
PCT/JP2018/036086 WO2019065904A1 (en) 2017-09-27 2018-09-27 Nanoelectrode devices and methods of fabrication thereof

Publications (2)

Publication Number Publication Date
EP3688449A1 EP3688449A1 (en) 2020-08-05
EP3688449A4 true EP3688449A4 (en) 2021-11-24

Family

ID=65901624

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18861291.5A Withdrawn EP3688449A4 (en) 2017-09-27 2018-09-27 Nanoelectrode devices and methods of fabrication thereof

Country Status (3)

Country Link
EP (1) EP3688449A4 (en)
TW (1) TW201928340A (en)
WO (1) WO2019065904A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9194838B2 (en) 2010-03-03 2015-11-24 Osaka University Method and device for identifying nucleotide, and method and device for determining nucleotide sequence of polynucleotide
CA2929929A1 (en) 2013-09-18 2015-03-26 Quantum Biosystems Inc. Biomolecule sequencing devices, systems and methods
JP2015077652A (en) 2013-10-16 2015-04-23 クオンタムバイオシステムズ株式会社 Nano-gap electrode and method for manufacturing same
US10438811B1 (en) 2014-04-15 2019-10-08 Quantum Biosystems Inc. Methods for forming nano-gap electrodes for use in nanosensors
WO2015170782A1 (en) 2014-05-08 2015-11-12 Osaka University Devices, systems and methods for linearization of polymers

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017189930A1 (en) * 2016-04-27 2017-11-02 Quantum Biosystems Inc. Systems and methods for measurement and sequencing of bio-molecules

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2450109A1 (en) * 2001-06-11 2003-05-22 Genorx, Inc. Electronic detection of biological molecules using thin layers
US9395352B2 (en) * 2007-04-06 2016-07-19 Arizona Board Of Regents On Behalf Of Arizona State University Devices and methods for target molecule characterization
US8652779B2 (en) * 2010-04-09 2014-02-18 Pacific Biosciences Of California, Inc. Nanopore sequencing using charge blockade labels
CN104011866B (en) * 2011-07-27 2017-06-09 伊利诺伊大学评议会 For the nanopore sensor that biomolecule is characterized
JP2013090576A (en) * 2011-10-24 2013-05-16 Hitachi Ltd Nucleic acid analyzing device and nucleic acid analyzer using the same
WO2013154999A2 (en) * 2012-04-09 2013-10-17 The Trustees Of Columbia University In The City Of New York Method of preparation of nanopore and uses thereof
US9551697B2 (en) * 2013-10-17 2017-01-24 Genia Technologies, Inc. Non-faradaic, capacitively coupled measurement in a nanopore cell array
JP6516000B2 (en) * 2014-05-08 2019-05-22 国立大学法人大阪大学 Nano gap electrode containing different materials
WO2016206593A1 (en) * 2015-06-23 2016-12-29 深圳华大基因研究院 Micro-porous electrode and method for analysis of chemical substances

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017189930A1 (en) * 2016-04-27 2017-11-02 Quantum Biosystems Inc. Systems and methods for measurement and sequencing of bio-molecules

Also Published As

Publication number Publication date
EP3688449A1 (en) 2020-08-05
WO2019065904A1 (en) 2019-04-04
TW201928340A (en) 2019-07-16

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Inventor name: OLDHAM, MARK F.

Inventor name: HONKURA, TOSHIHIKO

Inventor name: DIMITROV, VALENTIN V.

Inventor name: MIHARA, KAZUSUKE

Inventor name: KAWASAKI, HISAO

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