EP3367785A4 - COMPOSITIONS AND METHODS FOR ASSISTING ORGAN ASSISTED BY A CHIMERIC EMBRYO - Google Patents

COMPOSITIONS AND METHODS FOR ASSISTING ORGAN ASSISTED BY A CHIMERIC EMBRYO Download PDF

Info

Publication number: EP3367785A4
Authority: EP; European Patent Office
Prior art keywords: assisted; compositions; methods; chimeric embryo; organ production
Prior art date: 2015-10-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP16860830.5A

Other languages

German (de)

English (en)

French (fr)

Other versions

EP3367785A2 (en

Inventor

Atsushi Asakura

Raj ARAVALLI

Maxim C. CHEERAN

James Dutton

Daniel J. GARRY

Mary G. GARRY

Melanie Graham

Ling Li

Walter Low

Angela Panoskaltsis-Mortari

Timothy O'brien

Clifford Steer

Jakub Tolar

Daniel F. Carlson

Scott C. Fahrenkrug

Naoko KOYANO-NAKAGAWA

Ann PARR

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of Minnesota

Recombinetics Inc

Original Assignee

University of Minnesota

Recombinetics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-10-27

Filing date

2016-10-27

Publication date

2019-08-14

2016-10-27 Application filed by University of Minnesota, Recombinetics Inc filed Critical University of Minnesota

2018-09-05 Publication of EP3367785A2 publication Critical patent/EP3367785A2/en

2019-08-14 Publication of EP3367785A4 publication Critical patent/EP3367785A4/en

Status Withdrawn legal-status Critical Current

Links

210000001161 mammalian embryo Anatomy 0.000 title 1
239000000203 mixture Substances 0.000 title 1
210000000056 organ Anatomy 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
- A01K2267/025—Animal producing cells or organs for transplantation

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Environmental Sciences (AREA)
Biotechnology (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Animal Husbandry (AREA)
Animal Behavior & Ethology (AREA)
Biodiversity & Conservation Biology (AREA)
Cell Biology (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Physics & Mathematics (AREA)
Mycology (AREA)
Veterinary Medicine (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Materials For Medical Uses (AREA)

EP16860830.5A 2015-10-27 2016-10-27 COMPOSITIONS AND METHODS FOR ASSISTING ORGAN ASSISTED BY A CHIMERIC EMBRYO Withdrawn EP3367785A4 (en)

Applications Claiming Priority (11)

Application Number	Priority Date	Filing Date	Title
US201562247117P	2015-10-27	2015-10-27
US201562247092P	2015-10-27	2015-10-27
US201562246926P	2015-10-27	2015-10-27
US201562247122P	2015-10-27	2015-10-27
US201562246927P	2015-10-27	2015-10-27
US201562246929P	2015-10-27	2015-10-27
US201562247118P	2015-10-27	2015-10-27
US201562247096P	2015-10-27	2015-10-27
US201562247115P	2015-10-27	2015-10-27
US201562246947P	2015-10-27	2015-10-27
PCT/US2016/059206 WO2017075276A2 (en)	2015-10-27	2016-10-27	Compositions and methods for chimeric embryo-assisted organ production

Publications (2)

Publication Number	Publication Date
EP3367785A2 EP3367785A2 (en)	2018-09-05
EP3367785A4 true EP3367785A4 (en)	2019-08-14

Family

ID=58631806

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP16860830.5A Withdrawn EP3367785A4 (en)	2015-10-27	2016-10-27	COMPOSITIONS AND METHODS FOR ASSISTING ORGAN ASSISTED BY A CHIMERIC EMBRYO

Country Status (7)

Country	Link
EP (1)	EP3367785A4 (ja)
JP (1)	JP2019502400A (ja)
KR (1)	KR20180100303A (ja)
CN (1)	CN108697067A (ja)
AU (1)	AU2016344152A1 (ja)
CA (1)	CA3003652A1 (ja)
WO (1)	WO2017075276A2 (ja)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP3264891A4 (en)	2015-03-03	2018-09-05	Regents Of The University Of Minnesota	Etv2 and uses thereof
RU2018103234A (ru)	2015-06-30	2019-07-31	Реджентс Оф Зэ Юниверсити Оф Миннесота	Гуманизированная мышца сердца
MX2018000273A (es)	2015-06-30	2018-03-08	Univ Minnesota	Musculo esqueletico humanizado.
WO2017218675A1 (en) *	2016-06-14	2017-12-21	Riddle Institute	Organ regeneration method using somatic cell nuclear transfer (scnt) cell and blastocyst complementation
US20190045761A1 (en)	2017-08-11	2019-02-14	Recombinetics, Inc.	Inducible disease models methods of making them and use in tissue complementation
CN109258575B (zh) *	2018-12-10	2021-07-06	广东工业大学	一种蛙类动物胚胎的孵育方法
US11162079B2 (en)	2019-05-10	2021-11-02	The Regents Of The University Of California	Blood type O Rh-hypo-immunogenic pluripotent cells
US11859213B2 (en)	2019-05-16	2024-01-02	Regents Of The University Of Minnesota	Development of superior chimerism by hiPSC engineering and embryo aggregation
CA3144621A1 (en) *	2019-06-26	2020-12-30	The Regents Of The University Of California	Sirpalpha-silenced natural killer (nk) cells
US11576889B2 (en)	2019-09-23	2023-02-14	The Board Of Regents Of The University Of Texas System	Methods of identifying and treating patients with HIF-2 inhibitor resistance
CN116433652B (zh) *	2023-05-11	2024-02-23	中南大学	用于确定胚胎移植的妊娠结果的方法、处理器及装置

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20100122360A1 (en) *	2007-02-22	2010-05-13	The University Of Tokyo	Organ regeneration method utilizing blastocyst complementation

2016
- 2016-10-27 JP JP2018542691A patent/JP2019502400A/ja active Pending
- 2016-10-27 WO PCT/US2016/059206 patent/WO2017075276A2/en active Application Filing
- 2016-10-27 EP EP16860830.5A patent/EP3367785A4/en not_active Withdrawn
- 2016-10-27 CN CN201680074878.7A patent/CN108697067A/zh active Pending
- 2016-10-27 AU AU2016344152A patent/AU2016344152A1/en not_active Abandoned
- 2016-10-27 KR KR1020187014498A patent/KR20180100303A/ko unknown
- 2016-10-27 CA CA3003652A patent/CA3003652A1/en not_active Abandoned

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20100122360A1 (en) *	2007-02-22	2010-05-13	The University Of Tokyo	Organ regeneration method utilizing blastocyst complementation

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
MADHUSUDANA GIRIJA SANAL: "Future of liver transplantation: Non-human primates for patient-specific organs from induced pluripotent stem cells", WORLD JOURNAL OF GASTROENTEROLOGY, vol. 17, no. 32, 2011, CN, pages 3684, XP055602899, ISSN: 1007-9327, DOI: 10.3748/wjg.v17.i32.3684 *
PREETHI SWAMINATHAN: "Human Stem Cell Complementation in PITX3 Null Porcine Blastocysts: Lens Development", December 2014 (2014-12-01), XP055493473, Retrieved from the Internet <URL:https://conservancy.umn.edu/bitstream/handle/11299/185108/Swaminathan_umn_0130M_15713.pdf?sequence=1> [retrieved on 20180718] *
XIANLONG WANG ET AL: "Efficient CRISPR/Cas9-mediated biallelic gene disruption and site-specific knockin after rapid selection of highly active sgRNAs in pigs", SCIENTIFIC REPORTS, vol. 5, no. 1, 21 August 2015 (2015-08-21), XP055551206, DOI: 10.1038/srep13348 *
YUYU NIU ET AL: "Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos", CELL, vol. 156, no. 4, February 2014 (2014-02-01), AMSTERDAM, NL, pages 836 - 843, XP055422516, ISSN: 0092-8674, DOI: 10.1016/j.cell.2014.01.027 *

Also Published As

Publication number	Publication date
KR20180100303A (ko)	2018-09-10
CN108697067A (zh)	2018-10-23
CA3003652A1 (en)	2017-05-04
AU2016344152A1 (en)	2018-05-24
WO2017075276A3 (en)	2017-06-01
EP3367785A2 (en)	2018-09-05
WO2017075276A2 (en)	2017-05-04
JP2019502400A (ja)	2019-01-31

Legal Events

Date	Code	Title	Description
2017-05-05	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2018-08-03	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2018-08-03	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2018-09-05	17P	Request for examination filed	Effective date: 20180516
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2018-09-05	AX	Request for extension of the european patent	Extension state: BA ME
2018-11-07	RIN1	Information on inventor provided before grant (corrected)	Inventor name: PANOSKALTSIS-MORTARI, ANGELA Inventor name: PARR, ANN Inventor name: ASAKURA, ATSUSHI Inventor name: KOYANO-NAKAGAWA, NAOKO Inventor name: O'BRIEN, TIMOTHY Inventor name: GARRY, MARY, G. Inventor name: DUTTON, JAMES Inventor name: CHEERAN, MAXIN Inventor name: CARLSON, DANIEL, F. Inventor name: LOW, WALTER Inventor name: FAHRENKRUG, SCOTT, C. Inventor name: GARRY, DANIEL, J. Inventor name: ARAVALLI, RAJ Inventor name: GRAHAM, MELANIE Inventor name: STEER, CLIFFORD Inventor name: LI, LING Inventor name: TOLAR, JAKUP
2019-01-30	DAV	Request for validation of the european patent (deleted)
2019-01-30	DAX	Request for extension of the european patent (deleted)
2019-04-17	RIN1	Information on inventor provided before grant (corrected)	Inventor name: CHEERAN, MAXIM C. Inventor name: PARR, ANN Inventor name: STEER, CLIFFORD Inventor name: TOLAR, JAKUB Inventor name: O'BRIEN, TIMOTHY Inventor name: GARRY, DANIEL, J. Inventor name: KOYANO-NAKAGAWA, NAOKO Inventor name: DUTTON, JAMES Inventor name: CARLSON, DANIEL, F. Inventor name: PANOSKALTSIS-MORTARI, ANGELA Inventor name: GARRY, MARY, G. Inventor name: LOW, WALTER Inventor name: ASAKURA, ATSUSHI Inventor name: ARAVALLI, RAJ Inventor name: LI, LING Inventor name: FAHRENKRUG, SCOTT, C. Inventor name: GRAHAM, MELANIE
2019-05-15	RIC1	Information provided on ipc code assigned before grant	Ipc: C12N 15/90 20060101ALI20190410BHEP Ipc: A01K 67/027 20060101AFI20190410BHEP Ipc: A01N 1/02 20060101ALI20190410BHEP Ipc: C12N 15/85 20060101ALI20190410BHEP Ipc: A61D 19/04 20060101ALI20190410BHEP
2019-08-14	A4	Supplementary search report drawn up and despatched	Effective date: 20190712
2019-08-14	RIC1	Information provided on ipc code assigned before grant	Ipc: C12N 15/85 20060101ALI20190708BHEP Ipc: A01K 67/027 20060101AFI20190708BHEP Ipc: C12N 15/90 20060101ALI20190708BHEP Ipc: A61D 19/04 20060101ALI20190708BHEP Ipc: A01N 1/02 20060101ALI20190708BHEP
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2020-10-21	RIN1	Information on inventor provided before grant (corrected)	Inventor name: O'BRIEN, TIMOTHY Inventor name: ARAVALLI, RAJ Inventor name: FAHRENKRUG, SCOTT, C. Inventor name: PANOSKALTSIS-MORTARI, ANGELA Inventor name: PARR, ANN Inventor name: KOYANO, NAOKO Inventor name: GARRY, MARY, G. Inventor name: GARRY, DANIEL, J. Inventor name: CHEERAN, MAXIM C. Inventor name: LI, LING Inventor name: ASAKURA, ATSUSHI Inventor name: LOW, WALTER Inventor name: GRAHAM, MELANIE Inventor name: DUTTON, JAMES Inventor name: CARLSON, DANIEL, F. Inventor name: STEER, CLIFFORD Inventor name: TOLAR, JAKUB
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