EP2967049A4 - Procédés, composés et compositions pour le traitement de maladies liées à l'angiotensine - Google Patents

Procédés, composés et compositions pour le traitement de maladies liées à l'angiotensine Download PDF

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Publication number
EP2967049A4
EP2967049A4 EP14763703.7A EP14763703A EP2967049A4 EP 2967049 A4 EP2967049 A4 EP 2967049A4 EP 14763703 A EP14763703 A EP 14763703A EP 2967049 A4 EP2967049 A4 EP 2967049A4
Authority
EP
European Patent Office
Prior art keywords
angiotensin
compositions
compounds
treatment
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP14763703.7A
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German (de)
English (en)
Other versions
EP2967049B1 (fr
EP2967049A1 (fr
Inventor
Nicos A. Petasis
Kathleen E. Rodgers
Stan G. Louie
Gere S. Dizerega
Kevin J. GAFFNEY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Southern California USC
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University of Southern California USC
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Filing date
Publication date
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Priority to EP20188953.2A priority Critical patent/EP3935944A1/fr
Publication of EP2967049A1 publication Critical patent/EP2967049A1/fr
Publication of EP2967049A4 publication Critical patent/EP2967049A4/fr
Application granted granted Critical
Publication of EP2967049B1 publication Critical patent/EP2967049B1/fr
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/52—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
EP14763703.7A 2013-03-15 2014-03-15 Procédés, composés et compositions pour le traitement de maladies liées à l'angiotensine Active EP2967049B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP20188953.2A EP3935944A1 (fr) 2013-03-15 2014-03-15 Composés pour le traitement des maladies musculo-squelettiques

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361802259P 2013-03-15 2013-03-15
US201361809290P 2013-04-05 2013-04-05
PCT/US2014/030071 WO2014145331A1 (fr) 2013-03-15 2014-03-15 Procédés, composés et compositions pour le traitement de maladies liées à l'angiotensine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP20188953.2A Division EP3935944A1 (fr) 2013-03-15 2014-03-15 Composés pour le traitement des maladies musculo-squelettiques

Publications (3)

Publication Number Publication Date
EP2967049A1 EP2967049A1 (fr) 2016-01-20
EP2967049A4 true EP2967049A4 (fr) 2017-01-11
EP2967049B1 EP2967049B1 (fr) 2020-09-02

Family

ID=51537955

Family Applications (2)

Application Number Title Priority Date Filing Date
EP20188953.2A Pending EP3935944A1 (fr) 2013-03-15 2014-03-15 Composés pour le traitement des maladies musculo-squelettiques
EP14763703.7A Active EP2967049B1 (fr) 2013-03-15 2014-03-15 Procédés, composés et compositions pour le traitement de maladies liées à l'angiotensine

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP20188953.2A Pending EP3935944A1 (fr) 2013-03-15 2014-03-15 Composés pour le traitement des maladies musculo-squelettiques

Country Status (13)

Country Link
US (2) US9732074B2 (fr)
EP (2) EP3935944A1 (fr)
JP (1) JP6480909B2 (fr)
KR (1) KR102230461B1 (fr)
CN (1) CN105451554B (fr)
AU (1) AU2014233185B2 (fr)
CA (1) CA2911376C (fr)
DK (1) DK2967049T3 (fr)
ES (1) ES2834430T3 (fr)
HK (1) HK1220324A1 (fr)
NZ (1) NZ712479A (fr)
RU (1) RU2688163C2 (fr)
WO (1) WO2014145331A1 (fr)

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NZ712479A (en) * 2013-03-15 2019-01-25 Univ Southern California Methods, compounds, and compositions for the treatment of angiotensin-related diseases
CA2902619A1 (fr) 2013-03-15 2014-09-25 University Of Southern California Methodes de traitement de la sclerose en plaques
MX2015016143A (es) * 2013-05-24 2016-03-31 Tarix Pharmaceuticals Ltd Peptidos de angiotensina para tratar el sindrome de marfan y transtornos relacionados.
CN107073295A (zh) * 2014-07-17 2017-08-18 南加利福尼亚大学 用于治疗肌骨病的方法、化合物和组合物
AR108906A1 (es) 2016-06-29 2018-10-10 Bristol Myers Squibb Co Heterociclos de biarilmetilo
WO2018231614A1 (fr) * 2017-06-16 2018-12-20 Gaffney Kevin J Procédés de traitement de lupus érythémateux disséminé
WO2019027890A1 (fr) * 2017-08-04 2019-02-07 Gaffney Kevin J Méthodes de traitement de la myélosuppression
WO2019036267A1 (fr) * 2017-08-16 2019-02-21 Gaffney Kevin J Compositions pour augmenter les cellules souches mésenchymateuses circulantes
JOP20180092A1 (ar) 2017-10-13 2019-04-13 Gilead Sciences Inc مثبطات hiv بروتياز
US11833148B2 (en) 2018-05-11 2023-12-05 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods for treating or limiting development of cardiovascular disease-related neurological disorders
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
TW202104210A (zh) 2019-04-17 2021-02-01 美商基利科學股份有限公司 Hiv蛋白酶抑制劑
WO2021189038A1 (fr) * 2020-03-20 2021-09-23 The Board Of Trustees Of The Leland Stanford Junior University Ang-1-7 en tant qu'agent thérapeutique contre le coronavirus
CA3209749A1 (fr) * 2021-01-28 2022-08-04 Capacity Bio, Inc. Procedes et agents qui stimulent le renouvellement mitochondrial pour traiter une maladie
EP4220172A1 (fr) 2022-01-27 2023-08-02 Université Libre de Bruxelles Covid-19 théranostique

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See also references of WO2014145331A1 *

Also Published As

Publication number Publication date
ES2834430T3 (es) 2021-06-17
DK2967049T3 (da) 2020-12-07
KR102230461B1 (ko) 2021-03-22
AU2014233185A1 (en) 2015-10-29
CN105451554B (zh) 2019-06-11
CA2911376A1 (fr) 2014-09-18
EP2967049B1 (fr) 2020-09-02
RU2015138801A (ru) 2017-04-20
CA2911376C (fr) 2021-03-30
US9732074B2 (en) 2017-08-15
EP3935944A1 (fr) 2022-01-12
NZ712479A (en) 2019-01-25
KR20150138242A (ko) 2015-12-09
US20180030042A1 (en) 2018-02-01
CN105451554A (zh) 2016-03-30
AU2014233185B2 (en) 2018-03-15
HK1220324A1 (zh) 2017-05-05
US20160016946A1 (en) 2016-01-21
EP2967049A1 (fr) 2016-01-20
WO2014145331A1 (fr) 2014-09-18
US10301298B2 (en) 2019-05-28
RU2688163C2 (ru) 2019-05-20
JP6480909B2 (ja) 2019-03-13
JP2016514702A (ja) 2016-05-23

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