EP2812451A4 - Procédés et compositions concernant des fusions de ros1 pour diagnostiquer et traiter le cancer - Google Patents

Procédés et compositions concernant des fusions de ros1 pour diagnostiquer et traiter le cancer

Info

Publication number
EP2812451A4
EP2812451A4 EP13746869.0A EP13746869A EP2812451A4 EP 2812451 A4 EP2812451 A4 EP 2812451A4 EP 13746869 A EP13746869 A EP 13746869A EP 2812451 A4 EP2812451 A4 EP 2812451A4
Authority
EP
European Patent Office
Prior art keywords
ros1
fusions
diagnosing
methods
treating cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP13746869.0A
Other languages
German (de)
English (en)
Other versions
EP2812451A2 (fr
Inventor
David Hout
John Handshoe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Insight Genetics Inc
Original Assignee
Insight Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Insight Genetics Inc filed Critical Insight Genetics Inc
Publication of EP2812451A2 publication Critical patent/EP2812451A2/fr
Publication of EP2812451A4 publication Critical patent/EP2812451A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP13746869.0A 2012-02-08 2013-02-08 Procédés et compositions concernant des fusions de ros1 pour diagnostiquer et traiter le cancer Withdrawn EP2812451A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261596720P 2012-02-08 2012-02-08
PCT/US2013/025345 WO2013119950A2 (fr) 2012-02-08 2013-02-08 Procédés et compositions concernant des fusions de ros1 pour diagnostiquer et traiter le cancer

Publications (2)

Publication Number Publication Date
EP2812451A2 EP2812451A2 (fr) 2014-12-17
EP2812451A4 true EP2812451A4 (fr) 2016-01-06

Family

ID=48948165

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13746869.0A Withdrawn EP2812451A4 (fr) 2012-02-08 2013-02-08 Procédés et compositions concernant des fusions de ros1 pour diagnostiquer et traiter le cancer

Country Status (5)

Country Link
EP (1) EP2812451A4 (fr)
JP (1) JP2015508644A (fr)
CN (1) CN104364391A (fr)
AU (1) AU2013216904A1 (fr)
WO (1) WO2013119950A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014318821B2 (en) 2013-09-10 2018-04-19 Board Of Regents Of The University Of Texas System Therapeutics targeting truncated Adenomatous Polyposis Coli (APC) proteins
TWI672141B (zh) 2014-02-20 2019-09-21 美商醫科泰生技 投予ｒｏｓ１突變癌細胞之分子
EP3825421B1 (fr) * 2014-03-25 2022-06-22 Quest Diagnostics Investments Incorporated Détection de fusions de gènes par expression différentielle intragénique (ide) à l'aide de seuils de cycle moyen
US10082496B2 (en) * 2014-09-10 2018-09-25 Board Of Regents Of The University Of Texas System Targeting emopamil binding protein (EBP) with small molecules that induce an abnormal feedback response by lowering endogenous cholesterol biosynthesis
CN107207471B (zh) 2014-12-02 2020-06-26 伊尼塔公司 用于治疗神经母细胞瘤的组合
CN104830989A (zh) * 2015-05-25 2015-08-12 上海允英医疗科技有限公司 一种用于ros1与多种基因发生融合突变的检测试剂盒
EP3325667B1 (fr) * 2015-07-21 2020-11-11 Guardant Health, Inc. Acides nucléiques verrouillés pour capturer des gènes de fusion
BR112018012255A2 (pt) 2015-12-18 2018-12-04 Ignyta Inc método para tratar câncer
CA3069339A1 (fr) 2017-07-19 2019-01-24 Ignyta, Inc. Compositions pharmaceutiques contenant de l'entrectinib
CN111225662B (zh) 2017-10-17 2022-11-22 伊尼塔公司 药物组合物和剂型
JP2022508651A (ja) * 2018-10-08 2022-01-19 レヴォリューション・メディスンズ，インコーポレイテッド 癌を処置するためのｓｈｐ２阻害剤組成物および方法
WO2024072805A1 (fr) * 2022-09-26 2024-04-04 Lau, Johnson Yiu-Nam Compositions, systèmes et procédés pour la détection du cancer de l'ovaire

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007084631A2 (fr) * 2006-01-20 2007-07-26 Cell Signaling Technology, Inc. Translocation et kinase ros mutante dans un cancer du poumon non a petites cellules chez un etre humain
WO2011146945A2 (fr) * 2010-05-21 2011-11-24 Cell Signaling Technology, Inc. Kinase alk et ros dans le cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1454994A1 (fr) * 2003-03-07 2004-09-08 Université de la Méditerranée Procédé stamdardisé et optimisé d'amplification en chaine par transcription inversé et amplification quantitative en temps réel pour la détection d'une pathologie résiduelle minime de la leucémie
US20100143918A1 (en) * 2007-01-19 2010-06-10 Cell Signaling Technology, Inc. Translocation and mutant ros kinase in human non-small cell lung carcinoma
ES2637174T3 (es) * 2009-02-12 2017-10-11 Cell Signaling Technology, Inc. Expresión de ROS mutante en el cáncer de hígado humano
US20120208713A1 (en) * 2009-05-15 2012-08-16 Josh Nickols Methods and compositions relating to fusions of alk for diagnosing and treating cancer
JP5861244B2 (ja) * 2010-06-22 2016-02-16 公益財団法人がん研究会 新規ｒｏｓ１融合体の検出法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007084631A2 (fr) * 2006-01-20 2007-07-26 Cell Signaling Technology, Inc. Translocation et kinase ros mutante dans un cancer du poumon non a petites cellules chez un etre humain
WO2011146945A2 (fr) * 2010-05-21 2011-11-24 Cell Signaling Technology, Inc. Kinase alk et ros dans le cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHENGUANG LI ET AL: "Spectrum of Oncogenic Driver Mutations in Lung Adenocarcinomas from East Asian Never Smokers", PLOS ONE, vol. 6, no. 11, 30 November 2011 (2011-11-30), pages e28204, XP055209333, DOI: 10.1371/journal.pone.0028204 *

Also Published As

Publication number Publication date
JP2015508644A (ja) 2015-03-23
AU2013216904A1 (en) 2014-08-28
WO2013119950A3 (fr) 2014-11-13
WO2013119950A2 (fr) 2013-08-15
EP2812451A2 (fr) 2014-12-17
CN104364391A (zh) 2015-02-18

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Legal Events

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A4 Supplementary search report drawn up and despatched

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Effective date: 20160715