EP2637948B1 - Method for supplying a liquid to a fluidic assembly - Google Patents

Method for supplying a liquid to a fluidic assembly Download PDF

Info

Publication number
EP2637948B1
EP2637948B1 EP11778602.0A EP11778602A EP2637948B1 EP 2637948 B1 EP2637948 B1 EP 2637948B1 EP 11778602 A EP11778602 A EP 11778602A EP 2637948 B1 EP2637948 B1 EP 2637948B1
Authority
EP
European Patent Office
Prior art keywords
cavity
liquid
packaging
carrier
opening
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP11778602.0A
Other languages
German (de)
French (fr)
Other versions
EP2637948A1 (en
Inventor
Dirk Kurowski
Oliver Paul
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Microparts GmbH
Original Assignee
Boehringer Ingelheim Microparts GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Microparts GmbH filed Critical Boehringer Ingelheim Microparts GmbH
Priority to EP11778602.0A priority Critical patent/EP2637948B1/en
Publication of EP2637948A1 publication Critical patent/EP2637948A1/en
Application granted granted Critical
Publication of EP2637948B1 publication Critical patent/EP2637948B1/en
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D85/00—Containers, packaging elements or packages, specially adapted for particular articles or materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/36—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed
    • B65D75/367—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed and forming several compartments
    • B65D75/368—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed and forming several compartments the compartments being interconnected, e.g. by small channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2205/00—Venting means
    • B65D2205/02—Venting holes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2221/00—Small packaging specially adapted for product samples, single-use packages or échantillons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2575/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D2575/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by association or interconnecting two or more sheets or blanks
    • B65D2575/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D2575/36—One sheet or blank being recessed and the other formed or relatively stiff flat sheet material, e.g. blister packages
    • B65D2575/361—Details
    • B65D2575/362—Details with special means for gaining access to the contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2575/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D2575/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by association or interconnecting two or more sheets or blanks
    • B65D2575/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D2575/36—One sheet or blank being recessed and the other formed or relatively stiff flat sheet material, e.g. blister packages
    • B65D2575/361—Details
    • B65D2575/362—Details with special means for gaining access to the contents
    • B65D2575/367—Details with special means for gaining access to the contents through a preformed opening in the flat sheet, e.g. the opening being defined by weakened lines

Definitions

  • the present invention relates to a method for feeding liquid from a packaging, in particular blister pack, with at least one cavity for receiving the liquid in a fluidic arrangement.
  • the present invention is concerned with the inclusion of a liquid in a package, in particular a blister pack.
  • the liquid is received in a cavity of the package.
  • the following description is therefore directed in particular to a blister pack or to a blister for receiving a liquid, even if the present invention is not limited thereto, but preferably also in other liquid packaging can be used.
  • Blister packs are used in various industries and industries and are equipped with at least one cavity into which the content to be filled is received. As a rule, the content in the cavity is visible from the outside. However, the Blistezverpackungen the contents or the liquid absorbed can also cover or envelop light-tight or opaque.
  • a typical blister pack usually has two foils, which in turn may be constructed of several layers of different or the same materials.
  • the films are usually made of plastic and / or metal, e.g. Aluminum, wherein other materials, such as paper or the like, in principle or additionally can be used.
  • the two films are, in particular, a bottom layer or base film (carrier) and a cover layer or cover film (cover).
  • one or more troughs or depressions for receiving the liquid may be formed, into which the liquid, in particular a pharmaceutical formulation is filled.
  • the cover film or the cover is then placed on the base film or the carrier and fixed thereto or connected thereto, for example, at the edge locations or in a connection region, in particular flat surface areas, preferably by gluing, heat sealing, welding or the like takes place.
  • the DE 103 43 668 A1 discloses a particularly dense blister packaging for drugs, wherein the opening of the blister pack is not discussed in more detail.
  • the DE 20 2007 003 050 U1 discloses a blister pack for a liquid drug.
  • the active ingredient should be released by diffusion to the environment. However, this should be prevented just in the packaging according to the present invention.
  • the DE 299 07 740 U1 discloses a blister pack with a plurality of chambers, wherein a separation, in particular release film between the chambers is opened by the action of force.
  • the EP 1 710 169 A1 describes a blister pack with an integrated piercing element in a cap of a food container. By piercing a separator, the blister can be opened and deliver its contents into the container.
  • the FR 2 290 366 discloses a bottle with two chambers connected by a release film. By pressing the film, the contents of the chambers can be supplied to each other.
  • the US2007 / 0246395 A1 describes a blister assembly for receiving a drug, wherein the blister contents are made accessible by pressing an integrated piercing element.
  • the WO 2009/152952 A1 describes a method according to the preamble of claim 1.
  • the present invention is particularly concerned with the filling of a fluidic assembly of a blister pack, which on the fluidic assembly, preferably a medical cartridge (for example, a so-called biosensor) is attached, wherein the filled in the cavity of the blister, in particular provided with a reagent or a plurality of reagents liquid to trigger or allow a certain detection reaction in the arrangement.
  • a medical cartridge for example, a so-called biosensor
  • the opening of the cavity should be easy and / or defined if necessary.
  • the present invention has for its object to provide a method for supplying liquid to the fluidic device, wherein a simple and / or defined opening of the package or cavity is made possible or facilitated.
  • the packaging has an opening device integrated into the packaging for opening the cavity or, in particular, a lid of the packaging.
  • the opening device is in particular formed in or by a carrier of the packaging. This allows a simple and / or cost-effective implementation as well as a simple and / or defined opening of the packaging or the cavity filled with the liquid.
  • the packaging or a blister pack with an integrated opening device in the aforementioned sense as a reservoir for a liquid, in particular for a test liquid, a washing liquid, a reaction liquid, a solvent or the like, is used, wherein the packaging or cavity to a fluidic arrangement. is connected to receive the liquid after opening the package or cavity.
  • the fluidic arrangement is a microfluidic examination device, for example for determining at least one analyte in a biological sample, such as blood or blood components.
  • the supply of liquid from the packaging to a fluidic arrangement formed in particular in the aforementioned sense takes place in that the packaging is at least partially deformed in order to actuate the opening device and thereby open the packaging or cavity.
  • the packaging or cavity (additionally and / or in a second step) can be deformed in order to displace liquid from the packaging and / or to supply it to the fluidic arrangement, in particular under pressure.
  • the opening can in particular also be automated and / or by means of a stamp or other tool which deforms the packaging for opening.
  • the packaging 1 preferably closes the liquid 3 at least substantially liquid-tight and / or gas-tight.
  • the packaging 1 is designed in particular as a blister pack.
  • the cavity 2 is formed in particular by a blister of the packaging 1 or blister pack.
  • the liquid 3 is, in particular, an examination liquid, a washing liquid, a reaction liquid, a solvent or the like, particularly preferably for use in a microfluidic system for determining an analyte or value and / or for examination, in particular a preferably biological sample or the like ,
  • the packaging 1 has a carrier 4 and an associated lid 5.
  • the support 4 is an at least substantially flat or planar or planar element and / or surface material and / or a bottom layer or bottom foil or the like.
  • the carrier 4 may be formed relatively rigid or flexible and / or at least partially deformable.
  • the carrier 4 has a relatively high rigidity or strength in its main direction of extension or plane.
  • the carrier 4 is preferably stiffer or more rigid than the lid 5 and / or sufficiently rigid to at least significantly or primarily determine the shape of the package 1.
  • the cover 5 is preferably an at least substantially flat or planar and / or smooth element or surface material and / or a cover layer or covering film, particularly preferably for the planar covering of the associated support 4.
  • the carrier 4 and / or the lid 5 is formed as a film and / or made of film, plastic, metal and / or a particular plastic and / or metal-containing composite material.
  • the carrier 4 and the cover 5 can in principle be made of the same material. However, in the illustrated example, the carrier 4 and the lid 5 are preferably made of different materials.
  • the lid 5 is preferably designed to be flexible and / or deformable and in particular openable, for example by tearing, pressing, piercing or the like, particularly preferably for removal or dispensing of the liquid 3.
  • the carrier 4 can be opened in a corresponding manner.
  • At least one cavity 2 for receiving the liquid 3 is formed between the carrier 4 and the cover 5. Particularly preferably, a plurality of cavities 2 are formed.
  • the packaging 1 or the carrier 4 and / or lid 5 may be particularly preferably strip-like endless material or the like.
  • the endless material can then in individual packaging 1 with each at least one cavity 2 for receiving the liquid 3 before or preferably after the filling of the liquid 3, divided or separated, as needed.
  • only the preferred structure of a cavity 2 will be discussed in more detail, even if the endless material or the packaging 1 may have a plurality of such cavities 2, possibly also in different sizes and / or with different liquids 3.
  • a recess or bulge in the carrier 4 and / or lid 5 is preferably formed, in the illustrated embodiment, preferably only in the carrier 4, as in FIG Fig. 1 indicated.
  • the recess or bulge is formed in particular trough-like.
  • the depression or cavity 2 is produced in particular by thermoforming and / or deep-drawing, in this case the carrier 4.
  • the package 1 or cavity 2 is closed or closed.
  • the cover 5 is placed and at least partially connected to the carrier 4 in a connecting region 6.
  • the connecting region 6 is formed in particular in the region of flat surface areas of the carrier 4 and cover 5.
  • the connecting region 6 adjoins the cavity 2 in particular laterally and / or circumferentially.
  • the connection region may surround the cavity 2 in an annular manner.
  • the bonding of carrier 4 and lid 5 is preferably carried out by heat sealing, welding, gluing and / or in any other suitable manner.
  • Fig. 1 shows the proposed package 1 in the filled state.
  • the cavity 2 (the blister) is filled with liquid 3 and sealed.
  • the packaging 1 has an opening device 7 integrated therein for opening the packaging 1 or cavity 2 or the lid 5.
  • the opening device 7 is preferably formed integrally with the package 1 or the carrier 4 and / or formed in or from the carrier 4, as in Fig. 1 indicated by way of example.
  • the section 8 or its end or free end is particularly preferably conical and / or pointed and / or directed towards the cover 4 and the main extension plane E out.
  • the opening device 7 is preferably arranged or formed somewhat spaced from the actual cavity 2, in particular in a channel 9, which is particularly preferably laterally adjoining the cavity 2, or the like.
  • the channel 9 is in particular of the packaging 1 also formed, particularly preferably by a corresponding recess or bulge of the carrier 4.
  • the channel 9 is preferably fluidly connected to the cavity 2 even with the package 1 or closed lid 5 in fluid communication.
  • the opening device 7 is formed in the representation example in the region of one end of the channel 9.
  • the channel wall spaced from the lid 5 or any other wall portion of the carrier 4 or channel 9 spaced from the lid 5 is provided with the opening device 7 or the projecting section 8.
  • the opening device 7 or the projecting section 8 is provided with the opening device 7 or the projecting section 8.
  • the packaging 1 or opening device 7 is preferably designed such that by at least regional deformation or depression, in particular of the carrier 4 or lid 5, here the carrier 4 or the wall of the channel 9 and the projecting portion 8, in particular in a predetermined Area or adjacent to the opening device 7, the package 1 is opened.
  • a depression causes the opening device 7 or the protruding section 8 to open the cover 5, in particular by tearing open, cutting open, piercing or the like.
  • the lid 5 is opened in particular in a region which is immediately adjacent or opposite the opening device 7 or the projecting section 8.
  • the cover 5 may be provided in the opening region with at least one "predetermined breaking point", for example by corresponding weakening of the material or the like.
  • the packaging 1 or the opening device 8 has a deformation region, which here is formed in particular by a wave-like structure 10, which allows a particularly slight deformation of the packaging 1 or here of the carrier 4 for easy deformation or actuation of the opening device 7, in particular, in order to be able to press the protruding section 8 for opening the packaging 1 relatively easily against the lid 5.
  • Fig. 2 shows in a schematic, not true to scale section the proposed package 1 with an associated fluidic assembly 11.
  • the package 1 is permanently or permanently connected to the fluidic device 11.
  • the package 1 is liquid-tight and / or gas-tight connected to the fluidic device 11 or connectable, so that liquid 3 from the cavity 2 of the fluidic assembly 11 - particularly preferably after opening the package 1 or cavity 2 - can be fed.
  • the packaging 1 or cavity 2 is preferably arranged such that it covers at least partially with its opening region, ie the region which can be opened by the opening device 7, an outflow 14 of the fluidic device 11, in particular above it.
  • the drain 14 is formed for example by a depression, a channel or the like, in particular in the support part 12.
  • At the outlet 14 may be a channel 15 or another, in particular microfluidic structure of the fluidic device 11 connect.
  • the outflow 14 and / or channel 15 form part of a microfluidic structure of the fluidic arrangement 11.
  • "Microfluidic" is to be understood here as meaning volumes of preferably less than 1 ml.
  • the fluidic device 11 or microfluidic structure may further comprise an examination region or the like (not shown), for example for a biological sample such as blood, constituents of blood or the like.
  • the cavity 2 or the blister of the packaging 1 or blister pack formed therefrom is preferably used as a reservoir for the liquid 3, wherein the packaging 1 or cavity 2 to the fluidic assembly 11 for receiving the liquid 3 after opening the package. 1 or cavity 2 is connected.
  • the proposed packaging 1 can also be used for other purposes.
  • the packaging 1 is opened by means of the opening device 7, in particular by actuation of the opening device 7.
  • the packaging 1 or the support 4 is particularly preferably deformed in the region of the channel 9 or the opening device 7, so that the opening device 7 resp the projecting portion 8 in particular opens the lid 5, in particular tears, pierces, cuts or the like.
  • This - preferably only partial - deformation of the package 1 and the carrier 4 is preferably carried out by means of a tool, such as a in Fig. 2 indicated stamp 16, or the like.
  • the opening device 7 or 8 of the section for example, in a depression arranged below, such as the drain 14 and thereby locally deformed and overstressed until the lid 5 and the cover sheet in this area ruptures and thereby the cavity 2 - here via the channel 9 - opens to the fluidic assembly 11 out.
  • the liquid 3 can flow out of the cavity 2 into the fluidic arrangement 11 or the outflow 14 or the microfluidic system of the arrangement 11.
  • This leakage of the liquid 3 can be effected or promoted by gravitational force, capillary forces, suction force, pressing force, negative pressure, overpressure or the like.
  • the cavity 2 is preferably additionally deformed after opening the package 1 or the lid 5, in particular in a second step, in order to pressurize the liquid 3 and / or to force it out of the package 1 or cavity 2 and the fluidic assembly 11 zuzu meetings.
  • This deformation of the cavity 2 can be done, for example, by a tool, such as the indicated punch 17, or in any other suitable manner, if appropriate also by manual deformation with a finger or the like.
  • the opening of the package 1 or cavity 2 by means of the opening device 7 can, if necessary, also be effected by the fluidic arrangement 11, for example by means of a drive for the punch 16 assigned to the arrangement 11.
  • the packaging 1 may also be provided with a ventilation device, not shown, which is opened, for example, by corresponding deformation of the device 1 or of the carrier 4 or actuation of the opening device 7 and / or during deformation of the cavity 2 Ambient air can flow through a corresponding opening in the carrier 4 or cover 5 in the cavity 2.
  • the ventilation can also take place through the fluidic arrangement 11, possibly even via the opening produced by the opening device 7.
  • the opening device 7 for example, a correspondingly shaped or sufficiently large opening in the lid 5 or any other part of the package 1 and / or possibly also a plurality of openings, for example by a plurality of projecting portions 8, produce.
  • a particular advantage of the combination of the proposed packaging 1 with the fluidic arrangement 11 is that very simple such a connection, for example by the flat-side fastening, is made possible, so that a liquid-tight and preferably also gas-tight or closed to the ambient air connection between the Cavity 2 on the one hand and the fluidic device 11 or the microfluidic system formed or contained therein or the drain 14 or the like on the other hand can be produced.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Composite Materials (AREA)
  • Packages (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Description

Die vorliegende Erfindung betrifft ein Verfahren zum Zuführen von Flüssigkeit aus einer Verpackung, insbesondere Blisterverpackung, mit mindestens einer Kavität zur Aufnahme der Flüssigkeit in einer fluidischen Anordnung.The present invention relates to a method for feeding liquid from a packaging, in particular blister pack, with at least one cavity for receiving the liquid in a fluidic arrangement.

Die vorliegende Erfindung befasst sich mit der Aufnahme einer Flüssigkeit in eine Verpackung, insbesondere in eine Blisterverpackung- Die Flüssigkeit wird in eine Kavität der Verpackung aufgenommen. Die Kavität ist insbesondere durch einen Blister (englisch = Blase) gebildet. Die folgende Beschreibung ist daher insbesondere auf eine Blisterverpackung bzw. auf einen Blister zur Aufnahme einer Flüssigkeit gerichtet, auch wenn die vorliegende Erfindung hierauf nicht beschränkt ist, sondern vorzugsweise auch bei sonstigen Flüssigkeitsverpackungen einsetzbar ist.The present invention is concerned with the inclusion of a liquid in a package, in particular a blister pack. The liquid is received in a cavity of the package. The cavity is formed in particular by a blister (English = bubble). The following description is therefore directed in particular to a blister pack or to a blister for receiving a liquid, even if the present invention is not limited thereto, but preferably also in other liquid packaging can be used.

Die Befüllung einer oder mehrerer Kavitäten mit Stoffen, festen Körpern oder auch Flüssigkeiten ist beispielsweise aus dem Gebiet der sogenannten Sichtverpackungen oder Blisterverpackungen bekannt. Blisterverpackungen werden in unterschiedlichen Branchen und Industriebereichen verwendet und sind mit wenigstens einer Kavität ausgestattet, in die der zu befüllende Inhalt aufgenommen wird. Dabei ist in der Regel der Inhalt in der Kavität von außen sichtbar. Jedoch können die Blistezverpackungen den Inhalt bzw. die aufgenommene Flüssigkeit auch lichtdicht oder blickdicht abdecken oder umhüllen.The filling of one or more cavities with substances, solid bodies or even liquids is known, for example, from the field of so-called visual packaging or blister packs. Blister packs are used in various industries and industries and are equipped with at least one cavity into which the content to be filled is received. As a rule, the content in the cavity is visible from the outside. However, the Blistezverpackungen the contents or the liquid absorbed can also cover or envelop light-tight or opaque.

Eine typische Blisterverpackung weist üblicherweise zwei Folien auf, die ihrerseits aus mehreren Schichten verschiedener oder gleicher Materialien aufgebaut sein können. Die Folien sind in der Regel aus Kunststoff und/oder Metall, z.B. Aluminium, hergestellt, wobei andere Materialien, wie Papier oder dergleichen, grundsätzlich auch oder zusätzlich verwendet werden können. Bei den beiden Folien handelt es sich insbesondere um eine Bodenschicht bzw. Bodenfolie (Träger) und um eine Deckschicht oder Deckfolie (Deckel).A typical blister pack usually has two foils, which in turn may be constructed of several layers of different or the same materials. The films are usually made of plastic and / or metal, e.g. Aluminum, wherein other materials, such as paper or the like, in principle or additionally can be used. The two films are, in particular, a bottom layer or base film (carrier) and a cover layer or cover film (cover).

In der Bodenfolie bzw. im Träger können eine oder mehrere Wannen bzw. Vertiefungen zur Aufnahme der Flüssigkeit gebildet sein, in die die Flüssigkeit, insbesondere eine pharmazeutische Formulierung, eingefüllt wird. Die Deckfolie bzw. der Deckel wird dann auf die Bodenfolie bzw. den Träger auf gelegt und daran fixiert bzw. damit verbunden, wobei dies beispielsweise an den Randstellen oder in einem Verbindungsbereich, insbesondere in flach aufeinander liegenden Flächenbereichen, vorzugsweise durch Kleben, Heißsiegeln, Verschweißen oder dergleichen erfolgt.In the bottom foil or in the support, one or more troughs or depressions for receiving the liquid may be formed, into which the liquid, in particular a pharmaceutical formulation is filled. The cover film or the cover is then placed on the base film or the carrier and fixed thereto or connected thereto, for example, at the edge locations or in a connection region, in particular flat surface areas, preferably by gluing, heat sealing, welding or the like takes place.

Die DE 103 43 668 A1 offenbart eine besonders dichte Blisterverpackung für Arzneimittel, wobei auf das Öffnen der Blisterverpackung nicht näher eingegangen wird.The DE 103 43 668 A1 discloses a particularly dense blister packaging for drugs, wherein the opening of the blister pack is not discussed in more detail.

Die DE 20 2007 003 050 U1 offenbart eine Blisterverpackung für einen flüssigen Wirkstoff. Hier soll der Wirkstoff durch Diffusion an die Umgebung abgegeben werden. Dies soll jedoch gerade bei den Verpackungen gemäß der vorliegenden Erfindung verhindert werden.The DE 20 2007 003 050 U1 discloses a blister pack for a liquid drug. Here, the active ingredient should be released by diffusion to the environment. However, this should be prevented just in the packaging according to the present invention.

Die DE 299 07 740 U1 offenbart eine Blisterverpackung mit mehreren Kammern, wobei durch Krafteinwirkung eine Abtrennung, insbesondere Trennfolie zwischen den Kammern geöffnet wird.The DE 299 07 740 U1 discloses a blister pack with a plurality of chambers, wherein a separation, in particular release film between the chambers is opened by the action of force.

Die EP 1 710 169 A1 beschreibt eine Blisterverpackung mit einem integrierten Anstechelement in einer Kappe eines Lebensmittelbehälters. Durch anstechen eines Trennelements kann der Blister geöffnet werden und seinen Inhalt in den Behälter abgeben.The EP 1 710 169 A1 describes a blister pack with an integrated piercing element in a cap of a food container. By piercing a separator, the blister can be opened and deliver its contents into the container.

Die FR 2 290 366 offenbart einen Flacon mit zwei Kammern, die durch eine Trennfolie verbunden sind. Durch eindrücken der Folie könne die Inhalte der Kammern einander zugeführt werden.The FR 2 290 366 discloses a bottle with two chambers connected by a release film. By pressing the film, the contents of the chambers can be supplied to each other.

Die US2007/0246395 A1 beschreibt eine Blisteranordnung zur Aufnahme eines Arzneimittels, wobei durch Drücken eines integrierten Anstechelementes der Blisterinhalt zugänglich gemacht wird.The US2007 / 0246395 A1 describes a blister assembly for receiving a drug, wherein the blister contents are made accessible by pressing an integrated piercing element.

Die WO 2009/152952 A1 beschreibt ein Verfahren nach dem Oberbegriff des Anspruchs 1. Die vorliegende Erfindung befasst sich insbesondere mit dem Befüllen einer fluidischen Anordnung aus einer Blisterverpackung, die auf der fluidischen Anordnung, vorzugsweise einer medizinischen Cartridge (beispielsweise einem sogenannten Biosensor), angebracht wird, wobei die in die Kavität der Blisterverpackung gefüllte, insbesondere mit einem Reagenz oder mehreren Reagenzien versehene Flüssigkeit eine gewisse Nachweisreaktion in der Anordnung auslösen oder ermöglichen soll. Das Öffnen der Kavität soll bei Bedarf einfach und/oder definiert erfolgen können.The WO 2009/152952 A1 describes a method according to the preamble of claim 1. The present invention is particularly concerned with the filling of a fluidic assembly of a blister pack, which on the fluidic assembly, preferably a medical cartridge (for example, a so-called biosensor) is attached, wherein the filled in the cavity of the blister, in particular provided with a reagent or a plurality of reagents liquid to trigger or allow a certain detection reaction in the arrangement. The opening of the cavity should be easy and / or defined if necessary.

Der vorliegenden Erfindung liegt die Aufgabe zugrunde, ein Verfahren zum Zuführen von Flüssigkeit zu der fluidischen Anordnung anzugeben, wobei ein einfaches und/oder definiertes Öffnen der Verpackung bzw. Kavität ermöglicht oder erleichtert wird.The present invention has for its object to provide a method for supplying liquid to the fluidic device, wherein a simple and / or defined opening of the package or cavity is made possible or facilitated.

Die obige Aufgabe wird durch ein Verfahren gemäß Anspruch 1 gelöst.The above object is achieved by a method according to claim 1.

Vorschlagsgemäß weist die Verpackung eine in die Verpackung integrierte Öffnungseinrichtung zum Öffnen der Kavität oder insbesondere eines Deckels der Verpackung auf. Die Öffnungseinrichtung ist insbesondere in oder von einem Träger der Verpackung gebildet. Dies gestattet eine einfache und/oder kostengünstige Realisierung sowie ein einfaches und/oder definiertes Öffnen der Verpackung bzw. der mit der Flüssigkeit gefüllten Kavität.According to the proposal, the packaging has an opening device integrated into the packaging for opening the cavity or, in particular, a lid of the packaging. The opening device is in particular formed in or by a carrier of the packaging. This allows a simple and / or cost-effective implementation as well as a simple and / or defined opening of the packaging or the cavity filled with the liquid.

Vorschlagsgemäß wird die Verpackung bzw. eine Blisterverpackung mit einer integrierten Öffnungseinrichtung im vorgenannten Sinne als Reservoir für eine Flüssigkeit, insbesondere für eine Untersuchungsflüssigkeit, eine Waschflüssigkeit, eine Reaktionsflüssigkeit, ein Lösungsmittel oder dergleichen, verwendet, wobei die Verpackung oder Kavität an eine fluidische Anordnung. zur Aufnahme der Flüssigkeit nach Öffnen der Verpackung bzw. Kavität angeschlossen wird. Dies gestattet eine sehr einfache und kostengünstige Versorgung der fluidischen Anordnung mit der Flüssigkeit. Bei der fluidischen Anordnung handelt es sich insbesondere um eine mikrofluidische Untersuchungseinrichtung, beispielsweise zum Bestimmen mindestens eines Analyten in einer biologischen Probe, wie Blut oder Blutbestandteilen.According to the proposal, the packaging or a blister pack with an integrated opening device in the aforementioned sense as a reservoir for a liquid, in particular for a test liquid, a washing liquid, a reaction liquid, a solvent or the like, is used, wherein the packaging or cavity to a fluidic arrangement. is connected to receive the liquid after opening the package or cavity. This allows a very simple and inexpensive supply of the fluidic arrangement with the liquid. In particular, the fluidic arrangement is a microfluidic examination device, for example for determining at least one analyte in a biological sample, such as blood or blood components.

Vorschlagsgemäß erfolgt das Zuführen von Flüssigkeit aus der Verpackung zu einer insbesondere im vorgenannten Sinne ausgebildeten fluidischen Anordnun dadurch, dass die Verpackung zumindest partiell - verformt wird, um die Öffnungseinrichtung zu betätigen und dadurch die Verpackung bzw. Kavität zu öffnen. Weiter kann die Verpackung bzw. Kavität (zusätzlich und/oder in einem zweiten Schritt) verformt werden, um Flüssigkeit aus der Verpackung zu verdrängen und/oder der fluidischen Anordnung - insbesondere unter Druck - zuzuleiten. So wird ein sehr einfaches und/oder definiertes Öffnen ermöglicht, wobei das Öffnen insbesondere auch automatisiert und/oder mittels eines Stempels oder sonstigen Werkzeugs erfolgen kann, der bzw. das die Verpackung zum Öffnen verformt.According to the proposal, the supply of liquid from the packaging to a fluidic arrangement formed in particular in the aforementioned sense takes place in that the packaging is at least partially deformed in order to actuate the opening device and thereby open the packaging or cavity. Furthermore, the packaging or cavity (additionally and / or in a second step) can be deformed in order to displace liquid from the packaging and / or to supply it to the fluidic arrangement, in particular under pressure. In this way, a very simple and / or defined opening is made possible, wherein the opening can in particular also be automated and / or by means of a stamp or other tool which deforms the packaging for opening.

Weitere Vorteile, Merkmale, Eigenschaften und Aspekte der vorliegenden Erfindung ergeben sich aus dem Anspruch und der folgenden Beschreibung einer bevorzugten Ausführungsform anhand der Zeichnung. Es zeigt:

Fig. 1
einen schematischen Schnitt einer vorschlagsgemäßen Verpackung; und
Fig. 2
einen schematischen Schnitt der Verpackung mit einer zugeordneten fluidischen Anordnung.
Further advantages, features, characteristics and aspects of the present invention will become apparent from the claim and the following description of a preferred embodiment with reference to the drawing. It shows:
Fig. 1
a schematic section of a proposed packaging; and
Fig. 2
a schematic section of the packaging with an associated fluidic arrangement.

In den Figuren werden für gleiche oder ähnliche Teile dieselben Bezugszeichen verwendet, wobei entsprechende oder vergleichbare Eigenschaften und Vorteile erreicht werden, auch wenn eine wiederholte Beschreibung weggelassen ist.In the figures, the same reference numerals are used for the same or similar parts, and corresponding or comparable properties and advantages are achieved, even if a repeated description is omitted.

Fig. 1 zeigt in einem schematischen Schnitt eine vorschlagsgemäße Verpackung 1 mit mindestens einer Kavität 2 zur Aufnahme einer Flüssigkeit 3. Fig. 1 shows in a schematic section a proposed package 1 with at least one cavity 2 for receiving a liquid. 3

Die Verpackung 1 verschließt die Flüssigkeit 3 vorzugsweise zumindest im Wesentlichen flüssigkeitsdicht und/oder gasdicht.The packaging 1 preferably closes the liquid 3 at least substantially liquid-tight and / or gas-tight.

Die Verpackung 1 ist insbesondere als Blisterverpackung ausgebildet. Die Kavität 2 ist insbesondere durch einen Blister der Verpackung 1 bzw. Blisterverpackung gebildet.The packaging 1 is designed in particular as a blister pack. The cavity 2 is formed in particular by a blister of the packaging 1 or blister pack.

Bei der Flüssigkeit 3 handelt es sich insbesondere um eine Untersuchungsflüssigkeit, eine Waschflüssigkeit, eine Reaktionsflüssigkeit, ein Lösungsmittel oder dergleichen, besonders bevorzugt zum Einsatz in einen mikrofluidischen System zur Bestimmung eines Analyten oder Werts und/oder zur Untersuchung, insbesondere einer vorzugsweise biologischen Probe oder dergleichen.The liquid 3 is, in particular, an examination liquid, a washing liquid, a reaction liquid, a solvent or the like, particularly preferably for use in a microfluidic system for determining an analyte or value and / or for examination, in particular a preferably biological sample or the like ,

Die Verpackung 1 weist einen Träger 4 und einen zugeordneten Deckel 5 auf.The packaging 1 has a carrier 4 and an associated lid 5.

Bei dem Träger 4 handelt es sich insbesondere um ein zumindest im Wesentlichen flaches bzw. flächiges oder ebenes Element und/oder Flächenmaterial und/oder um eine Bodenschicht bzw. Bodenfolie oder dergleichen.In particular, the support 4 is an at least substantially flat or planar or planar element and / or surface material and / or a bottom layer or bottom foil or the like.

Der Träger 4 kann relativ steif oder auch flexibel und/oder zumindest bereichsweise verformbar ausgebildet sein. Vorzugsweise weist der Träger 4 eine relativ große Steifigkeit oder Festigkeit in seiner Haupterstreckungsrichtung bzw. -ebene auf.The carrier 4 may be formed relatively rigid or flexible and / or at least partially deformable. Preferably, the carrier 4 has a relatively high rigidity or strength in its main direction of extension or plane.

Beim Darstellungsbeispiel ist der Träger 4 vorzugsweise steifer oder starrer als der Deckel 5 ausgebildet und/oder ausreichend steif, um die Formgebung der Verpackung 1 zumindest maßgeblich oder primär zu bestimmen.In the illustrated embodiment, the carrier 4 is preferably stiffer or more rigid than the lid 5 and / or sufficiently rigid to at least significantly or primarily determine the shape of the package 1.

Bei dem Deckel 5 handelt es sich vorzugsweise um ein zumindest im Wesentlichen flaches oder ebenes und/oder glattes Element bzw. Flächenmaterial und/oder um eine Deckschicht bzw. Deckfolie, besonders bevorzugt zur flächigen Abdeckung des zugeordneten Trägers 4.The cover 5 is preferably an at least substantially flat or planar and / or smooth element or surface material and / or a cover layer or covering film, particularly preferably for the planar covering of the associated support 4.

Vorzugsweise ist bzw. sind der Träger 4 und/oder der Deckel 5 als Folie ausgebildet und/oder aus Folie, Kunststoff, Metall und/oder einem insbesondere Kunststoff und/oder Metall enthaltenden Verbundmaterial hergestellt.Preferably, the carrier 4 and / or the lid 5 is formed as a film and / or made of film, plastic, metal and / or a particular plastic and / or metal-containing composite material.

Der Träger 4 und der Deckel 5 können grundsätzlich aus dem gleichen Material hergestellt sein. Beim Darstellungsbeispiel sind der Träger 4 und der Deckel 5 jedoch vorzugsweise aus unterschiedlichen Materialien hergestellt.The carrier 4 and the cover 5 can in principle be made of the same material. However, in the illustrated example, the carrier 4 and the lid 5 are preferably made of different materials.

Der Deckel 5 ist vorzugsweise flexibel und/oder verformbar ausgebildet und insbesondere öffenbar, beispielsweise durch Aufreißen, Eindrücken, Anstechen oder dergleichen, besonders bevorzugt zur Entnahme oder Abgabe der Flüssigkeit 3. Alternativ oder zusätzlich kann der Träger 4 in entsprechender Weise öffenbar sein.The lid 5 is preferably designed to be flexible and / or deformable and in particular openable, for example by tearing, pressing, piercing or the like, particularly preferably for removal or dispensing of the liquid 3. Alternatively or additionally, the carrier 4 can be opened in a corresponding manner.

Mindestens eine Kavität 2 zur Aufnahme der Flüssigkeit 3 ist zwischen dem Träger 4 und dem Deckel 5 gebildet. Besonders bevorzugt sind eine Vielzahl von Kavitäten 2 gebildet.At least one cavity 2 for receiving the liquid 3 is formed between the carrier 4 and the cover 5. Particularly preferably, a plurality of cavities 2 are formed.

Insbesondere kann es sich bei der Verpackung 1 bzw. dem Träger 4 und/oder Deckel 5 um besonders bevorzugt streifenartiges Endlosmaterial oder dergleichen handeln. Das Endlosmaterial kann dann in einzelne Verpackungen 1 mit jeweils mindestens einer Kavität 2 zur Aufnahme der Flüssigkeit 3 vor oder bevorzugt nach dem Einfüllen der Flüssigkeit 3, unterteilt oder getrennt werden, je nach Bedarf. Nachfolgend wird immer nur auf den bevorzugten Aufbau einer Kavität 2 näher eingegangen, auch wenn das Endlosmaterial bzw. die Verpackung 1 mehrere derartige Kavitäten 2, ggf. auch in unterschiedlichen Größen und/oder mit unterschiedlichen Flüssigkeiten 3, aufweisen kann.In particular, the packaging 1 or the carrier 4 and / or lid 5 may be particularly preferably strip-like endless material or the like. The endless material can then in individual packaging 1 with each at least one cavity 2 for receiving the liquid 3 before or preferably after the filling of the liquid 3, divided or separated, as needed. In the following, only the preferred structure of a cavity 2 will be discussed in more detail, even if the endless material or the packaging 1 may have a plurality of such cavities 2, possibly also in different sizes and / or with different liquids 3.

Zur Bildung der Kavität 2 ist vorzugsweise eine Vertiefung oder Auswölbung im Träger 4 und/oder Deckel 5, beim Darstellungsbeispiel bevorzugt nur im Träger 4, gebildet, wie in Fig. 1 angedeutet. Die Vertiefung bzw. Auswölbung ist insbesondere wannenartig ausgebildet. Die Vertiefung bzw. Kavität 2 ist insbesondere durch Thermoformen und/oder Tiefziehen, hier des Trägers 4, hergestellt.To form the cavity 2, a recess or bulge in the carrier 4 and / or lid 5 is preferably formed, in the illustrated embodiment, preferably only in the carrier 4, as in FIG Fig. 1 indicated. The recess or bulge is formed in particular trough-like. The depression or cavity 2 is produced in particular by thermoforming and / or deep-drawing, in this case the carrier 4.

Nach dem Einfüllen der Flüssigkeit 3 in die Vertiefung bzw. Auswölbung bzw. Kavität 2 - beim Darstellungsbeispiel im Träger 4 - wird die Verpackung 1 bzw. Kavität 2 geschlossen bzw. verschlossen. Hierzu wird der Deckel 5 aufgelegt und mit dem Träger 4 in einem Verbindungsbereich 6 zumindest bereichsweise verbunden. Der Verbindungsbereich 6 ist insbesondere im Bereich von flach aufeinanderliegenden Flächenbereichen des Trägers 4 und Deckels 5 gebildet. Der Verbindungsbereich 6 schließt sich insbesondere seitlich und/oder umlaufend an die Kavität 2 an. Beispielsweise kann der Verbindungsbereich die Kavität 2 ringartig umgeben.After filling the liquid 3 in the recess or bulge or cavity 2 - in the representation example in the carrier 4 - the package 1 or cavity 2 is closed or closed. For this purpose, the cover 5 is placed and at least partially connected to the carrier 4 in a connecting region 6. The connecting region 6 is formed in particular in the region of flat surface areas of the carrier 4 and cover 5. The connecting region 6 adjoins the cavity 2 in particular laterally and / or circumferentially. For example, the connection region may surround the cavity 2 in an annular manner.

Der Verbindungsbereich 6 bzw. bei mehreren Kavitäten 2 mehrere Verbindungsbereiche 6 liegen vorzugsweise in einer Ebene E und/oder Haupterstreckungsebene E und/oder auf einer Flachseite der Verpackung 1, des Trägers 4 und/oder Deckels 5. Insbesondere umgibt der Verbindungsbereich 6 die jeweilige Kavität 2 umlaufend und/oder ringartig.The connection region 6 or, in the case of several cavities 2, a plurality of connection regions 6 are preferably located in a plane E and / or main extension plane E and / or on a flat side of the packaging 1, the carrier 4 and / or cover 5. In particular, the connection region 6 surrounds the respective cavity 2 circumferential and / or ring-like.

Das Verbinden von Träger 4 und Deckel 5 erfolgt vorzugsweise durch Heißsiegeln, Schweißen, Kleben und/oder auf sonstige geeignete Art und Weise.The bonding of carrier 4 and lid 5 is preferably carried out by heat sealing, welding, gluing and / or in any other suitable manner.

Der Träger 4 und der Deckel 5 sind im Verbindungsbereich 6 zumindest im Wesentlichen flüssigkeitsdicht, insbesondere zumindest weitestgehend gasdicht, vollflächig, ringartig und/oder umlaufend miteinander verbunden oder verbindbar.The carrier 4 and the cover 5 are at least substantially liquid-tight in the connection region 6, in particular at least as far as possible gas-tight, full-surface, ring-like and / or circumferentially connected or connectable.

Fig. 1 zeigt die vorschlagsgemäße Verpackung 1 im gefüllten Zustand. Die Kavität 2 (der Blister) ist mit Flüssigkeit 3 gefüllt und verschlossen. Fig. 1 shows the proposed package 1 in the filled state. The cavity 2 (the blister) is filled with liquid 3 and sealed.

Die Verpackung 1 weist vorschlagsgemäß eine darin integrierte Öffnungseinrichtung 7 zum Öffnen der Verpackung 1 bzw. Kavität 2 oder des Deckels 5 auf. Die Öffnungseinrichtung 7 ist vorzugsweise einstückig mit der Verpackung 1 oder dem Träger 4 ausgebildet und/oder im oder vom Träger 4 gebildet, wie in Fig. 1 beispielhaft angedeutet.According to the proposal, the packaging 1 has an opening device 7 integrated therein for opening the packaging 1 or cavity 2 or the lid 5. The opening device 7 is preferably formed integrally with the package 1 or the carrier 4 and / or formed in or from the carrier 4, as in Fig. 1 indicated by way of example.

Die Öffnungseinrichtung 7 weist vorzugsweise einen in die Kavität 2 oder zum Deckel 5 hin vorspringenden Abschnitt 8 auf oder ist davon gebildet.The opening device 7 preferably has a section 8 projecting into the cavity 2 or the cover 5 or is formed therefrom.

Besonders bevorzugt ist die Öffnungseinrichtung 7 bzw. der Abschnitt 8 durch Thermoformen oder Tiefziehen des Trägers 4 bzw. des den Träger 4 bildenden Materials hergestellt. Alternativ oder zusätzlich kann die Öffnungseinrichtung 7 oder der Vorsprung 8 auch durch ein zusätzliches, insbesondere fest mit dem Träger 4 verbundenes Element, Materialstück oder dergleichen und/oder durch eine Verdickung gebildet sein. Insbesondere kann die Öffnungseinrichtung 7 bzw. der Abschnitt 8 auch gegenüber sonstigen Abschnitten oder Bereichen des Trägers 4 verstärkt sein, beispielsweise durch eine nicht dargestellte Verstärkungsstruktur, wie Rippen oder dergleichen, und/oder durch eine Materialverdickung, durch eine Materialverstärkung, durch eine Einlage, durch eine zusätzliche Schicht und/oder durch zusätzliches oder anderes oder modifiziertes Material oder dergleichen.The opening device 7 or the section 8 is particularly preferably produced by thermoforming or deep drawing of the carrier 4 or of the material forming the carrier 4. Alternatively or additionally, the opening device 7 or the projection 8 may also be formed by an additional, in particular fixedly connected to the carrier 4 element, piece of material or the like and / or by a thickening. In particular, the opening device 7 or the section 8 can also be reinforced with respect to other sections or areas of the carrier 4, for example by a reinforcing structure, not shown, such as ribs or the like, and / or by a material thickening, by a material reinforcement, by an insert an additional layer and / or by additional or different or modified material or the like.

Der Abschnitt 8 oder dessen Endbereich bzw. freies Ende ist besonders bevorzugt kegelartig und/oder spitz ausgebildet und/oder zu dem Deckel 4 bzw. der Haupterstreckungsebene E hin gerichtet.The section 8 or its end or free end is particularly preferably conical and / or pointed and / or directed towards the cover 4 and the main extension plane E out.

Beim Darstellungsbeispiel ist die Öffnungseinrichtung 7 vorzugsweise etwas beabstandet von der eigentlichen Kavität 2 angeordnet oder gebildet, insbesondere in einem sich an die Kavität 2 besonders bevorzugt seitlich anschließenden Kanal 9 oder dergleichen. Der Kanal 9 ist insbesondere von der Verpackung 1 ebenfalls gebildet, besonders bevorzugt durch eine entsprechende Vertiefung oder Auswölbung des Trägers 4. Der Kanal 9 steht vorzugsweise direkt fluidisch mit der Kavität 2 auch bei geschlossener Verpackung 1 bzw. geschlossenem Deckel 5 in fluidischer Verbindung. Besonders bevorzugt ist die Öffnungseinrichtung 7 beim Darstellungsbeispiel im Bereich eines Endes des Kanals 9 gebildet.In the illustrated example, the opening device 7 is preferably arranged or formed somewhat spaced from the actual cavity 2, in particular in a channel 9, which is particularly preferably laterally adjoining the cavity 2, or the like. The channel 9 is in particular of the packaging 1 also formed, particularly preferably by a corresponding recess or bulge of the carrier 4. The channel 9 is preferably fluidly connected to the cavity 2 even with the package 1 or closed lid 5 in fluid communication. Particularly preferably, the opening device 7 is formed in the representation example in the region of one end of the channel 9.

Vorzugsweise ist die von dem Deckel 5 beabstandete Kanalwandung oder ein sonstiger zum Deckel 5 beabstandeter Wandungsabschnitt des Trägers 4 bzw. Kanal 9 mit der Öffnungseinrichtung 7 bzw. dem vorspringenden Abschnitt 8 versehen. Jedoch sind auch andere konstruktive Lösungen oder Anordnungen möglich.Preferably, the channel wall spaced from the lid 5 or any other wall portion of the carrier 4 or channel 9 spaced from the lid 5 is provided with the opening device 7 or the projecting section 8. However, other constructive solutions or arrangements are possible.

Die Verpackung 1 bzw. Öffnungseinrichtung 7 ist vorzugsweise derart ausgebildet, dass durch zumindest bereichsweises Verformen oder Niederdrücken, insbesondere des Trägers 4 oder Deckels 5, hier des Trägers 4 bzw. der Wandung des Kanals 9 bzw. des vorspringenden Abschnitts 8, insbesondere in einem vorbestimmten Bereich oder benachbart zu der Öffnungseinrichtung 7, die Verpackung 1 geöffnet wird. Insbesondere bewirkt ein Niederdrücken, dass die Öffnungseinrichtung 7 bzw. der vorspringende Abschnitt 8 den Deckel 5 öffnet, insbesondere durch Aufreißen, Aufschneiden, Anstechen oder dergleichen. Das Öffnen des Deckels 5 erfolgt insbesondere in einem Bereich, der der Öffnungseinrichtung 7 bzw. dem vorspringenden Abschnitt 8 unmittelbar benachbart ist bzw. gegenüberliegt.The packaging 1 or opening device 7 is preferably designed such that by at least regional deformation or depression, in particular of the carrier 4 or lid 5, here the carrier 4 or the wall of the channel 9 and the projecting portion 8, in particular in a predetermined Area or adjacent to the opening device 7, the package 1 is opened. In particular, a depression causes the opening device 7 or the protruding section 8 to open the cover 5, in particular by tearing open, cutting open, piercing or the like. The lid 5 is opened in particular in a region which is immediately adjacent or opposite the opening device 7 or the projecting section 8.

Zur Erleichterung des Öffnens kann der Deckel 5 in dem Öffnungsbereich mit mindestens einer "Sollbruchstelle", beispielsweise durch entsprechende Materialschwächung oder dergleichen, versehen sein.To facilitate opening, the cover 5 may be provided in the opening region with at least one "predetermined breaking point", for example by corresponding weakening of the material or the like.

Alternativ oder zusätzlich kann zur Erleichterung des Öffnens der Träger 4 im Bereich der Öffnungseinrichtung 7, insbesondere um den vorspringenden Abschnitt 8 herum, besonders leicht bzw. mit verhältnismäßig geringer oder geringerer Kraft verformbar ausgebildet sein. Dies kann beispielsweise durch entsprechende Materialschwächung und/oder Formgebung des Trägers 4 in diesem Bereich erreicht werden. Als eine solche Formgebung kommt beispielsweise eine Ausbildung einer entsprechenden nachgiebigen Welle um den vorspringenden Abschnitt 8 herum oder dergleichen in Betracht.Alternatively or additionally, to facilitate the opening of the carrier 4 in the region of the opening means 7, in particular around the projecting portion 8 around, particularly easily or with relatively less or less force be formed deformable. This can be achieved for example by appropriate weakening and / or shaping of the carrier 4 in this area. As such a shaping comes for example a formation of a corresponding resilient wave around the projecting portion 8 or the like into consideration.

Vorzugsweise weist die Verpackung 1 bzw. die Öffnungseinrichtung 8 einen Verformungsbereich auf, der hier insbesondere durch eine wellenartige Struktur 10 gebildet ist, die ein besonders leichtes Verformen der Verpackung 1 bzw. hier des Trägers 4 zur leichten Verformung bzw. Betätigung der Öffnungseinrichtung 7 ermöglicht, insbesondere um den vorspringenden Abschnitt 8 zum Öffnen der Verpackung 1 relativ leicht gegen den Deckel 5 drücken zu können.Preferably, the packaging 1 or the opening device 8 has a deformation region, which here is formed in particular by a wave-like structure 10, which allows a particularly slight deformation of the packaging 1 or here of the carrier 4 for easy deformation or actuation of the opening device 7, in particular, in order to be able to press the protruding section 8 for opening the packaging 1 relatively easily against the lid 5.

Fig. 2 zeigt in einem schematischen, nicht maßstabsgetreuen Schnitt die vorschlagsgemäße Verpackung 1 mit einer zugeordneten fluidischen Anordnung 11. Insbesondere ist die Verpackung 1 fest oder unlösbar mit der fluidischen Anordnung 11 verbunden. Insbesondere ist die Verpackung 1 flüssigkeitsdicht und/oder gasdicht an die fluidische Anordnung 11 angeschlossen oder anschliessbar, so dass Flüssigkeit 3 aus der Kavität 2 der fluidischen Anordnung 11 - besonders bevorzugt nach Öffnen der Verpackung 1 bzw. Kavität 2 - zuführbar ist. Fig. 2 shows in a schematic, not true to scale section the proposed package 1 with an associated fluidic assembly 11. In particular, the package 1 is permanently or permanently connected to the fluidic device 11. In particular, the package 1 is liquid-tight and / or gas-tight connected to the fluidic device 11 or connectable, so that liquid 3 from the cavity 2 of the fluidic assembly 11 - particularly preferably after opening the package 1 or cavity 2 - can be fed.

Beim Darstellungsbeispiel ist die Verpackung 1 insbesondere mit ihrer Flachseite oder dem Deckel 5 an der fluidischen Anordnung 10 angebracht bzw. befestigt, beispielsweise durch Kleben, Heißsiegeln, Schweißen oder dergleichen. Beim dem Darstellungsbeispiel gemäß Fig. 2 ist schematisch angedeutet, dass die verschlossene Verpackung 1 bzw. Kavität 2 auf einem Trägerteil 12 der fluidischen Anordnung 11 insbesondere mittels einer Siegel- oder Klebschicht 13, beispielsweise Doppelklebeband, befestigt ist. Jedoch ist auch eine sonstige Verbindung und/oder sind andere konstruktive Lösungen möglich.In the illustrated example, the packaging 1 is attached or fastened, in particular with its flat side or the cover 5, to the fluidic arrangement 10, for example by gluing, heat-sealing, welding or the like. In the illustration example according to Fig. 2 is schematically indicated that the sealed package 1 or cavity 2 on a support member 12 of the fluidic device 11 in particular by means of a sealing or adhesive layer 13, for example, double-sided adhesive tape is attached. However, another connection and / or other constructive solutions is possible.

Die Verpackung 1 bzw. Kavität 2 ist vorzugsweise derart angeordnet, dass sie mit ihrem Öffnungsbereich, also dem Bereich, der durch die Öffnungseinrichtung 7 öffenbar ist, einen Abfluss 14 der fluidischen Anordnung 11 zumindest teilweise überdeckt, insbesondere darüber angeordnet ist. Der Abfluss 14 ist beispielsweise durch eine Vertiefung, einen Kanal oder dergleichen, insbesondere in dem Trägerteil 12, gebildet. An den Abfluss 14 kann sich ein Kanal 15 oder eine sonstige, insbesondere mikrofluidische Struktur der fluidischen Anordnung 11 anschließen. Besonders bevorzugt bilden der Abfluss 14 und/oder Kanal 15 einen Teil einer mikrofluidischen Struktur der fluidischen Anordnung 11. Unter "mikrofluidisch" sind hier Volumina von vorzugsweise weniger als 1 ml zu verstehen.The packaging 1 or cavity 2 is preferably arranged such that it covers at least partially with its opening region, ie the region which can be opened by the opening device 7, an outflow 14 of the fluidic device 11, in particular above it. The drain 14 is formed for example by a depression, a channel or the like, in particular in the support part 12. At the outlet 14 may be a channel 15 or another, in particular microfluidic structure of the fluidic device 11 connect. Particularly preferably, the outflow 14 and / or channel 15 form part of a microfluidic structure of the fluidic arrangement 11. "Microfluidic" is to be understood here as meaning volumes of preferably less than 1 ml.

Die fluidische Anordnung 11 bzw. mikrofluidische Struktur kann weiter einen nicht dargestellten Untersuchungsbereich oder dergleichen, beispielsweise für eine biologische Probe, wie Blut, Bestandteile von Blut oder dergleichen, aufweisen.The fluidic device 11 or microfluidic structure may further comprise an examination region or the like (not shown), for example for a biological sample such as blood, constituents of blood or the like.

Beim Darstellungsbeispiel wird die Kavität 2 bzw. der davon gebildete Blister der Verpackung 1 bzw. Blisterverpackung vorzugsweise als Reservoir für die Flüssigkeit 3 verwendet, wobei die Verpackung 1 bzw. Kavität 2 an die fluidische Anordnung 11 zur Aufnahme der Flüssigkeit 3 nach Öffnen der Verpackung 1 bzw. Kavität 2 angeschlossen ist. Grundsätzlich kann die vorschlagsgemäße Verpackung 1 jedoch auch für sonstige Zwecke verwendet werden.In the illustrated embodiment, the cavity 2 or the blister of the packaging 1 or blister pack formed therefrom is preferably used as a reservoir for the liquid 3, wherein the packaging 1 or cavity 2 to the fluidic assembly 11 for receiving the liquid 3 after opening the package. 1 or cavity 2 is connected. In principle, however, the proposed packaging 1 can also be used for other purposes.

Zum Öffnen der Kavität 2 bzw. zur Abgabe von Flüssigkeit 3 wird die Verpackung 1 mittels der Öffnungseinrichtung 7 geöffnet, insbesondere durch Betätigen der Öffnungseinrichtung 7.To open the cavity 2 or to dispense liquid 3, the packaging 1 is opened by means of the opening device 7, in particular by actuation of the opening device 7.

Zum Öffnen der Kavität 2 bzw. des Deckels 5 bzw. zum Betätigen der Öffnungseinrichtung 7 wird die Verpackung 1 bzw. der Träger 4, beim Darstellungsbeispiel besonders bevorzugt im Bereich des Kanals 9 bzw. der Öffnungseinrichtung 7, verformt, so dass die Öffnungseinrichtung 7 bzw. der vorspringende Abschnitt 8 insbesondere den Deckel 5 öffnet, insbesondere zerreißt, ansticht, zerschneidet oder dergleichen. Dieses - vorzugsweise nur partielle - Verformen der Verpackung 1 bzw. des Trägers 4 erfolgt vorzugsweise mittels eines Werkzeugs, wie einem in Fig. 2 angedeuteten Stempel 16, oder dergleichen.In order to open the cavity 2 or the cover 5 or to actuate the opening device 7, the packaging 1 or the support 4 is particularly preferably deformed in the region of the channel 9 or the opening device 7, so that the opening device 7 resp the projecting portion 8 in particular opens the lid 5, in particular tears, pierces, cuts or the like. This - preferably only partial - deformation of the package 1 and the carrier 4 is preferably carried out by means of a tool, such as a in Fig. 2 indicated stamp 16, or the like.

Zum Öffnen des Deckels 5 bzw. der Deckfolie wird diese von der Öffnungseinrichtung 7 bzw. von dem Abschnitt 8 beispielsweise in eine darunter angeordnete Vertiefung, wie den Abfluss 14, gedrückt und dadurch lokal verformt und überbeansprucht, bis der Deckel 5 bzw. die Deckfolie in diesem Bereich reißt und dadurch die Kavität 2 - hier über den Kanal 9 - zur fluidischen Anordnung 11 hin öffnet.To open the cover 5 or the cover film, this is pressed by the opening device 7 or 8 of the section, for example, in a depression arranged below, such as the drain 14 and thereby locally deformed and overstressed until the lid 5 and the cover sheet in this area ruptures and thereby the cavity 2 - here via the channel 9 - opens to the fluidic assembly 11 out.

Nach dem Öffnen der Verpackung 1 bzw. des Deckels 5 kann die Flüssigkeit 3 aus der Kavität 2 in die fluidische Anordnung 11 bzw. den Abfluss 14 bzw. das mikrofluidische System der Anordnung 11 strömen. Dieses Ausströmen der Flüssigkeit 3 kann durch die Gravitationskraft, Kapillarkräfte, eine Saugkraft, Druckkraft, Unterdruck, Überdruck oder dergleichen, bewirkt oder unterstützt werden.After opening the package 1 or the lid 5, the liquid 3 can flow out of the cavity 2 into the fluidic arrangement 11 or the outflow 14 or the microfluidic system of the arrangement 11. This leakage of the liquid 3 can be effected or promoted by gravitational force, capillary forces, suction force, pressing force, negative pressure, overpressure or the like.

Beim Darstellungsbeispiel erfolgt vorzugsweise zusätzlich ein Verformen der Kavität 2 nach dem Öffnen der Verpackung 1 bzw. des Deckels 5, insbesondere in einem zweiten Schritt, um die Flüssigkeit 3 vorzugsweise unter Druck zu setzen und/oder aus der Verpackung 1 bzw. Kavität 2 zu verdrängen und der fluidischen Anordnung 11 zuzuleiten. Dieses Verformen der Kavität 2 kann beispielsweise durch ein Werkzeug, wie den angedeuteten Stempel 17, oder auf sonstige geeignete Art und Weise, ggf. auch durch manuelles Verformen mit einem Finger oder dergleichen, erfolgen.In the illustrated embodiment, the cavity 2 is preferably additionally deformed after opening the package 1 or the lid 5, in particular in a second step, in order to pressurize the liquid 3 and / or to force it out of the package 1 or cavity 2 and the fluidic assembly 11 zuzuleiten. This deformation of the cavity 2 can be done, for example, by a tool, such as the indicated punch 17, or in any other suitable manner, if appropriate also by manual deformation with a finger or the like.

Das Öffnen der Verpackung 1 bzw. Betätigen der Öffnungseinrichtung 7 bzw. des hierzu erforderlichen (partiellen) Verformen der Verpackung 1 bzw. Trägers 4 einerseits und das Verformen der Kavität 2, um die Flüssigkeit 3 unter Druck zu setzen und/oder aus der Kavität 2 zu verdrängen, andererseits erfolgt gekoppelt, wie durch die gestrichelte Verbindung der beiden Stempel 16 un 17 angedeutet. Hierzu ist es beispielsweise auch möglich, dass die Stempel 16 und 17 durch ein gemeinsames Werkzeug oder dergleichen gebildet und/oder entsprechend korreliert gesteuert bzw. bewegt werden.Opening the packaging 1 or actuating the opening device 7 or the (partial) deformation of the packaging 1 or carrier 4 required for this purpose and deforming the cavity 2 in order to pressurize the liquid 3 and / or out of the cavity 2 to displace, on the other hand is coupled, as indicated by the dashed connection of the two punches 16 un 17. For this purpose, it is also possible, for example, for the punches 16 and 17 to be formed or moved by a common tool or the like and / or to be correspondingly correlated.

Das Öffnen der Verpackung 1 bzw. Kavität 2 mittels der Öffnungseinrichtung 7 kann bedarfsweise auch durch die fluidische Anordnung 11, beispielsweise mittels eines der Anordnung 11 zugeordneten Antriebs für den Stempel 16, erfolgen. Entsprechendes gilt für ein mögliches Verformen der Kavität 2, um die Flüssigkeit 3 unter Druck zu setzen und/oder aus der Kavität 2 in die fluidische Anordnung 11 zu fördern.The opening of the package 1 or cavity 2 by means of the opening device 7 can, if necessary, also be effected by the fluidic arrangement 11, for example by means of a drive for the punch 16 assigned to the arrangement 11. The same applies to a possible deformation of the cavity 2 in order to pressurize the liquid 3 and / or to convey it from the cavity 2 into the fluidic arrangement 11.

Zusätzlich kann je nach Ausführung und Bedarf die Verpackung 1 auch mit einer nicht dargestellten Belüftungseinrichtung versehen sein, die beispielsweise durch entsprechendes Verformen der Vorrichtung 1 bzw. des Trägers 4 bzw. Betätigen der Öffnungseinrichtung 7 und/oder bei Verformen der Kavität 2 geöffnet wird und beispielsweise Umgebungsluft durch eine entsprechende Öffnung im Träger 4 oder Deckel 5 in die Kavität 2 nachströmen lässt. Die Belüftung kann bedarfsweise auch durch die fluidische Anordnung 11 erfolgen, ggf. sogar über die von der Öffnungseinrichtung 7 erzeugte Öffnung. Hierzu kann die Öffnungseinrichtung 7 beispielsweise eine entsprechend geformte oder ausreichend große Öffnung im Deckel 5 oder einen sonstigen Teil der Verpackung 1 und/oder ggf. auch mehrere Öffnungen, beispielsweise durch mehrere vorspringende Abschnitte 8, erzeugen.In addition, depending on the design and requirements, the packaging 1 may also be provided with a ventilation device, not shown, which is opened, for example, by corresponding deformation of the device 1 or of the carrier 4 or actuation of the opening device 7 and / or during deformation of the cavity 2 Ambient air can flow through a corresponding opening in the carrier 4 or cover 5 in the cavity 2. If required, the ventilation can also take place through the fluidic arrangement 11, possibly even via the opening produced by the opening device 7. For this purpose, the opening device 7, for example, a correspondingly shaped or sufficiently large opening in the lid 5 or any other part of the package 1 and / or possibly also a plurality of openings, for example by a plurality of projecting portions 8, produce.

Ein besonderer Vorteil der Kombination der vorschlagsgemäßen Verpackung 1 mit der fluidischen Anordnung 11 liegt darin, dass sehr einfach ein derartiger Anschluss, beispielsweise durch das flachseitige Befestigen, ermöglicht wird, so dass eine flüssigkeitsdichte und vorzugsweise auch gasdichte bzw. gegenüber der Umgebungsluft abgeschlossene Verbindung zwischen der Kavität 2 einerseits und der fluidischen Anordnung 11 bzw. dem davon gebildeten oder darin enthaltenen mikrofluidischen System bzw. dem Abfluss 14 oder dergleichen anderseits herstellbar ist.A particular advantage of the combination of the proposed packaging 1 with the fluidic arrangement 11 is that very simple such a connection, for example by the flat-side fastening, is made possible, so that a liquid-tight and preferably also gas-tight or closed to the ambient air connection between the Cavity 2 on the one hand and the fluidic device 11 or the microfluidic system formed or contained therein or the drain 14 or the like on the other hand can be produced.

Bezugszeichenliste:LIST OF REFERENCE NUMBERS

11
Verpackungpackaging
22
Kavitätcavity
33
Flüssigkeitliquid
44
Trägercarrier
55
Deckelcover
66
Verbindungsbereichconnecting area
77
Öffnungseinrichtungopening device
88th
Abschnittsection
99
Kanalchannel
1010
Strukturstructure
1111
fluidische Anordnungfluidic arrangement
1212
Trägerteilsupport part
1313
Klebeschichtadhesive layer
1414
Abflussoutflow
1515
Kanalchannel
1616
Stempelstamp
1717
Stempelstamp
Ee
Ebenelevel

Claims (1)

  1. Method of supplying liquid (3) from a packaging (1) to a fluidic assembly (11), wherein the packaging (1) comprises a support (4) and a cover (5), between which a cavity (2) is formed, and wherein the cavity (2) is deformed by means of a first punch (17) and the liquid (3) is thereby put under pressure, characterised in that the packaging (1) comprises an opening device (7) integrated in the packaging (1) for opening the cavity (2), the actuation of the opening device (7) by means of a second punch (16) being coupled thereto.
EP11778602.0A 2010-11-10 2011-11-03 Method for supplying a liquid to a fluidic assembly Not-in-force EP2637948B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP11778602.0A EP2637948B1 (en) 2010-11-10 2011-11-03 Method for supplying a liquid to a fluidic assembly

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10014438 2010-11-10
PCT/EP2011/069327 WO2012062648A1 (en) 2010-11-10 2011-11-03 Blister packaging for liquid and use thereof and method for supplying a liquid to a fluidic assembly
EP11778602.0A EP2637948B1 (en) 2010-11-10 2011-11-03 Method for supplying a liquid to a fluidic assembly

Publications (2)

Publication Number Publication Date
EP2637948A1 EP2637948A1 (en) 2013-09-18
EP2637948B1 true EP2637948B1 (en) 2015-09-16

Family

ID=43836563

Family Applications (1)

Application Number Title Priority Date Filing Date
EP11778602.0A Not-in-force EP2637948B1 (en) 2010-11-10 2011-11-03 Method for supplying a liquid to a fluidic assembly

Country Status (4)

Country Link
US (1) US20130327672A1 (en)
EP (1) EP2637948B1 (en)
JP (1) JP2014502236A (en)
WO (1) WO2012062648A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012078696A2 (en) * 2010-12-06 2012-06-14 Aktivpak, Inc. Aseptic cartridge and dispenser arrangement
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
JP1628115S (en) 2012-10-24 2019-04-01
WO2014138563A1 (en) * 2013-03-07 2014-09-12 Quidel Corporation Dual chamber liquid packaging system
AU2014235532B2 (en) 2013-03-15 2018-08-09 Genmark Diagnostics, Inc. Systems, methods, and apparatus for manipulating deformable fluid vessels
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
DE102013018722B4 (en) 2013-11-08 2017-07-13 Trw Automotive Gmbh Belt tensioner for a safety belt system
CN105980058A (en) 2014-01-07 2016-09-28 达克雷诊断器材有限公司 Fluid delivery devices, systems, and methods
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
DE102015205906B4 (en) * 2015-04-01 2024-05-23 Robert Bosch Gmbh Storage unit, method for producing a storage unit and method for releasing a fluid stored in a storage unit
JP6966242B2 (en) * 2017-07-04 2021-11-10 アークレイ株式会社 Liquid container
EP3769804A4 (en) * 2018-03-19 2021-11-24 Smhers Medical tube holder
FR3103325B1 (en) 2019-11-15 2022-04-08 Centre Nat Rech Scient Device for producing energy comprising a reservoir
EP4090608A4 (en) * 2020-01-16 2024-05-08 Picodya Technologies Ltd. Blister pack and blister pack holder
US20220331802A1 (en) * 2021-04-16 2022-10-20 The Regents Of The University Of California Burstable liquid storage package for biological materials and valve substitution

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007100820A2 (en) * 2006-02-28 2007-09-07 Sharp Corporation Child-resistant packaging for pharmaceutical products
WO2009152952A1 (en) * 2008-06-19 2009-12-23 Boehringer Ingelheim Microparts Gmbh Fluid metering container

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3184121A (en) * 1963-08-01 1965-05-18 Ivers Lee Co Package with self sealing closure
DE6946391U (en) * 1969-11-29 1970-05-14 Koellner Sigrune MULTI-CHAMBER CONTAINER FOR THE SEPARATE ACCOMMODATION OF REACTING SUBS ANZES FOR THE MANUFACTURING OF READY-TO-USE DENTAL PREPARATIONS.
US3635376A (en) * 1970-06-05 1972-01-18 Hellstrom Harold R Quick-open flexible package
FR2290366A1 (en) * 1974-11-08 1976-06-04 Contrapac Container for two substances mixed before use - has one substance in plastic envelope and forced into second substance by pressing on cap
US4592493A (en) * 1984-10-15 1986-06-03 Unette Corporation Reclosable dispenser
US4574954A (en) * 1984-12-07 1986-03-11 Medication Services Inc. Pill dispenser
US4785931A (en) * 1987-09-24 1988-11-22 Letica Corporation Molded plastic closure having integral stacking support ribs and rupturable mix compartments
US5111932A (en) * 1989-08-03 1992-05-12 Land O'lakes, Inc. Spreadable material package with spreader
US5131760A (en) * 1990-07-03 1992-07-21 Farmer Bert E Packaging device
EP0726863B1 (en) * 1993-11-01 1998-12-09 The Procter & Gamble Company Self-closing liquid dispensing package
US5529224A (en) * 1993-11-01 1996-06-25 The Procter & Gamble Company Self-closing liquid dispensing package
TR199801476T2 (en) * 1996-02-02 1999-05-21 Redmond Sanford Improved coffee creamer and other containers.
US5839609A (en) * 1997-08-27 1998-11-24 Colgate-Palmolive Company Thermoformed pack with ridge valve
DE29907740U1 (en) * 1999-05-03 1999-09-30 Klocke Verpackungs-Service GmbH, 76356 Weingarten Multi-chamber container
AU2001255233A1 (en) * 2000-04-05 2001-10-23 Sanford Redmond Inc. Easy opening liquid pouch with swab device
US6976578B1 (en) * 2002-05-07 2005-12-20 Antony Austin Kenihan Dispensing lid closure for beverage container and method of making and using the closure
DE10243401B4 (en) * 2002-09-18 2004-07-29 Voco Gmbh Packaging for storing substances and method for producing a directly applicable mixture of two substances from this packaging
JP2005082195A (en) * 2003-09-09 2005-03-31 Sumika Life Tech Co Ltd Container for single dose of home gardening chemical
DE10343668A1 (en) 2003-09-18 2005-04-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg pharmaceutical blister
US7073692B2 (en) * 2004-02-19 2006-07-11 Pieter Weyts Conical reinforced re-sealable dispenser
JP4582644B2 (en) * 2004-06-08 2010-11-17 憲司 中村 Liquid-impregnated package
US7243798B2 (en) * 2004-08-04 2007-07-17 Fisher Clinical Services System and a method for a V-indent blister opening cavity
NL1028729C2 (en) * 2005-04-08 2006-10-10 Campina Nederland Holding Bv Holder.
MX2008012293A (en) * 2006-03-31 2008-10-08 Wyeth Corp A tear and spill resistant package for dispensing liquids in a controlled manner.
US7644821B2 (en) * 2006-04-10 2010-01-12 Poppack, Llc Sealed product delivery unit with rupturing pump
DE202007003050U1 (en) 2007-02-28 2007-05-10 Swif Gmbh South West International Fragrance Additives container for delivering liquid/gel additives into the environment by means of diffusion has a trough to form a cavity for a gaseous additive with a diffusive membrane foil
CN101715428B (en) * 2007-05-16 2016-08-24 神秘制药公司 For carrying the formulation of pharmaceutical compositions and including the dosage band of this formulation
WO2009008715A1 (en) * 2007-07-06 2009-01-15 Friesland Brands B.V. Container for holding a liquid for consumption, such as a dairy product, in unfoamed form and for dispensing the liquid for obtaining the liquid in foamed form
DK2138233T3 (en) * 2008-06-02 2011-01-31 Boehringer Ingelheim Micropart Microfluidic film structure for dosing liquids
JP2012512789A (en) * 2008-12-19 2012-06-07 インターベツト・インターナシヨナル・ベー・ベー Suitable package for storing liquids
US9061796B2 (en) * 2009-04-23 2015-06-23 H.J. Heinz Company Multi-function condiment container
PL2499060T3 (en) * 2009-11-12 2014-04-30 Mds Global Holding Ltd Container for dispensing a substance

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007100820A2 (en) * 2006-02-28 2007-09-07 Sharp Corporation Child-resistant packaging for pharmaceutical products
WO2009152952A1 (en) * 2008-06-19 2009-12-23 Boehringer Ingelheim Microparts Gmbh Fluid metering container

Also Published As

Publication number Publication date
US20130327672A1 (en) 2013-12-12
EP2637948A1 (en) 2013-09-18
WO2012062648A1 (en) 2012-05-18
JP2014502236A (en) 2014-01-30

Similar Documents

Publication Publication Date Title
EP2637948B1 (en) Method for supplying a liquid to a fluidic assembly
EP2637933B1 (en) Method for filling a blister packaging with liquid
US8631953B2 (en) Closure for container for holding biological samples
DE3873787T2 (en) ANALYTICAL TEST STRIP.
EP1542612B1 (en) Packaging for storing substances
EP2931428B1 (en) Film bag for storing a fluid and device for providing a fluid and method of making a film bag
EP2687290B1 (en) Microfluidic storage device for storing a fluid, method for its manufacture and use of the same
WO2006099768A1 (en) 'push-pull' type closure for a container
WO2008049420A1 (en) Package with a sealing region
DE102011004125A1 (en) Device for the hermetically sealed storage of liquids for a microfluidic system
WO2016000999A1 (en) Reagent reservoir for fluids
WO2012062444A1 (en) Blister packaging for liquid
EP2905079A1 (en) Device for storing a fluid in a microfluidic system, method for operating and method for producing such a device
DE102015205906B4 (en) Storage unit, method for producing a storage unit and method for releasing a fluid stored in a storage unit
EP1144265B1 (en) Liquid container with seal
EP1853493B1 (en) Tubular bag provided with a cover
DE102005010639A1 (en) Packaging container, in particular can-like container
US20230372929A1 (en) Integrated fluid module and test device
DE102014202342A1 (en) Device for pre-storing a fluid in a microfluidic system, method for operating and method for producing such a device
EP2730336A2 (en) Valve assembly in a microfluidic system
EP3652083B1 (en) Container closure with a standard capsule
EP2154081A1 (en) Closing device for medical containers and the like including a temporary receptacle
WO2017036605A1 (en) Adapter with reservoir for a container
EP1585678B1 (en) Tear-tab pouring part consisting of plastic and injection mould for producing said part
DE20103937U1 (en) Closure in the form of a lid or cap for containers

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20130610

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DAX Request for extension of the european patent (deleted)
17Q First examination report despatched

Effective date: 20141118

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

INTG Intention to grant announced

Effective date: 20150424

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

Free format text: LANGUAGE OF EP DOCUMENT: GERMAN

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 749610

Country of ref document: AT

Kind code of ref document: T

Effective date: 20151015

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 502011007899

Country of ref document: DE

REG Reference to a national code

Ref country code: NL

Ref legal event code: MP

Effective date: 20150916

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20151217

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20151216

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160116

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160118

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 502011007899

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

Ref country code: LU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20151103

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20151130

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20151130

26N No opposition filed

Effective date: 20160617

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20151216

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

Effective date: 20160729

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20151103

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20151216

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20160601

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20151130

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20111103

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20151130

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

REG Reference to a national code

Ref country code: AT

Ref legal event code: MM01

Ref document number: 749610

Country of ref document: AT

Kind code of ref document: T

Effective date: 20161103

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20161103

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916