EP2536406A4 - Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses - Google Patents
Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other usesInfo
- Publication number
- EP2536406A4 EP2536406A4 EP11740333.7A EP11740333A EP2536406A4 EP 2536406 A4 EP2536406 A4 EP 2536406A4 EP 11740333 A EP11740333 A EP 11740333A EP 2536406 A4 EP2536406 A4 EP 2536406A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- antiseptics
- thiols
- bismuth
- including treatment
- bacterial biofilms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
- A01N55/02—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing metal atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/29—Antimony or bismuth compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/245—Bismuth; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2010/023108 WO2010091124A2 (en) | 2009-02-03 | 2010-02-03 | Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications |
US37318810P | 2010-08-12 | 2010-08-12 | |
PCT/US2011/023549 WO2011097347A2 (en) | 2010-02-03 | 2011-02-03 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2536406A2 EP2536406A2 (en) | 2012-12-26 |
EP2536406A4 true EP2536406A4 (en) | 2014-04-09 |
Family
ID=51355699
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP11740333.7A Pending EP2536406A4 (en) | 2010-02-03 | 2011-02-03 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP2536406A4 (en) |
JP (1) | JP2013518895A (en) |
CN (2) | CN107308186A (en) |
AU (1) | AU2011212941B2 (en) |
CA (1) | CA2788669C (en) |
MX (1) | MX346409B (en) |
WO (1) | WO2011097347A2 (en) |
Families Citing this family (34)
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WO2005072710A2 (en) | 2004-01-28 | 2005-08-11 | Johns Hopkins University | Drugs and gene carrier particles that rapidly move through mucous barriers |
US11596599B2 (en) | 2012-05-03 | 2023-03-07 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
US9827191B2 (en) | 2012-05-03 | 2017-11-28 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
JP6360040B2 (en) | 2012-05-03 | 2018-07-18 | カラ ファーマシューティカルズ インコーポレイテッド | Mucus-permeable coated particles, compositions, pharmaceutical compositions, pharmaceutical formulations, and methods for forming them |
EP4008355A1 (en) | 2012-05-03 | 2022-06-08 | Kala Pharmaceuticals, Inc. | Pharmaceutical nanoparticles showing improved mucosal transport |
ES2688381T3 (en) * | 2012-09-28 | 2018-11-02 | Stelo Technologies | Methods for making silver nanoparticles and their applications |
CN103667119B (en) * | 2013-11-26 | 2015-07-29 | 浙江大学 | For the bacterial strain of sulfur alcohol of degrading and cultural method thereof and application |
US11039620B2 (en) | 2014-02-19 | 2021-06-22 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
US9622483B2 (en) | 2014-02-19 | 2017-04-18 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
US11039621B2 (en) | 2014-02-19 | 2021-06-22 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
ES2941460T3 (en) * | 2014-03-07 | 2023-05-23 | Mark Tuffley | Composition and method for improving wound healing |
CN105572126B (en) * | 2015-04-07 | 2018-10-23 | 湖南华纳大药厂股份有限公司 | A kind of colloidal bismmth pectin pharmaceutical composition |
MX2017012727A (en) | 2015-04-08 | 2018-05-28 | Biomendics Llc | Formulation and process for modulating wound healing. |
WO2017145142A1 (en) | 2016-02-25 | 2017-08-31 | Nobio Ltd. | Micro and nanoparticulate compositions comprising anti-microbially active groups |
ES2912268T3 (en) * | 2016-12-05 | 2022-05-25 | Technophage Investig E Desenvolvimento Em Biotecnologia Sa | Bacteriophage compositions comprising respiratory antibacterial phages and methods of using same |
AU2017381394A1 (en) * | 2016-12-22 | 2019-07-25 | The University Of Sydney | Biofilm disrupting composition |
JP7337778B2 (en) | 2017-08-30 | 2023-09-04 | ノビオ リミテッド | Compositions and medical devices containing antimicrobial particles |
ES2892077T3 (en) * | 2017-11-16 | 2022-02-02 | Dsm Ip Assets Bv | Use of phytantriol as an antimicrobial agent in the preservation of a composition |
CN110387416B (en) * | 2018-04-16 | 2022-06-17 | 华东理工大学 | Nano-gold dual-probe system with controllable polymerization regulation function and application thereof |
WO2020028561A1 (en) * | 2018-07-31 | 2020-02-06 | Microbion Corporation | Bismuth-thiol compositions and methods for treating wounds |
WO2020028558A1 (en) | 2018-07-31 | 2020-02-06 | Microbion Corporation | Bismuth-thiol compositions and methods of use |
CN110870874A (en) * | 2018-08-13 | 2020-03-10 | 中山大学 | Medicine with antibacterial effect and application thereof |
KR102054341B1 (en) * | 2019-06-20 | 2019-12-10 | 한국지질자원연구원 | A pharmaceutical composition for oral administration for eradicating helicobacter pylori which is resistant to antibiotics comprising a complex of non-absorbable antibiotic and clay mineral |
EP3917320A4 (en) * | 2019-01-31 | 2022-11-09 | Pulsethera Corporation | Bacterialcidal methods and compositions |
EP3941461A4 (en) * | 2019-03-18 | 2022-12-14 | Cedars-Sinai Medical Center | Compositions and methods to treat gastrointestinal diseases and disorders |
CN112425608B (en) * | 2019-08-23 | 2023-07-21 | 香港科技大学 | Elastase inhibitor and antibacterial agent with anti-biofilm activity |
CN111034711B (en) * | 2019-12-19 | 2022-04-05 | 海南一龄医疗产业发展有限公司 | Composition and method for efficiently removing microbial contamination in cell culture process |
CN111175103B (en) * | 2020-01-16 | 2023-07-04 | 江西业力医疗器械有限公司 | Leucorrhea sample pretreatment liquid for fluorescent detection of mycotic vaginitis and preparation method thereof |
WO2021195236A1 (en) * | 2020-03-24 | 2021-09-30 | Microbion Corporation | Bismuth thiol compounds and compositions and methods of treating microbial co-infections |
CN113712842B (en) * | 2020-05-25 | 2023-06-13 | 基元美业生物科技(上海)有限公司 | Composition and application thereof in preparation of cosmetics and medical devices |
CN112618716B (en) * | 2021-01-11 | 2022-04-08 | 福州大学 | Photodynamic combined lysozyme antibacterial method |
CN113930462A (en) * | 2021-10-19 | 2022-01-14 | 江南大学 | Method for synthesizing hexanoic acid by using homoserine lactone signal molecule to promote carbon chain elongation microorganisms |
CN114984746B (en) * | 2022-08-05 | 2022-11-01 | 山东建筑大学 | System method and device for treating VOCs waste gas in disinfectant and aquaculture wastewater pool |
CN115532295B (en) * | 2022-09-27 | 2023-07-25 | 苏州大学 | Application of nanomaterial containing Zn-N-C active center in removal of bacterial biofilm |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020197282A1 (en) * | 1999-02-23 | 2002-12-26 | Mohseni Saeed H. | Sonic method of enhancing chemical reactions to provide uniform, non-agglomerated particles |
WO2010091124A2 (en) * | 2009-02-03 | 2010-08-12 | Microbion Corporation | Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6086921A (en) * | 1995-04-25 | 2000-07-11 | Wintrop-University Hospital | Metal/thiol biocides |
US5999828A (en) * | 1997-03-19 | 1999-12-07 | Qualcomm Incorporated | Multi-user wireless telephone having dual echo cancellers |
AU2656799A (en) * | 1998-02-04 | 1999-08-23 | Winthrop-University Hospital | Metal-thiols as imminomodulating agents |
US7381751B2 (en) * | 2003-08-26 | 2008-06-03 | Shantha Sarangapani | Antimicrobial composition for medical articles |
US8343536B2 (en) * | 2007-01-25 | 2013-01-01 | Cook Biotech Incorporated | Biofilm-inhibiting medical products |
-
2011
- 2011-02-03 CN CN201710523562.8A patent/CN107308186A/en active Pending
- 2011-02-03 AU AU2011212941A patent/AU2011212941B2/en active Active
- 2011-02-03 JP JP2012552075A patent/JP2013518895A/en active Pending
- 2011-02-03 MX MX2012009054A patent/MX346409B/en active IP Right Grant
- 2011-02-03 CN CN2011800153054A patent/CN103079557A/en active Pending
- 2011-02-03 EP EP11740333.7A patent/EP2536406A4/en active Pending
- 2011-02-03 CA CA2788669A patent/CA2788669C/en active Active
- 2011-02-03 WO PCT/US2011/023549 patent/WO2011097347A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020197282A1 (en) * | 1999-02-23 | 2002-12-26 | Mohseni Saeed H. | Sonic method of enhancing chemical reactions to provide uniform, non-agglomerated particles |
WO2010091124A2 (en) * | 2009-02-03 | 2010-08-12 | Microbion Corporation | Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications |
Also Published As
Publication number | Publication date |
---|---|
AU2011212941A1 (en) | 2012-09-27 |
CA2788669C (en) | 2021-05-25 |
JP2013518895A (en) | 2013-05-23 |
MX346409B (en) | 2017-03-17 |
WO2011097347A2 (en) | 2011-08-11 |
EP2536406A2 (en) | 2012-12-26 |
CN107308186A (en) | 2017-11-03 |
CA2788669A1 (en) | 2011-08-11 |
MX2012009054A (en) | 2012-12-17 |
WO2011097347A3 (en) | 2011-12-22 |
CN103079557A (en) | 2013-05-01 |
AU2011212941B2 (en) | 2016-03-03 |
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