EP2446903A3 - Verfahren, Zusammensetzungen und Kits zur Behandlung von Schmerzen und Juckreiz - Google Patents

Verfahren, Zusammensetzungen und Kits zur Behandlung von Schmerzen und Juckreiz Download PDF

Info

Publication number
EP2446903A3
EP2446903A3 EP11007949A EP11007949A EP2446903A3 EP 2446903 A3 EP2446903 A3 EP 2446903A3 EP 11007949 A EP11007949 A EP 11007949A EP 11007949 A EP11007949 A EP 11007949A EP 2446903 A3 EP2446903 A3 EP 2446903A3
Authority
EP
European Patent Office
Prior art keywords
channels
compound
voltage
pruritis
kits
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP11007949A
Other languages
English (en)
French (fr)
Other versions
EP2446903B1 (de
EP2446903A2 (de
Inventor
Bruce P. Bean
Clifford J. Woolf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard College
General Hospital Corp
Original Assignee
Harvard College
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, General Hospital Corp filed Critical Harvard College
Publication of EP2446903A2 publication Critical patent/EP2446903A2/de
Publication of EP2446903A3 publication Critical patent/EP2446903A3/de
Application granted granted Critical
Publication of EP2446903B1 publication Critical patent/EP2446903B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
EP11007949.8A 2006-11-20 2007-11-19 Zusammensetzungen zur Behandlung von Juckreiz Active EP2446903B1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US86012406P 2006-11-20 2006-11-20
US95859407P 2007-07-06 2007-07-06
US99751007P 2007-10-03 2007-10-03
PCT/US2007/024174 WO2008063603A2 (en) 2006-11-20 2007-11-19 Methods, compositions, and kits for treating pain and pruritis
EP07862114A EP2101819B1 (de) 2006-11-20 2007-11-19 Verfahren, zusammensetzungen und sets zur behandlung von schmerzen und pruritis

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP07862114A Division EP2101819B1 (de) 2006-11-20 2007-11-19 Verfahren, zusammensetzungen und sets zur behandlung von schmerzen und pruritis
EP07862114.1 Division 2007-11-19

Publications (3)

Publication Number Publication Date
EP2446903A2 EP2446903A2 (de) 2012-05-02
EP2446903A3 true EP2446903A3 (de) 2012-11-14
EP2446903B1 EP2446903B1 (de) 2019-10-09

Family

ID=39430358

Family Applications (3)

Application Number Title Priority Date Filing Date
EP20110007950 Withdrawn EP2425858A3 (de) 2006-11-20 2007-11-19 Zusammensetzungen zur Behandlung von Schmerzen und Juckreiz
EP11007949.8A Active EP2446903B1 (de) 2006-11-20 2007-11-19 Zusammensetzungen zur Behandlung von Juckreiz
EP07862114A Active EP2101819B1 (de) 2006-11-20 2007-11-19 Verfahren, zusammensetzungen und sets zur behandlung von schmerzen und pruritis

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP20110007950 Withdrawn EP2425858A3 (de) 2006-11-20 2007-11-19 Zusammensetzungen zur Behandlung von Schmerzen und Juckreiz

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP07862114A Active EP2101819B1 (de) 2006-11-20 2007-11-19 Verfahren, zusammensetzungen und sets zur behandlung von schmerzen und pruritis

Country Status (10)

Country Link
US (4) US20100099772A1 (de)
EP (3) EP2425858A3 (de)
JP (4) JP2010510227A (de)
KR (2) KR20090082507A (de)
CN (1) CN103933572B (de)
AU (1) AU2007322033B2 (de)
CA (2) CA3002443A1 (de)
DK (1) DK2101819T3 (de)
ES (1) ES2402789T3 (de)
WO (1) WO2008063603A2 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010510227A (ja) 2006-11-20 2010-04-02 プレジデント アンド フェロウズ オブ ハーバード カレッジ 痛みおよび痒みの治療方法、組成物およびキット
WO2008095297A1 (en) * 2007-02-06 2008-08-14 Origin Biomed Inc. Composition comprising terpene compounds and methods for inhibiting nerve transmission
DK2229391T3 (da) 2007-12-19 2014-10-13 Cancer Res Inst Royal Pyrido[2,3-B]pyrazin-8-substituerede forbindelser og deres anvendelse
WO2009114139A2 (en) * 2008-03-11 2009-09-17 President And Fellows Of Harvard College Methods, compositions, and kits for treating pain and pruritis
WO2009143175A2 (en) * 2008-05-19 2009-11-26 Children's Medical Center Corporation Sensory-specific local anesthesia and prolonged duration local anesthesia
US9415023B2 (en) 2008-08-13 2016-08-16 Neuroquest Inc. Compositions comprising terpene compounds for treating negative sensory phenomena
KR101188945B1 (ko) 2009-01-29 2012-10-08 서울대학교산학협력단 설포라판 및 이의 유사체를 포함하는 통증치료제
US8642334B2 (en) 2009-02-17 2014-02-04 Memorial Sloan Kettering Cancer Center Methods of neural conversion of human embryonic stem cells
US8952152B2 (en) 2009-03-24 2015-02-10 Proteus S.A. Methods for purifying phycotoxins, pharmaceutical compositions containing purified phycotoxins, and methods of use thereof
WO2011006073A1 (en) * 2009-07-10 2011-01-13 President And Fellows Of Harvard College Permanently charged sodium and calcium channel blockers as anti-inflammatory agents
AU2011258634B2 (en) * 2010-05-25 2015-03-26 Memorial Sloan-Kettering Cancer Center Method of nociceptor differentiation of human embryonic stem cells and uses thereof
EP2629610B1 (de) 2010-07-27 2017-09-06 Flex Pharma, Inc. Verfahren und zusammensetzungen zur vorbeugung und linderung von muskelkrämpfen und zur erholung von neuromuskulärer reizbarkeit und erschöpfung nach dem training
KR20200125765A (ko) * 2011-02-18 2020-11-04 아사나 바이오사이언시스 엘엘씨 아미노인단 화합물 및 통증 치료에서 그것의 용도
DK2771320T3 (en) 2011-10-24 2016-10-03 Endo Pharmaceuticals Inc Cyclohexylamines
US10280398B2 (en) 2011-11-04 2019-05-07 Memorial Sloan-Kettering Cancer Center Midbrain dopamine (DA) neurons for engraftment
JP4979830B1 (ja) * 2011-11-10 2012-07-18 重憲 青木 無痛注射用外用剤
KR101357980B1 (ko) * 2011-12-07 2014-02-05 서울대학교산학협력단 유제놀을 포함하는 기계적 이질통 치료용 약학적 조성물
KR101243430B1 (ko) * 2012-04-23 2013-03-13 서울대학교산학협력단 설포라판 및 이의 유사체를 포함하는 건강 기능 식품 조성물
US9044482B2 (en) 2012-08-15 2015-06-02 Asana Biosciences, Llc Use of aminoindane compounds in treating overactive bladder and interstitial cystitis
WO2014124209A1 (en) 2013-02-08 2014-08-14 General Mills, Inc. Reduced sodium food products
PE20160011A1 (es) 2013-03-15 2016-02-10 Childrens Medical Center Formulaciones combinadas de neosaxitoxina para una anestesia local prolongada
CA2910394A1 (en) 2013-04-26 2014-10-30 Memorial Sloan-Kettering Cancer Center Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells
EP2842428B1 (de) * 2013-08-27 2018-08-08 Symrise AG Orale Zubereitung
KR101856589B1 (ko) 2015-07-30 2018-05-10 (주)에이엔티랩스 라모트리진의 피부성 약물 부작용 예측 방법
AU2016301282B2 (en) 2015-08-03 2022-03-17 Children's Medical Center Corporation Charged ion channel blockers and methods for use
WO2017199199A1 (en) * 2016-05-19 2017-11-23 Glaxosmithkline Intellectual Property (No.2) Limited Trpv4 antagonist
US11253493B2 (en) 2017-01-23 2022-02-22 Cliff-Cartwright Corporation Compositions and methods affecting exercise performance
WO2019191200A1 (en) 2018-03-27 2019-10-03 American Genomics, Llc Method and formulation for producing anesthesia of internal aspect of eye wall by topical application
US20210283098A1 (en) * 2018-07-05 2021-09-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Methods and Compositions for Treating Pain and Itch
MA55320A (fr) 2019-03-11 2022-01-19 Nocion Therapeutics Inc Bloqueurs de canaux ioniques substitués par un ester et méthodes d'utilisation
JP2022527690A (ja) 2019-03-11 2022-06-03 ノシオン セラピューティクス，インコーポレイテッド 荷電したイオンチャンネル遮断薬および使用方法
US10828287B2 (en) 2019-03-11 2020-11-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
EP3937945A4 (de) 2019-03-11 2023-01-04 Nocion Therapeutics, Inc. Geladene ionenkanalblocker und verfahren zur verwendung
US10780083B1 (en) 2019-03-11 2020-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US11617727B2 (en) 2019-04-30 2023-04-04 Bayer Healthcare Llc Topical analgesic gel compositions
CN114828845A (zh) 2019-11-06 2022-07-29 诺西恩医疗公司 带电的离子通道阻滞剂及其使用方法
US10933055B1 (en) 2019-11-06 2021-03-02 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
JP2023515874A (ja) * 2020-03-04 2023-04-14 ノイキュアズ，インコーポレーテッド Ｔｒｐｖ１調節物質の投与に関連する交感神経興奮を防止するためのｑｘ３１４の使用
JP2023517604A (ja) * 2020-03-11 2023-04-26 ノシオン セラピューティクス，インコーポレイテッド 荷電したイオンチャンネル遮断薬および使用方法
WO2022081742A1 (en) * 2020-10-13 2022-04-21 New York Blood Center, Inc. Compounds for treatment of hemolysis-and inflammasome-associated diseases
WO2022099284A1 (en) * 2020-11-05 2022-05-12 Young Biopharma, Llc Novel capsaicin analogs and uses thereof

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3519631A (en) * 1965-08-18 1970-07-07 Boehringer Sohn Ingelheim Quaternary derivatives of 1,2,3,4-tetra-hydro-9-amino-acridine
US4069309A (en) * 1972-09-19 1978-01-17 Avon Products, Inc. Cationic skin substantive sunscreen composition and method
WO1998024428A1 (en) * 1996-12-02 1998-06-11 Brigham & Women's Hospital, Inc. Long-acting local anesthetics
WO1999011252A2 (en) * 1997-09-03 1999-03-11 Nortran Pharmaceuticals, Inc. N,n-bis (phenylcarbamoylmethyl) dimethylammonium chloride and derivatives in the treatment of pain
WO2001044218A1 (en) * 1999-12-15 2001-06-21 Ucb Farchim S.A. Quaternary salts of n-substituted cyclic or acyclic amines as pharmaceuticals
WO2001045678A2 (de) * 1999-12-21 2001-06-28 Id Pharma Gmbh Arzneimittel, verfahren zu dessen herstellung und dessen verwendung
US6362197B1 (en) * 1998-06-09 2002-03-26 Cardiome Pharma Corp. Compositions and method for treatment of cough
US6413961B1 (en) * 1995-12-12 2002-07-02 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain and inflammation
WO2006010587A1 (en) * 2004-07-24 2006-02-02 Laboratorios Del Dr. Esteve, S.A. Use of compounds active on the sigma receptor for the treatment of mechanical allodynia

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US812554A (en) 1905-11-08 1906-02-13 Hoechst Ag Alkamin esters of para-aminobenzoic acid.
US1889645A (en) 1930-12-22 1932-11-29 Winthrop Chem Co Inc Beta-dimethylaminoethyl ester of para-butylamino-benzoic acid
US2441498A (en) 1943-07-15 1948-05-11 Astra Apotekarnes Kem Fab Alkyl glycinanilides
US2689248A (en) 1950-06-17 1954-09-14 Sterling Drug Inc Tertiary-aminoalkyl 4-amino-2-alkoxybenzoates and their synth esis
US2799679A (en) 1955-04-28 1957-07-16 Bofors Ab Process of preparing amides of heterocyclic carboxylic acids
US2955111A (en) 1957-01-28 1960-10-04 Bofors Ab Synthesis of n-alkyl-piperidine and n-alkyl-pyrrolidine-alpha-carboxylic acid amides
US3160662A (en) 1957-06-26 1964-12-08 Astra Apotekarnes Kem Fab Lower alkylaminoacyl amide anesthetics
NL281394A (de) 1961-07-25
US3812147A (en) 1970-12-22 1974-05-21 Astra Pharma Prod Acylxylidide local anaesthetics
US3931195A (en) 1971-03-03 1976-01-06 Mead Johnson & Company Substituted piperidines
US3900481A (en) 1974-04-01 1975-08-19 Riker Laboratories Inc Derivatives of pyrrolidine and piperidine
ATE40994T1 (de) 1983-08-01 1989-03-15 Astra Laekemedel Ab L-n-n-propylpipekolsaeure-2,6-xylidid und dessen herstellung.
US5591317A (en) 1994-02-16 1997-01-07 Pitts, Jr.; M. Michael Electrostatic device for water treatment
US5716622A (en) 1995-01-06 1998-02-10 The Rockefeller University Functionally active regions of signal transducer and activators of transcription
US5783683A (en) 1995-01-10 1998-07-21 Genta Inc. Antisense oligonucleotides which reduce expression of the FGFRI gene
US5747470A (en) 1995-06-07 1998-05-05 Gen-Probe Incorporated Method for inhibiting cellular proliferation using antisense oligonucleotides to gp130 mRNA
SE508357C2 (sv) 1996-01-02 1998-09-28 Kay Laserow Mätinstrument för mätning av smärta jämte ett förfarande för att med ett mätinstrument mäta smärta
SE9604751D0 (sv) 1996-12-20 1996-12-20 Astra Ab New therapy
US5837713A (en) 1997-02-26 1998-11-17 Mayo Foundation For Medical Education And Research Treatment of eosinophil-associated pathologies by administration of topical anesthetics and glucocorticoids
US6623040B1 (en) 1997-09-03 2003-09-23 Recot, Inc. Method for determining forced choice consumer preferences by hedonic testing
EP1216243A1 (de) 1999-10-01 2002-06-26 Advanced Medicine, Inc. Quinazolinone und analoga und ihre verwendung als lokalanästhetika
EE200200314A (et) 1999-12-15 2003-08-15 Ucb Farchim S.A. Tsüklilised kvaternaarsed ammooniumiühendid
WO2001083828A1 (en) 2000-05-04 2001-11-08 Dzgenes, Llc TGFβ-RII PROMOTER POLYMORPHISMS
AU7138601A (en) 2000-06-23 2002-01-08 Mayo Foundation Methods of treating neutrophil-related diseases with topical anesthetics
DE10039449A1 (de) * 2000-08-11 2003-07-24 Id Pharma Gmbh I Ins Verwendung einer lokalanästhetikumhaltigen Zusammensetzung zur Behandlung von Hyperalgesien
US6766319B1 (en) 2000-10-31 2004-07-20 Robert J. Might Method and apparatus for gathering and evaluating information
US6884782B2 (en) 2000-11-08 2005-04-26 Amgen Inc. STAT modulators
US20040146590A1 (en) * 2001-03-22 2004-07-29 Iadarola Michael J Molecular neurochirurgie for pain control administering locally capsaicin or resinferatoxin
CA2446060A1 (en) * 2001-05-07 2002-11-14 Corium International Compositions and delivery systems for administration of a local anesthetic agent
US6825190B2 (en) 2001-06-15 2004-11-30 Vertex Pharmaceuticals Incorporated Protein kinase inhibitors and uses thereof
US7585511B2 (en) 2002-08-02 2009-09-08 Universite Libre De Bruxelles Apolipoprotein L-I and/or derivated polypeptide for the treatment of and/or the prevention of diseases induced by trypanosoma
US7943166B2 (en) * 2003-04-10 2011-05-17 Neurogesx, Inc. Methods and compositions for administration of TRPV1 agonists
US20040220187A1 (en) 2003-04-22 2004-11-04 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a sodium ion channel blocker for the treatment of pain, inflammation or inflammation mediated disorders
ES2223277B1 (es) 2003-06-19 2006-03-01 Fernando Bouffard Fita Composicion anestesica para administracion topica.
US20070149469A1 (en) 2003-10-02 2007-06-28 Christian Korherr Medical use of tbk-1 or of inhibitors thereof
US20050142596A1 (en) 2003-11-14 2005-06-30 Krolewski Andrzej S. Methods of diagnosing renal and cardiovascular disease
JP4751336B2 (ja) 2003-12-11 2011-08-17 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 細胞増殖性疾患を治療する化合
US20070196866A1 (en) * 2004-03-13 2007-08-23 Irm Llc Modulators of ion channel trpa1
US20060106020A1 (en) 2004-04-28 2006-05-18 Rodgers James D Tetracyclic inhibitors of Janus kinases
ES2542847T3 (es) * 2004-06-02 2015-08-12 Neurogesx Inc. Formulaciones que comprenden capsaicina, un anestésico local y/o un agente antipruriginoso para el tratamiento del dolor
JP2008513444A (ja) 2004-09-20 2008-05-01 コラス ファーマ インコーポレイテッド リドカイン及び他の局所麻酔剤の標的運搬並びに咳そう及び咳の発作の処置のための方法
US7947682B2 (en) 2004-12-29 2011-05-24 University Of Southern California Substituted N′-pyrrolo[1,2-a]quinoxalin-4-yl-hydrazides as anti-cancer agents
EP1824466A4 (de) 2004-12-16 2008-03-05 Advanced Inhalation Res Inc Zusammensetzungen und verfahren für lungenleiden
AR054416A1 (es) 2004-12-22 2007-06-27 Incyte Corp Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas.
US20070149506A1 (en) 2005-09-22 2007-06-28 Arvanitis Argyrios G Azepine inhibitors of Janus kinases
CN104278037B (zh) 2005-10-12 2020-09-15 艾德拉药物股份有限公司 基于变异应答调制Toll样受体的免疫调节寡核苷酸(IRO)化合物
TWI468162B (zh) 2005-12-13 2015-01-11 英塞特公司 作為傑納斯激酶（ＪＡＮＵＳ ＫＩＮＡＳＥ）抑制劑之經雜芳基取代之吡咯并〔２，３-ｂ〕吡啶及吡咯并〔２，３-ｂ〕嘧啶
CA2634491A1 (en) 2005-12-21 2007-06-28 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
GB0526244D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
EP1867338A1 (de) 2006-05-30 2007-12-19 Université Libre De Bruxelles Pharmazeutische Zusammensetzung enthaltend Apolipoproteine
JP2010510227A (ja) 2006-11-20 2010-04-02 プレジデント アンド フェロウズ オブ ハーバード カレッジ 痛みおよび痒みの治療方法、組成物およびキット
US8513270B2 (en) 2006-12-22 2013-08-20 Incyte Corporation Substituted heterocycles as Janus kinase inhibitors
WO2009026107A1 (en) 2007-08-17 2009-02-26 Portola Pharmaceuticals, Inc. Protein kinase inhibitors
CN101156851A (zh) 2007-09-27 2008-04-09 刘全胜 盐酸尼卡地平分散片及其制备方法
WO2009114139A2 (en) 2008-03-11 2009-09-17 President And Fellows Of Harvard College Methods, compositions, and kits for treating pain and pruritis
US8138339B2 (en) 2008-04-16 2012-03-20 Portola Pharmaceuticals, Inc. Inhibitors of protein kinases
US8258144B2 (en) 2008-04-22 2012-09-04 Portola Pharmaceuticals, Inc. Inhibitors of protein kinases
EP2307367B1 (de) 2008-07-08 2014-09-24 Board of Regents, The University of Texas System Neue hemmer der proliferation und aktivierung signalübertragender und transkriptionsaktivierender (stat) proteine
DE102008037682A1 (de) 2008-08-14 2010-04-08 Strackharn, Klaus, Dr.med. Verwendung äquipotenter Dosierungen von Lokalanästetika oder Derivaten davon zur Therapie chronischer Schmerzen
CN101347427A (zh) 2008-09-22 2009-01-21 北京理工大学 一种沙坦化合物或其可药用盐和钙通道阻断剂或可药用盐的复方
CL2009001884A1 (es) 2008-10-02 2010-05-14 Incyte Holdings Corp Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco.
CA2738816A1 (en) 2008-10-06 2010-04-15 Idera Pharmaceuticals, Inc. Use of inhibitors of toll-like receptors in the prevention and treatment of hypercholesterolemia and hyperlipidemia and diseases related thereto
EP2411019A2 (de) 2009-03-27 2012-02-01 Merck Sharp&Dohme Corp. Rna-interferenz-vermittelte hemmung der signal transducer and activator of transcription 1 (stat1) gen-expression mittels sina (short interfering nucleic acid)
WO2011006073A1 (en) 2009-07-10 2011-01-13 President And Fellows Of Harvard College Permanently charged sodium and calcium channel blockers as anti-inflammatory agents
US9023355B2 (en) 2010-04-13 2015-05-05 Beth Israel Deaconess Medical Center, Inc. Compositions and methods for treating renal disease
US9828637B2 (en) 2010-04-18 2017-11-28 Wake Forest University Health Sciences Methods of predicting predisposition to or risk of kidney disease
US20130225578A1 (en) 2010-09-01 2013-08-29 Ambit Biosciences Corporation 7-cyclylquinazoline derivatives and methods of use thereof

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3519631A (en) * 1965-08-18 1970-07-07 Boehringer Sohn Ingelheim Quaternary derivatives of 1,2,3,4-tetra-hydro-9-amino-acridine
US4069309A (en) * 1972-09-19 1978-01-17 Avon Products, Inc. Cationic skin substantive sunscreen composition and method
US6413961B1 (en) * 1995-12-12 2002-07-02 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain and inflammation
WO1998024428A1 (en) * 1996-12-02 1998-06-11 Brigham & Women's Hospital, Inc. Long-acting local anesthetics
WO1999011252A2 (en) * 1997-09-03 1999-03-11 Nortran Pharmaceuticals, Inc. N,n-bis (phenylcarbamoylmethyl) dimethylammonium chloride and derivatives in the treatment of pain
US6362197B1 (en) * 1998-06-09 2002-03-26 Cardiome Pharma Corp. Compositions and method for treatment of cough
WO2001044218A1 (en) * 1999-12-15 2001-06-21 Ucb Farchim S.A. Quaternary salts of n-substituted cyclic or acyclic amines as pharmaceuticals
WO2001045678A2 (de) * 1999-12-21 2001-06-28 Id Pharma Gmbh Arzneimittel, verfahren zu dessen herstellung und dessen verwendung
WO2006010587A1 (en) * 2004-07-24 2006-02-02 Laboratorios Del Dr. Esteve, S.A. Use of compounds active on the sigma receptor for the treatment of mechanical allodynia

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CAHALAN M D ET AL: "Interactions between quaternary lidocaine, the sodium channel gates, and tetrodotoxin.", BIOPHYSICAL JOURNAL JUL 1979, vol. 27, no. 1, July 1979 (1979-07-01), pages 39 - 55, XP002486709, ISSN: 0006-3495 *
KIRKPATRICK W E ET AL: "Comparison of the effects of procaine, chlorpromazine and their quaternary derivatives on nerve action potentials.", RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY JAN 1970, vol. 1, no. 1, January 1970 (1970-01-01), pages 149 - 155, XP009102648, ISSN: 0034-5164 *
NIELSEN A B ET AL: "Assessment of the combined approach of N-alkylation and salt formation to enhance aqueous solubility of tertiary amines using bupivacaine as a model drug", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, ELSEVIER, AMSTERDAM, NL, vol. 24, no. 1, 1 January 2005 (2005-01-01), pages 85 - 93, XP027803616, ISSN: 0928-0987, [retrieved on 20050101] *
NIELSEN A B ET AL: "Bioreversible quaternary N-acyloxymethyl derivatives of the tertiary amines bupivacaine and lidocaine-synthesis, aqueous solubility and stability in buffer, human plasma and simulated intestinal fluid", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, ELSEVIER, AMSTERDAM, NL, vol. 24, no. 5, 1 April 2005 (2005-04-01), pages 433 - 440, XP027803766, ISSN: 0928-0987, [retrieved on 20050401] *
OMANA-ZAPATA I ET AL: "QX-314 inhibits ectopic nerve activity associated with neuropathic pain.", BRAIN RESEARCH 17 OCT 1997, vol. 771, no. 2, 17 October 1997 (1997-10-17), pages 228 - 237, XP002486707, ISSN: 0006-8993 *
RICH T C ET AL: "Quaternary quinidine derivatives as a tool to study: Block of human potassium channels", BIOPHYSICAL JOURNAL, vol. 66, no. 2 PART 2, 1994, & THIRTY-EIGHTH ANNUAL MEETING OF THE BIOPHYSICAL SOCIETY; NEW ORLEANS, LOUISIANA, USA; MARCH 6-10, 1994, pages A143, XP009102646, ISSN: 0006-3495 *
STRICHARTZ G R: "The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine.", THE JOURNAL OF GENERAL PHYSIOLOGY JUL 1973, vol. 62, no. 1, July 1973 (1973-07-01), pages 37 - 57, XP002486708, ISSN: 0022-1295 *

Also Published As

Publication number Publication date
JP2010510227A (ja) 2010-04-02
EP2425858A3 (de) 2012-03-28
CA2668652C (en) 2018-06-12
ES2402789T3 (es) 2013-05-08
JP2018039788A (ja) 2018-03-15
EP2101819B1 (de) 2013-01-09
EP2446903B1 (de) 2019-10-09
US20150087714A1 (en) 2015-03-26
WO2008063603A2 (en) 2008-05-29
US20170319517A1 (en) 2017-11-09
JP5926301B2 (ja) 2016-05-25
CA2668652A1 (en) 2008-05-29
CN103933572A (zh) 2014-07-23
KR20090082507A (ko) 2009-07-30
AU2007322033B2 (en) 2013-07-11
JP2016185955A (ja) 2016-10-27
EP2425858A2 (de) 2012-03-07
JP2014111626A (ja) 2014-06-19
EP2101819A2 (de) 2009-09-23
US20100099772A1 (en) 2010-04-22
US10179116B2 (en) 2019-01-15
AU2007322033A2 (en) 2009-07-16
CN103933572B (zh) 2017-10-13
DK2101819T3 (da) 2013-04-29
WO2008063603A3 (en) 2008-12-11
AU2007322033A1 (en) 2008-05-29
US20210186906A1 (en) 2021-06-24
CA3002443A1 (en) 2008-05-29
US9603817B2 (en) 2017-03-28
EP2446903A2 (de) 2012-05-02
KR20140097446A (ko) 2014-08-06

Similar Documents

Publication Publication Date Title
EP2446903A3 (de) Verfahren, Zusammensetzungen und Kits zur Behandlung von Schmerzen und Juckreiz
WO2008049930A3 (en) A method for profiling kinase inhibitors
MX2010009951A (es) Metodos, composiciones y kits para tratar dolor y prurito.
WO2007130646A3 (en) Hcv coreceptor and methods of use thereof
BRPI0605921B8 (pt) compostos orgânicos, seus métodos de preparo e uso, bem como composições farmacêuticas
EA200501724A1 (ru) Соединения, специфичные к меланокортиновым рецепторам
BRPI0906104B8 (pt) derivado de ácido peptonucleico, composição farmacêutica contendo uma quantidade terapeuticamente eficaz do derivado de ácido peptonucleico, método de utilização do derivado de ácido peptonucleico e composto
WO2005092066A8 (en) Imidazole compounds
NZ609344A (en) Method for treatment of diarrhea-predominant irritable bowel syndrome
EA200870029A1 (ru) Способ применения антагонистов il-6 с ингибиторами протеасом
TW200716622A (en) Substituted piperidines
AU2009236256A8 (en) Small molecule inhibitors of the pleckstrin homology domain and methods for using same
WO2007028088A3 (en) Methods for enhancing the dewaterability of sludge with alpha-amylase treatment
WO2006078503A3 (en) Compositions for modulation of parp and methods for screening for same
EA200900635A1 (ru) Антагонисты прогестеронового рецептора
EP2101772A4 (de) Neuromuskuläre blocker mit mittlerer dauer und antagonisten advon
WO2007111948A3 (en) Inhibitors of protein prenyltransferases
WO2008156677A3 (en) Cyclic peptide melanocortin receptor ligands
WO2008038127A3 (en) Junctional adhesion molecule-c (jam-c) binding compounds and methods of their use
WO2007005780A3 (en) Compositions and methods for treating gastrointestinal hypomotility and associated disorders
WO2007018671A3 (en) Compositions and methods for treating conditions related to ephrin signaling with cupredoxins
UA101018C2 (ru) Пирролопиримидинкарбоксамиды
NO20072832L (no) Smertestillende middel
WO2008118319A3 (en) Mineralocorticoid receptor modulators
ATE538184T1 (de) Chromfreie, zinkarme, korrosionshemmende pigmentmischung, verfahren zu ihrer herstellung und ihre verwendung

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AC Divisional application: reference to earlier application

Ref document number: 2101819

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 29/00 20060101ALI20120618BHEP

Ipc: A61K 31/085 20060101ALI20120618BHEP

Ipc: A61K 31/167 20060101ALI20120618BHEP

Ipc: A61K 45/06 20060101AFI20120618BHEP

Ipc: A61K 31/165 20060101ALI20120618BHEP

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 45/06 20060101AFI20121005BHEP

Ipc: A61K 31/165 20060101ALI20121005BHEP

Ipc: A61K 31/167 20060101ALI20121005BHEP

Ipc: A61P 29/00 20060101ALI20121005BHEP

Ipc: A61K 31/085 20060101ALI20121005BHEP

REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1169953

Country of ref document: HK

17P Request for examination filed

Effective date: 20130514

17Q First examination report despatched

Effective date: 20160104

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Ref document number: 602007059352

Country of ref document: DE

Free format text: PREVIOUS MAIN CLASS: A61K0045060000

Ipc: A61K0031085000

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 31/14 20060101ALI20190410BHEP

Ipc: A61K 31/165 20060101ALI20190410BHEP

Ipc: A61P 17/04 20060101ALI20190410BHEP

Ipc: A61P 29/00 20060101ALI20190410BHEP

Ipc: A61K 9/00 20060101ALI20190410BHEP

Ipc: A61K 45/06 20060101ALI20190410BHEP

Ipc: A61K 31/085 20060101AFI20190410BHEP

Ipc: A61K 31/167 20060101ALI20190410BHEP

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTG Intention to grant announced

Effective date: 20190520

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

AC Divisional application: reference to earlier application

Ref document number: 2101819

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602007059352

Country of ref document: DE

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 1187972

Country of ref document: AT

Kind code of ref document: T

Effective date: 20191115

REG Reference to a national code

Ref country code: NL

Ref legal event code: MP

Effective date: 20191009

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 1187972

Country of ref document: AT

Kind code of ref document: T

Effective date: 20191009

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20200210

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20200110

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20200109

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20200224

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 602007059352

Country of ref document: DE

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG2D Information on lapse in contracting state deleted

Ref country code: IS

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20191119

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20191130

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20191130

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20200209

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20191130

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

26N No opposition filed

Effective date: 20200710

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200603

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20191209

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20191119

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20191130

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20071119

Ref country code: MT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191009

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230505

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1169953

Country of ref document: HK

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20231127

Year of fee payment: 17