EP1877195A1 - Multi-stage coating device for moulded bodies - Google Patents
Multi-stage coating device for moulded bodiesInfo
- Publication number
- EP1877195A1 EP1877195A1 EP06742531A EP06742531A EP1877195A1 EP 1877195 A1 EP1877195 A1 EP 1877195A1 EP 06742531 A EP06742531 A EP 06742531A EP 06742531 A EP06742531 A EP 06742531A EP 1877195 A1 EP1877195 A1 EP 1877195A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- drum
- moldings
- segment
- coating
- coating device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D1/00—Processes for applying liquids or other fluent materials
- B05D1/02—Processes for applying liquids or other fluent materials performed by spraying
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/0002—Processes of manufacture not relating to composition and compounding ingredients
- A23G3/0063—Coating or filling sweetmeats or confectionery
- A23G3/0089—Coating with atomised liquid, droplet bed, liquid spray
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/005—Coating of tablets or the like
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B13/00—Machines or plants for applying liquids or other fluent materials to surfaces of objects or other work by spraying, not covered by groups B05B1/00 - B05B11/00
- B05B13/02—Means for supporting work; Arrangement or mounting of spray heads; Adaptation or arrangement of means for feeding work
- B05B13/0221—Means for supporting work; Arrangement or mounting of spray heads; Adaptation or arrangement of means for feeding work characterised by the means for moving or conveying the objects or other work, e.g. conveyor belts
- B05B13/025—Means for supporting work; Arrangement or mounting of spray heads; Adaptation or arrangement of means for feeding work characterised by the means for moving or conveying the objects or other work, e.g. conveyor belts the objects or work being present in bulk
- B05B13/0257—Means for supporting work; Arrangement or mounting of spray heads; Adaptation or arrangement of means for feeding work characterised by the means for moving or conveying the objects or other work, e.g. conveyor belts the objects or work being present in bulk in a moving container, e.g. a rotatable foraminous drum
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C3/00—Apparatus in which the work is brought into contact with a bulk quantity of liquid or other fluent material
- B05C3/02—Apparatus in which the work is brought into contact with a bulk quantity of liquid or other fluent material the work being immersed in the liquid or other fluent material
- B05C3/04—Apparatus in which the work is brought into contact with a bulk quantity of liquid or other fluent material the work being immersed in the liquid or other fluent material with special provision for agitating the work or the liquid or other fluent material
- B05C3/08—Apparatus in which the work is brought into contact with a bulk quantity of liquid or other fluent material the work being immersed in the liquid or other fluent material with special provision for agitating the work or the liquid or other fluent material the work and the liquid or other fluent material being agitated together in a container, e.g. tumbled
Definitions
- the invention relates to a device according to the preamble of claim 1. It is a quasi-continuous coating device for coating moldings, especially for pharmaceutical products, such as tablets, dragees, pellets and granules.
- the coating device comprises a rotating coating drum, which is subdivided by a transport element into several segments, wherein the supply of process media for all segments can be done individually and depending on the stage of the coating process and the molded body by means of this transport element in the axial direction through the Drum be transported.
- this transport element is shaped as a spindle.
- the invention also relates to an associated method or the use of the device.
- the coating layer is thus adjusted very precisely in pharmaceuticals, often not several different coating layers are required to meet all the above requirements. Furthermore, due to regulatory requirements, the concentrations and masses of all substances per single tablet must be kept within very narrow tolerances, so that previously continuous processes were hardly realized. Essentially, two systems are described in the prior art, both of which work batchwise.
- the first system is a kind of rotating pan or kettle with a generally central opening through which the moldings are filled.
- the heap of moldings is formed by the rotation of the pan in a continuous flow and roll held and over nozzles with a coating medium, usually a liquid, evenly sprayed.
- a coating medium usually a liquid, evenly sprayed.
- the axis of rotation of the boiler is oriented at an angle of approx. 30-50 ° to the horizontal, so that the boiler opening points diagonally upwards.
- volatile constituents are filtered off with suction and then the coated and moist shaped bodies are dried.
- EP 0 088 317 A1 discloses such a system in which the shaped bodies are sprayed with coating medium via nozzles which are attached to a fixed pipe, the pipe projecting through the free opening into the interior of the boiler.
- the suction and drying is realized by a grating, which is mounted inside the boiler and is covered as far as possible by the debris in the filled state even during the rotation.
- the suction line of the device according to EP 0 088 317 A1 is also guided by the aforementioned boiler opening to the outside.
- a comparable device is also disclosed in DE 27 31 351 A1, FR 2 222 957 A1 or in DE 24 23 933 A1. In this first system, the fully coated charge is discharged from the supply lines through the one boiler opening after decoupling.
- the uncoated molded bodies are filled on one side or through a wall opening of a coating drum or container.
- the coating drum rotates during the coating process about a substantially horizontal axis.
- EP 0 198 929 A1, DE 44 45 618 A1 or FR 2,053,554 A5 disclose such coating devices for shaped bodies.
- Another prior art coating apparatus provides multiple directions of movement of the drum and drum internals to hold the moldings in suspension.
- DE 31 49 421 A1 in conjunction with DE-2218729 A discloses such a device.
- the built in the drum mixing, stirring and conveying devices improve the mixing throughout the drum interior, but do not allow continuous production operation.
- a disadvantage of the known in the prior art devices for coating of pharmaceutical moldings is that these are all devices for batch processes that do not allow continuous or quasi-continuous operation and sometimes required multiple Um colllvorêtn are consuming, delay the Process and require expensive suction or encapsulation devices.
- Coating apparatus for coating moldings comprising a perforated drum accommodated in a housing, a mold body conduit for guiding the moldings into the interior of the drum, at least one fluid conduit and nozzles for spraying fluids inside the drum, wherein, in operation, the drum rotates about its horizontal axis to move the body heap.
- the coating device comprises at least one gas suction line to remove moisture and dust from the housing and drum interior of the coating device.
- the drum has several so-called. Segments (drum longitudinal sections), wherein the segments are formed by a transport element, and leads to at least one segment at least one fluid line, are arranged at which nozzles to spray the moldings within the segment. The number of segments is arbitrary and limited only by the mechanical requirements of the drum or the transport element and the other internals.
- the coating device comprises as a transport element, a cylindrical spiral or helix.
- the cylindrical spiral is rotatably mounted and the segments and the pitch of the cylindrical spiral are dimensioned such that by the rotation of the cylindrical spiral by a maximum of one revolution, the molded body of a segment completely moved into the respective subsequent segment or from the coating device be transported out.
- the radius of the cylindrical spiral is ideally chosen such that a small gap remains between the inner side of the drum and the outer edge of the cylindrical spiral, which gap is less than or equal to half the smallest diameter of the shaped bodies to be coated. way smaller than one-fifth of this diameter is.
- the separating element is arranged in a grinding manner in the drum.
- the rotation of the drum and the cylindrical spiral with respect to rotational direction and speed of each other completely independent.
- the segments in the interior of the drum in the region of the axis of rotation are connected to each other by a through opening.
- each individual segment can be supplied with one or more process media independently of the adjacent segment.
- An improved embodiment of the invention is that in at least one segment, one or more mixer elements are arranged, which are mounted so movable that they can be immersed in the bed of the moldings and lifted out of this bed. In the immersed position, these mixing elements produce a transverse mixing in the heap of shaped bodies moved by the rotation of the drum.
- the mixing element is fastened to the transport element, wherein it is shaped such that during the movement of the transport element and the associated transport of the shaped body in the axial direction, no shaped body is lifted out of the total drive ,
- a particular advantage of the invention is the fact that not a single molding can leave the respective segment via a short circuit flow before the end of a coating stage, which is very essential for pharmaceutical products.
- the individual stages within the coating process are just as sharply demarcated as in a known in the art batch device.
- the transition of the moldings in the next treatment stage or the discharge can be done with moving or stationary drum, wherein the cylindrical spiral is rotated by half a maximum or a full rotation, depending on the dimensioning of the segments.
- the invention further includes a process for coating spherical particles, in which the coating device according to the invention and described above is used.
- From the invention is further included to use the coating device according to the invention or the coating process for coating moldings, for manufacturing processes of pharmaceutical products or food.
- the coating device according to the invention can thus be directly connected to the tablet press and the subsequent primary packaging plant, such as a blister machine. This avoids intermediate storage with all the disadvantages of the break and the additional residence times. In particular, for highly effective substances such a closed process from granules to finished packaging can be realized.
- Fig. 1 shows the coating device 1 according to the invention, consisting of an outer housing 2 in which a rotatably mounted perforated drum 3 is arranged.
- an open cylindrical spiral 4 is further provided, which divides the drum interior into three segments A to C.
- the molded bodies 6 to be coated are introduced into the segment A via the molded body conduit 7 and, after complete treatment, leave the coating apparatus via the conduit 8 in all segments.
- FIG. 1 also shows an exhaust element 5 in the form of a shell, which faces a partial surface of the drum 3 with a very small gap width.
- This exhaust air element 5 is connected via the Gasabsaug réelle 9 with a vacuum pump, not shown, and sucks the moisture and dust from the interior of the housing 2 and especially the bed of moldings 6 on the perforated wall of the drum 3 to the outside.
- the moldings 6 are raised by the rotation of the drum 3 at the foot of the bed and rolls due to gravity, especially on the Haufwerksober Structure down, the lowest point of the drum 3 from.
- the exhaust air element 5 is shaped in such a way that it mainly covers completely the drum surface covered by the molded bodies 6 in operation from the rear side.
- nozzles 10 are arranged, which are supplied via a line 11 with fluid, wherein the line 11 in the example shown as an attachment for the nozzles 10 acts.
- the nozzles are arranged in the segments A and B, in which the coating liquid is applied to the moldings 6.
- the segment C the drying and cooling of the coated moldings 6, wherein in the example shown via a gas pressure line 14 and a gas outlet 13 targeted a suitable gas is passed into the segment C in order to optimize the drying and cooling process.
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Food Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Polymers & Plastics (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
- Spray Control Apparatus (AREA)
- Coating Apparatus (AREA)
Abstract
The invention relates to a quasi-continuously operating coating device for the coating of moulded bodies, in particular for pharmaceutical products, such as tablets, drops, pressed moldings and granulates. The coating device comprises a rotating coating drum, divided into several drum longitudinal sections by a transport element, whereby the introduction of the process medium for all segments occurs individually and depending on the appropriate stage of the coating process. The moulded bodies are conveyed through the drum in an axial direction by means of said transport element. In an ideal embodiment the transport element is in the form of a cylindrical screw.
Description
MEHRSTUFIGE COATINGVORRICHTUNG FÜR FORMKÖRPER MULTI-STAGE COATING DEVICE FOR MOLDING BODY
[0001] Die Erfindung betrifft eine Vorrichtung gemäß Oberbegriff von Anspruch 1. Es geht um eine quasi kontinuierlich arbeitende Coatingvorrichtung zur Beschichtung von Formkörpern, insbesondere für pharmazeutische Produkte, wie Tabletten, Dragees, Presslinge und Granulat. Dabei umfasst die Coatingvorrichtung eine rotierende Coa- tingtrommel, die durch ein Transportelement in mehrere Segmente unterteilt ist, wobei die Zuführung der Prozessmedien für alle Segmente einzeln und abhängig von der jeweiligen Stufe des Coatingprozesses erfolgen kann und die Formkörper mittels diesem Transportelement in axialer Richtung durch die Trommel befördert werden. In einer idea- len Ausführungsform ist dieses Transportelement als Spindel geformt. Die Erfindung betrifft auch ein zugehöriges Verfahren beziehungsweise die Verwendung der Vorrichtung.The invention relates to a device according to the preamble of claim 1. It is a quasi-continuous coating device for coating moldings, especially for pharmaceutical products, such as tablets, dragees, pellets and granules. In this case, the coating device comprises a rotating coating drum, which is subdivided by a transport element into several segments, wherein the supply of process media for all segments can be done individually and depending on the stage of the coating process and the molded body by means of this transport element in the axial direction through the Drum be transported. In an ideal embodiment, this transport element is shaped as a spindle. The invention also relates to an associated method or the use of the device.
[0002] Im Stand der Technik sind Vorrichtungen zum Überziehen von Tabletten, Dragees und Granulaten bekannt. Bei Lebensmitteln dient der Überzug von Produkten in der Regel dazu, das Produkt optisch zu verbessern, aber auch zur Optimierung der mechani- sehen Eigenschaften bei Lagerung oder Verzehr und zum Schutz gegen Luftfeuchtigkeit nach dem Öffnen der Verpackung.In the prior art devices for coating tablets, dragees and granules are known. In the case of food, the coating of products usually serves to visually improve the product, but also to optimize the mechanical properties during storage or consumption and to protect against atmospheric moisture after opening the packaging.
[0003] Für Pharmazeutika haben derartige Überzüge oder Coatings neben dem optischen und mechanisch-stabilisierenden Effekt, in der Regel auch physiologische Bedeutung, nämlich das sensorische Empfinden im Mund zu verbessern, das Verschlucken zu erleichtern, eine verlangsamte oder definierte Wirkstofffreigabe sicherzustellen oder die Tablette zu konservieren, bis beispielsweise der vorgesehene Wirkort im Magen-Darm- Trakt erreicht ist. Dabei werden in der Regel drei Behandlungsstufen durchlaufen: Entstauben und Aufwärmen, Besprühen und anschließendes Trocknen der Formkörper. Diese Behandlungsstufen werden in der Regel seriell nacheinander im gleichen Apparat durchgeführt.For pharmaceuticals such coatings or coatings in addition to the optical and mechanical stabilizing effect, usually also physiological significance, namely to improve the sensory perception in the mouth to facilitate swallowing, to ensure a slowed or defined drug release or the tablet conserve until, for example, the intended site of action in the gastrointestinal tract is reached. There are usually three treatment steps go through: Dusting and warming, spraying and subsequent drying of the moldings. These treatment stages are usually carried out serially one after the other in the same apparatus.
[0004] Die Coatingschicht ist bei Pharmazeutika somit sehr exakt einzustellen, wobei nicht selten mehrere unterschiedliche Coatingschichten erforderlich sind, um allen vorgenannten Anforderungen gerecht zu werden. Weiterhin sind aufgrund behördlicher Vorgaben die Konzentrationen und Massen aller Stoffe pro Einzeltablette in sehr engen ToIe- ranzen einzuhalten, so dass bisher kontinuierliche Prozesse kaum realisiert wurden. Im Stand der Technik sind im Wesentlichen zwei Systeme beschrieben, die beide batchwei- se arbeiten.The coating layer is thus adjusted very precisely in pharmaceuticals, often not several different coating layers are required to meet all the above requirements. Furthermore, due to regulatory requirements, the concentrations and masses of all substances per single tablet must be kept within very narrow tolerances, so that previously continuous processes were hardly realized. Essentially, two systems are described in the prior art, both of which work batchwise.
[0005] Das erste System ist eine Art rotierende Pfanne oder Kessel mit einer in der Regel zentralen Öffnung, über welche die Formkörper eingefüllt werden. Das Haufwerk aus Formkörpern wird durch die Rotation der Pfanne in einer ständigen Fließ- und Rollbewe-
gung gehalten und über Düsen mit einem Coatingmedium, in der Regel eine Flüssigkeit, gleichmäßig besprüht. Die Rotationsachse des Kessels ist beim Coatingvorgang in einem ca. 30-50° Winkel zur Horizontalen ausgerichtet, so dass die Kesselöffnung schräg nach oben weist. [0006] Zeitgleich oder im Anschluss an die Benetzung mit einem Fluid, werden flüchtige Bestandteile abgesaugt und dann die beschichteten und feuchten Formkörper getrocknet. EP 0 088 317 A1 offenbart ein derartiges System, bei welchem die Formkörper mit Coatingmedium über Düsen besprüht werden, welche an einem feststehenden Rohr angebrachten sind, wobei das Rohr durch die freie Öffnung in das Innere des Kessels ragt. Die Absaugung und Trocknung wird über ein Gitter realisiert, das im Inneren des Kessels angebracht und im befüllten Zustand auch während der Rotation weitestgehend vom Haufwerk überdeckt wird.The first system is a kind of rotating pan or kettle with a generally central opening through which the moldings are filled. The heap of moldings is formed by the rotation of the pan in a continuous flow and roll held and over nozzles with a coating medium, usually a liquid, evenly sprayed. During the coating process, the axis of rotation of the boiler is oriented at an angle of approx. 30-50 ° to the horizontal, so that the boiler opening points diagonally upwards. At the same time or following the wetting with a fluid, volatile constituents are filtered off with suction and then the coated and moist shaped bodies are dried. EP 0 088 317 A1 discloses such a system in which the shaped bodies are sprayed with coating medium via nozzles which are attached to a fixed pipe, the pipe projecting through the free opening into the interior of the boiler. The suction and drying is realized by a grating, which is mounted inside the boiler and is covered as far as possible by the debris in the filled state even during the rotation.
[0007] Die Saugleitung der Vorrichtung gemäß EP 0 088 317 A1 , ist ebenfalls durch die vorgenannte Kesselöffnung nach außen geführt. Eine vergleichbare Vorrichtung ist auch in DE 27 31 351 A1 , FR 2.222.957 A1 oder in der DE 24 23 933 A1 offenbart. Bei diesem ersten System, wird die vollständig gecoatete Charge nach Abkopplung von den Versorgungsleitungen durch die eine Kesselöffnung entleert.The suction line of the device according to EP 0 088 317 A1, is also guided by the aforementioned boiler opening to the outside. A comparable device is also disclosed in DE 27 31 351 A1, FR 2 222 957 A1 or in DE 24 23 933 A1. In this first system, the fully coated charge is discharged from the supply lines through the one boiler opening after decoupling.
[0008] Bei dem zweiten Coatingsystem, welches in wesentlichen Teilen identisch mit dem ersten ist, werden die ungecoateten Formkörper auf einer Seite oder durch eine Wandöffnung einer Coatingtrommel oder -Containers eingefüllt. Die Coatingtrommel rotiert beim Coatingvorgang um eine im Wesentlichen horizontale Achse. EP 0 198 929 A1 , DE 44 45 618 A1 oder FR 2.053.554 A5 offenbaren derartige Coatingvorrichtungen für Formkörper.In the second coating system, which is substantially identical to the first, the uncoated molded bodies are filled on one side or through a wall opening of a coating drum or container. The coating drum rotates during the coating process about a substantially horizontal axis. EP 0 198 929 A1, DE 44 45 618 A1 or FR 2,053,554 A5 disclose such coating devices for shaped bodies.
[0009] Eine weitere Coatingvorrichtung im Stand der Technik sieht mehrere Bewegungs- richtungen der Trommel und der Trommeleinbauten vor, um so die Formkörper in der Schwebe zu halten. DE 31 49 421 A1 in Verbindung mit der DE- 2218729 A offenbart eine derartige Vorrichtung. Die in der Trommel eingebauten Misch-, Rühr- und Fördereinrichtungen verbessern dabei die Durchmischung im gesamten Trommelinneren, ermöglichen aber keinen kontinuierlichen Produktionsbetrieb. [0010] Nachteilig an den im Stand der Technik bekannten Vorrichtungen zum Coating von pharmazeutischen Formkörpern ist, dass dies alles Vorrichtungen für Batch- Prozesse sind, die keinen kontinuierlichen oder quasi-kontinuierlichen Betrieb erlauben und die zum Teil erforderlichen mehrfachen Umfüllvorgängen sind aufwändig, verzögern den Prozess und erfordern aufwändige Absaugungs- oder Kapselungsvorrichtungen.
[0011] Somit ist eine Aufgabe der Erfindung eine Vorrichtung sowie ein Verfahren zur Verfügung zu stellen, welche auch bei einem mehrstufigen Coatingprozess die Durchlaufgeschwindigkeit des Produktes verbessert, ohne die Produktsicherheit, wie sie im Stand der Technik durch die batchweise Behandlung gegeben ist, herabzusetzen. [0012] Diese Aufgabe wird mit der Vorrichtung gemäß vorliegender Erfindung mit den Merkmalen des Anspruchs 1 bzw. 9 erreicht. Vorteilhafte Weiterentwicklungen des Verfahrens und der Vorrichtung gehen aus den abhängigen Ansprüchen hervor.[0009] Another prior art coating apparatus provides multiple directions of movement of the drum and drum internals to hold the moldings in suspension. DE 31 49 421 A1 in conjunction with DE-2218729 A discloses such a device. The built in the drum mixing, stirring and conveying devices improve the mixing throughout the drum interior, but do not allow continuous production operation. A disadvantage of the known in the prior art devices for coating of pharmaceutical moldings is that these are all devices for batch processes that do not allow continuous or quasi-continuous operation and sometimes required multiple Umfüllvorgängen are consuming, delay the Process and require expensive suction or encapsulation devices. Thus, it is an object of the invention to provide an apparatus and a method which, even in a multistage coating process, improves the flow rate of the product without degrading product safety as provided by batchwise treatment in the prior art. This object is achieved with the device according to the present invention having the features of claim 1 and 9, respectively. Advantageous developments of the method and the device are evident from the dependent claims.
[0013] Coatingvorrichtung zur Beschichtung von Formkörpern, umfassend eine in einem Gehäuse untergebrachte gelochte oder perforierte Trommel, eine Formkörper-Leitung, um die Formkörper in das Innere der Trommel zu leiten, mindestens eine Fluidleitung und Düsen zum Versprühen von Fluiden im Inneren der Trommel, wobei die Trommel im Betrieb um ihre horizontale Achse rotiert, um das Formkörperhaufwerk zu bewegen. Weiterhin umfasst die Coatingvorrichtung mindestens eine Gasabsaugleitung, um Feuchtigkeit und Stäube aus Gehäuse- und Trommelinnenraum der Coatingvorrichtung zu entfernen. [0014] Die Trommel weist dabei mehrere sog. Segmente (Trommellängsabschnitte) auf, wobei die Segmente durch ein Transportelement gebildet werden, und zu mindestens einem Segment mindestens eine Fluidleitung führt, an welcher Düsen angeordnet sind, um die Formkörper innerhalb des Segments anzusprühen. Die Anzahl der Segmente ist dabei beliebig und lediglich von den mechanischen Erfordernissen an die Trommel be- ziehungsweise des Transportelements und der sonstigen Einbauten begrenzt.Coating apparatus for coating moldings, comprising a perforated drum accommodated in a housing, a mold body conduit for guiding the moldings into the interior of the drum, at least one fluid conduit and nozzles for spraying fluids inside the drum, wherein, in operation, the drum rotates about its horizontal axis to move the body heap. Furthermore, the coating device comprises at least one gas suction line to remove moisture and dust from the housing and drum interior of the coating device. The drum has several so-called. Segments (drum longitudinal sections), wherein the segments are formed by a transport element, and leads to at least one segment at least one fluid line, are arranged at which nozzles to spray the moldings within the segment. The number of segments is arbitrary and limited only by the mechanical requirements of the drum or the transport element and the other internals.
[0015] Die Bewegung des Transportelements erfolgt dabei unabhängig von der Rotation der Trommel, wobei die Formkörper durch die Bewegung des Transportelementes in axialer Richtung in das nachfolgende Segment bzw. aus der Coatingvorrichtung heraus gefördert werden. [0016] In einer optimierten Ausführungsvariante umfasst die erfindungsgemäße Coatingvorrichtung als Transportelement eine zylindrische Spirale beziehungsweise Helix.The movement of the transport element takes place independently of the rotation of the drum, wherein the moldings are conveyed by the movement of the transport element in the axial direction in the subsequent segment or from the coating device out. In an optimized embodiment, the coating device according to the invention comprises as a transport element, a cylindrical spiral or helix.
[0017] Idealerweise ist die zylindrische Spirale rotierbar gelagert und die Segmente und die Steigung der zylindrische Spirale sind derart dimensioniert, dass durch die Rotation der zylindrische Spirale um maximal eine Umdrehung, die Formkörper eines Segments vollständig in das jeweils nachfolgende Segment verschoben beziehungsweise aus der Coatingvorrichtung heraus transportiert werden. Dabei ist der Radius der zylindrische Spirale idealerweise derart gewählt, dass zwischen Trommelinnenseite und der Außenkante der zylindrische Spirale ein geringer Spalt bleibt, welcher kleiner oder gleich der Hälfte des kleinsten Durchmessers der zu beschichtenden Formkörper ist und idealer-
weise kleiner als ein Fünftel dieses Durchmessers beträgt. In einer Ausführungsvariante der erfindungsgemäßen Vorrichtung ist das Trennelement schleifend in der Trommel angeordnet.Ideally, the cylindrical spiral is rotatably mounted and the segments and the pitch of the cylindrical spiral are dimensioned such that by the rotation of the cylindrical spiral by a maximum of one revolution, the molded body of a segment completely moved into the respective subsequent segment or from the coating device be transported out. The radius of the cylindrical spiral is ideally chosen such that a small gap remains between the inner side of the drum and the outer edge of the cylindrical spiral, which gap is less than or equal to half the smallest diameter of the shaped bodies to be coated. way smaller than one-fifth of this diameter is. In an embodiment variant of the device according to the invention, the separating element is arranged in a grinding manner in the drum.
[0018] Vorteilhafterweise ist die Rotation der Trommel und die der zylindrischen Spirale hinsichtlich Rotationsrichtung und -geschwindigkeit voneinander völlig unabhängig.Advantageously, the rotation of the drum and the cylindrical spiral with respect to rotational direction and speed of each other completely independent.
[0019] In einer verbesserten Ausführungsvariante der Coatingvorrichtung sind die Segmente im Inneren der Trommel im Bereich der Rotationsachse durch eine durchgehende Öffnung miteinander verbunden.In an improved embodiment of the coating apparatus, the segments in the interior of the drum in the region of the axis of rotation are connected to each other by a through opening.
[0020] Idealerweise kann jedes einzelne Segment unabhängig vom benachbarten Seg- ment, mit einem oder mehreren Prozessmedien versorgt werden.[0020] Ideally, each individual segment can be supplied with one or more process media independently of the adjacent segment.
[0021] Eine verbesserte Ausführungsvariante der Erfindung besteht darin, dass in mindestens einem Segment ein oder mehrere Mischerelemente angeordnet sind, welche derart beweglich gelagert sind, dass diese in die Schüttung der Formkörper eingetaucht und aus dieser Schüttung herausgehoben werden können. Dabei erzeugen diese Misch- elemente in der eingetauchten Position eine Quervermischung in dem durch die Rotation der Trommel bewegten Haufwerk von Formkörpern.An improved embodiment of the invention is that in at least one segment, one or more mixer elements are arranged, which are mounted so movable that they can be immersed in the bed of the moldings and lifted out of this bed. In the immersed position, these mixing elements produce a transverse mixing in the heap of shaped bodies moved by the rotation of the drum.
[0022] In einer weiter verbesserten Ausführungsvariante der Vorrichtung ist das Mischelement an dem Transportelement befestigt, wobei dieses derart geformt ist, dass bei der Bewegung des Transportelements und dem damit verbundenen Transport der Formkör- per in axialer Richtung, kein Formkörper aus dem Gesamthaufwerk gehoben wird.In a further improved embodiment variant of the device, the mixing element is fastened to the transport element, wherein it is shaped such that during the movement of the transport element and the associated transport of the shaped body in the axial direction, no shaped body is lifted out of the total drive ,
[0023] Somit ist ein besonderer Vorteil der Erfindung darin zu sehen, dass nicht ein einzelner Formkörper vor dem Ende einer Coatingstufe das jeweilige Segment über eine Kurzschlussströmung verlassen kann, was für Pharmaprodukte ganz wesentlich ist. Somit sind die einzelnen Stufen innerhalb des Coatingvorgangs genauso scharf abgegrenzt, wie bei einer im Stand der Technik bekannten Batch-Vorrichtung.Thus, a particular advantage of the invention is the fact that not a single molding can leave the respective segment via a short circuit flow before the end of a coating stage, which is very essential for pharmaceutical products. Thus, the individual stages within the coating process are just as sharply demarcated as in a known in the art batch device.
[0024] Die Überleitung der Formkörper in die nächste Behandlungsstufe oder der Austrag kann bei bewegter oder stehender Trommel erfolgen, wobei die zylindrische Spirale um eine halbe oder maximal eine ganze Rotation gedreht wird, abhängig von der Dimensionierung der Segmente. [0025] Vorteilhafterweise ist durch diesen in sich sehr geschlossenen und vereinfachten Transportvorgang, ein Einsatz in Reinräumen stark erleichtert, da keine zusätzlichen E- missionen bei der Überführung der Formkörper von einer Behandlungsstufe in die nachfolgende auftreten.
[0026] Weiterhin ist von der Erfindung ein Verfahren zum Coating von sphärischen Teilchen umfasst, bei welchem die erfindungsgemäße und vorstehend beschriebenen Coa- tingvorrichtung eingesetzt wird.The transition of the moldings in the next treatment stage or the discharge can be done with moving or stationary drum, wherein the cylindrical spiral is rotated by half a maximum or a full rotation, depending on the dimensioning of the segments. Advantageously, by this in itself very closed and simplified transport process, a use in clean rooms greatly facilitated because no additional e-missions occur in the transfer of the moldings from one treatment stage in the subsequent. [0026] The invention further includes a process for coating spherical particles, in which the coating device according to the invention and described above is used.
[0027] Von der Erfindung ist weiterhin eingeschlossen, die erfindungsgemäße Coating- Vorrichtung oder das Coatingverfahren zum Beschichten von Formkörpern, für Herstellungsverfahren von pharmazeutischen Produkten oder Lebensmitteln zu verwenden.From the invention is further included to use the coating device according to the invention or the coating process for coating moldings, for manufacturing processes of pharmaceutical products or food.
[0028] Die erfindungsgemäße Coatingvorrichtung kann somit direkt mit der häufig davor liegenden Tablettenpresse und der nachfolgenden Primärverpackungsanlage, wie einer Blistermaschine, verbunden werden. Damit werden Zwischenlagerungen mit allen Nachteilen des Bruches und der zusätzlichen Verweilzeiten vermieden. Insbesondere für höchstwirksame Substanzen kann so ein geschlossener Prozess vom Granulat bis zur fertigen Verpackung realisiert werden.The coating device according to the invention can thus be directly connected to the tablet press and the subsequent primary packaging plant, such as a blister machine. This avoids intermediate storage with all the disadvantages of the break and the additional residence times. In particular, for highly effective substances such a closed process from granules to finished packaging can be realized.
[0029] Gleichzeitig werden die Nachteile einer echten kontinuierlichen Fertigung vermieden, da immer definierte Teilchargen vorliegen, womit genaue Sprühmengen und defi- nierte Zeiten realisiert werden können.At the same time, the disadvantages of a true continuous production are avoided since there are always defined partial charges, with which precise spray quantities and defined times can be realized.
[0030] Der Erfindungsgegenstand wird in der Zeichnung anhand einer Ausführungsvariante beispielhaft näher beschrieben. In der Zeichnung zeigt die Fig. 1 die erfindungsgemäße Coatingvorrichtung 1, bestehend aus einem äußeren Gehäuse 2 in welchem eine drehbar gelagerte perforierte Trommel 3 angeordnet ist. In der Trommel 3 ist weiterhin eine offene zylindrische Spirale 4 vorgesehen, die den Trommelinnenraum in drei Segmente A bis C teilt. Die zu beschichtenden Formkörper 6 werden über die Formkörper- Leitung 7 in das Segment A eingefüllt und verlässt nach der vollständigen Behandlung in allen Segmenten über die Leitung 8 die Coatingvorrichtung.The subject invention is described in more detail by way of example in the drawing with reference to an embodiment. In the drawing, Fig. 1 shows the coating device 1 according to the invention, consisting of an outer housing 2 in which a rotatably mounted perforated drum 3 is arranged. In the drum 3, an open cylindrical spiral 4 is further provided, which divides the drum interior into three segments A to C. The molded bodies 6 to be coated are introduced into the segment A via the molded body conduit 7 and, after complete treatment, leave the coating apparatus via the conduit 8 in all segments.
[0031] In Fig. 1 ist weiterhin ein Abluftelement 5 in Form einer Schale dargestellt, wel- ches einer Teilfläche der Trommel 3 mit sehr geringer Spaltweite gegenüberliegt. Dieses Abluftelement 5 ist über die Gasabsaugleitung 9 mit einer nicht dargestellten Vakuumpumpe verbunden und saugt die Feuchtigkeit und den Staub aus dem Inneren des Gehäuses 2 und vor allem der Schüttung aus Formkörpern 6 über die perforierte Wand der Trommel 3 nach außen. [0032] Im Betrieb der Coatingvorrichtung 1 werden die Formkörper 6 durch die Rotation der Trommel 3 am Fuß der Schüttung angehoben und rollt aufgrund der Schwerkraft vor allem auf der Haufwerksoberfläche nach unten, dem tiefsten Punkt der Trommel 3 ab. Das Abluftelement 5 ist derart geformt, dass es vorrangig die von den Formkörpern 6 im Betrieb überdeckte Trommelfläche von der Rückseite vollständig überdeckt.
[0033] Im zentralen achsnahen Raum 12 der Trommel 3, in welchen die Wände der zylindrische Spirale 4 nicht hinein ragen, sind Düsen 10 angeordnet, die über eine Leitung 11 mit Fluid versorgt werden, wobei die Leitung 11 im gezeigten Beispiel auch als Befestigung für die Düsen 10 fungiert.FIG. 1 also shows an exhaust element 5 in the form of a shell, which faces a partial surface of the drum 3 with a very small gap width. This exhaust air element 5 is connected via the Gasabsaugleitung 9 with a vacuum pump, not shown, and sucks the moisture and dust from the interior of the housing 2 and especially the bed of moldings 6 on the perforated wall of the drum 3 to the outside. In operation of the coating device 1, the moldings 6 are raised by the rotation of the drum 3 at the foot of the bed and rolls due to gravity, especially on the Haufwerksoberfläche down, the lowest point of the drum 3 from. The exhaust air element 5 is shaped in such a way that it mainly covers completely the drum surface covered by the molded bodies 6 in operation from the rear side. In the central near-axis space 12 of the drum 3, in which the walls of the cylindrical spiral 4 do not protrude, nozzles 10 are arranged, which are supplied via a line 11 with fluid, wherein the line 11 in the example shown as an attachment for the nozzles 10 acts.
[0034] Die Düsen sind in den Segmenten A und B angeordnet, in welchen die Coa- tingflüssigkeit auf die Formkörper 6 gebracht wird. Im Segment C erfolgt die Trocknung und Abkühlung der gecoateten Formkörper 6, wobei in dem gezeigten Beispiel über eine Gasdruckleitung 14 und einen Gasauslass 13 gezielt ein geeignetes Gas in das Segment C geleitet wird, um den Trocknungs- und Kühlvorgang zu optimieren.The nozzles are arranged in the segments A and B, in which the coating liquid is applied to the moldings 6. In the segment C, the drying and cooling of the coated moldings 6, wherein in the example shown via a gas pressure line 14 and a gas outlet 13 targeted a suitable gas is passed into the segment C in order to optimize the drying and cooling process.
BezugszeichenlisteLIST OF REFERENCE NUMBERS
1 Coatingvorrichtung1 coating device
2 Gehäuse2 housings
3 Trommel3 drum
4 Spirale4 spiral
5 Abluftelement5 exhaust air element
6 Formkörper/-schüttung6 shaped body / fill
7 Formkörper-Leitung7 molded body pipe
8 Formkörper-Leitung8 molded body pipe
9 Gasabsaugleitung9 Gas suction line
10 Düse10 nozzles
11 Fluidleitung11 fluid line
12 achsnaher Raum12 near-axis space
13 Gasauslass13 gas outlet
14 Gasdruckleitung A - C Segmente der Trommel
14 Gas pressure line A - C Segments of the drum
Claims
PATENTANSPRÜCHE
1) Coatingvorrichtung zur Beschichtung von Formkörpern, umfassend eine in einem Gehäuse untergebrachte, gelochte oder perforierte Trommel, eine Formkörper- Leitung, um die Formkörper in das innere der Trommel zu leiten, mindestens eine Fluidleitung und Düsen zum Versprühen von Fluiden im Inneren der Trommel sowie mindestens eine Gasabsaugleitung, wobei die Trommel im Betrieb um ihre horizontale Achse rotiert, wobei der Gehäuse- und Trommelinnenraum über die Gasabsaugleitung absaugbar ist,1) Coating apparatus for coating moldings, comprising a perforated drum housed in a housing, a mold body conduit for guiding the moldings into the interior of the drum, at least one fluid conduit and nozzles for spraying fluids inside the drum and at least one Gasabsaugleitung, wherein the drum rotates in operation about its horizontal axis, wherein the housing and drum interior is sucked through the Gasabsaugleitung,
dadurch gekennzeichnet, dasscharacterized in that
■ die Trommel von einer Vorrichtung zum Transport der Formkörper in mehrere Segmente (Trommellängsabschnitte) aufgeteilt wird,Is divided ■ the drum of a device for transport of the molded body into a plurality of segments (drum longitudinal sections),
■ zu mindestens einem Segment mindestens eine Fluidleitung führt, an welcher Düsen angeordnet sind, mit denen die Formkörper im Segment ansprühbar sind, wobei Leading to at least one segment at least one fluid line to which nozzles are arranged, with which the moldings are sprayed in the segment, wherein
■ die Trommel unabhängig von der Bewegung der Vorrichtung zum Transport der Formkörper rotierbar ist, und ■ the drum is rotatable independently of the movement of the device for transporting the moldings, and
■ die Formkörper durch die Bewegung der Transportvorrichtung in Richtung der Trommelachse in das nachfolgende Segment beziehungsweise aus der Coatingvorrichtung heraus transportierbar sind. ■ the shaped bodies by the movement of the transport device in the direction of the drum axis in the subsequent segment are respectively transported from the coating device out.
2) Coatingvorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass die Vorrichtung zum Transport der Formkörper als zylindrische Spirale ausgebildet ist.2) Coating device according to claim 1, characterized in that the device for transporting the shaped body is designed as a cylindrical spiral.
3) Coatingvorrichtung nach Anspruch 2, dadurch gekennzeichnet, dass die zylindrische Spirale rotierbar gelagert ist und die Formkörper eines Segmentes durch die Rotation der zylindrische Spirale um maximal eine Umdrehung in das jeweils nächstfolgende Segment verschoben beziehungsweise aus der Coatingvorrichtung heraus transportiert werden.3) Coating device according to claim 2, characterized in that the cylindrical spiral is rotatably mounted and the shaped body of a segment by the rotation of the cylindrical spiral by a maximum of one revolution in the respective next segment shifted or transported out of the coating device out.
4) Coatingvorrichtung nach einem der Ansprüche 2 oder 3, dadurch gekennzeichnet, dass die Rotation der Trommel und die der zylindrischen Spirale hinsichtlich Rotationsrichtung und Rotationsgeschwindigkeit voneinander unabhängig erfolgen können.
5) Coatingvorrichtung nach einem der Ansprüche 1 bis 4, dadurch gekennzeichnet, dass die Vorrichtung zum Transport der Formkörper schleifend in der Trommel angeordnet ist.4) Coating device according to one of claims 2 or 3, characterized in that the rotation of the drum and that of the cylindrical spiral with respect to rotational direction and rotational speed can be independent of each other. 5) Coating device according to one of claims 1 to 4, characterized in that the device for transporting the moldings is arranged to be abrasive in the drum.
6) Coatingvorrichtung nach einem der Ansprüche 2 bis 4, dadurch gekennzeichnet, dass zwischen Trommelinnenseite und der Außenkante der zylindrischen Spirale ein Spalt bleibt, welcher kleiner oder gleich der Hälfte des kleinsten Durchmessers der zu beschichtenden Formkörper ist und idealerweise kleiner als ein Fünftel dieses Durchmessers ist.6) Coating device according to one of claims 2 to 4, characterized in that between the drum inner side and the outer edge of the cylindrical spiral, a gap remains, which is less than or equal to half the smallest diameter of the molded body to be coated and ideally less than one fifth of this diameter ,
7) Coatingvorrichtung nach einem der Ansprüche 1 bis 6, dadurch gekennzeichnet, dass jedes einzelne Segment, unabhängig vom benachbarten Segment, mit einem oder mehreren Prozessmedien versorgt werden kann.7) Coating device according to one of claims 1 to 6, characterized in that each individual segment, regardless of the adjacent segment, can be supplied with one or more process media.
8) Coatingvorrichtung nach einem der Ansprüche 1 bis 7, dadurch gekennzeichnet, dass in mindestens einem Segment ein oder mehrere Mischerelemente angeordnet sind, welche derart beweglich gelagert sind, dass diese in die Schüttung der Formkörper eingetaucht und herausgehoben werden können.8) Coating device according to one of claims 1 to 7, characterized in that in at least one segment, one or more mixer elements are arranged, which are mounted so movable that they can be immersed in the bed of the moldings and lifted out.
9) Verfahren zum Beschichten von Formkörpern wie Dragees, Tabletten, Pastillen oder dergleichen, wobei eine Coatingvorrichtung gemäß einem der vorstehenden Ansprüche eingesetzt wird, und in einem ersten Schritt die Formkörper in das erste Segment eingefüllt werden, in einem zweiten Schritt die Formkörper entsprechend den jeweiligen Erfordernissen mit Fluid benetzt werden, im dritten Schritt die Vorrichtung zum Transport der Formkörper maximal um eine ganze Umdrehung rotiert wird, wodurch das erste Segment entleert und die Formkörper in das zweite Segment in Richtung der Achse verschoben werden, im vierten Schritt das erste Segment gemäß dem ersten Schritt erneut befüllt wird, während im zweiten Segment die Formkörper entsprechend den jeweiligen Erfordernissen erneut mit Fluid benetzt beziehungsweise gekühlt oder erwärmt werden, wobei Luft oder ein Gas direkt in das Segment geleitet oder durch die Perforation der Trommelwand angesaugt und über die Formkörper geleitet wird, im fünften Schritt die Vorrichtung zum Transport der Formkörper erneut um maximal eine ganze Umdrehung rotiert wird, wodurch die Formkörper des zweiten Segments in das dritte und die Formkörper des ersten Segments in das zweite ge-
leitet werden, und der erste bis zum vierten Schritt beliebig häufig wiederholt werden, wobei die Formkörper im letzten Segment der Coatingvorrichtung aus der Trommel hinausgeleitet werden, und während des Verfahrens die Trommel rotiert und der Innenraum der Coatingvorrichtung und das Trommelinnere über die Gasabsaugleitung abgesaugt werden.9) A method for coating shaped bodies such as dragees, tablets, lozenges or the like, wherein a coating apparatus is used according to any one of the preceding claims, and in a first step, the moldings are filled in the first segment, in a second step, the moldings corresponding to the respective Be wetted with fluid, in the third step, the device for transporting the moldings is rotated a maximum of one revolution, whereby the first segment is emptied and the moldings are moved in the second segment in the direction of the axis, in the fourth step, the first segment according to the the first step is refilled, while in the second segment, the moldings wetted or cooled or heated according to the respective requirements again with fluid, wherein air or a gas passed directly into the segment or sucked through the perforation of the drum wall and passed over the moldings w In the fifth step, the device for transporting the moldings is again rotated by a maximum of one complete revolution, whereby the moldings of the second segment are rotated into the third and the moldings of the first segment into the second mold. and the first to fourth steps are repeated as often as desired, the moldings being led out of the drum in the last segment of the coating apparatus, and during the process the drum is rotated and the inside of the coating apparatus and the inside of the drum are sucked out via the gas suction duct.
10) Verwendung der Coatingvorrichtung nach einem der Ansprüche 1 bis 8, dadurch gekennzeichnet, dass die Coatingvorrichtung für Herstellungsverfahren von pharmazeutischen Produkten eingesetzt wird.10) Use of the coating device according to one of claims 1 to 8, characterized in that the coating device is used for manufacturing processes of pharmaceutical products.
11) Verwendung der Coatingvorrichtung nach einem der Ansprüche 1 bis 8, dadurch gekennzeichnet, dass die Coatingvorrichtung für Herstellungsverfahren von Lebensmitteln eingesetzt wird.
11) Use of the coating device according to one of claims 1 to 8, characterized in that the coating device is used for manufacturing processes of food.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005020992A DE102005020992B3 (en) | 2005-05-03 | 2005-05-03 | Multi-stage coating device for moldings |
PCT/EP2006/002993 WO2006117046A1 (en) | 2005-05-03 | 2006-04-01 | Multi-stage coating device for moulded bodies |
Publications (1)
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EP1877195A1 true EP1877195A1 (en) | 2008-01-16 |
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EP06742531A Withdrawn EP1877195A1 (en) | 2005-05-03 | 2006-04-01 | Multi-stage coating device for moulded bodies |
Country Status (7)
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US (1) | US20090220676A1 (en) |
EP (1) | EP1877195A1 (en) |
JP (1) | JP2008540072A (en) |
CN (1) | CN101193710A (en) |
DE (1) | DE102005020992B3 (en) |
MX (1) | MX2007013820A (en) |
WO (1) | WO2006117046A1 (en) |
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DE102005010005A1 (en) * | 2005-03-04 | 2006-12-28 | Nunner, Dieter | Apparatus and method for coating small parts |
US7908992B2 (en) * | 2007-01-09 | 2011-03-22 | R.P. Scherer Technologies, Llc | System and method for dusting soft capsules |
DE102008001104A1 (en) * | 2008-04-10 | 2009-10-15 | Gebrüder Lödige Maschinenbau GmbH | Closed fully perforated coating drum |
US20100092694A1 (en) * | 2008-10-14 | 2010-04-15 | Ulf Bohlmann | Method for coating objects |
IT1392568B1 (en) * | 2008-12-24 | 2012-03-09 | Soremartec Sa | METHOD AND MACHINE FOR CONTINUOUS COATING OF SOURCES OF PRODUCTS, IN PARTICULAR, SWEET PRODUCTS |
IT1401362B1 (en) * | 2010-06-10 | 2013-07-18 | Soremartec Sa | METHOD FOR COATING SOURCES OF SWEET PRODUCTS |
CN103044134B (en) * | 2012-12-10 | 2014-08-20 | 金正大生态工程集团股份有限公司 | Device for carrying out anti-floating treatment on and adding microelements to coated controlled-release fertilizer, and working method of device |
CN105944875B (en) * | 2016-06-21 | 2018-07-20 | 上海平耐实业有限公司 | A kind of automatic painting device and its lackering method |
CN106694312A (en) * | 2017-02-28 | 2017-05-24 | 贾建胜 | Sealing ring lubricating device for household water purifier production |
CN107242600A (en) * | 2017-08-09 | 2017-10-13 | 李占福 | A kind of feed addictive coating device |
CN107625649B (en) * | 2017-10-10 | 2020-04-14 | 吉林农业科技学院 | Traditional chinese medicine pill ball coating device |
CN108654925B (en) * | 2018-05-11 | 2021-09-17 | 江苏武专科技有限公司 | Paint dipping device for small workpieces such as bolts |
CN111374890A (en) * | 2018-12-29 | 2020-07-07 | 甘肃康华制药机械设备有限公司 | Traditional Chinese medicine frying machine |
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GB1115517A (en) * | 1966-04-13 | 1968-05-29 | Plastic Coatings Ltd | Improvements in or relating to methods of and means for coating, cleaning or otherwise treating articles |
FR2053554A5 (en) * | 1969-07-08 | 1971-04-16 | Dumoulin Et Cie Ets | Variable tilt coating drum |
DE2218729B1 (en) * | 1972-04-18 | 1974-03-21 | Barmag Barmer Maschinenfabrik Ag, 5600 Wuppertal | DEVICE FOR MIXING AND GRANULATING |
DE2315882C3 (en) * | 1973-03-30 | 1975-10-23 | Glatt, Werner, 7859 Haltingen | Drying device for a coating drum |
DE2323194A1 (en) * | 1973-05-08 | 1974-11-28 | Driam Metallprodukt Gmbh & Co | DEVICE FOR THE CONTINUOUS PRODUCTION OF DRAGEES |
JPS5621466Y2 (en) * | 1976-10-05 | 1981-05-21 | ||
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DE3207869A1 (en) * | 1982-03-05 | 1983-09-15 | Boehringer Mannheim Gmbh, 6800 Mannheim | DEVICE FOR COATING A PACKAGE |
JPS60133838A (en) * | 1983-12-21 | 1985-07-17 | Takeda Chem Ind Ltd | Pan coater |
EP0198929A1 (en) * | 1983-12-21 | 1986-10-29 | Takeda Chemical Industries, Ltd. | Coating apparatus |
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FR2688710B1 (en) * | 1992-03-17 | 1995-09-29 | Rhone Poulenc Agrochimie | METHOD AND APPARATUS FOR CONTINUOUS TREATMENT OF PARTICLES. |
DE4445618C2 (en) * | 1994-12-21 | 1997-09-04 | Loedige Maschbau Gmbh Geb | Device for film coating and / or sugar coating |
DE102004004470A1 (en) * | 2003-08-01 | 2005-08-18 | Driam Anlagenbau Gmbh | Process for the continuous coating of cores with a coating device and separation chambers |
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2005
- 2005-05-03 DE DE102005020992A patent/DE102005020992B3/en not_active Expired - Fee Related
-
2006
- 2006-04-01 MX MX2007013820A patent/MX2007013820A/en unknown
- 2006-04-01 CN CNA2006800200853A patent/CN101193710A/en active Pending
- 2006-04-01 EP EP06742531A patent/EP1877195A1/en not_active Withdrawn
- 2006-04-01 JP JP2008509314A patent/JP2008540072A/en not_active Withdrawn
- 2006-04-01 WO PCT/EP2006/002993 patent/WO2006117046A1/en active Application Filing
- 2006-04-01 US US11/919,725 patent/US20090220676A1/en not_active Abandoned
Non-Patent Citations (1)
Title |
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US20090220676A1 (en) | 2009-09-03 |
MX2007013820A (en) | 2008-02-05 |
JP2008540072A (en) | 2008-11-20 |
WO2006117046A1 (en) | 2006-11-09 |
DE102005020992B3 (en) | 2006-12-14 |
CN101193710A (en) | 2008-06-04 |
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