EP1671897B1 - Reservoir d'evacuation dote d'un filtre - Google Patents
Reservoir d'evacuation dote d'un filtre Download PDFInfo
- Publication number
- EP1671897B1 EP1671897B1 EP20040817116 EP04817116A EP1671897B1 EP 1671897 B1 EP1671897 B1 EP 1671897B1 EP 20040817116 EP20040817116 EP 20040817116 EP 04817116 A EP04817116 A EP 04817116A EP 1671897 B1 EP1671897 B1 EP 1671897B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- filter
- inner layer
- bottle
- outer layer
- discharging
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000007788 liquid Substances 0.000 claims abstract description 35
- 238000007599 discharging Methods 0.000 claims abstract description 23
- 238000001914 filtration Methods 0.000 claims abstract description 15
- 239000012080 ambient air Substances 0.000 claims description 11
- 238000011144 upstream manufacturing Methods 0.000 abstract description 5
- 238000010030 laminating Methods 0.000 abstract description 2
- 239000003570 air Substances 0.000 description 14
- 239000004033 plastic Substances 0.000 description 5
- 229920003023 plastic Polymers 0.000 description 5
- 239000011148 porous material Substances 0.000 description 5
- 238000000071 blow moulding Methods 0.000 description 4
- 239000006196 drop Substances 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 230000002093 peripheral effect Effects 0.000 description 3
- 230000000903 blocking effect Effects 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000004417 polycarbonate Substances 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- 229920003002 synthetic resin Polymers 0.000 description 2
- 239000000057 synthetic resin Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- -1 polyethylene terephthalate Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000013341 scale-up Methods 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D47/00—Closures with filling and discharging, or with discharging, devices
- B65D47/04—Closures with discharging devices other than pumps
- B65D47/20—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge
- B65D47/2018—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D23/00—Details of bottles or jars not otherwise provided for
- B65D23/02—Linings or internal coatings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D47/00—Closures with filling and discharging, or with discharging, devices
- B65D47/04—Closures with discharging devices other than pumps
- B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
- B65D47/18—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages for discharging drops; Droppers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D47/00—Closures with filling and discharging, or with discharging, devices
- B65D47/40—Closures with filling and discharging, or with discharging, devices with drip catchers or drip-preventing means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/0055—Containers or packages provided with a flexible bag or a deformable membrane or diaphragm for expelling the contents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
- A61J1/145—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using air filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
- A61J1/1456—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using liquid filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1468—Containers characterised by specific material properties
Definitions
- the present invention relates to a discharging container with a filter, which is suitable for use as an aseptic eyedropper, according to the preamble of claim 1.
- These prior aseptic eyedroppers have a bottle which contains a squeezable outer layer with a laminated inner layer peelable from the outer layer, and a plug body mounted onto the opening of the bottle.
- the plug body has a discharging channel to discharge the liquid kept in a body portion of the inner layer.
- There is a distribution valve and a filter in the discharging channel and this distribution valve consists of a flange, a valve head, and a connector sleeve, and is integrally molded from elastic materials such as silicon rubber.
- the valve head has an orifice incised in a crisscross manner on its center position; the connector sleeve has a flexible structure, which has a relatively thin wall which can be easily deformed.
- the distribution valve is elastically deformed so as to displace the valve head downstream and open the orifice at the same time, so that the liquid flows down from the filter to the downstream side and the content is dribbled. Also, when the pressure in the body portion of the inner layer is eliminated, the distribution valve is re-deformed so that the liquid staying in the discharging channel is sucked back to the upperstream of the filter by displacing the valve head to the upperstream with the orifice closed. This prevents the possibility of the liquid in the body portion being outerly contaminated.
- the object of the present invention is to provide a discharging container with a filter, which is able to drop the content with precision by sucking back the liquid staying in the downstream of the filter to the upperstream of the filter without so-called "airlock", moreover, to enable cost reduction.
- the present invention is a discharging container with a filter comprising a bottle which is formed in a manner wherein an inner layer, peelable from an outer layer, is formed on an inner surface of the outer layer, a plug body placed on a mouth portion of the bottle, and a filter provided in a discharging pass which is provided in the plug body for discharging liquid kept in a body of the inner layer provided, wherein said inner layer has a memory which expands the inner layer in a manner wherein the difference between an inner negative pressure and the ambient air is higher than the filtration resistance of the filter, and wherein the negative pressure is caused by the memory of the inner layer and by that liquid remained in a second side of the filter is sucked into a primary side of the filter.
- the inner layer is deformed, so that the liquid inside is dropped from the body through the discharging pass. Also, by stopping pushing the body of the bottle, the negative pressure is caused by the memory of the inner layer and by that, liquid remained in the second side (lower stream of discharging) of the filter is sucked into the primary side (upper stream of discharging) of the filter.
- the negative pressure is caused by the memory of the inner layer and by that, liquid remained in the second side (lower stream of discharging) of the filter is sucked into the primary side (upper stream of discharging) of the filter.
- the discharging container with a filter of the present invention is preferably formed wherein said filter has hydrophilicity.
- the liquid inside is filled in the filter, so that it is possible to prevent the ambient air from entering the upper stream side of the filter without fail.
- the elastic memory of the inner layer is preferably formed in a manner wherein the difference between the inner pressure of the inner layer and the ambient air is lower than the resistance, in which the air is able to pass through the filter filled with the liquid inside. That can prevent the air from entering in to the upper stream of the filter more surely.
- the body of the inner layer is made from synthetic resin, the average thickness of the body is over 0.1mm, more preferably, over 0.35mm, and the average thickness of the body is less than 0.5mm, more preferably, less than 0.4mm.
- the inner layer can be formed to have a desired elastic-memory.
- the composition in which the outer layer has an entry opening to bring the outside air in between the outer layer and the inner layer.
- the ambient air flows in through the entry opening and the pressure between the outer layer and the inner layer becomes the ambient pressure, so that the difference of the pressure between the upper stream of the filter and the lower stream of the filter caused by the elastic-memory of the inner layer can be in the desired range without fail.
- Figs. 1 and 2 illustrate an eyedropper as a laminated bottle with an outer layer and an inner layer according to an embodiment of the present invention.
- This eyedropper 10 has a laminated film-peeling bottle 11, which is produced by blow molding from a laminated parison and composed of the inner layer and the outer layer, a plug body 12, which is fixed on a mouth portion 11a of the bottle 11, and a protection cap 13. It is formed in a manner whereby when a user detaches the cap 13, makes the laminated bottle 11 resupinate, and squeezes the body portion 11b by pushing, eye drops (fluids) are dropped from a point nozzle part 15 through a discharging pass inside of the plug body 12.
- Said laminated bottle 11 has a laminated structure composed of an outer layer bottle 1 (squeezing bottle) which composes the outer layer and an inner layer bag 16 (fluids storing bag) which composes the inner layer.
- an outer layer bottle 1 squeeze bottle
- an inner layer bag 16 fluids storing bag
- both the outer layer bottle 1 and the inner layer bag 16 have a cylindrical mouth portion and a flat body portion from the cross sectional view.
- the outer layer bottle 1 may be molded from a PET (viz., polyethylene terephthalate), and PC (viz. polycarbonate) or like synthetic resin. Additionally, the mouth portion of the bag 16 forms an opening for discharging liquid.
- the outer bottle 1 is formed in a manner wherein a cylindrical mouth portion 4 is provided at an upper end of a body portion 2, which is resiliently squeezable and formed in a cylindrical shape with a bottom, through a shoulder portion 3 whose diameter is getting smaller as it goes upwards.
- a peripheral wall of the body portion 2 is constituted in a shape of a long flat circle, in which the before-and-behind width is smaller than the right-and-left width of the body portion 2, from a pair of before and behind rigid wall parts 5 facing each other having a specified distance and right and left flexible connecting wall parts 6, which connect either side of edge parts of these rigid wall parts 5.
- Each rigid wall part 5 (before-and-behind wall parts) has a rectangular shape of which the long side is in an up and down direction in a front view, and almost flat in a cross-section in a vertical-section. However, it may be unnecessary to be perfectly flat and it may be slightly curved.
- Each flexible connecting wall part 6 (right-and-left wall parts) has an arc shape in which longitudinal center portion projects toward a right-and-left direction, and its curvature radius is smaller than the minor axis of the body portion 2.
- an upper end portion of each rigid wall part 5 is connected to the shoulder portion 3 through an upper flexible connecting part 7, and a lower end of each rigid wall part 5 is connected to a bottom portion 2a of the body 2 through a lower flexible connecting part 8. Therefore, a periphery of each rigid wall part 5 is surrounded only by said flexible parts 6, 7, and 8. Also before and behind rigid wall parts 5, the bottom portion 2a, and the shoulder portion 3 are connected integrally only by flexible parts 6, 7, and 8.
- the upper flexible connecting part 7 and the lower flexible connecting part 8 are located more outwardly than the rigid wall part 5 in the direction of before and behind. Therefore, when the bottle 1 is blow-molded from said plastic parison, the elongation rate of the plastic becomes larger and each connecting part 7 and 8 is formed relatively thin-walled, so that the easily deformable flexibility is applied to these connecting parts 7 and 8. While the rigid wall part 5 is formed thick-walled, so that the difficult-to-deform rigidity is applied to the wall part 5. It is preferable to compose average wall thickness of these connecting parts 7 and 8 to be thinner than half of the average wall thickness of the rigid wall part 5.
- horizontal width of the body 2 of the squeeze bottle 1 is 1.5 times larger than the longitudinal width (i.e. the distance between the outside surface of the before and behind rigid wall parts 5), at the time of the blow molding. Also the elongation rate of the plastic at the portion which forms right and left flexible connecting wall parts 6, so that the average wall thickness of right and left flexible connecting wall parts 6 is thinner than the average wall thickness of the rigid wall part 5. Further, at the stage of the parison for blow molding, it is possible to make the thickness of the portion which forms the rigid wall part 5 thicker than the thickness of the portion which forms the flexible connecting part.
- the outer layer bottle 1 is composed in the aforementioned manner, when the before and behind rigid wall parts 5 are made close to each other till the distance between the center portion of the top-to-bottom direction of the before and behind rigid wall parts 5 becomes half by pressing the center portion with two fingers, the right and left connecting parts 6 and the upper and lower connecting parts 7 and 8 are deformed in their elastic region in a manner wherein the upper and lower edges of the rigid wall part 5 move following the said center.
- an entry opening 17 for leading ambient air to the room between the body portion of the bottle 2 and a body 16a of the inner layer bag 16 is bored at the center portion of the both top-to-bottom and right-to-left direction of the front side of the rigid wall part 5 (front wall part) of the outer layer bottle 1 of this embodiment.
- This entry opening 17 is formed from the opening going through the outer layer bottle 1 from the inside to the outside, and not bored on the inner layer bag 16.
- a circular formed concave part 18 whose diameter is larger than the one of the entry opening 17 is formed on the center portion of the both top-to-bottom and right-to-left of the rigid wall part 5.
- This concave part 18 is formed in a manner wherein it is caved in the bottle, and the diameter of which is approximately 5mm.
- Aforementioned entry opening 17 is formed in the concave part 18.
- the entry opening 17 may be blocked by blocking the concave part 18 with a finger.
- the entry opening 17 doesn't have a check valve and constantly remains open, and the dimensions of this opening are approximately between 1mm 2 and 2mm 2 .
- an examination opening 19 which communicates with the entry opening 17 through the room between the outer layer bottle 1 and the inner layer bag 16 is bored on a midway portion of the top-to-bottom direction of a mouth portion 4.
- two examination openings 19 are formed at the points facing in the direction of the diameter.
- This examination opening 19 is also going through the outer layer bottle 1 from the inside to the outside, and not bored on the inner layer bag 16.
- This examination opening 19 is blocked up with a mouth 16a of the inner layer bag 16 from inside, so that air between the outer and inner layer 1 and 16 is prevented from going out from the examination opening 19 during use of the eyedropper 10.
- the mouth 16a of the inner layer bag 16 is pressed to the examination opening 19 by the after-mentioned inside plug 21.
- the examination opening 19 is blocked up with the inner layer bag 16 and the inside plug 21.
- the average thickness of the mouth 16a of the inner layer bag 16 is approximately 0.5mm.
- the body 16b of the inner layer bag 16 may have approximately 0.35 to 0.4mm average thickness, and it easily shrinks as the liquid inside decreases, however it also has an elastic-memory toward the direction of expanding.
- This elastic-memory of the body 16b of the inner layer bag 16 is set out in a manner wherein the difference between the pressure in the inner layer bag 16 and the ambient pressure is to be between 40hPa and 60hPa.
- the elastic-memory of the body 16b is set out to be bigger than the filtration resistance of the after-mentioned filter.
- the body 16b of the inner layer bag 16 has the elastic-memory wherein the body 16b is easily deformed under the pressure between 400hPa and 600hPa, which affects during the stage of the dropping by squeezing.
- the center of a bottom portion of the bag 16 is fixed to the center of the bottom portion of the outer layer bottle 1, so that the bottom portion of the bag 16 is prevented from being lifted.
- Aforementioned plug body 12 mainly includes an inside plug 21 fitted in the bottle mouth portion 4 and a nozzle cap 22 axially connected to the inside plug 21 and fitted around the bottle mouth portion 4.
- the inside plug 21 is such that a first cylindrical portion 21a with its proximal end abutting against a distal end surface of the bottle mouth portion 4, a flange 21c which is placed inwardly in the direction of the diameter on the abutting point of said first cylindrical portion 21a and the bottle mouth portion 4, and a second cylindrical portion which extends from inside of this flange 21c to upstream side, are integrally molded.
- the second cylindrical portion 21b is fitted in the bottle mouth portion 4 air tightly and fluid tightly.
- the second cylindrical portion 21b extends toward lower (upstream side) than the examination opening 19, and aforementioned examination opening 19 is closed air tightly from inside with this second cylindrical portion 21b.
- the nozzle cap 22 is a generally cylindrical member, which includes a top plate provided with the nozzle portion 15 at its axially distal end, and they are integrally molded.
- the first cylindrical portion 21a of the inside plug 21 is fitted in the inner peripheral wall of the nozzle cap 22.
- the nozzle cap 22 has a smaller diameter cylindrical portion provided in a distal outer peripheral portion thereof with a step.
- the protection cap 13 is threadingly fitted around the smaller diameter cylindrical portion.
- a filter 25 is provided in a lower surface of the top plate of the nozzle cap 22.
- This filter 25 comprises a filtration film 25a and an inner liquid holding member 25b provided in the primary side (upstream side) of the filter 25.
- the filter 25 include a hydrophilic porous planar film, a membrane filter, a sintered filter and a hydrophobic porous planar film, all of which are capable of preventing passage of pathogenic bacteria from a downstream side (outside) to an upstream side (inside).
- this filtration film 25a like such whose average diameter of the bore is between 0.1 ⁇ m and 0.3 ⁇ m are preferably adopted. More preferably, as the filtration film 25a, "Millipore Express Plus membrane filter" manufactured by Millipore Co. is adopted.
- This Millipore Express is like such of which the diameters of pores of the primary side and the second side are different.
- the average diameter of pores around a surface of the second side is approximately 0.22 ⁇ m and the diameter of pores becomes larger as it goes to the primary side.
- the inner liquid holding member 25b is made in a discotic shape from a silicone pad or the like and the microscopic pores (the diameter of which is from 10m to 0.1mm) on it are able to hold the liquid inside.
- a rim of this inner liquid holding member 25b may or may not abut on the end of the first cylindrical portion 21a of the inside plug 21. Also, it is not necessary to use said inner liquid holding member 25b, in the case wherein the inner liquid holding member is not used, it is preferable to provide a backup member (backstay member) to a back side of the filtration film 25a to prevent the filtration film 25a from being damaged.
- a backup member backstay member
- the filtration resistance of the filter 25 is preferably approximately between 10hPa and 50hPa and designed to be smaller than the difference between a negative pressure in the inner room, which is caused by the elastic-memory of the body 16a of the inner layer bag 16 and the ambient pressure.
- This design is available by, in concrete, molding multiples of laminated film-peeling bottles which differ from each other in their inner layer body thickness, carrying out the examination, and selecting the most preferable thickness which is agreeable to the shape and size of the plastic and the bottle used.
- the filter 25 (in the present embodiment, the whole of the filtration film and inner liquid holding member) is provided in a manner wherein the pressure for vacuuming the air from the lower side is between 689hPa and 4826hPa, and the resistance is higher than the difference between the inner pressure of the inner bag 16 caused by the elastic memory of the body 16b of the inner bag 16, and the ambient air pressure. Additionally, the difference between the inner pressure of the inner bag 16, caused by the elastic memory of the inner layer, is smaller than the one at the bubble point of the filter 25 (and the filtration film 25a).
- a communicating channel 22a which communicates with the nozzle part 15 is provided on the lower surface of the top plate of the nozzle cap 22.
- the liquid inside flowing from the filter 22 is provided to the nozzle part 15 through the communicating channel 22a.
- This communicating channel 22a comprises a first channel which radiates outwardly from the nozzle part 15 in the basal plane view, and multiples of circular second channels whose center is the nozzle part 15.
- the user makes the laminated bottle 11 resupinate, and squeezes the body portion 2 of the outer layer bottle 1 by pushing in a manner wherein the entry opening 17 is closed by a finger, so that the air between the inner and outer layer 1 and 16 is supercharged and the inner layer bag 16 is compressed.
- the liquid inside is dropped from the nozzle 15 through the filter 25.
- leaving the finger from the entry opening 17 lets in the ambient air between the inner and outer layer 1 and 16 thorough the entry opening 17. After that, the liquid staying inside of a pass in the nozzle (i.e.
- a discharging pass point opening is vacuumed to the upper stream side of the filter 25 caused by the elastic-memory of the inner layer bag 16.
- the liquid inside is sheltered from the ambient air by the filter 25.
- the filtration film 25a of the filter 25 is composed of a hydrophilic filter, it is possible to prevent the ambient air from entering into the inner layer since the ambient air cannot pass through the filter 25.
- the present invention is preferably used as an aseptic eyedropper.
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Closures For Containers (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
Abstract
Claims (2)
- Réservoir d'évacuation doté d'un filtre comprenant:- une bouteille qui est formée d'une manière où une couche intérieure (16) pelable d'une couche extérieure (1) est formée sur une surface intérieure de la couche extérieure;- un corps de bouchon (12) placé sur une portion de bouche (11a) de la bouteille (11); et- un filtre (25) pourvu dans un col de décharge qui est pourvu dans le corps de bouchon (12) pour décharger le liquide tenu dans un corps (16b) de la couche intérieure (16) pourvue;caractérisé en ce que ladite couche intérieure (16) présente une mémoire qui fait élargir la couche intérieure (16) d'une manière où une différence entre une pression négative intérieure et l'air ambiant est plus haute q'une résistance de filtration du filtre (25); et
que la pression négative est causée par la mémoire de la couche intérieure (16) et ainsi le liquide resté dans une secondaire partie du filtre (25) est aspiré dans une partie primaire du filtre (25). - Réservoir d'évacuation doté d'un filtre selon la revendication 1, où ledit filtre (25) présente l'hydrophilie.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003351313A JP4405775B2 (ja) | 2003-10-09 | 2003-10-09 | フィルター付き吐出容器 |
PCT/JP2004/013630 WO2005032965A1 (fr) | 2003-10-09 | 2004-09-17 | Reservoir d'evacuation dote d'un filtre |
Publications (3)
Publication Number | Publication Date |
---|---|
EP1671897A1 EP1671897A1 (fr) | 2006-06-21 |
EP1671897A4 EP1671897A4 (fr) | 2009-04-15 |
EP1671897B1 true EP1671897B1 (fr) | 2011-04-27 |
Family
ID=34419787
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP20040817116 Active EP1671897B1 (fr) | 2003-10-09 | 2004-09-17 | Reservoir d'evacuation dote d'un filtre |
Country Status (5)
Country | Link |
---|---|
US (1) | US20070028988A1 (fr) |
EP (1) | EP1671897B1 (fr) |
JP (1) | JP4405775B2 (fr) |
DE (1) | DE602004032453D1 (fr) |
WO (1) | WO2005032965A1 (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2897599B1 (fr) * | 2006-02-23 | 2010-08-27 | Rexam Pharma | Ensemble de conditionnement et de distribution de liquide. |
JP5224915B2 (ja) * | 2008-06-03 | 2013-07-03 | 大成化工株式会社 | フィルター付き吐出容器 |
JP5208876B2 (ja) * | 2009-07-31 | 2013-06-12 | 株式会社吉野工業所 | 二重容器 |
FR2963329B1 (fr) * | 2010-07-30 | 2013-06-28 | Thea Lab | Tete de distribution d'un liquide goutte a goutte |
JP5710226B2 (ja) * | 2010-11-26 | 2015-04-30 | 大成化工株式会社 | 点眼ノズル構造 |
FR2988015B1 (fr) * | 2012-03-19 | 2015-12-11 | Rexam Healthcare La Verpillier | Dispositif de distribution de liquide muni d'un capuchon amovible |
DK177651B1 (en) * | 2012-10-26 | 2014-02-03 | Mbh Internat A S | Method of preparing a ready-to-use urinary catheter and a catheter assembly for use in said method |
JP5988257B2 (ja) * | 2014-02-28 | 2016-09-07 | 株式会社悠心 | 滴下式包装体および滴下式包装構造体 |
JP7295393B2 (ja) * | 2019-03-27 | 2023-06-21 | キョーラク株式会社 | 積層剥離容器 |
EP3730101A1 (fr) * | 2019-04-26 | 2020-10-28 | Aptar Radolfzell GmbH | Capuchon de protection ventilé pour un distributeur de liquide |
US11931749B2 (en) * | 2022-08-03 | 2024-03-19 | Gerresheimer Boleslawiec Spolka Akcyjna | Dispenser for dispensing liquids |
US20240174413A1 (en) * | 2022-11-25 | 2024-05-30 | Chen Whua International Co., Ltd. | Water bottle cap |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2715980A (en) * | 1950-10-09 | 1955-08-23 | Leo M Harvey | Liquid handling dispenser |
US3010583A (en) * | 1959-10-23 | 1961-11-28 | Millipore Filter Corp | Fluid sampling device |
US3240399A (en) * | 1963-08-14 | 1966-03-15 | Ned W Frandeen | Dispensing receptacle |
US4020978A (en) * | 1975-08-15 | 1977-05-03 | Harry Szczepanski | Manually-operated dispenser |
US5012956A (en) * | 1989-08-07 | 1991-05-07 | Stoody William R | Squeeze bottle with bag, dispensing system |
US4978451A (en) * | 1989-09-05 | 1990-12-18 | Separation Dynamics, Inc. | Supported hydrophilic membrane |
US5158721A (en) * | 1989-11-30 | 1992-10-27 | Millipore Corporation | Porous membrane formed from interpenetrating polymer network having hydrophilic surface |
FR2661401B1 (fr) * | 1990-04-27 | 1992-07-24 | Transphyto Sa | Procede de conditionnement pour conserver et distribuer par portions du liquide sterile. |
US5497910A (en) * | 1994-05-05 | 1996-03-12 | Allergan, Inc. | Dropwise liquid dispensing system particularly suitable for liquids having low surface tension |
JP4485627B2 (ja) * | 1999-10-08 | 2010-06-23 | 大成化工株式会社 | 積層剥離ボトル、並びに、ポンプ容器 |
JP2002225910A (ja) * | 2001-01-26 | 2002-08-14 | Material Eng Tech Lab Inc | 液体容器 |
JP4749572B2 (ja) * | 2001-03-13 | 2011-08-17 | 大成化工株式会社 | 分与容器の口栓構造 |
-
2003
- 2003-10-09 JP JP2003351313A patent/JP4405775B2/ja not_active Expired - Lifetime
-
2004
- 2004-09-17 US US10/575,014 patent/US20070028988A1/en not_active Abandoned
- 2004-09-17 WO PCT/JP2004/013630 patent/WO2005032965A1/fr active Application Filing
- 2004-09-17 DE DE200460032453 patent/DE602004032453D1/de active Active
- 2004-09-17 EP EP20040817116 patent/EP1671897B1/fr active Active
Also Published As
Publication number | Publication date |
---|---|
JP2005111094A (ja) | 2005-04-28 |
US20070028988A1 (en) | 2007-02-08 |
WO2005032965A1 (fr) | 2005-04-14 |
DE602004032453D1 (de) | 2011-06-09 |
EP1671897A4 (fr) | 2009-04-15 |
EP1671897A1 (fr) | 2006-06-21 |
JP4405775B2 (ja) | 2010-01-27 |
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