EP1545596A4 - Utilisation de modulateurs du recepteur h4 de l'histamine pour le traitement des allergies et de l'asthme - Google Patents

Utilisation de modulateurs du recepteur h4 de l'histamine pour le traitement des allergies et de l'asthme

Info

Publication number
EP1545596A4
EP1545596A4 EP03794649A EP03794649A EP1545596A4 EP 1545596 A4 EP1545596 A4 EP 1545596A4 EP 03794649 A EP03794649 A EP 03794649A EP 03794649 A EP03794649 A EP 03794649A EP 1545596 A4 EP1545596 A4 EP 1545596A4
Authority
EP
European Patent Office
Prior art keywords
histamine
allergy
asthma
treatment
receptor modulators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03794649A
Other languages
German (de)
English (en)
Other versions
EP1545596A2 (fr
Inventor
Pragnya J Desai
Paul J Dunford
Claudia L Hofstra
Lars Karlsson
Wai-Ping Leung
Ping Ling
Robin L Thurmond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of EP1545596A2 publication Critical patent/EP1545596A2/fr
Publication of EP1545596A4 publication Critical patent/EP1545596A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP03794649A 2002-09-06 2003-09-05 Utilisation de modulateurs du recepteur h4 de l'histamine pour le traitement des allergies et de l'asthme Withdrawn EP1545596A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40873602P 2002-09-06 2002-09-06
US408736P 2002-09-06
PCT/US2003/027943 WO2004021999A2 (fr) 2002-09-06 2003-09-05 Utilisation de modulateurs du récepteur h4 de l'histamine pour le traitement des allergies et de l'asthme

Publications (2)

Publication Number Publication Date
EP1545596A2 EP1545596A2 (fr) 2005-06-29
EP1545596A4 true EP1545596A4 (fr) 2005-12-28

Family

ID=31978667

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03794649A Withdrawn EP1545596A4 (fr) 2002-09-06 2003-09-05 Utilisation de modulateurs du recepteur h4 de l'histamine pour le traitement des allergies et de l'asthme

Country Status (6)

Country Link
EP (1) EP1545596A4 (fr)
JP (1) JP2006510590A (fr)
AU (1) AU2003265961A1 (fr)
CA (1) CA2497788A1 (fr)
MX (1) MXPA05002577A (fr)
WO (1) WO2004021999A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1846409A1 (fr) * 2004-11-24 2007-10-24 Pfizer Limited Dérivés d' octahydropyrrolo[3,4-c]pyrrole
EP1671972A1 (fr) * 2004-11-24 2006-06-21 Pfizer Limited Dérivés d' octahydropyrrolo[3,4-c]pyrrole
WO2007117465A2 (fr) 2006-03-31 2007-10-18 Abbott Laboratories Composés d'indazole
US8492405B2 (en) * 2006-10-18 2013-07-23 Takeda Pharmaceutical Company Limited Glucokinase-activating fused heterocyclic compounds and methods of treating diabetes and obesity
KR100954138B1 (ko) * 2007-12-31 2010-04-20 부산대학교 산학협력단 지방조직 유래 줄기세포를 함유하는 알레르기 비염 또는천식 예방 및 치료제
EP2201982A1 (fr) 2008-12-24 2010-06-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Antagonistes du récepteur H4 de l'histamine pour le traitement de troubles vestibulaires
JP2012102017A (ja) * 2009-03-03 2012-05-31 Astellas Pharma Inc インドール化合物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002072548A2 (fr) * 2001-03-09 2002-09-19 Ortho-Mcneil Pharmaceutical, Inc. Composes heterocycliques
WO2003057919A2 (fr) * 2001-12-21 2003-07-17 Ortho-Mcneil Pharmaceutical, Inc. Utilisation de l'antagoniste du recepteur h4 de l'histamine pour traiter les reponses inflammatoires
WO2004022061A1 (fr) * 2002-09-06 2004-03-18 Janssen Pharmaceutica, N.V. Methode de traitement de rhinite allergique
WO2004022060A2 (fr) * 2002-09-06 2004-03-18 Janssen Pharmaceutica, N.V. Composes heterocycliques

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001085786A2 (fr) * 2000-05-05 2001-11-15 Wyeth Recepteur a l'histamine h4 humain
AU2001241713C1 (en) * 2000-05-31 2006-11-30 Ortho-Mcneil Pharmaceutical, Inc. DNAs encoding mammalian histamine receptor of the H4 subtype
GB0101223D0 (en) * 2001-01-17 2001-02-28 Pfizer Ltd Histamine receptor antagonists

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002072548A2 (fr) * 2001-03-09 2002-09-19 Ortho-Mcneil Pharmaceutical, Inc. Composes heterocycliques
WO2003057919A2 (fr) * 2001-12-21 2003-07-17 Ortho-Mcneil Pharmaceutical, Inc. Utilisation de l'antagoniste du recepteur h4 de l'histamine pour traiter les reponses inflammatoires
WO2004022061A1 (fr) * 2002-09-06 2004-03-18 Janssen Pharmaceutica, N.V. Methode de traitement de rhinite allergique
WO2004022060A2 (fr) * 2002-09-06 2004-03-18 Janssen Pharmaceutica, N.V. Composes heterocycliques

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HOFSTRA C L ET AL: "Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells.", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 305, no. 3, June 2003 (2003-06-01), pages 1212 - 1221, XP002352480, ISSN: 0022-3565 *
LIU C ET AL: "Comparison of human, mouse, rat and guinea pig histamine H4 receptors reveals substantial pharmacological species variation", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, AMERICAN SOCIETY FOR PHARMACOLOGY AND, US, vol. 299, no. 1, 2001, pages 121 - 130, XP009013631, ISSN: 0022-3565 *
O'REILLY M ET AL: "Identification of a histamine H4 receptor of human eosinophils - role in eosinophil chemotaxis", JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH, MARCEL DEKKER, NEW YORK, NY, US, vol. 22, no. 1-4, February 2002 (2002-02-01), pages 431 - 448, XP009047851, ISSN: 1079-9893 *
THURMOND R L ET AL: "A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 309, no. 1, 1 April 2004 (2004-04-01), pages 404 - 413, XP002352481, ISSN: 0022-3565 *

Also Published As

Publication number Publication date
EP1545596A2 (fr) 2005-06-29
JP2006510590A (ja) 2006-03-30
AU2003265961A1 (en) 2004-03-29
WO2004021999A2 (fr) 2004-03-18
WO2004021999A3 (fr) 2004-10-07
MXPA05002577A (es) 2005-09-20
CA2497788A1 (fr) 2004-03-18

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Effective date: 20051115

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Ipc: 7G 01N 33/53 B

Ipc: 7C 07K 16/00 B

Ipc: 7A 61K 47/00 B

Ipc: 7A 61K 39/00 A

RIN1 Information on inventor provided before grant (corrected)

Inventor name: THURMOND, ROBIN, L.

Inventor name: LING, PING

Inventor name: LEUNG, WAI-PING

Inventor name: KARLSSON, LARS

Inventor name: HOFSTRA, CLAUDIA, L.

Inventor name: DUNFORD, PAUL, J.

Inventor name: DESAI, PRAGNYA, J.

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Effective date: 20070305