EP1369430A3 - Two human G-Protein coupled receptors: EBV-induced GPCR 2(EBI-2) and EBG-1-like GPCR - Google Patents

Two human G-Protein coupled receptors: EBV-induced GPCR 2(EBI-2) and EBG-1-like GPCR Download PDF

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Publication number
EP1369430A3
EP1369430A3 EP03015456A EP03015456A EP1369430A3 EP 1369430 A3 EP1369430 A3 EP 1369430A3 EP 03015456 A EP03015456 A EP 03015456A EP 03015456 A EP03015456 A EP 03015456A EP 1369430 A3 EP1369430 A3 EP 1369430A3
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EP
European Patent Office
Prior art keywords
gpcr
protein coupled
human
ebg
ebi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03015456A
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German (de)
French (fr)
Other versions
EP1369430A2 (en
Inventor
Steven M. Ruben
Yi Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Human Genome Sciences Inc
Original Assignee
Human Genome Sciences Inc
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Filing date
Publication date
Application filed by Human Genome Sciences Inc filed Critical Human Genome Sciences Inc
Publication of EP1369430A2 publication Critical patent/EP1369430A2/en
Publication of EP1369430A3 publication Critical patent/EP1369430A3/en
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A human G-protein coupled receptor polypeptide and DNA (RNA) encoding this polypeptide and a procedure for producing said polypeptide by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the nucleic acid sequence of the G-protein coupled receptor.
EP03015456A 1997-05-07 1998-05-07 Two human G-Protein coupled receptors: EBV-induced GPCR 2(EBI-2) and EBG-1-like GPCR Withdrawn EP1369430A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/852,824 US6060272A (en) 1997-05-07 1997-05-07 Human G-protein coupled receptors
US852824 1997-05-07
EP98920965A EP1007670B1 (en) 1997-05-07 1998-05-07 Two human g-protein coupled receptors: ebv-induced gpcr 2 (ebi-2) and edg-1-like gpcr

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP98920965A Division EP1007670B1 (en) 1997-05-07 1998-05-07 Two human g-protein coupled receptors: ebv-induced gpcr 2 (ebi-2) and edg-1-like gpcr

Publications (2)

Publication Number Publication Date
EP1369430A2 EP1369430A2 (en) 2003-12-10
EP1369430A3 true EP1369430A3 (en) 2004-01-28

Family

ID=25314306

Family Applications (2)

Application Number Title Priority Date Filing Date
EP98920965A Expired - Lifetime EP1007670B1 (en) 1997-05-07 1998-05-07 Two human g-protein coupled receptors: ebv-induced gpcr 2 (ebi-2) and edg-1-like gpcr
EP03015456A Withdrawn EP1369430A3 (en) 1997-05-07 1998-05-07 Two human G-Protein coupled receptors: EBV-induced GPCR 2(EBI-2) and EBG-1-like GPCR

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP98920965A Expired - Lifetime EP1007670B1 (en) 1997-05-07 1998-05-07 Two human g-protein coupled receptors: ebv-induced gpcr 2 (ebi-2) and edg-1-like gpcr

Country Status (8)

Country Link
US (5) US6060272A (en)
EP (2) EP1007670B1 (en)
JP (1) JP2002508657A (en)
AT (1) ATE370233T1 (en)
CA (1) CA2289046A1 (en)
DE (1) DE69838254T2 (en)
ES (1) ES2289780T3 (en)
WO (1) WO1998050549A2 (en)

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US6060272A (en) * 1997-05-07 2000-05-09 Human Genome Sciences, Inc. Human G-protein coupled receptors
WO1999035106A2 (en) * 1997-12-30 1999-07-15 Nps Allelix Corp. Mammalian edg-7 receptor homologs
WO2000015784A2 (en) * 1998-09-11 2000-03-23 Max-Delbrück-Centrum für Molekulare Medizin Human and murine g-protein-coupled edg6 receptor (endothelial differentiation gene) and use of same
US20020156246A1 (en) * 1998-11-06 2002-10-24 Millennium Pharmaceuticals, Inc. 15625 receptor, a novel G-protein coupled receptor
ES2275358T3 (en) * 1998-11-06 2007-06-01 Bayer Healthcare Ag RECEPTORS COUPLED TO PROTEIN G, APPROVED TO GPCR 2 (EB1-2) INDUCED BY EBV. PROCEDURES FOR LOOKING FOR SIGNS OF THE SAME.
US20030017528A1 (en) 1998-11-20 2003-01-23 Ruoping Chen Human orphan G protein-coupled receptors
CA2645717A1 (en) * 1998-11-20 2000-06-02 Arena Pharmaceuticals, Inc. Human orphan g protein-coupled receptors
USRE42190E1 (en) 1998-11-20 2011-03-01 Arena Pharmaceuticals, Inc. Method of identifying a compound for inhibiting or stimulating human G protein-coupled receptors
US7816492B2 (en) 1998-11-20 2010-10-19 Arena Pharmaceuticals, Inc. Human G protein-coupled receptors
SE9804274D0 (en) * 1998-12-10 1998-12-10 Astra Pharma Inc Novel receptor
WO2001009321A1 (en) * 1999-07-29 2001-02-08 Helix Research Institute Gene encoding novel tsp1-like protein
WO2001009328A1 (en) 1999-08-03 2001-02-08 Millennium Pharmaceuticals, Inc. 15571, a novel gpcr-like molecule of the secretin-like family and uses thereof
WO2001036473A2 (en) * 1999-11-16 2001-05-25 Pharmacia & Upjohn Company Human g protein-coupled receptors
US20030082534A1 (en) * 1999-11-16 2003-05-01 Peter Lind Novel G protein-coupled receptors
CA2395416A1 (en) 1999-12-23 2001-06-28 Millennium Pharmaceuticals, Inc. P2y12 receptor
WO2001059113A2 (en) * 2000-02-08 2001-08-16 Curagen Corporation G-protein coupled receptor proteins and nucleic acids encoding same
EP1265925A2 (en) * 2000-02-23 2002-12-18 PHARMACIA & UPJOHN COMPANY G protein-coupled receptors
AU2001281933A1 (en) * 2000-06-30 2002-01-14 Ingenium Pharmaceuticals Ag Human g protein-coupled receptor igpcr17, and uses therof
US6790608B2 (en) * 2000-09-20 2004-09-14 The Regents Of The University Of California Methods of identifying and ADP-glucose receptor ligand, agonist or antagonist
DE60127435T2 (en) 2000-11-01 2007-11-29 Astellas Pharma Inc. METHOD FOR SCREENING A PLATFORM HEMMERS
US20070003980A1 (en) * 2001-03-27 2007-01-04 Woods Daniel F Efficient methods to isolate effectors of proteins involved in olfactory or chemosensory pathways and efficient methods to use these effectors to alter organism olfaction, chemosensation, or behavior
US20100248268A1 (en) * 2001-03-27 2010-09-30 Woods Daniel F Methods to utilize invertebrate chemosensory proteins for industrial and commercial uses
EP1381272B1 (en) * 2001-03-27 2009-04-29 Inscent, Inc. Efficient methods for isolating functional g-protein coupled receptors and identifying active effectors and efficient methods to isolate proteins involved in olfaction and efficient methods to isolate and identifying active effectors
WO2002079435A2 (en) * 2001-03-29 2002-10-10 Deltagen, Inc. Transgenic mice containing gpcr-like gene disruptions
GB0119920D0 (en) * 2001-08-15 2001-10-10 Pfizer Ltd New use
US7115724B2 (en) * 2001-08-22 2006-10-03 Wyeth Murine genomic polynucleotide sequence encoding a G-protein coupled receptor and methods of use therefor
US6977152B2 (en) * 2001-09-07 2005-12-20 Virtual Arrays, Inc. Biological assays using coded RNA reporters
US20030170744A1 (en) * 2002-03-05 2003-09-11 Beske Oren E. Multiplexed analysis of cellular responses using endogenous reporter genes
EP1523556A1 (en) * 2002-07-18 2005-04-20 Sri International Methods of treating conditions associated with an edg-1 receptor
US7220734B2 (en) 2002-12-20 2007-05-22 Merck & Co., Inc. 1-(amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles as Edg receptor agonists
JP2007275027A (en) * 2006-04-12 2007-10-25 Fujifilm Corp Method for diagnosing cancer using cancer-related deletion gene marker
JP5764071B2 (en) 2009-02-24 2015-08-12 エスバテック − ア ノバルティスカンパニー エルエルシー Methods for identifying immunobinders of cell surface antigens
US8791100B2 (en) 2010-02-02 2014-07-29 Novartis Ag Aryl benzylamine compounds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991015583A1 (en) * 1990-04-05 1991-10-17 The American National Red Cross A protein family related to immediate-early protein expressed by human endothelial cells during differentiation
WO1998048016A1 (en) * 1997-04-24 1998-10-29 Incyte Pharmaceuticals, Inc. Edg-1-like receptor
WO1999035106A2 (en) * 1997-12-30 1999-07-15 Nps Allelix Corp. Mammalian edg-7 receptor homologs

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AU5325694A (en) * 1992-11-25 1994-06-22 Brigham And Women's Hospital Epstein barr virus induced genes
US5585476A (en) * 1994-02-15 1996-12-17 Maclennan; Alexander J. Molecular cloning and expression of G-protein coupled receptors
US5834587A (en) * 1996-10-08 1998-11-10 Smithkline Beecham Corporation G-protein coupled receptor, HLTEX 11
US6060272A (en) * 1997-05-07 2000-05-09 Human Genome Sciences, Inc. Human G-protein coupled receptors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991015583A1 (en) * 1990-04-05 1991-10-17 The American National Red Cross A protein family related to immediate-early protein expressed by human endothelial cells during differentiation
WO1998048016A1 (en) * 1997-04-24 1998-10-29 Incyte Pharmaceuticals, Inc. Edg-1-like receptor
WO1999035106A2 (en) * 1997-12-30 1999-07-15 Nps Allelix Corp. Mammalian edg-7 receptor homologs

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 18 March 1997 (1997-03-18), "va16c04.r1 Soares mouse lymph node NbMLN Mus musculus cDNA clone IMAGE:723078 5', mRNA sequence.", XP002262738, Database accession no. AA254425 *

Also Published As

Publication number Publication date
DE69838254D1 (en) 2007-09-27
US6060272A (en) 2000-05-09
EP1007670A2 (en) 2000-06-14
EP1007670B1 (en) 2007-08-15
US20090104619A1 (en) 2009-04-23
DE69838254T2 (en) 2008-05-08
US6887683B1 (en) 2005-05-03
WO1998050549A2 (en) 1998-11-12
CA2289046A1 (en) 1998-11-12
ATE370233T1 (en) 2007-09-15
ES2289780T3 (en) 2008-02-01
WO1998050549A3 (en) 2000-04-06
US20050123961A1 (en) 2005-06-09
US20020052043A1 (en) 2002-05-02
JP2002508657A (en) 2002-03-19
EP1369430A2 (en) 2003-12-10

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