EP1003767A4 - Human tumor necrosis factor receptor tr10 - Google Patents

Human tumor necrosis factor receptor tr10

Info

Publication number
EP1003767A4
EP1003767A4 EP98925009A EP98925009A EP1003767A4 EP 1003767 A4 EP1003767 A4 EP 1003767A4 EP 98925009 A EP98925009 A EP 98925009A EP 98925009 A EP98925009 A EP 98925009A EP 1003767 A4 EP1003767 A4 EP 1003767A4
Authority
EP
European Patent Office
Prior art keywords
necrosis factor
tumor necrosis
factor receptor
human tumor
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98925009A
Other languages
German (de)
French (fr)
Other versions
EP1003767A1 (en
Inventor
Jian Ni
Craig A Rosen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Human Genome Sciences Inc
Original Assignee
Human Genome Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Human Genome Sciences Inc filed Critical Human Genome Sciences Inc
Publication of EP1003767A1 publication Critical patent/EP1003767A1/en
Publication of EP1003767A4 publication Critical patent/EP1003767A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to a novel protein, TR10, which is a member of the tumor necrosis factor (TNF) receptor superfamily and the TRAIL receptor subfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR10 protein. TR10 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR10 activity.
EP98925009A 1997-05-30 1998-05-29 Human tumor necrosis factor receptor tr10 Withdrawn EP1003767A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5093697P 1997-05-30 1997-05-30
US50936P 1997-05-30
US6911297P 1997-12-09 1997-12-09
US69112P 1997-12-09
PCT/US1998/010981 WO1998054202A1 (en) 1997-05-30 1998-05-29 Human tumor necrosis factor receptor tr10

Publications (2)

Publication Number Publication Date
EP1003767A1 EP1003767A1 (en) 2000-05-31
EP1003767A4 true EP1003767A4 (en) 2003-01-02

Family

ID=26728870

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98925009A Withdrawn EP1003767A4 (en) 1997-05-30 1998-05-29 Human tumor necrosis factor receptor tr10

Country Status (6)

Country Link
US (2) US6214580B1 (en)
EP (1) EP1003767A4 (en)
JP (1) JP2002511070A (en)
AU (1) AU7705198A (en)
CA (1) CA2292790A1 (en)
WO (1) WO1998054202A1 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7964190B2 (en) 1996-03-22 2011-06-21 Human Genome Sciences, Inc. Methods and compositions for decreasing T-cell activity
US6635743B1 (en) 1996-03-22 2003-10-21 Human Genome Sciences, Inc. Apoptosis inducing molecule II and methods of use
EP1003767A4 (en) 1997-05-30 2003-01-02 Human Genome Sciences Inc Human tumor necrosis factor receptor tr10
US6506569B1 (en) 1997-05-30 2003-01-14 Human Genome Sciences, Inc. Antibodies to human tumor necrosis factor receptor TR10
CA2295719A1 (en) * 1997-07-15 1999-01-28 Immunex Corporation Trail receptor
US20030143632A1 (en) * 1997-08-04 2003-07-31 Millennium Pharmaceuticals, Inc. Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic and other uses
DE69841176D1 (en) * 1997-08-26 2009-11-05 Genentech Inc Rtd receptor
US20030175856A1 (en) * 1997-08-26 2003-09-18 Genetech, Inc. Rtd receptor
CA2363779A1 (en) 1999-02-26 2000-08-31 Human Genome Sciences, Inc. Human endokine alpha and methods of use
WO2000073321A1 (en) * 1999-05-28 2000-12-07 Human Genome Sciences, Inc. Human tumor necrosis factor receptor tr10
WO2001012671A1 (en) * 1999-08-12 2001-02-22 Human Genome Sciences, Inc. Human tumor necrosis factor receptor tr16
AU2001259063A1 (en) 2000-04-12 2001-10-30 Human Genome Sciences, Inc. Albumin fusion proteins
AU2001282856A1 (en) 2000-06-15 2001-12-24 Human Genome Sciences, Inc. Human tumor necrosis factor delta and epsilon
AU6842701A (en) 2000-06-16 2002-01-14 Human Genome Sciences Inc Antibodies that immunospecifically bind to blys
KR100436089B1 (en) * 2000-07-06 2004-06-14 설대우 DNA cassette for the production of secretable recombinant trimeric TRAIL protein, Tetracycline/Doxycycline-inducible Adeno-associated virus(AAV), and combination of both and the gene therapy method thereof
CN100594935C (en) 2001-05-25 2010-03-24 人体基因组科学有限公司 Antibodies that immunospecifically bind to trail receptors
US20030059850A1 (en) * 2001-09-26 2003-03-27 Psychiatric Genomics, Inc. Fluorescence proximity assay
EP1463751B1 (en) 2001-12-21 2013-05-22 Human Genome Sciences, Inc. Albumin fusion proteins
WO2007142667A2 (en) 2005-10-13 2007-12-13 Human Genome Sciences, Inc. Treatment of patients with autoantibody positive disease
JP2009150799A (en) * 2007-12-21 2009-07-09 Sysmex Corp Analyzer, computer program, and analysis method
CN105624193B (en) 2008-09-26 2021-07-13 索元生物医药(美国)有限公司 Recombinant vector
WO2012068540A2 (en) 2010-11-19 2012-05-24 Toshio Imai Neutralizing anti-ccl20 antibodies
JP6419706B2 (en) 2012-10-25 2018-11-07 トカジェン インコーポレーテッド Retroviral vector containing a mini promoter cassette
LT2970473T (en) 2013-03-14 2017-10-25 Bristol-Myers Squibb Company Combination of dr5 agonist and anti-pd-1 antagonist and methods of use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998032856A1 (en) * 1997-01-28 1998-07-30 Human Genome Sciences, Inc. Death domain containing receptor 4 (dr4: death receptor 4), member of the tnf-receptor superfamily and binding to trail (ap02-l)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5705379A (en) * 1996-10-23 1998-01-06 Cornell Research Foundation, Inc. Nucleotide sequences encoding a thermostable alkaline protease
US6313269B1 (en) * 1997-03-14 2001-11-06 Smithkline Beecham Corporation Tumor necrosis factor related receptor, TR6
US6342369B1 (en) * 1997-05-15 2002-01-29 Genentech, Inc. Apo-2-receptor
EP1003767A4 (en) 1997-05-30 2003-01-02 Human Genome Sciences Inc Human tumor necrosis factor receptor tr10
CA2295719A1 (en) 1997-07-15 1999-01-28 Immunex Corporation Trail receptor
CA2299226A1 (en) 1997-08-06 1999-02-18 Millennium Biotherapeutics, Inc. Tango-71, tango-73, tango-74, tango-76, and tango-83 nucleic acid molecules and polypeptides
DE69841176D1 (en) 1997-08-26 2009-11-05 Genentech Inc Rtd receptor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998032856A1 (en) * 1997-01-28 1998-07-30 Human Genome Sciences, Inc. Death domain containing receptor 4 (dr4: death receptor 4), member of the tnf-receptor superfamily and binding to trail (ap02-l)

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
ADAMS M D ET AL: "INITIAL ASSESSMENT OF HUMAN GENE DIVERSITY AND EXPRESSION PATTERNS BASED UPON 83 MILLION NUCLEOTIDES OF CDNA SEQUENCE", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 377, AA345927, 28 September 1995 (1995-09-28), pages 3 - 17, XP002042918, ISSN: 0028-0836, Retrieved from the Internet <URL:EMBL> *
DATABASE EMBL [online] 18 April 1997 (1997-04-18), "EST52005 Gall bladder I Homo sapens cDNA 5' end", XP002217853, retrieved from EMBL Database accession no. AA345927 *
DATABASE EMBL [online] 18 March 1997 (1997-03-18), "EST86507 GSC127 cells I Homo sapeins cDNA 5' end", XP002217852, retrieved from EMBL Database accession no. AA374242 *
DEGLI ESPOSITI M A ET AL: "The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain", IMMUNITY, CELL PRESS, US, vol. 7, no. 6, 1 December 1997 (1997-12-01), pages 813 - 820, XP002087442, ISSN: 1074-7613 *
MARIAPIA A DEGLI-ESPOSTI ET AL: "Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 186, no. 7, 6 October 1997 (1997-10-06), pages 1165 - 1170, XP002083922, ISSN: 0022-1007 *
MENG R D ET AL: "The TRAIL Decoy Receptor TRUNDD (DcR2, TRAIL-R4) is induced by Adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis", MOLECULAR THERAPY, vol. 1, no. 2, - February 2000 (2000-02-01), pages 130-144, XP002217851 *
PAN G ET AL: "AN ANTAGONIST DECOY RECEPTOR AND A DEATH DOMAIN-CONTAINING RECEPTOR FOR TRAIL", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 277, 8 August 1997 (1997-08-08), pages 815 - 818, XP002065147, ISSN: 0036-8075 *
PAN G ET AL: "THE RECEPTOR FOR THE CYTOTOXIC LIGAND TRAIL", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 276, no. 5306, 4 April 1997 (1997-04-04), pages 111 - 113, XP000676684, ISSN: 0036-8075 *
See also references of WO9854202A1 *
SHERIDAN J P ET AL: "CONTROL OF TRAIL-INDUCED APOPTOSIS BY A FAMILY OF SIGNALING AND DECOY RECEPTORS", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 277, 8 August 1997 (1997-08-08), pages 818 - 821, XP002065023, ISSN: 0036-8075 *

Also Published As

Publication number Publication date
WO1998054202A1 (en) 1998-12-03
JP2002511070A (en) 2002-04-09
EP1003767A1 (en) 2000-05-31
AU7705198A (en) 1998-12-30
US6214580B1 (en) 2001-04-10
US6607726B1 (en) 2003-08-19
CA2292790A1 (en) 1998-12-03

Similar Documents

Publication Publication Date Title
EP1003767A4 (en) Human tumor necrosis factor receptor tr10
AU6250098A (en) Death domain containing receptor 4 (dr4: death receptor 4), member of the tnf-receptor superfamily and binding to trail (ap02-l)
WO1998030694A3 (en) TUMOR NECROSIS FACTOR RECEPTORS 6α AND 6$g(b)
CA2285040A1 (en) Death domain containing receptor 5
WO1998031818A3 (en) Tace-like and matrilysin-like polypeptides
AU9482498A (en) Interleukin-17 receptor-like protein
WO1998031806A3 (en) Fc receptors and polypeptides
AU6238698A (en) Tumor necrosis factor receptor 5
EP1015468A4 (en) Follistatin-3
WO1999035262A3 (en) Apoptosis inducing molecule ii
CA2266439A1 (en) Neutrokine .alpha.
AU6847896A (en) Human endokine alpha
WO2000066156A8 (en) Death domain containing receptor 5
WO2000067793A8 (en) Death domain containing receptor 4
WO2000043493A8 (en) Metalloproteinase adam 22
WO2000054651A3 (en) Human tumor necrosis factor receptor-like genes
WO2000056405A3 (en) Human tumor necrosis factor receptor-like 2
AU5166200A (en) Human tumor necrosis factor receptor tr10
WO1998027932A3 (en) Cerebellum and embryo specific protein
EP1655382A3 (en) Colon specific gene and protein
WO2000050620A3 (en) Human endokine alpha and methods of use
WO2001005834A9 (en) Human tumor necrosis factor receptors tr13 and tr14
WO1998025957A3 (en) Human prt1-like subunit protein (hprt1) and human eif4g-like protein (p97) genes
WO2001032128A3 (en) Human chemokine beta-13
WO2002018622A3 (en) TUMOR NECROSIS FACTOR RECEPTORS 6α AND 6$g(b)

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19991229

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 20021113

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

RA4 Supplementary search report drawn up and despatched (corrected)

Effective date: 20021125

RA4 Supplementary search report drawn up and despatched (corrected)

Effective date: 20021218

17Q First examination report despatched

Effective date: 20030929

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20061201